Part of membrane-bound Aβ exists in rafts within senile plaques in Tg2576 mouse brain

Neurobiology of Aging

Volumn 26, Issue 4, 2005, Pages 409-418

  Kokubo, Hideko ^a,b   Saido, Takaomi C ^c   Iwata, Nobuhisa ^c   Helms, J Bernd ^d   Shinohara, Rumi ^a   Yamaguchi, Haruyasu ^a  

^a GUNMA UNIVERSITY   (Japan)

^b GERIATRICS RESEARCH INSTITUTE AND HOSPITAL   (Japan)

^c RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

^d UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Alzheimer's disease; Amyloid ; Flotillin 1; Immunoelectron microscope; Microdomain; Raft; Tg2576 mouse

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-42]; BRAIN PROTEIN; FLOTILLIN 1; MEMBRANE PROTEIN; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN REGION; CELL MEMBRANE; CONTROLLED STUDY; ELECTRON MICROSCOPE; LIPID RAFT; MICROSCOPY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SENILE PLAQUE; ULTRASTRUCTURE;

AMYLOID BETA-PROTEIN; ANIMALS; BRAIN; CELL MEMBRANE; HUMANS; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; MICROSCOPY, IMMUNOELECTRON; PEPTIDE FRAGMENTS; SENILE PLAQUES;

EID: 11844250511     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2004.04.008     Document Type: Article

References (28)

