CCR4-deficient mice show prolonged graft survival in a chronic cardiac transplant rejection model

European Journal of Immunology

Volumn 35, Issue 1, 2005, Pages 128-138

  Hüser, Norbert ^a   Tertilt, Christine ^a   Gerauer, Klaus ^a   Maier, Stefan ^b   Traeger, Tobias ^b   Aßfalg, Volker ^a   Reiter, Rudolf ^a   Heidecke, Claus Dieter ^b   Pfeffer, Klaus ^a,c  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF GREIFSWALD   (Germany)

^c HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Chemokines; Mice; Transplantation

Indexed keywords

CHEMOKINE RECEPTOR CCR4; GALLIUM NITRATE; LIGAND;

ACUTE GRAFT REJECTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARDIAC GRAFT REJECTION; CELLULAR IMMUNITY; CHRONIC GRAFT REJECTION; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; GRAFT FAILURE; GRAFT SURVIVAL; HEART TRANSPLANTATION; HISTOLOGY; LEUKOCYTE FUNCTION; LYMPHOCYTIC INFILTRATION; MACROPHAGE; MOUSE; NONHUMAN; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; RECIPIENT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; THYMUS; WILD TYPE;

ANIMALS; ANTIGENS; ANTIGENS, SURFACE; BASE SEQUENCE; CD8-POSITIVE T-LYMPHOCYTES; CHEMOKINES, CC; CHRONIC DISEASE; DNA; FEMALE; GENE EXPRESSION; GRAFT REJECTION; GRAFT SURVIVAL; HEART TRANSPLANTATION; KILLER CELLS, NATURAL; LECTINS, C-TYPE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; PROTEINS; RECEPTORS, ANTIGEN, T-CELL; RECEPTORS, CHEMOKINE; T-LYMPHOCYTE SUBSETS; TIME FACTORS; TRANSPLANTATION, HOMOLOGOUS;

EID: 12344332499     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200324745     Document Type: Article

References (51)

