Environmental exposure, DNA methylation, and gene regulation: Lessons from diethylstilbesterol-induced cancers

Annals of the New York Academy of Sciences

Volumn 983, Issue , 2003, Pages 161-169

  Li, Shuanfang ^a   Hursting, Stephen D ^a   Davis, Barbara J ^b   McLachlan, John A ^c   Barrett, J Carl ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^c TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Carcinogenesis; Diethylstilbesterol; Estrogen; Methylation; Perinatal exposure

Indexed keywords

CATECHOL DERIVATIVE; CATECHOL METHYLTRANSFERASE; CHLORPHENOTANE; DIETHYLSTILBESTROL; DNA METHYLTRANSFERASE; EPIDERMAL GROWTH FACTOR; ESTROGEN RECEPTOR; GENOMIC DNA; HYDROXYL GROUP; LACTOFERRIN; MAGNESIUM; METHOXYCHLOR; PESTICIDE; PROTEIN P16; S ADENOSYLMETHIONINE; STRESS ACTIVATED PROTEIN KINASE; UVOMORULIN; XENOBIOTIC AGENT;

CANCER RISK; CANCER SUSCEPTIBILITY; CARCINOGENESIS; CHROMOSOME STRUCTURE; CHRONIC DISEASE; CONFERENCE PAPER; DEMETHYLATION; DNA METHYLATION; DNA SEQUENCE; ENVIRONMENTAL EXPOSURE; EPITHELIUM TUMOR; ESTROGEN RESPONSIVE ELEMENT; GENE CONTROL; GENE EXPRESSION REGULATION; GENITAL SYSTEM DISEASE; HUMAN; MOLECULAR STABILITY; NONHUMAN; NUTRITIONAL STATUS; ORGANOGENESIS; PERINATAL DRUG EXPOSURE; PROMOTER REGION; STRESS; UTERINE CERVIX CANCER; UTERUS TUMOR; VAGINA CANCER;

MAMMALIA;

EID: 0037356315     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2003.tb05971.x     Document Type: Conference Paper

References (62)

