Congenic rats for hypertension: How useful are they for the hunting of hypertension genes?

Clinical and Experimental Pharmacology and Physiology

Volumn 27, Issue 4, 2000, Pages 251-256

  Nabika, Toru ^a   Kobayashi, Yuta ^a   Yamori, Yukio ^b  

^a SHIMANE UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

Congenic rats; Dahl salt sensitive rats; Essential hypertension; Genetics; Multifactorial disease; Quantitative trait loci; Spontaneously hypertensive rats

Indexed keywords

EXPERIMENTAL MODEL; GENE LOCUS; GENE MAPPING; GENETIC ANALYSIS; GENOME; HYPERTENSION; MARKER GENE; NONHUMAN; RAT; RAT STRAIN; REVIEW; SPONTANEOUSLY HYPERTENSIVE RAT;

ANIMALS; ANIMALS, CONGENIC; BLOOD PRESSURE; DISEASE MODELS, ANIMAL; HUMANS; HYPERTENSION; QUANTITATIVE TRAIT, HERITABLE; RATS;

EID: 0034116716     PISSN: 03051870     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1681.2000.03242.x     Document Type: Review

References (53)

1. 1. Darvasi A, Weinreb A, Minke V, Welker JI, Soller M. Detecting marker-QTL linkage and estimating QTL gene effect and map location using a saturated genetic map. Genetics 1993; 134: 943-51.
2. 2. Rapp JP, Deng AY. Detection and positional cloning of blood pressure quantitative trait loci: Is it possible? Hypertension 1995; 25: 1121-8.
3. 3. Markel P, Shu P, Ebeling C et al. Theoretical and empirical issues for maker-assisted breeding of congenic mouse strains. Nature Genet. 1997; 17: 280-4.
4. 4. St Lezin EM, Pravenec M, Wong AL et al. Effects of renin gene transfer on blood pressure and renin gene expression in a congenic strain of Dahl salt-resistant rats. J. Clin. Invest. 1996; 97: 522-7.
5. 5. Jiang J, Stec DE, Drummond H et al. Transfer of a salt-resistant renin allele raises blood pressure in Dahl salt-sensitive rats. Hypertension 1997; 29: 619-27.
6. 6. Cicila GT, Dukhanina OI, Kurtz TW et al. Blood pressure and survival of a chromosome 7 congenic strain bred from Dahl rats. Mamm. Genome 1997; 8: 896-902.
7. 7. Kren V, Pravenec M, Lu S et al. Genetic isolation of a region of chromosome 8 that exerts major effects on blood pressure and cardiac mass in the spontaneously hypertensive rat. J. Clin. Invest. 1997; 99: 577-81.
8. 8. St Lezin E, Liu W, Wang N et al. Effect of renin gene transfer on blood pressure in the spontaneously hypertensive rat. Hypertension 1998; 31: 373-7.
9. 9. Frantz SA, Kaiser M, Gardiner SM et al. Successful isolation of a rat chromosome 1 blood pressure quantitative trait locus in reciprocal congenic strains. Hypertension 1998; 32: 639-46.
10. 10. St Lezin E, Liu W, Wang J-M et al. Genetic isolation of a chromosome 1 region affecting blood pressure in the spontaneously hypertensive rat. Hypertension 1997; 30: 854-9.
11. 11. Iwai N, Tsujita Y, Kinoshita M. Isolation of a chromosome 1 region that contributes to high blood pressure and salt sensitivity. Hypertension 1998; 32: 636-8.
12. 12. Deng AY, Dene H, Rapp JP. Congenic strains for the blood pressure quantitative trait locus on rat chromosome 2. Hypertension 1997; 30: 199-202.
13. 13. Dukhanina O, Dene H, Deng AY, Choi CR, Hoebee B, Rapp JP. Linkage map and congenic strains to localize blood pressure QTL on rat chromosome 10. Mamm. Genome 1997; 8: 229-35.
14. 14. Garrett MR, Dene H, Walder R et al. Genome scan and congenic strains for blood pressure QTL using Dahl salt-sensitive rats. Genome Res. 1998; 8: 711-23.
15. 15. Watanabe TK, Bihoreau M-T, McCarthy LC et al. A radiation hybrid map of the rat genome containing 5255 markers. Nature Genet. 1999; 22: 27-36.
16. 16. Nabika T, Ito T, Kitada K et al. Comparative mapping of novel simple sequence repeat markers in a hypertension-related region on rat chromosome 1. Mamm. Genome 1997; 8: 215-17.
