SU1498, an Inhibitor of Vascular Endothelial Growth Factor Receptor 2, Causes Accumulation of Phosphorylated ERK Kinases and Inhibits Their Activity in Vivo and in Vitro

Journal of Biological Chemistry

Volumn 279, Issue 7, 2004, Pages 5716-5724

  Boguslawski, George ^a   McGlynn, Patrick W ^a   Harvey, Kevin A ^a   Kovala, A Thomas ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOASSAY; CELLS; PRECIPITATION (CHEMICAL); PROTEINS;

ENDOTHELIAL CELLS; PROTEIN GROWTH FACTORS;

BIOCHEMISTRY;

4 (3 BROMOANILINO) 6,7 DIMETHOXYQUINAZOLINE; 6,7 DIMETHOXY 2 PHENYLQUINOXALINE; AG 1433; EPIDERMAL GROWTH FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PLATELET DERIVED GROWTH FACTOR; RAF PROTEIN; RECEPTOR BLOCKING AGENT; SPHINGOSINE 1 PHOSPHATE; SU 1498; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR 2;

ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG STRUCTURE; ENDOTHELIUM CELL; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

AORTA; BLOTTING, WESTERN; CELL MOVEMENT; CELLS, CULTURED; CHEMOTAXIS; CINNAMATES; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; HUMANS; MICROSCOPY, FLUORESCENCE; MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, BIOLOGICAL; MODELS, CHEMICAL; PHOSPHORYLATION; PRECIPITIN TESTS; SIGNAL TRANSDUCTION; TIME FACTORS; UMBILICAL VEINS; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 1242294427     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M308625200     Document Type: Article

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