Abnormalities in 5-HT1A and 5-HT1B receptor binding in severe-seizure genetically epilepsy-prone rats (GEPR-9s)

Neuropharmacology

Volumn 35, Issue 1, 1996, Pages 111-118

  Statnick, M A ^a   Dailey, J W ^b   Jobe, P C ^b   Browning, R A ^a  

^a SOUTHERN ILLINOIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF ILLINOIS   (United States)

Author keywords

5 HT1A receptor; 5 HT1B receptor; Epilepsy; Rat; Seizure; Serotonin

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; CYANOPINDOLOL; SEROTONIN 1A RECEPTOR; SEROTONIN 1B RECEPTOR; DRUG DERIVATIVE; PINDOLOL; SEROTONIN ANTAGONIST; SEROTONIN RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN REGION; CONTROLLED STUDY; EPILEPSY; HIPPOCAMPUS; MALE; MUTANT; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; ANIMAL; BINDING COMPETITION; DOSE RESPONSE; METABOLISM; RAT;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; ANIMALS; BINDING, COMPETITIVE; DOSE-RESPONSE RELATIONSHIP, DRUG; EPILEPSY; MALE; PINDOLOL; RATS; RECEPTORS, SEROTONIN; SEROTONIN ANTAGONISTS;

EID: 0029670753     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/0028-3908(95)00141-7     Document Type: Article

References (53)

