6-Aryl-2,4-dioxo-5-hexenoic acids, novel integrase inhibitors active against HIV-1 multiplication in cell-based assays

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 7, 2004, Pages 1745-1749

  Costi, Roberta ^a   Di Santo, Roberto ^a   Artico, Marino ^a   Roux, Alessandra ^a   Ragno, Rino ^b   Massa, Silvio ^a   Tramontano, Enzo ^c   La Colla, Massimiliano ^c   Loddo, Roberta ^c   Marongiu, M Elena ^c   Pani, Alessandra ^c   La Colla, Paolo ^c  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b UNIVERSITY OF SIENA   (Italy)

^c Sezione di Microbiologia   (Italy)

Author keywords

Anti HIV 1 IN agents; Aryldioxohexenoic acids; Diketoacids; Pyrrole derivatives; QSAR studies

Indexed keywords

4 [1 (4 FLUOROBENZYL) 2 PYRROLYL] 2,4 DIOXOBUTYRIC ACID; 5 CITEP; ANTIVIRUS AGENT; ENZYME INHIBITOR; HEXENOIC ACID DERIVATIVE; INTEGRASE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CELL ASSAY; DRUG CONFORMATION; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITOR INTERACTION; HUMAN IMMUNODEFICIENCY VIRUS 1; IC 50; QUANTITATIVE STRUCTURE ACTIVITY RELATION; VIRUS INHIBITION; VIRUS REPLICATION;

ANTI-HIV AGENTS; CELL SURVIVAL; HIV INTEGRASE INHIBITORS; HIV-1; VIRUS REPLICATION;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 12144288755     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.01.037     Document Type: Article

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