Anticonvulsant doses of carbamazepine increase hippocampal extracellular serotonin in genetically epilepsy-prone rats: Dose response relationships

Neuroscience Letters

Volumn 227, Issue 1, 1997, Pages 13-16

  Dailey, John W ^a   Reith, Maarten E A ^a   Yan, Qing Shan ^a   Li, Ming Ya ^a   Jobe, Phillip C ^a  

^a UNIVERSITY OF ILLINOIS   (United States)

Author keywords

Antiepileptic drug; Carbamazepine; Convulsions; Genetically epilepsy prone rats; Hippocampus; Microdialysis; Seizures; Serotonin

Indexed keywords

ANTICONVULSIVE AGENT; CARBAMAZEPINE;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ARTICLE; DOSE RESPONSE; EPILEPSY; FEMALE; GENETIC SUSCEPTIBILITY; INTRAPERITONEAL DRUG ADMINISTRATION; NONHUMAN; PRIORITY JOURNAL; RAT; SEIZURE; SEROTONIN RELEASE; STRAIN DIFFERENCE;

ANALYSIS OF VARIANCE; ANIMALS; ANTICONVULSANTS; CARBAMAZEPINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; EPILEPSY; GENETIC PREDISPOSITION TO DISEASE; HIPPOCAMPUS; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN;

EID: 0031011626     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(97)00288-7     Document Type: Article

References (26)