1. EHRLICH, M. et al. 1982. Amount and distribution of 5-methylcytosine in human DNA from different types of tissues of cells. Nucleic Acids Res. 10: 2709-2721.
2. BESTOR, T.H. 1988. Cloning of a mammalian DNA methyltransferase. Gene 74: 9-12.
3. XIE, S. et al. 1999. Cloning, expression and chromosome locations of the human DNMT3 gene family. Gene 236: 87-95.
4. BOUCHARD, J. & R.L. MOMPARLER. 1983. Incorporation of 5-Aza-2′-deoxycytidine-5′-triphosphate into DNA. Interactions with mammalian DNA polymerase alpha and DNA methylase. Mol. Pharmacol. 24: 109-114.
5. LAIRD, P.W. 1997. Oncogenic mechanisms mediated by DNA methylation. Mol. Med. Today 3: 223-229.
6. JONES, P.A. & P.W. LAIRD. 1999. Cancer epigenetics comes of age. Nat. Genet. 21: 163-167.
7. ESTELLER, M. & J.G. HERMAN. 2002. Cancer as an epigenetic disease: DNA methylation and chromatin alterations in human tumours. J. Pathol. 196: 1-7.
8. RAKYAN, V.K. et al. 2001. The marks, mechanisms and memory of epigenetic states in mammals. Biochem. J. 356: 1-10.
9. STOGER, R. et al. 1993. Maternal-specific methylation of the imprinted mouse Igf2r locus identifies the expressed locus as carrying the imprinting signal. Cell 73: 61-71.
10. ARIEL, M. et al. 1993. Allele-specific structures in the mouse lgf2-H19 domain. Cold Spring Harb. Symp, Quant. Biol. 58: 307-313.
11. TREMBLAY, K.D. et al. 1995. A paternal-specific methylation imprint marks the alleles of the mouse H19 gene. Nat. Genet. 9: 407-413.
12. KAFRI, T. et al. 1992. Developmental pattern of gene-specific DNA methylation in the mouse embryo and germ line. Genes Dev. 6: 705-714.
13. LI, E., T.H. BESTOR & R. JAENISCH. 1992. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 69: 915-926.
14. RAZIN, A. & T. KAFRI. 1994. DNA methylation from embryo to adult. Prog. Nucleic Acid Res. Mol. Biol. 48: 53-81.
15. RIGGS, A.D. & G.P. PFEIFER. 1992. X-chromosome inactivation and cell memory. Trends Genet. 8: 169-174.
16. ROBERTSON, K.D. & P.A. JONES. 2000. DNA methylation: past, present and future directions. Carcinogenesis 21: 461-467.
17. GAMA-SOSA, M.A. et al. 1983. Tissue-specific differences in DNA methylation in various mammals. Biochim. Biophys. Acta 740: 212-219.
18. MIZUNO, S. et al. 2001. Expression of DNA methyltransferases DNMT1, 3A, and 3B in normal hematopoiesis and in acute and chronic myelogenous leukemia. Blood 97: 1172-1179.
19. SAITO, Y. et al. 2001. Expression of mRNA for DNA methyltransferases and methyl-CpG-binding proteins and DNA methylation status on CpG islands and pericentromeric satellite regions during human hepatocarcinogenesis. Hepatology 33: 561-568.
20. TAO, L. et al. 2000. Hypomethylation and overexpression of c-jun and c-myc protooncogenes and increased DNA methyltransferase activity in dichloroacetic and trichloroacetic acid-promoted mouse liver tumors. Cancer Lett. 158: 185-193.
21. MOMPARLER, R.L. & V. BOVENZI. 2000. DNA methylation and cancer. J. Cell. Physiol. 183: 145-154.
22. ISSA, J.P. & S.B. BAYLIN. 1996. Epigenetics and human disease. Nat. Med. 2: 281-282.
23. JIRTLE, R.L. 1999. Genomic imprinting and cancer. Exp. Cell. Res. 248: 18-24.
24. HERBST, A.L., H. ULFELDER & D.C. POSKANZER. 1971. Adenocarcinoma of the vagina. Association of maternal stilbestrol therapy with tumor appearance in young women. N. Engl. J. Med. 284: 878-881.
25. HERBST, A.L., R.E. SCULLY & S.J. ROBBOY. 1979. Prenatal diethylstilbestrol exposure and human genital tract abnormalities. Natl. Cancer Inst. Monogr. May(51): 25-35.
26. KNIGHT, W.A., 3RD et al. 1980. Steroid hormone receptors in the management of human breast cancer. Ann. Clin. Res. 12: 202-207.
27. MCLACHLAN, J.A. 2001. Environmental signaling: what embryos and evolution teach us about endocrine disrupting chemicals. Endocr. Rev. 22: 319-341.
28. WAGNER, J.D., M.S. ANTHONY & J.M. CLINE. 2001. Soy phytoestrogens: research on benefits and risks. Clin. Obstet. Gynecol. 44: 843-852.
29. HERTZ, R. 1976. The estrogen-cancer hypothesis. Cancer 38: 534-540.
30. DEGEN, G.H. & M. METZLER. 1987. Sex hormones and neoplasia: genotoxic effects in short term assays. Arch. Toxicol. Suppl. 10: 264-278.
31. BARRETT, J.C., A. WONG & J.A. MCLACHLAN. 1981. Diethylstilbestrol induces neoplastic transformation without measurable gene mutation at two loci. Science 212: 1402-1404.
32. MCLACHLAN, J.A. et al. 1982. Morphologic and neoplastic transformation of Syrian hamster embryo fibroblasts by diethylstilbestrol and its analogs. Cancer Res. 42: 3040-3045.
33. TSUTSUI, T. et al. 1983. Aneuploidy induction and cell transformation by diethylstilbestrol: a possible chromosomal mechanism in carcinogenesis. Cancer Res. 43: 3814-3821.
34. LI, J.J. & S.A. LI. 1990. Estrogen carcinogenesis in hamster tissues: a critical review. Endocr. Rev. 11: 524-531.
35. NEWBOLD, R.R., B.C. BULLOCK & J.A. MCLACHLAN. 1990. Uterine adenocarcinoma in mice following developmental treatment with estrogens: a model for hormonal carcinogenesis. Cancer Res. 50: 7677-7681.
