β2-Microglobulin-dependent T cells are dispensable for allergen- induced T helper 2 responses

Journal of Experimental Medicine

Volumn 184, Issue 4, 1996, Pages 1507-1512

  Zhang, Yu ^a   Rogers, Kathleen H ^a   Lewis, David B ^a,b  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 2 MICROGLOBULIN; IMMUNOGLOBULIN E; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5; OVALBUMIN;

ALLERGIC PNEUMONITIS; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRONCHUS; CONTROLLED STUDY; HELPER CELL; LOEFFLER PNEUMONIA; LYMPH NODE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ALLERGENS; ANIMALS; ANTIGENS; ANTIGENS, SURFACE; BETA 2-MICROGLOBULIN; BRONCHOALVEOLAR LAVAGE FLUID; IMMUNOGLOBULIN E; INTERLEUKIN-13; INTERLEUKIN-4; INTERLEUKIN-5; LECTINS, C-TYPE; LYMPH NODES; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; OVALBUMIN; PROTEINS; PULMONARY EOSINOPHILIA; RESPIRATORY HYPERSENSITIVITY; T-LYMPHOCYTE SUBSETS; TH2 CELLS;

EID: 0029854521     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.184.4.1507     Document Type: Article

References (29)

1. Mosmann, T.R. 1995. Cytokines, differentiation and functions of subsets of CD4 and CD8 T cells. Behring Inst. Mitt. 96:1-5.
2. Reiner, S.L., and R.A. Seder. 1995. T helper cell differentiation in immune response. Curr. Opin. Immunol. 7:360-366.
3. Romagnani, S. 1995. Atopic allergy and other hypersensitivities. Curr. Opin. Immunol. 7:745-750.
4. Kuhn, R., K. Rajewsky, and W. Muller. 1991. Generation and analysis of interleukin-4 deficient mice. Science (Wash. DC). 254:707-710.
5. Foster, P.S., S.P. Hogan, A.J. Ramsay, K.I. Matthaei, and I.G. Young. 1996. Interleukin 5 deficiency abolishes eosinophilia, airway hyperreactivity, and lung damage in a mouse asthma model. J. Exp. Med. 183:195-201.
6. + B-1 cells and lack eosinophilia but have normal antibody and cytotoxic T cell responses. Immunity. 4:15-24.
7. Corry, D.B., H.G. Folkesson, M.L. Warnock, D.J. Erle, M.A. Matthay, J.P. Wiener-Kronish, and R.M. Locksley. 1996. Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity. J. Exp. Med. 183:109-117.
8. + cells can switch to interleukin 5 production and induce airway eosinophilia. J. Exp. Med. 181:1229-1233.
9. Kopf, M., G. Le Gros, M. Bachmann, M.C. Lamers, H. Bluethmann, and G. Kohler. 1993. Disruption of the murine IL-4 gene blocks Th2 cytokine responses. Nature (Lond.). 362:245-248.
10. Bruselle, G.G., J.C. Kips, J.H. Tavernier, J.G. van der Heyden, C.A. Cuvelier, R.A. Pauwels, and H. Bluethmann. 1994. Attenuation of allergic airway inflammation in IL-4 deficient mice. Clin. Exp. Allergy. 24:73-80.
11. Gross, A., S.Z. Ben-Sasson, and W.E. Paul. 1993. Anti-IL-4 diminishes in vivo priming for antigen-specific IL-4 production by T cells. J. Immunol. 150:2112-2120.
12. Mu, H.-H., and W.A. Sewell. 1994. Regulation of DTH and IgE responses by IL-4 and IFN-γ in immunized mice given pertussis toxin. Immunology. 83:639-645.
13. O'Garra, A., and K. Murphy. 1994. Role of cytokines in determining T-lymphocyte function. Curr. Opin. Immunol. 6: 458-466.
14. Lewis, D.B., K.S. Prickett, A. Larsen, K. Grabstein, M. Weaver, and C.B. Wilson. 1988. Restricted production of interleukin 4 by activated T cells. Proc. Natl. Acad. Sci. USA. 85:9743-9747.
15. Aoki, I., C. Kinzer, A. Shirai, W.E. Paul, and D.M. Klinman. 1995. IgE receptor-positive non-B/non-T cells dominate the production of interleukin 4 and interleukin 6 in immunized mice. Proc. Natl. Acad. Sci. USA. 92:2534-2538.
16. Vicari, A., and A. Zlotnik. 1996. Mouse NK1.1+ T cells: a new family of T cells. Immunol. Today. 17:71-75.
17. pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3. J. Exp. Med. 179:1285-1295.
18. + thymocytes selected by MHC class I molecules. Science (Wash. DC). 263:1774-1778.
19. H2 response and in immunoglobulin E production. Science (Wash. DC). 270: 1845-1847.
20. + T cells. Science (Wash. DC). 248:1227-1230.
21. Zhang, Y, W.J.E. Lamm, R.K. Albert, E.Y. Chi, W.R. Henderson, Jr., and D.B. Lewis. 1996. Influence of the route of allergen administration and genetic background on the murine allergic pulmonary response. Am. J. Respir. Dis. Crit. Care Med. In press.
22. Reiner, S.L., S. Zheng, D.B. Corry, and R.M. Locksley 1993. Constructing polycompetitor cDNAs for quantitative PCR. J. Immunol. Methods. 165:37-46.
23. Finkelman, F.D., D.K. Goroff, M. Fultz, S.C. Morris, J.M. Holmes, and J.J. Mond. 1990. Polyclonal activation of the murine immune system by an antibody to IgD. J. Immunol. 145:3562-3569.
24. Holt, P.G. 1993. Macrophage-dendritic cell interaction in regulation of the IgE response in asthma. Clin. Exp. Immunol. 23:4-6.
25. Guery, J.-C., F. Galbiati, S. Smiroldo, and L. Adorini. 1996. Selective development of T helper (Tb)2 cells induced by continuous administration of low dose soluble proteins to normal and β2-microglobulin-deficient BALB/c mice. J. Exp. Med. 183:485-497.
26. von der Weid, T., M. Kopf, G. Kohler, and J. Langhorne. 1994. The immune response to Plasmodium chabaudi malaria in interleukin-4 deficient mice. Eur. J. Immunol. 24:2285-2293.
27. + T cells in the development of airway hyperresponsiveness in a murine model of airway sensitization. J. Exp. Med. 183:1719-1729.
28. Correa, I., M. Bix, N.S. Liao, M. Zijlstra, R. Jaenisch, and D. Raulet. 1992. Most gamma delta T cells develop normally in beta 2-microglobulin-deficient mice. Proc. Natl. Acad. Sci. USA. 89:653-657.
29. + thymocytes. Eur. J. Immunol. 26:1424-1429.