1. Paul, L. C. and Fellstrom, B., Chronic vascular rejection of the heart and the kidney-have rational treatment options emerged? Transplantation 1992. 53: 1169-1179.
2. Tullius, S. G. and Tilney, N. L., Both alloantigen-dependent and -independent factors influence chronic allograft rejection. Transplantation 1995. 59: 313-318.
3. Tilney, N. L., Whitley, W. D., Diamond, J. R., Kupiec-Weglinski, J. W. and Adams, D. H., Chronic rejection-an undefined conundrum. Transplantation 1991. 52: 389-398.
4. Fairchild, R. L., VanBuskirk, A. M., Kondo, T., Wakely, M. E. and Orosz, C. G., Expression of chemokine genes during rejection and long-term acceptance of cardiac allografts. Transplantation 1997. 63: 1807-1812.
5. Haskell, C. A., Hancock, W. W., Salant, D. J., Gao, W., Csizmadia, V., Peters, W., Faia, K., Fituri, O., Rottman, J. B. and Charo, I. F., Targeted deletion of CX(3)CR1 reveals a role for fractalkine in cardiac allograft rejection. J. Clin. Invest. 2001. 108: 679-688.
6. Butcher, E. C., Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity. Cell 1991. 67: 1033-1036.
7. Springer, T. A., Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 1994. 76: 301-314.
8. Butcher, E. C. and Picker, L. J., Lymphocyte homing and homeostasis. Science 1996. 272: 60-66.
9. Hancock, W. W., Gao, W., Faia, K. L. and Csizmadia, V., Chemokines and their receptors in allograft rejection. Curr. Opin. Immunol. 2000. 12: 511-516.
10. Rossi, D. and Zlotnik, A., The biology of chemokines and their receptors. Annu. Rev. Immunol. 2000. 18: 217-242.
11. Sallusto, F., Mackay, C. R. and Lanzavecchia, A., The role of chemokine receptors in primary, effector, and memory immune responses. Annu. Rev. Immunol. 2000. 18: 593-620.
12. Campbell, J. J. and Butcher, E. C., Chemokines in tissue-specific and microenvironment-specific lymphocyte homing. Curr Opin Immunol 2000. 12: 336-341.
13. Kim, C. H., Butcher, E. C. and Johnston, B., Distinct subsets of human Valpha24-invariant NKT cells: cytokine responses and chemokine receptor expression. Trends Immunol. 2002. 23: 516-519.
14. Gao, W., Topham, P. S., King, J. A., Smiley, S. T., Csizmadia, V., Lu, B., Gerard, C. J. and Hancock, W. W., Targeting of the chemokine receptor CCR1 suppresses development of acute and chronic cardiac allograft rejection. J. Clin. Invest. 2000. 105: 35-44.
15. Hancock, W. W., Lu, B., Gao, W., Csizmadia, V., Faia, K., King, J. A., Smiley, S. T., Ling, M., Gerard, N. P. and Gerard, C., Requirement of the chemokine receptor CXCR3 for acute allograft rejection. J. Exp. Med. 2000. 192: 1515-1520.
16. Chvatchko, Y., Hoogewerf, A. J., Meyer, A., Alouani, S., Juillard, P., Buser, R., Conquet, F., Proudfoot, A. E., Wells, T. N. and Power, C. A., A key role for CC chemokine receptor 4 in lipopolysaccharide-induced endotoxic shock. J. Exp. Med. 2000. 191: 1755-1764.
17. Bonecchi, R., Bianchi, G., Bordignon, P. P., D'Ambrosio, D., Lang, R., Borsatti, A., Sozzani, S., Allavena, P., Gray, P. A., Mantovani, A. and Sinigaglia, F., Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s. J. Exp. Med. 1998. 187: 129-134.
18. Sallusto, F., Lenig, D., Mackay, C. R. and Lanzavecchia, A., Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes. J. Exp. Med. 1998. 187: 875-883.
19. D'Ambrosio, D., Iellem, A., Bonecchi, R., Mazzeo, D., Sozzani, S., Mantovani, A. and Sinigaglia, F., Selective up-regulation of chemokine receptors CCR4 and CCR8 upon activation of polarized human type 2 Th cells. J. Immunol. 1998. 161: 5111-5115.
20. Power, C. A., Meyer, A., Nemeth, K., Bacon, K. B., Hoogewerf, A. J., Proudfoot, A. E. and Wells, T. N., Molecular cloning and functional expression of a novel CC chemokine receptor cDNA from a human basophilic cell line. J. Biol. Chem. 1995. 270: 19495-19500.
21. Power, C. A., Clemetson, J. M., Clemetson, K. J. and Wells, T. N., Chemokine and chemokine receptor mRNA expression in human platelets. Cytokine 1995. 7: 479-482.
22. Inngjerdingen, M., Damaj, B. and Maghazachi, A. A., Human NK cells express CC chemokine receptors 4 and 8 and respond to thymus and activation-regulated chemokine, macrophage-derived chemokine, and I-309. J. Immunol. 2000. 164: 4048-4054.
23. Kim, C. H., Johnston, B. and Butcher, E. C., Trafficking machinery of NKT cells: shared and differential chemokine receptor expression among V alpha 24(+)V beta 11(+) NKT cell subsets with distinct cytokine-producing capacity. Blood 2002. 100: 11-16.
24. Lee, P. T., Benlagha, K., Teyton, L. and Bendelac, A., Distinct functional lineages of human V(alpha)24 natural killer T cells. J. Exp. Med. 2002. 195: 637-641.
25. Imai, T., Baba, M., Nishimura, M., Kakizaki, M., Takagi, S. and Yoshie, O., The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4. J. Biol. Chem. 1997 272: 15036-15042.
26. Godiska, R., Chantry, D., Raport, C. J., Sozzani, S., Allavena, P., Leviten, D., Mantovani, A. and Gray, P. W., Human macrophage-derived chemokine (MDC), a novel chemoattractant for monocytes, monocyte-derived dendritic cells, and natural killer cells. J. Exp. Med. 1997. 185: 1595-1604.
27. Schaniel, C., Pardali, E., Sallusto, F., Speletas, M., Ruedl, C., Shimizu, T., Seidl, T., Andersson, J., Melchers, F., Rolink, A. G. and Sideras, P., Activated murine B lymphocytes and dendritic cells produce a novel CC chemokine which acts selectively on activated T cells. J. Exp. Med. 1998. 188: 451-463.
