PET imaging of 5-HT1A receptor binding in patients with temporal lobe epilepsy

Neurology

Volumn 60, Issue 5, 2003, Pages 749-756

  Toczek, M T ^a   Carson, R E ^b   Lang, L ^b   Ma, Y ^b   Spanaki, M V ^a   Der, M G ^b   Fazilat, S ^a   Kopylev, L ^a   Herscovitch, P ^b   Eckelman, W C ^b   Theodore, William H ^a  

^a NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 FLUORO N [2 [4 (2 METHOXYPHENYL)PIPERAZIN 1 YL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE F 18; AMIDE; CYCLOHEXANE DERIVATIVE; FLUORODEOXYGLUCOSE F 18; OXYGEN 15; SEROTONIN 1A ANTAGONIST; SEROTONIN 1A RECEPTOR; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BRAIN BLOOD FLOW; BRAIN METABOLISM; BRAIN SIZE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; ELECTROENCEPHALOGRAPHY; EPILEPTIC FOCUS; FEMALE; GLUCOSE METABOLISM; HIPPOCAMPUS; HUMAN; IMAGE ANALYSIS; MALE; METABOLIC RATE; NUCLEAR MAGNETIC RESONANCE IMAGING; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; TEMPORAL LOBE EPILEPSY; THALAMUS;

EID: 12244308494     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/01.WNL.0000049930.93113.20     Document Type: Article

References (52)