36. LEAVITT, W.W., R.W. EVANS & W.J. HENDRY, 3RD. 1981. Etiology of DES-induced uterine tumors in the Syrian hamster. Adv. Exp. Med. Biol. 138: 63-86.
37. NELSON, K.G. et al. 1994. Exposure to diethylstilbestrol during a critical developmental period of the mouse reproductive tract leads to persistent induction of two estrogen-regulated genes. Cell Growth Differ. 5: 595-606.
38. KAMIYA, K. et al. 1996. Expression of estrogen receptor and proto-oncogene messenger ribonucleic acids in reproductive tracts of neonatally diethylstilbestrol-exposed female mice with or without post-puberal estrogen administration. Exp. Clin. Endocrinol. Diabetes 104: 111-122.
39. YAMASHITA, S., A. TAKAYANAGI & N. SHIMIZU. 2001. Effects of neonatal diethylstilbestrol exposure on c-fos and c-jun protooncogene expression in the mouse uterus. Histol. Histopathol. 16: 131-140.
40. FALCK, L. & J.G. FORSBERG. 1996. Immunohistochemical studies on the expression and estrogen dependency of EGF and its receptor and C-fos proto-oncogene in the uterus and vagina of normal and neonatally estrogen-treated mice. Anat. Rec. 245: 459-471.
41. MA, L. et al. 1998. Abdominal B (AbdB) Hoxa genes: regulation in adult uterus by estrogen and progesterone and repression in mullerian duct by the synthetic estrogen diethylstilbestrol (DES). Dev. Biol. 197: 141-154.
42. COUSE, J.F., D. DIXON, M. YATES, et al. 2001. Estrogen receptor-α knockout mice exhibit resistance to the developmental effects of neonatal diethylstilbestrol exposure on the female reproductive tract. Dev. Biol. 238: 1-15.
43. BLOCK, K. et al. 2000. In utero diethylstilbestrol (DES) exposure alters Hox gene expression in the developing mullerian system. FASEB J. 14: 1101-1108.
44. LI, S. et al. 1997. Developmental exposure to diethylstilbestrol elicits demethylation of estrogen-responsive lactoferrin gene in mouse uterus. Cancer Res. 57: 4356-4359.
45. LI, S. et al. 2001. Promoter CpG methylation of Hox-a 10 and Hox-a 11 in mouse uterus not altered upon neonatal diethylstilbestrol exposure. Mol. Carcinog. 32: 213-219.
46. FERGUSON, A.T. et al. 2000. High frequency of hypermethylation at the 14-3-3 sigma locus leads to gene silencing in breast cancer. Proc. Natl. Acad. Sci. USA 97: 6049-6054.
47. JUBERG, D.R. 2000. An evaluation of endocrine modulators: implications for human health. Ecotoxicol. Environ. Saf. 45: 93-105.
48. CHEEK, A.O. et al. 1998. Environmental signaling: a biological context for endocrine disruption. Environ. Health Perspect. 106(Suppl 1.): 5-10.
49. XIE, T., S.L. HO & D. RAMSDEN. 1999. Characterization and implications of estrogenic down-regulation of human catechol-O-methyltransferase gene transcription. Mol. Pharmacol. 56: 31-38.
50. MOYAD, M.A. 1999. Soy, disease prevention, and prostate cancer. Semin. Urol. Oncol. 17: 97-102.
51. NEWBOLD, R.R. et al. 2001. Uterine adenocarcinoma in mice treated neonatally with genistein. Cancer Res. 61: 4325-4328.
52. LYN-COOK, B.D. et al. 1995. Methylation profile and amplification of proto-oncogenes in rat pancreas induced with phytoestrogens. Proc. Soc. Exp. Biol. Med. 208: 116-119.
53. BARKER, D.J. & C. OSMOND. 1986. Infant mortality, childhood nutrition, and ischaemic heart disease in England and Wales. Lancet 1: 1077-1081.
54. BENEDIKTSSON, R. et al. 1993. Glucocorticoid exposure in utero: new model for adult hypertension. Lancet 341: 339-341.
55. HOET, J.J. & M.A. HANSON. 1999. Intrauterine nutrition: its importance during critical periods for cardiovascular and endocrine development. J. Physiol. 514: 617-627.
56. KHOSLA, S. et al. 2001. Culture of preimplantation mouse embryos affects fetal development and the expression of imprinted genes. Biol. Reprod. 64: 918-926.
57. KHOSLA, S. et al. 2001. Culture of preimplantation embryos and its long-term effects on gene expression and phenotype. Hum. Reprod. Update 7: 419-427.
58. HOLM, P., S.K. WALKER & R.F. SEAMARK. 1996. Embryo viability, duration of gestation and birth weight in sheep after transfer of in vitro matured and in vitro fertilized zygotes cultured in vitro or in vivo. J. Reprod. Fertil. 107: 175-181.
59. YOUNG, L.E., K.D. SINCLAIR & I. WILMUT. 1998. Large offspring syndrome in cattle and sheep. Rev. Reprod. 3: 155-163.
60. DAVIS, C.D. & E.O. UTHUS. 2002. Dietary selenite and azadeoxycytidine treatments affect dimethylhydrazine-induced aberrant crypt formation in rat colon and DNA methylation in HT-29 cells. J. Nutr. 132: 292-297.
61. FIALA, E.S. et al. 1998. Inhibition of DNA cytosine methyltransferase by chemopreventive selenium compounds, determined by an improved assay for DNA cytosine methyltransferase and DNA cytosine methylation. Carcinogenesis 19: 597-604.
62. REES, W.D. et al. 2000. Maternal protein deficiency causes hypermethylation of DNA in the livers of rat fetuses. J. Nutr. 130: 1821-1826.