1. Andrade R. and Nicoll R. A. (1987) Pharmacologically distinct actions of serotonin on single pyramidal neurons of the rat hippocampus recorded in vitro. J. Physiol. 394: 99-124.
2. 3H-5-hydroxytryptamine in the rat CNS. J. Neurochem. 46: 1392-1398.
3. 1B heteroceptors inhibiting acetylcholine release. Eur. J. Pharmac. 242: 1-6.
4. Booker J. G., Dailey J. W., Jobe P. C. and Lane J. D. (1986) Cerebral cortical GABA and benzodiazepine binding sites in genetically epilepsy-prone rats. Life Sci. 39: 799-806.
5. Brown L. M., Smith D. L., Williams G. M. and Smith D. J. (1989) Alterations in serotonin binding sites after 5,7-dihydroxytryptamine treatment in the rat spinal cord. Neurosci. Lett. 102: 103-107.
6. Browning R. A. (1986) Neurobiology of seizure disposition: the genetically epilepsy-prone rat. VII. Neuroanatomical localization of structures responsible for seizures in the GEPR: lesion studies. Life Sci. 39: 857-867.
7. Browning R. A. (1987) The role of neurotransmitters in electroshock seizure models. In Neurotransmitters and Epilepsy (Jobe P. C. and Laird II H. E., Eds), pp. 277-320. The Humana Press, Clifton.
8. Browning R. A., Wang C., Lanker M. L. and Jobe P. C. (1990) Electroshock-and pentylenetetrazol-induced seizures in genetically epilepsy-prone rats (GEPRs): differences in threshold and pattern. Epilepsy Res. 6: 1-11.
9. Browning R. A., Statnick M. A., Dailey J. W. and Jobe P. C. (1993) Regional reductions in serotonin high affinity uptake in the central nervous system of severe seizure genetically epilepsy-prone rats (GEPR-9s). Epilepsia 34: (suppl. 6), 14.
10. Buterbaugh G. G. (1978) Effect of drugs modifying central serotonergic function on the response of extensor and nonextensor rats to maximal electroshock. Life Sci. 23: 2393-2404.
11. Coffey L. L., Reith M. E. A., Chen N. H. and Jobe P. C. (1994) Brainstem seizures in amygdala-kindled genetically epilepsy-prone rats (GEPRs). Soc. Neurosci. Abst. 20: 1458.
12. Dailey J. W., Reigel C. E., Mishra P. K. and Jobe P. C. (1989) Neurobiology of seizure predisposition in the genetically epilepsy-prone rat. Epilepsy Res. 3: 3-17.
13. Dailey J. W., Yan Q. S., Mishra P. K., Burger R. L. and Jobe P. C. (1992a) Effects of fluoxetine on convulsions and on brain serotonin as detected by microdialysis in genetically epilepsy-prone rats. J. Pharmac. exp. Ther. 260: 533-540.
14. Dailey J. W., Mishra P. K., Ko K. H., Penny J. E. and Jobe P. C. (1992b) Serotonergic abnormalities in the central nervous system of seizure-naive genetically epilepsy-prone rats. Life Sci. 50: 319-326.
15. 1A receptor: an overview of recent advances. Neurochem. Res. 16, 1-10.
16. Faingold C. L., Gehlbach G., Travis M. A. and Caspary D. M. (1986) Neurobiology of seizure disposition of the genetically epilepsy-prone rat. VIII. Inferior colliculus neuronal response abnormalities in genetically epilepsy-prone rats: evidence for a deficit of inhibition. Life Sci. 39: 869-878.
17. Faingold C. L., Naritoku D. K., Copley C. A., Randall M. E., Riaz A., Boersma-Anderson C. A. and Arneric S. P. (1992) Glutamate in the inferior colliculus plays a critical role in audiogenic seizure initiation. Epilepsy Res. 13: 95-105.
18. 1 and serotonin2 receptors throughout the rat central nervous system using quantitative autoradiography. Brain Res. 421: 263-279.
19. 2 receptor number in brain as a probable explanation for the enhanced 5-hydroxytryptamine-mediated behavior following repeated electroconvulsive shock administration in rats. Br. J. Pharmac. 80: 173-177.
20. 3H]8-Hydroxy-2-(di-N-propylamino)tetralin binding to pre-and postsynaptic 5-hydroxytryptamine sites in various regions of the rat brain. J. Neurochem. 44: 1685-1696.
21. 1A receptors in the rat hippocampus. Biogenic Amines 9: 295-306.
22. 1A receptor regulation: effect of 5,7-dihydroxytryptamine and antidepressant treatments. Neuropsychopharmacology 4: 131-144.
23. Hirsch E., Maton B., Vergnes M., Depaulis A. and Marescaux C. (1992) Positive transfer of audiogenic kindling to electrical hippocampal kindling in rats. Epilepsy Res. 11: 159-166.
24. 125I]iodocyanopindolol. Eur. J. Pharmac. 118: 1-12.
25. 3H-ketanserin. Eur. J. Pharmac. 118: 13-23.
26. Jobe P. C., Picchioni A. L. and Chin L. (1973a) Role of brain 5-hydroxytryptamine in audiogenic seizure in the rat. Life Sci. 13: 1-13.
27. Jobe P. C., Picchioni A. L. and Chin L. (1973b) Role of brain norepinephrine in audiogenic seizure in the rat. J. Pharmac. exp. Ther. 184: 1-10.
28. Jobe P. C., Reigel C. E., Mishra P. K. and Dailey J. W. (1986) Neurotransmitter abnormalities as determinants of seizure predisposition in the genetically epilepsy-prone rat. In Neurotransmitters, Seizures, and Epilepsy III (Nistico G., Morselli P. L., Lloyd K. G., Farriello R. G. and Engel Jr. J.), pp. 387-397. Raven Press, New York.