1. Avdulov N.A., Chochina S.V., Igbavboa U., Warden C.S., Vassiliev A.V., Wood W.G. Lipid binding to amyloid β-peptide aggregates: preferential binding of cholesterol as compared with phosphatidylcholine and fatty acids. J Neurochem. 69:1997;1746-1752
2. Bickel P.E., Scherer P.E., Schnitzer J.E., Oh P., Lisanti M.P., Lodish H.F. Flotillin and epidermal surface antigen define a new family of caveolae-associated integral membrane proteins. J Biol Chem. 272:1997;13793-13802
3. Giannakopoulos P., Hof P.R., Savioz A., Guimon J., Antonarakis S.E., Bouras C. Early-onset dementias: clinical neuropathological and genetic characteristics. Acta Nueropathol. 91:1996;451-465
4. Gkantiragas I., Brügger B., Stüven E., Kaloyanova D., Löhr K., Lottspeich F., et al. Sphingomyelin-enriched microdomains at the Golgi complex. Mol Biol Cell. 12:2001;1819-1833
5. Hsiao K., Chapman P., Nilsen S., Eckman C., Harigaya Y., Younkin S., et al. Correlative memory deficits, Aβ elevation, and amyloid plaques in transgenic mice. Science. 274:1996;99-102
6. Irizarry M.C., McNamara M., Fedorchak K., Hsiao K., Hyman B.T. APPsw transgenic mice develop age-related Aβ deposits and neuropil abnormalities, but no neuronal loss in CA1. J Neuropathol Exp Neurol. 56:1997;965-973
7. Kakio A., Nishimoto S., Yanagisawa K., Kozutsumi Y., Matsuzaki K. Cholesterol-dependent formation of GM1 ganglioside-bound amyloid β-protein, an endogeneous seed for alzheimer amyloid. J Biol Chem. 276:2001;24985-24990
8. Kawarabayashi T., Younkin L.H., Saido T.C., Shoji M., Ashe K.H., Younkin S.G. Age-dependent changes in brain, CSF, and plasma amyloid β protein in the Tg2576 transgenic mouse model of Alzheimer's disease. J Neurosci. 21:2001;372-381
9. Kokubo H., Lemere C.A., Yamaguchi H. Localization of flotillins in human brain and their accumulation with the progression of Alzheimer's disease pathology. Neurosci Lett. 290:2000;93-96
10. Kokubo H., Helms J.B., Ohno-Iwashita Y., Shimada Y., Horikoshi Y., Yamaguchi H. Ultrastructural localization of flotillin-1 to cholesterol-rich membrane microdomains, rafts, in rat brain tissue. Brain Res. 965:2003;83-90
11. Lafont F., Verkade P., Galli T., Wimmer C., Louvard D., Simons K. Raft association of SNAP receptors acting in apical trafficking in Madin-Darby canine kidney cells. Proc Natl Acad Sci U.S.A. 96:1999;3734-3738
12. Lainé J., Marc M.-E., Sy M.-S., Axelrad H. Cellular and subcellular morphological localization of normal prion protein in rodent cerebellum. Eur J Neurosci. 14:2001;47-56
13. Lee S.J., Liyanage U., Bickel P.E., Xia W., Lansbury P.T. Jr., Kosik K.S. A detergent-insoluble membrane compartment contains Aβ in vivo. Nat Med. 4:1998;730-734
14. Mann D.M.A., Jones D., Snowden J.S., Neary D., Hardy J. Pathological changes in the brain of the patient with familial Alzheimer's disease having missense mutation at codon 717 in the amyloid precursor protein gene. Neurosci Lett. 137:1992;225-228
15. Mayor S., Rothberg K.G., Maxfield F.R. Sequestration of GPI-anchored proteins in caveolae triggered by cross-linking. Science. 264:1994;1948-1951
16. Mizuno T., Nakata M., Naiki H., Michikawa M., Wang R., Haass C., et al. Cholesterol-dependent generation of a seeding amyloid β protein in cell culture. J Biol Chem. 274:1999;15110-15114
17. Morishima-Kawashima M., Ihara Y. The presence of amyloid β-protein in the detergent-insoluble membrane compartment of human neuroblastoma cells. Biochemistry. 37:1998;15247-15253
18. Ohshima N., Morishima-Kawashima M., Yamaguchi H., Yoshimura M., Sugihara S., Khan K., et al. Accumulation of amyloid β-protein in the low-density membrane domain accurately reflects the extent of β-amyloid deposition in the brain. Am J Pathol. 158:2001;2209-2218
19. Parkin E.T., Hussain I., Karran E.H., Turner A.J., Hooper N.M. Characterization of detergent-insoluble complexes containing the familial Alzheimer's disease-associated presenilins. J Neurochem. 72:1999;1534-1543
20. Reilly J.F., Games D., Rydel R.E., Freedman S., Schenk D., Young W.G., et al. Amyloid deposition in the hippocampus and entorhinal cortex: quantitative analysis of a transgenic mouse model. Proc Natl Acad Sci U.S.A. 100:2003;4837-4842
21. Riddell D.R., Christie G., Hussain I., Dingwall C. Compartmentalization of β-secretase (Asp2) into low-buoyant density, noncaveolar lipid rafts. Curr Biol. 11:2001;1288-1293
22. Sawamura N., Morishima-Kawashima M., Waki H., Kobayashi K., Kuramochi T., Ito M., et al. Mutant presenilin 2 transgenic mice. A large increase in the levels of Aβ42 is presumably associated with the low density membrane domain that contains decreased levels of glycerophospholipids and sphingomyelin. J Biol Chem. 275:2000;27901-27908
23. Simons K., Ikonen E. Functional rafts in cell membranes. Nature. 387:1997;569-572
24. Takahashi R.H., Milner T.A., Li F., Nam E.E., Edger M.A., Yamaguchi H., et al. Intraneuronal Alzheimer Aβ42 accumulates in multivesicular bodies and is associated with synaptic pathology. Am J Pathol. 161:2002;1869-1879
25. Tomlinson BE. Aging and the dementias. In: Adams JH, Duchen LW, editors. Greenfield's neuropathology. 5th ed. London: Edward Arnold; 1992. p. 1284-410.
26. Vey M., Pilkuhn S., Wille H., Nixon R., DeArmond S.J., Smart E.J., et al. Subcellular colocalization of the cellular and scrapie prion proteins in caveolae-like membranous domains. Proc Natl Acad Sci U.S.A. 93:1996;14945-14949
27. Yamaguchi H., Maat-Schieman M.L.C., van Duinen S.G., Prins F.A., Neeskens P., Natté R., et al. Amyloid (protein (Aβ) starts to deposit as plasma membrane-bound form in diffuse plaques of brains from hereditary cerebral hemorrhage with amyloidosis-Dutch type, Alzheimer disease and nondemented aged subjects. J Neuropathol Exp Neurol. 59:2000;723-732
28. Yanagisawa K., Okada A., Suzuki N., Ihara Y. GM1 ganglioside-bound amyloid β-protein (Aβ): a possible form of preamyloid in Alzheimer's disease. Nature Med. 1:1995;1062-1066