28. + T cells. Eur. J. Immunol. 1999. 29: 2684-2694.
29. Imai, T., Chantry, D., Raport, C. J., Wood, C. L., Nishimura, M., Godiska, R., Yoshie, O. and Gray, P. W., Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4. J. Biol. Chem. 1998. 273: 1764-1768.
30. Campbell, J. J., Haraldsen, G., Pan, J., Rottman, J., Qin, S., Ponath, P., Andrew, D. P., Warnke, R., Ruffing, N., Kassam, N., Wu, L. and Butcher, E. C., The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells. Nature 1999. 400: 776-780.
31. Reiss, Y., Proudfoot, A. E., Power, C. A., Campbell, J. J. and Butcher, E. C., CC chemokine receptor (CCR)4 and the CCR10 ligand cutaneous T cell-attracting chemokine (CTACK) in lymphocyte trafficking to inflamed skin. J. Exp. Med. 2001. 194: 1541-1547.
32. Orosz, C. G., Wakely, E., Sedmak, D. D., Bergese, S. D. and VanBuskirk, A. M., Prolonged murine cardiac allograft acceptance: characteristics of persistent active alloimmunity after treatment with gallium nitrate versus anti-CD4 monoclonal antibody. Transplantation 1997. 63: 1109-1117.
33. Maier, S., Tertilt, C., Chambron, N., Gerauer, K., Huser, N., Heidecke, C. D. and Pfeffer, K., Inhibition of natural killer cells results in acceptance of cardiac allografts in CD28-/- mice. Nat. Med. 2001. 7: 557-562.
34. Orosz, C. G., Wakely, E., Bergese, S. D., VanBuskirk, A. M., Ferguson, R. M., Mullet, D., Apseloff, G. and Gerber, N., Prevention of murine cardiac allograft rejection with gallium nitrate. Comparison with anti-CD4 monoclonal antibody. Transplantation 1996. 61: 783-791.
35. Armstrong, A. T., Strauch, A. R., Starling, R. C., Sedmak, D. D. and Orosz, C. G., Morphometric analysis of neointimal formation in murine cardiac allografts. Transplantation 1997. 63: 941-947.
36. Hancock, W. W., Chemokines and transplant immunobiology. J. Am. Soc. Nephrol. 2002. 13: 821-824.
37. + cells: new clues to their origin, specificity, and function. J. Exp. Med. 1995. 182: 633-638.
38. Kawano, T., Cui, J., Koezuka, Y., Toura, I., Kaneko, Y., Motoki, K., Ueno, H., Nakagawa, R., Sato, H., Kondo, E., Koseki, H. and Taniguchi, M., CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramides. Science 1997. 278: 1626-1629.
39. + T cells in a TH2 response and in immunoglobulin E production. Science 1995. 270: 1845-1847.
40. Cui, J., Watanabe, N., Kawano, T., Yamashita, M., Kamata, T., Shimizu, C., Kimura, M., Shimizu, E., Koike, J., Koseki, H., Tanaka, Y., Taniguchi, M. and Nakayama, T., Inhibition of T helper cell type 2 cell differentiation and immunoglobulin E response by ligand-activated Valpha14 natural killer T cells. J. Exp. Med. 1999. 190: 783-792.
41. + T cells are not essential for T helper cell 2 immune responses. J. Exp. Med. 1996. 184: 1295-1304.
42. Zhang, Y., Rogers, K. H. and Lewis, D. B., Beta 2-microglobulin-dependent T cells are dispensable for allergen-induced T helper 2 responses. J. Exp. Med. 1996. 184: 1507-1512.
43. Seino, K. I., Fukao, K., Muramoto, K., Yanagisawa, K., Takada, Y., Kakuta, S., Iwakura, Y., Van Kaer, L., Takeda, K., Nakayama, T., Taniguchi, M., Bashuda, H., Yagita, H. and Okumura, K., Requirement for natural killer T (NKT) cells in the induction of allograft tolerance. Proc. Natl. Acad. Sci. USA 2001. 98: 2577-2581.
44. Godfrey, D. I., Hammond, K. J., Poulton, L. D., Smyth, M. J. and Baxter, A. G., NKT cells: facts, functions and fallacies. Immunol. Today 2000. 21: 573-583.
45. Imai, T., Nagira, M., Takagi, S., Kakizaki, M., Nishimura, M., Wang, J., Gray, P. W., Matsushima, K. and Yoshie, O., Selective recruitment of CCR4-bearing Th2 cells toward antigen-presenting cells by the CC chemokines thymus and activation-regulated chemokine and macrophage-derived chemokine. Int. Immunol. 1999. 11: 81-88.
46. Hancock, W. W., Shi, C., Picard, M. H., Bianchi, C. and Russell, M. E., LEW-to-F344 carotid artery allografts: analysis of a rat model of posttransplant vascular injury involving cell-mediated and humoral responses. Transplantation 1995. 60: 1565-1572.
47. Gao, W., Faia, K. L., Csizmadia, V., Smiley, S. T., Soler, D., King, J. A., Danoff, T. M. and Hancock, W. W., Beneficial effects of targeting CCR5 in allograft recipients. Transplantation 2001. 72: 1199-1205.
48. Hancock, W. W., Gao, W., Csizmadia, V., Faia, K. L., Shemmeri, N. and Luster, A. D., Donor-derived IP-10 initiates development of acute allograft rejection. J. Exp. Med. 2001. 193: 975-980.
49. Alferink, J., Lieberam, I., Reindl, W., Behrens, A., Weiss, S., Hüser, N., Gerauer, K., Ross, R., Reske-Kunz, AB., Ahmad-Nejad, P., Wagner, H. and Förster, I., Compartmentalized production of CCL17 in vivo: stron inducibility in peripheral dendritic cells contrasts selective absence from the spleen. J. Exp. Med. 2003. 197: 585-599.
50. Corry, R. J., Winn, H. J. and Russell, P. S., Primarily vascularized allografts of hearts in mice. The role of H-2D, H-2 K, and non-H-2 antigens in rejection. Transplantation 1973. 16: 343-350.
51. Endres, R., Luz, A., Schulze, H., Neubauer, H., Futterer, A., Holland, S. M., Wagner, H. and Pfeffer, K., Listeriosis in p47(phox-/-) and TRp55-/-mice: protection despite absence of ROI and susceptibility despite presence of RNI. Immunity 1997. 7: 419-432.