29. Jobe P. C., Mishra P. K. and Dailey J. W. (1992) Genetically epilepsy-prone rats: actions of antiepileptic drugs and monoaminergic neurotransmitters. In Drugs for the Control of Epilepsy: Actions on Neuronal Networks Involved in Seizures (Faingold C. L. and Fromm G. H., Eds), pp. 253-275. CRC Press, Boca Raton.
30. Kellar K., Cascio C. S., Butler J. A. and Kurtzke R. N. (1981) Differential effects of electroconvulsive shock and antidepressant drugs on serotonin-2 receptors in rat brain. Eur. J. Pharmac. 69: 515-518.
31. Laird II, H. E. and Jobe P. C. (1987) The genetically epilepsyprone rat. In Neurotransmitters and Epilepsy (Jobe P. C. and Laird II, H. E., Eds), pp. 57-94. Humana Press, Clifton.
32. Lowry O. H., Rosenbrough N. J., Farr A. L. and Randall R. J. (1951) Protein measurement with the Folin phenol reagent. J. biol. Chem. 193: 265-275.
33. Manrique C., Segu L., Hery F., Faudon M. and Francois-Bellen A. M. (1993) Increase in central 5-HT1B binding sites following 5, 7-dihydroxytryptamine axotomy in the adult rat. Brain Res. 623: 345-348.
34. Marescaux C., Vergnes M., Kiesmann M., Depaulis A., Micheletti G. and Warter J. M. (1987) Kindling of audiogenic seizures in Wistar rats: an EEG study. Exp. Neurol. 97: 160-168.
35. Millan M. H., Wardley-Smith B., Durmuller N. and Meldrum B.S. (1991) The high pressure neurological syndrome in genetically epilepsy-prone rats: protective effect of 2-amino7-phosphonoheptanoate. Exp. Neurol. 112: 317-320.
36. 1B receptors on the sympathetic nerve terminals of the rat inferior vena cava. N.S. Arch. Pharmac. 341: 391-397.
37. Munson P. J. and Rodbard D. (1980) Ligand: a versatile computerized approach for characterization of ligand-binding systems. Analyt. Biochem. 107: 220-239.
38. Naritoku D. K., Mecozzi L. B., Aiello M. T. and Faingold C. L. (1992) Repetition of audiogenic seizures in genetically epilepsy-prone rats induces cortical epileptiform activity and additional seizure behaviors. Exp. Neurol. 115: 317-324.
39. Nelson D. L., Herbet A., Bourgoin S., Glowinski J. and Hamon M. (1978) Characteristics of central 5-HT receptors and their adaptive changes following intracerebral 5,7-dihydroxytryptamine administration in the rat. Molec. Pharmac. 14: 983-995.
40. 1B receptors in the brain of the rat. J. Pharmac. exp. Ther. 244: 144-153.
41. Pazos A., Hoyer D. and Palacios J. M. (1985) Mesulergine, a selective serotonin-2 ligand in the rat cortex, does not label these receptors in porcine and human cortex: evidence for species differences in brain serotonin-2 receptors. Eur. J. Pharmac. 106: 531-538.
42. Pranzatelli M. R. (1994) Serotonin in human myoclonus-rationale for the use of serotonin receptor agonists and antagonists. Arch. Neurol. 51: 605-617.
43. Prendiville S. and Gale K. (1993) Anticonvulsant effect of fluoxetine on focally evoked limbic motor seizures in rats. Epilepsia 34: 381-384.
44. Racine R. and Coscina D. V. (1979) Effects of midbrain raphe lesions or systemic p-chlorophenylalanine on the development of kindled seizures in rats. Brain Res. Bull. 4: 1-7.
45. Reigel C. E., Dailey J. W. and Jobe P. C. (1986) The genetically epilepsy-prone rat: an overview of seizure-prone characteristics and responsiveness to anticonvulsant drugs. Life Sci. 39: 763-774.
46. Salgado D. and Alkadhi K. A. (1995) Inhibition of epileptiform activity by serotonin in rat CAl neurons. Brain Res. 669: 176-182.
47. Savage D. D., Reigel C. E. and Jobe P. C. (1986) Angular bundle kindling is accelerated in rats with a genetic predisposition to acoustic stimulus-induced seizures. Brain Res. 367: 412-415.
48. Statnick M. A., Dailey J. W., Jobe P. C. and Browning R. A. (1991) Abnormalities in brain serotonin uptake and steady-state concentration in the genetically epilepsy-prone rat. Soc. Neurosci. Abstr. 17: 171.
49. Statnick M. A., Dailey J. W., Jobe P. C. and Browning R. A. (1993) Abnormalities in serotonin synthesis in severe seizure genetically epilepsy-prone rats (GEPR-9s). Soc. Neurosci. Abstr. 19: 608.
50. 1 receptor subtypes in the brain of control and 5,7-DHT treated rats. J. Neurosci. 6: 3474-3482.
51. Wada J. A., Balzamo E., Meldrum B. S. and Naquet R. (1972) Behavioral and electrographic effects of L-5-hydroxytryptophan and D, L-parachlorophenylalanine on epileptic Senegalese baboon (Papio papio). Electroencephalogr. Clin. Neurophysiol. 33: 520-526.
52. Wada Y., Nakamura M., Hasegawa H. and Yamaguchi N. (1992) Role of serotonin receptor subtype in seizures kindled from the feline hippocampus. Neurosci. Lett. 141: 21-24.
53. Wada Y., Nakamura M., Hasegawa H. and Yamaguchi N. (1993) Intra-hippocampal injection of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) inhibits partial and generalized seizures induced by kindling stimulation in cats. Neurosci. Lett. 159: 179-182.