17. 17. Aitman TJ, Glazier AM, Wallace CA et al. Identification of Cd36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats. Nature Genet. 1999; 21: 76-83.
18. 18. Kato N, Tamada T, Nabika T et al. Identification of quantitative trait loci for serum cholesterol levels in stroke-prone spontaneously hypertensive rats. Arterioscler. Thromb. Vasc. Biol. 2000; 20: 223-9.
19. 19. Jacob HJ, Brown DM, Bunker RK et al. A genetic linkage map of the laboratory rat, Rattus norvegicus. Nature Genet. 1995; 9: 63-9.
20. 20. Hamet P, Orlov SN, Tremblay J. Intracellular signaling mechanisms in hypertension. In: Laragh JH, Brenner BM (eds). Hypertension: Pathophysiology, Diagnosis, and Management. Raven Press Ltd, New York. 1995; 575-607.
21. 21. Luscher TF, Dubey RK. Endothelium and platelet-derived vasoactive substances: Role in the regulation of vascular tone and growth. In: Laragh JH, Brenner BM (eds). Hypertension: Pathophysiology, Diagnosis, and Management. Raven Press Ltd, New York. 1995; 609-30.
22. 22. Hermsmeyer K, Erne P. Vascular muscle ion channels and cellular calcium regulation in hypertension. In: Laragh JH, Brenner BM (eds). Hypertension: Pathophysiology, Diagnosis, and Management. Raven Press Ltd, New York. 1995; 673-83.
23. 23. Rapp JP, Garrett MR, Deng AY. Construction of a double congenic strain to prove an epistatic interaction on blood pressure between rat chromosome 2 and 10. J. Clin. Invest. 1998; 101: 1591-5.
24. 24. Hibert P, Lindpaintner K, Beckmann JS et al. Chromosomal mapping of two genetic loci associated with blood-pressure regulation in hereditary hypertensive rats. Nature 1991; 353: 521-9.
25. 25. Okamoto K, Yamamoto K, Morita N, Ohta Y. Establishment and characteristics of rat with precocious and severe hypertension (M-SHRSP). Acta Med. Kinki Univ. 1985; 10: 73-95.
26. 26. Kreutz R, Hubner N, James MR et al. Dissection of a quantitative trait locus for genetic hypertension on rat chromosome 10. Proc. Natl Acad. Sci. USA 1995; 92: 8778-82.
27. 27. Samani NJ, Lodwick D, Vincent M et al. A gene differentially expressed in the kidney of the spontaneously hypertensive rat cosegregates wtih increased blood pressure. J. Clin. Invest. 1993; 92: 1099-103.
28. 28. Iwai N, Inagami T. Identification of a candidate gene responsible for the high blood pressure of spontaneously hypertensive rats. J. Hypertens. 1992; 10: 1155-7.
29. 29. Iwai N, Kurtz TW, Inagami T. Further evidence of the SA gene as a candidate gene contributing to the hypertension in spontaneously hypertensive rat. Biochem. Biophys. Res. Commun. 1992; 188: 64-9.
30. 30. Kovacs P, Voigt B, Kloting I. Novel quantitative trait loci for blood pressure and related traits on rat chromosomes 1, 10, and 18. Biochem. Biophys. Res. Commun. 1997; 235: 343-8.
31. 31. Innes BA, McLaughlin MG, Kapuscinski MK, Jacob HJ, Harrap SB. Independent genetic susceptibility to cardiac hypertrophy in inherited hypertension. Hypertension 1998; 31: 741-6.
32. 32. Lindpaintner K, Hilbert P, Ganten D, Nadal-Ginard B, Inagami T, Iwai N. Molecular genetics of the SA gene: Cosegregation with hypertension and mapping to rat chromosome 1. J. Hypertens. 1993; 11: 12-23.
33. 33. Nara Y, Nabika T, Ikeda K et al. Basal high blood pressure cosegregates with the loci on chromosome 1 in the F2 generation from crosses between normotensive Wistar Kyoto rats and the stroke-prone spontaneously hypertensive rats. Biochem. Biophys. Res. Commun. 1993; 194: 1344-51.
34. 34. Mashimo T, Nabika T, Matsumoto C et al. Aging and salt-loading modulate blood pressure QTLs in rats. Am. J. Hypertens. 1999; 12: 1098-104.