1. Bonnycastle DD, Giarman NJ, Paasonen MK. Anticonvulsant compounds and 5-hydroxytryptamine in rat brain. Br J Pharmacol 1957;12:228-231.
2. Andrade R, Nicoll RA. Pharmacologically distinct actions of serotonin on single pyramidal neurons of the rat hippocampus recorded in vitro. J Physiol 1987;394:99-124.
3. Beck SG, Choi KC. 5-Hydroxytryptamine hyperpolarizes CA3 hippocampal pyramidal cells through an increase in potassium conductance. Neurosci Lett 1991;133:93-96.
4. Okuhara DY, Beck SG. 5-HT1A receptor linked to inward-rectifying potassium current in hippocampal CA3 pyramidal cells. J Neurophysiol 1994;71:2161-2167.
5. 2A receptor mRNA in human brain. Brain Res 1995;676:157-168.
6. 11C]WAY-100635. Brain Res 1997;745:96-108.
7. Barnes NM, Sharp T. A review of central 5-HT receptors and their function. Neuropharmacology 1999;38:1083-1152.
8. 1A receptors: regional distribution and functional characteristics. Nucl Med Biol 2000;27:429-435.
9. Wada Y, Nakamura M, Hasegawa H, Yamaguchi N. Role of serotonin receptor subtype in seizures kindled from the feline hippocampus. Neurosci Lett 1992;141:21-24.
10. Wada Y, Nakamura M, Hasegawa H, Yamaguchi N. Intra-hippocampal injection of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) inhibits partial and generalized seizures induced by kindling stimulation in cats. Neurosci Lett 1993;159:179-182.
11. 1A receptor activation. Neuroscience 1998;86:729-737.
12. Salgado D, Alkadhi KA. Inhibition of epileptiform activity by serotonin in rat CA1 neurons. Brain Res 1995;669:176-182.
13. 1A receptors in CA1 pyramidal neurons. Neuropharmacology 1997;36:1705-1712.
14. 1A receptors in the dorsal hippocampus and inhibition of limbic seizures induced by kainic acid in rats. Br J Pharmacol 1996;119:813-818.
15. Klančnik JM, Obenaus A, Phillips AG, Baimbridge KG. The effects of serotonergic compounds on evoked responses in the dentate gyrus and CA1 region of the hippocampal formation of the rat. Neuropharmacology 1991;30:1201-1209.
16. 1B receptor binding in severe-seizure genetically epilepsy-prone rats (GEPR-9s). Neuropharmacology 1996;35:111-118.
17. 1A receptors. Proc Natl Acad Sci USA 2000;97:14731-14736.
18. 1A receptor antagonist. Behav Brain Res 1996;73:337-353.
19. 11C]WAY-100635. Eur J Pharmacol 1995;283:R1-R3.
20. 11C]WAY-100635. Eur J Pharmacol 1996;301:R5-R7.
21. 1A antagonists. J Med Chem 1999;42:1576-1586.
22. 1A receptor antagonist, WAY-100635. Nucl Med Biol 2000;27:493-497.
23. 18F]FCWAY. Neuroimage 2000;11:545. Abstract.
24. Drevets WC, Frank E, Price JC, Kupfer DJ, Greer PJ, Mathis C. Serotonin type-1A receptor imaging in depression. Nucl Med Biol 2000;27:499-507.
25. Herscovitch P, Markham J, Raichle ME. Brain blood flow measured with intravenous H2(15)O: I: theory and error analysis. J Nucl Med 1983;24:782-789.
26. 1A antagonists, N-N-(2-pyridyl) trans- and cis-4-fluorocyclohexanecarboxamide, produced by human and rat hepatocytes. J Chromatogr 2001;755:47-56.
27. 18F]cyclofoxy and positron emission tomography. J Cereb Blood Flow Metab 1993;13:24-42.
28. Weinberg IN, Huang SC, Hoffman EJ, et al. Validation of PET-acquired input functions for cardiac studies. J Nucl Med 1988;29:241-247.
29. Phelps ME, Huang SC, Hoffman EJ, et al. Tomographic measurement of local cerebral glucose metabolic rate in humans with (F-18)2-fluoro-2-deoxy-D-glucose: validation of method. Ann Neurol 1979;6:371-388.
30. Brooks RA. Alternative formula for glucose utilization using labeled deoxyglucose. J Nucl Med 1982;23:538-539.
31. 15O water positron emission tomography study. Epilepsia 1996;37:515-521.
32. Duvernoy HM. The human hippocampus: functional anatomy, vascularization and serial sections with MRI, 2nd ed. Berlin: Springer, 1998.
33. 18FDG-PET in children with new-onset partial epilepsy: a prospective study. Neurology 2002;58:717-722.
34. DeCarli C, Hatta J, Fazilat S, Fazilat S, Gaillard WD, Theodore WH. Extratemporal atrophy in patients with complex partial seizures of left temporal origin. Ann Neurol 1998;43:41-45.
35. Dreifuss S, Vingerhoets FJG, Lazeyras F, et al. Volumetric measurements of subcortical nuclei in patients with temporal lobe epilepsy. Neurology 2001;57:1636-1641.
36. 11C-flumazenil PET, volumetric MRI, and quantitative pathology in mesial temporal lobe epilepsy. Neurology 1997;49:764-773.
37. Hand KSP, Baird VH, Van Paesschen W, et al. Central benzodiazepine receptor autoradiography in hippocampal sclerosis. Br J Pharmacol 1997;122:358-364.
38. Clark M, Weiss SRB, Post RM. Autoradiographic analysis of serotonin receptors and transporter in kindled rat brain. Neurosci Lett 1993;161:21-26.
39. 4 receptor subtypes in the kindled rat dentate gyrus: dissociation from local presynaptic effects. J Neurochem 1998;70:850-857.
40. 1A receptors in the rat hippocampus. Biogenic Amines 1993;9:295-306.
41. 1A receptors in the KA model of limbic epilepsy in the rat. Epilepsy Res 2001;47:127-139.
42. 1A-mediated inhibition of adenylyl cyclase in dorsal raphe of male and female rats. J Pharmacol Exp Ther 1996;277:1259-1266.
43. Le Poul E, Boni C, Hanoun N, et al. Differential adaptation of brain 5-HT1A and 5-HT1B receptors and 5-HT transporter in rats treated chronically with fluoxetine. Neuropharmacology 2000;39:110-122.
44. Yan QS, Mishra PK, Burger RL, Bettendorf AF, Jobe PC, Dailey JW. Evidence that carbamazepine and antiepilepsirine may produce a component of their anticonvulsant effects by activating serotonergic neurons in genetically epilepsy-prone rats. J Pharmacol Exp Ther 1992;261:652-659.
45. Dailey JW, Reith ME, Yan QS, Li MY, Jobe PC. Anticonvulsant doses of carbamazepine increase hippocampal extracellular serotonin in genetically epilepsy-prone rats: dose response relationships. Neurosci Lett 1997;227:13-16.
46. Biggs CS, Pearce BR, Fowler LJ, Whitton PS. Regional effects of sodium valproate on extracellular concentrations of 5-hydroxytryptamine, dopamine and their metabolites in the rat brain: an in vivo microdialysis study. J Neurochem 1992;59:1702-1708.
47. Southam E, Kirkby D, Higgins GA, Hagan RM. Lamotrigine inhibits monoamine uptake in vitro and modulates hydroxytryptamine uptake in rats. Eur J Pharmacol 1998;358:19-24.
48. Pintor M, Mefford IN, Hutter I, Pocotte SL, Wyler AR, Nadi NS. Levels of biogenic amines, their metabolites, and tyrosine hydroxylase activity in the human epileptic temporal cortex. Synapse 1990;5:152-156.
49. 11C]methyl-L-tryptophan positron emission tomography. Ann Neurol 1998;44:858-866.
50. Fedi M, Reutens D, Okazawa H, et al. Localizing value of α-methyl-L-tryptophan PET in intractable epilepsy of neocortical origin. Neurology 2001;57:1629-1636.
51. Moroni F. Tryptophan metabolism and brain function: focus on kynurenine and other indole metabolites. Eur J Pharmacol 1999;375:87-100.
52. 11C] methyl-L-tryptophan PET maps brain serotonin synthesis and kynurenine pathway metabolism. J Cereb Blood Flow Metab 2000;20:2-9.