1. Biggs C.S., Pearce B.R., Fowler L.J., Whitton P.S. Regional effects of sodium valproate on extracellular concentrations of 5-hydroxytryptamine, dopamine, and their metabolites in the rat brain: an in vivo microdialysis study. J. Neurochem. 59:1992;1702-1708.
2. Booker J.G., Dailey J.W., Jobe P.C., Lane J.D. Cerebral cortical GABA and benzodiazepine binding sites in genetically seizure prone rats. Life Sci. 39:1986;799-806.
3. Browning R.A., Wade D.R., Marcinczyk M., Long G.L., Jobe P.C. Regional brain abnormalities in norepinephrine uptake and dopamine beta-hydroxylase activity in the genetically epilepsy-prone rat. J. Pharmacol. Exp. Ther. 249:1989;229-235.
4. Browning R.A., Wang C., Lanker M.L., Jobe P.C. Electroshock- and pentylenetetrazol-induced seizures in genetically epilepsy-prone rats (GEPRs): differences in threshold and pattern. Epilepsy Res. 6:1990;1-11.
5. Dailey J.W., Cheong J.H., Ko K.H., Adams-Curtis L.E., Jobe P.C. Anticonvulsant properties of D-20443 in genetically epilepsy-prone rats: prediction of clinical response. Neurosci. Lett. 195:1995;77-80.
6. Dailey J.W., Jobe P.C. Anticonvulsant drugs and the genetically epilepsy-prone rat. Fed. Proc. 44:1985;2640-2644.
7. Dailey J.W., Reigel C.E., Mishra P.K., Jobe P.C. Neurobiology of seizure predisposition in the genetically epilepsy-prone rat. Epilepsy Res. 3:1989;3-17.
8. Dailey, J.W., Reith, M.E.A., Yan, Q.S., Li, M.Y. and Jobe, P.C., Carbamazepine increases extracellular serotonin: lack of antagonism by tetrodotoxin or zero calcium, Eur. J. Pharmacol., (1997) accepted.
9. Dailey J.W., Seo D., Yan Q.S., Ko K., Jo M., Jobe P.C. The anticonvulsant effect of the broad spectrum anticonvulsant loreclezole may be mediated in part by serotonin in rats: a microdialysis study. Neurosci. Lett. 178:1994;179-183.
10. Dailey J.W., Yan Q.S., Adams-Curtis L.E., Ryu J.R., Ko K.H., Mishra P.K., Jobe P.C. Neurochemical correlates of antiepileptic drugs in the genetically epilepsy-prone rats (GEPR). Life Sci. 58:1996;259-266.
11. Dailey J.W., Yan Q.S., Mishra P.K., Burger R.L., Jobe P.C. Effects of fluoxetine on convulsions and on brain serotonin as detected by microdialysis in genetically epilepsy-prone rats. J. Pharmacol. Exp. Ther. 260:1992;533-540.
12. Faingold C.L., Gehlbach G., Caspary D.M. On the role of GABA as an inhibitory neurotransmitter in inferior colliculus neurons: iontophoretic studies. Brain Res. 500:1989;302-312.
13. Jobe P.C., Mishra P.K., Adams-Curtis L.E., Deoskar V.U., Ko K.H., Browning R.A., Dailey J.W. The genetically epilepsy-prone rat (GEPR). Ital. J. Neurol. Sci. 16:1995;91-99.
14. Jobe P.C., Mishra P.K., Browning R.A., Wang C.D., Adams-Curtis L.E., Ko K.H., Dailey J.W. Noradrenergic abnormalities in the genetically epilepsy-prone rat. Brain Res. Bull. 35:1994;493-504.
15. Jobe P.C., Mishra P.K., Ludvig N., Dailey J.W. Scope and contribution of genetic models to an understanding of the epilepsies. CRC Crit. Rev. Neurobiol. 6:1991;183-220.
16. Jobe P.C., Picchioni A.L., Chin L. Role of brain norepinephrine in audiogenic seizure in the rat. J. Pharmacol. Exp. Ther. 184:1973;1-10.
17. Lasley S.M. Roles of neurotransmitter amino acids in seizure severity and experience in the genetically epilepsy-prone rat. Brain Res. 560:1991;63-70.
18. Lasley S.M., Yan Q.S. Diminished potassium-stimulated GABA release in vivo in genetically epilepsy-prone rats. Neurosci. Lett. 175:1994;145-148.
19. Paxinos, G. and Watson, C., The Rat Brain in Stereotaxic Coordinates, 2nd edn., Academic Press Australia, Sydney, 1986, vii pp.
20. Reigel C.E., Dailey J.W., Jobe P.C. The genetically epilepsy-prone rat: an overview of seizure-prone characteristics and responsiveness to anticonvulsant drugs. Life Sci. 39:1986;763-774.
21. Roberts R.C., Ribak C.E. An electron microscopic study of GABAergic neurons and terminals in the central nucleus of the inferior colliculus of the rat. J. Neurocytol. 16:1987;333-345.
22. Statnick M.A., Dailey J.W., Jobe P.C., Browning R.A. Abnormalities in 5-HT1A and 5-HT1B receptor binding in severe-seizure genetically epilepsy-prone rats (GEPR-9s). Neuropharmacology. 35:1996;111-118.
23. Statnick M.A., Dailey J.W., Jobe P.C., Browning R.A. Abnormalities in brain serotonin concentration, high-affinity uptake, and tryptophan hydroxylase activity in severe-seizure genetically epilepsy-prone rats. Epilepsia. 37:1996;311-321.
24. Whitton P.S., Fowler L.J. The effect of valproic acid on 5-hydroxytryptamine and 5-hydroxyindoleacetic acid concentration in hippocampal dialysates in vivo. Eur. J. Pharmacol. 200:1991;167-169.
25. Yan Q.S., Jobe P.C., Dailey J.W. Further evidence of anticonvulsant role for 5-hydroxytryptamine in genetically epilepsy-prone rats. Br. J. Pharmacol. 115:1995;1314-1318.
26. Yan Q.S., Mishra P.K., Burger R.L., Bettendorf A.F., Jobe P.C., Dailey J.W. Evidence that carbamazepine and antiepilepsirine may produce a component of their anticonvulsant effects by activating serotonergic neurons in genetically epilepsy-prone rats. J. Pharmacol. Exp. Ther. 261:1992;652-659.