α[C-11]methyl-L-tryptophan PET maps brain serotonin synthesis and Kynurenine pathway metabolism

Journal of Cerebral Blood Flow and Metabolism

Volumn 20, Issue 1, 2000, Pages 2-9

  Chugani, Diane C ^a,b   Muzik, Otto ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CHILDREN'S HOSPITAL OF MICHIGAN   (United States)

Author keywords

Kynurenine pathway.; Positron emission tomography; Serotonin synthesis; methyl L tryptophan

Indexed keywords

DEOXYGLUCOSE; KYNURENINE; SEROTONIN; TRYPTOPHAN DERIVATIVE;

ADOLESCENT; ADULT; AGE; BLOOD BRAIN BARRIER; BRAIN DISEASE; CHILD; FEMALE; GENDER; GLUCOSE METABOLISM; HUMAN; MALE; METABOLISM; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM; REVIEW;

EID: 0033961681     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-200001000-00002     Document Type: Review

References (31)

1. Bloxam DL, Tricklebank MD, Patel AJ, Curzon G (1980) Effects of albumin, amino acids, and clofibrate on the uptake of tryptophan by the rat brain. J Neurochem 34:43-49
2. Bucht G, Adolfsson R, Gottfries CG, Roos B-E, Winblad B (1981) Distribution of 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in human brain in relation to age, drug influence, agonal status and circadian variation. J Neural Transm 51:185-203
3. Carlsson M, Svensson K, Eriksson E, Carlsson A (1985) Rat brain serotonin: biochemical and functional evidence for a sex difference. J Neural Transm 63:297-313
4. Carlsson M, Carlsson A (1988) In vivo evidence for a greater brain tryptophan hydroxylase capacity in female than in male rats. Naunyn Schmiedebergs Arch Pharmacol 338:345-349
5. Chugani DC, Muzik O, Rothermel R, Behen M, Chakraborty P, Mangner T, DaSilva E, Chugani HT (1997) Altered serotonin synthesis in the dentatothalamocortical pathway in autistic boys. Ann Neurol 42:666-669
6. Chugani DC, Muzik O, Chakraborty PK, Mangner TJ, Chugani HT (1998a) Human brain serotonin synthesis capacity measured in vivo with α[C-11]methyl-L-tryptophan. Synapse 28:33-43
7. Chugani DC, Heyes MP, Kuhn DM, Chugani HT (1998b) Evidence that α[C-11]methyl-L-tryptophan PET traces tryptophan metabolism via the kynurenine pathway in tuberous sclerosis complex. Soc Neurosci Abstr 24:1757
8. Chugani DC, Chugani HT, Muzik O, Shah JR, Shah AK, Canady AI, Mangner TJ, Chakraborty PK (1998c) Imaging epileptogenic tubers in children with tuberous sclerosis complex using α[11C]-methyl-L-tryptophan PET. Ann Neurol 44:858-866
9. Chugani DC, Muzik O, Behen ME, Rothermel RD, Lee J, Chugani HT (1999) Developmental changes in brain serotonin synthesis capacity in autistic and non-autistic children. Ann Neurol 45:287-295
10. Chugani DC, Niimura K, Chaturvedi S, Muzik O, Fakhouri M, Lee M-L, Chugani HT (1999) Increased brain serotonin synthesis in migraine. Neurology 53:1473-1479
11. Cochran E, Robins E, Grote S (1976) Regional serotonin levels in brain. A comparison of depressive suicides and alcoholic suicides with controls. Biol Psychiatry 11:283-294
12. Cohen Z, Tsuiki K, Takada A, Beaudet A, Diksic M, Hamel E (1995) In vivo-synthesis radioactively labelled α-methyl serotonin as a selective tracer for visualization of brain serotonin neurons. Synapse 21:21-28
13. Cook EH, Leventhal BL (1996) The serotonin system in autism. Curr Opin Pediatr 8:348-354
14. Costa E, Aprison MH (1958) Studies on the 5-hydroxytryptamine (serotonin) content in human brain. J Nerv Ment Dis 126:289-293
15. Diksic M, Nagahiro S, Sourkes TL, Yamamoto YL (1990) A new method to measure brain serotonin synthesis in vivo. I. Theory and basic data for a biological model. J Cereb Blood Flow Metab 9:1-12
16. Diksic M, Nagahiro S, Chaly T, Sourkes TL, Yamamoto YL, Feindel W (1991) Serotonin synthesis rate measured in living dog brain by positron emission tomography. J Neurochem 56:153-162
17. Fernstrom JD, Wurtman RJ (1971) Brain serotonin content: physiological dependence on plasma tryptophan levels. Science 173:149-151
18. Ferrari MD, Odink J, Tapparelli C, Van Kempen GM, Pennings EJ, Bruyn GW (1989) Serotonin metabolism in migraine. Neurology 39:1239-1242
19. Gharib A, Balende C, Sarda N, Weissmann D, Plenevaux A, Luxen A, Bobillier P, Pujol J-F (1999) Biochemical and autoradiographic measurements of brain serotonin synthesis rate in the freely moving rat: a reexamination of the α-methyl-L-tryptophan method. J Neurochem 72:2593-2600
20. Goldman-Rakic PS, Brown RM (1982) Postnatal development of monoamine content and synthesis in the cerebral cortex of rhesus monkeys. Dev Brain Res 4:339-349
21. Haber R, Bessette D, Hulihan-Giblin B, Durcan MJ, Goldman D (1993) Identification of tryptophan 2,3-dioxygenase RNA in rodent brain. J Neurochem 60:1159-1162
22. Hamon M, Bourgoin S, Artaud F, El Mestikawy S (1981) The respective roles of tryptophan uptake and tryptophan hydroxylase in the
23. Mackay AVP, Yates CM, Wright A, Hamilton P, Davies P (1978) Regional distribution of monoamines and their metabolites in the human brain. J Neurochem 30:841-848
24. Madras BK, Sourkes TL (1965) Metabolism of α-methyl-tryptophan. Biochem Pharmacol 14:1499-1506
25. Missala K, Sourkes TL (1988) Functional cerebral activity of an analogue of serotonin formed in situ. Neurochem Int 12:209-214.
26. Muzik O, Chugani DC, Chakraborty PK, Mangner TJ, Chugani HT (1997) Analysis of [C-11]alpha-methyl-tryptophan kinetics for the estimation of serotonin synthesis rate in vivo. J Cereb Blood Flow Metab 17:659-669
27. Nishizawa S, Benkelfat C, Young SN, Leyton M, Mzengeza S, De Montigny C, Blier P, Diksic M (1997) Differences between males and females in rates of serotonin synthesis in human brain. Proc Natl Acad Sci USA 94:5308-5313
28. Oldendorf WH (1971) Brain uptake of radiolabeled amino acids, amines and hexoses after arterial injection. Am J Physiol 221:1629-1639
29. Pardridge WM (1977) Kinetics of competitive inhibition of neutral amino acid transport across the blood-brain barrier. J Neurochem 28:103-108
30. Patlak CS, Blasberg RG, Fenstermacher JD (1983) Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. J Cereb Blood Flow Metab 3:1-7
31. Perkins MN, Stone TW (1982) An iontophoretic investigation of the actions of convulsant kynurenines and their interaction with the endogenous excitant quinolinic acid. Brain Res 247:184-187