35. 35. Gu L, Dene H, Deng AY et al. Genetic mapping of two blood pressure quantitative trait loci on rat chromosome 1. J. Clin. Invest. 1996; 97: 777-88.
36. 36. Brown DM, Provoost AP, Duly MJ, Lander ES, Jacob HJ. Renal disease susceptibility and hypertension are under independent genetic control in the fawn-hooded rat. Nature Genet. 1996; 12: 44-51.
37. 37. Yagil C, Sapojnikov M, Kreutz R et al. Salt susceptibility maps to chromosomes 1 and 17 with sex specificity in the Sabra rat model of hypertension. Hypertension 1998; 31: 119-24.
38. 38. Pravenec M, Gauguier D, Schott J-J et al. Mapping of quantitative trait loci for blood pressure and cardiac mass in the rat by genome scanning of recombinant inbred strains. J. Clin. Invest. 1995; 96: 1973-8.
39. 39. Samani NJ, Gauguier D, Vincent M et al. Analysis of quantitative trait loci for blood pressure on rat chromosome 2 and 13: Age-related differences in effect. Hypertension 1996; 28: 1118-22.
40. 40. Schork NJ, Krieger JE, Trolliet MR et al. A biometrical genome search in rats reveals the mutigenic basis of blood pressure variation. Genome Res. 1995; 5: 164-72.
41. 41. Clark JS, Jeffs B, Davidson AO et al. Quantitative trait loci in genetically hypertensive rats: Possible sex specificity. Hypertension 1996; 28: 898-906.
42. 42. Jacob HJ, Lindpaintner K, Lincoln SE et al. Genetic mapping of a gene causing hypertension in the stroke-prone spontaneously hypertensive rat. Cell 1991; 67: 213-24.
43. 43. Deng Y, Rapp JP. Cosegregation of blood pressure with angiotensin converting enzyme and atrial natriuretic peptide receptor genes using Dahl salt-sensitive rats. Nature Genet. 1992; 1: 267-72.
44. 44. Deng AY, Dene H, Rapp JP. Mapping of a quantitative trait locus for blood pressure on rat chromosome 2. J. Clin. Invest. 1994; 94: 431-6.
45. 45. Dubay C, Vincent M, Samani NJ et al. Genetic determinants of diastolic and pulse pressure map to different loci in Lyon hypertensive rats. Nature Genet. 1993; 3: 354-7.
46. 46. Matsumoto C, Nara Y, Ikeda K et al. Cosegregation of the new region on chromosome 3 with salt-induced hypertension in female F2 progeny from stroke-prone spontaneously hypertensive and Wistar-Kyoto rats. Clin. Exp. Pharmacol. Physiol. 1996; 23: 1028-34.
47. 47. Katsuya T, Higaki J, Zhao Y et al. A neuropeptide Y locus on chromosome 4 cosegregates with blood pressure in the spontaneously hypertensive rat. Biochem. Biophys. Res. Commun. 1993; 192: 261-7.
48. 48. Cicila GT, Rapp JP, Wang J-M, St Lezin E, Ng SC, Kurtz TW. Linkage of 11β-hydroxylase mutations with altered steroid biosynthesis and blood pressure in the Dahl rat. Mature Genet. 1993; 3: 346-53.
49. 49. Rapp JP, Wang S-M, Dene H. A genetic polymorphism in the renin gene of Dahl rats cosegregates with blood pressure. Science 1989; 243: 542-4.
50. 50. Ely D, Turner ME. Hypertension in the spontaneously hypertensive rat is linked to the Y chromosome. Hypertension 1990; 16: 277-81.
51. 51. Davidson AO, Schork N, Jaques BC et al. Blood pressure in genetically hypertensive rats: Influence of the Y chromosome. Hypertension 1995; 26: 452-9.
52. 52. Ely DL, Daneshvar H, Turner ME, Johnson ML, Salisbury RL. The hypertensive Y chromosome elevates blood pressure in F11 normotensive rats. Hypertension 1993; 21: 1071-5.
53. 53. Nara Y, Nabika T, Ikeda K, Sawamura M, Endo J, Yamori Y. Blood pressure cosegregates with a microsatellite of angiotensin I converting enzyme (ACE) in F2 generation from a cross between original normotensive Wistar-Kyoto rat (WKY) and stroke-prone spontaneously hypertensive rats (SHRSP). Biochem. Biophys. Res. Commun. 1991; 181: 941-6.