메뉴 건너뛰기




Volumn 1727, Issue 1, 2005, Pages 45-57

Transcriptional regulation of the human reduced folate carrier promoter C: Synergistic transactivation by Sp1 and C/EBP β and identification of a downstream repressor

Author keywords

C EBP; Methotrexate; Reduced folate carrier; Sp1; Transcription

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN BETA; REDUCED FOLATE CARRIER; TRANSCRIPTION FACTOR SP1;

EID: 11844257571     PISSN: 01674781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbaexp.2004.11.006     Document Type: Article
Times cited : (17)

References (35)
  • 1
    • 0033808685 scopus 로고    scopus 로고
    • Folic acid: Nutritional biochemistry, molecular biology, and role in disease processes
    • M. Lucock Folic acid: nutritional biochemistry, molecular biology, and role in disease processes Mol. Genet. Metab. 71 2000 121 138
    • (2000) Mol. Genet. Metab. , vol.71 , pp. 121-138
    • Lucock, M.1
  • 2
    • 0041305877 scopus 로고    scopus 로고
    • Membrane transport of folates
    • L.H. Matherly, and I.D. Goldman Membrane transport of folates Vitam. Horm. 66 2003 403 456
    • (2003) Vitam. Horm. , vol.66 , pp. 403-456
    • Matherly, L.H.1    Goldman, I.D.2
  • 3
    • 0000921074 scopus 로고    scopus 로고
    • Receptor- and carrier-mediated transport systems for folates and antifolates. Exploitation for folate chemotherapy and immunotherapy
    • A.L. Jackman Humana Press Totowa, NJ
    • G. Jansen Receptor- and carrier-mediated transport systems for folates and antifolates. Exploitation for folate chemotherapy and immunotherapy A.L. Jackman Anticancer Development Guide: Antifolate Drugs in Cancer Therapy 1999 Humana Press Totowa, NJ 293 321
    • (1999) Anticancer Development Guide: Antifolate Drugs in Cancer Therapy , pp. 293-321
    • Jansen, G.1
  • 4
    • 0035230890 scopus 로고    scopus 로고
    • Molecular and cellular biology of the human reduced folate carrier
    • L.H. Matherly Molecular and cellular biology of the human reduced folate carrier Prog. Nucleic Acid Res. Mol. Biol. 67 2001 131 161
    • (2001) Prog. Nucleic Acid Res. Mol. Biol. , vol.67 , pp. 131-161
    • Matherly, L.H.1
  • 5
    • 0036987083 scopus 로고    scopus 로고
    • Molecular, biochemical, and cellular pharmacology of pemetrexed
    • I.D. Goldman, and R. Zhao Molecular, biochemical, and cellular pharmacology of pemetrexed Semin. Oncol. 29 2002 3 17
    • (2002) Semin. Oncol. , vol.29 , pp. 3-17
    • Goldman, I.D.1    Zhao, R.2
  • 6
    • 0021838288 scopus 로고
    • The cellular pharmacology of methotrexate
    • I.D. Goldman, and L.H. Matherly The cellular pharmacology of methotrexate Pharmacol. Ther. 28 1985 77 100
    • (1985) Pharmacol. Ther. , vol.28 , pp. 77-100
    • Goldman, I.D.1    Matherly, L.H.2
  • 8
    • 0013065232 scopus 로고    scopus 로고
    • Antifolates
    • B.A. Chabner D.L. Longo 3rd edition Lippincott-Raven Philadelphia
    • R.A. Messmann, and C.J. Allegra Antifolates B.A. Chabner D.L. Longo Cancer Chemotherapy and Biotherapy 3rd edition 2001 Lippincott-Raven Philadelphia 139 184
    • (2001) Cancer Chemotherapy and Biotherapy , pp. 139-184
    • Messmann, R.A.1    Allegra, C.J.2
  • 10
    • 0031669954 scopus 로고    scopus 로고
    • Reduced folate carrier gene expression in childhood acute lymphoblastic leukemia: Relationship to immunophenotype and ploidy
    • L. Zhang, J.W. Taub, M. Williamson, S.C. Wong, B. Hukku, J. Pullen, Y. Ravindranath, and L.H. Matherly Reduced folate carrier gene expression in childhood acute lymphoblastic leukemia: relationship to immunophenotype and ploidy Clin. Cancer Res. 4 1998 2169 2177
    • (1998) Clin. Cancer Res. , vol.4 , pp. 2169-2177
    • Zhang, L.1    Taub, J.W.2    Williamson, M.3    Wong, S.C.4    Hukku, B.5    Pullen, J.6    Ravindranath, Y.7    Matherly, L.H.8
  • 11
    • 0030948473 scopus 로고    scopus 로고
    • Defective transport is a common mechanism of acquired methotrexate resistance in acute lymphocytic leukemia and is associated with decreased reduced folate carrier expression
    • R. Gorlick, E. Goker, T. Trippett, P. Steinherz, Y. Elisseyeff, M. Mazumdar, W.F. Flintoff, and J.R. Bertino Defective transport is a common mechanism of acquired methotrexate resistance in acute lymphocytic leukemia and is associated with decreased reduced folate carrier expression Blood 89 1997 1013 1018
    • (1997) Blood , vol.89 , pp. 1013-1018
    • Gorlick, R.1    Goker, E.2    Trippett, T.3    Steinherz, P.4    Elisseyeff, Y.5    Mazumdar, M.6    Flintoff, W.F.7    Bertino, J.R.8
  • 13
    • 0036846897 scopus 로고    scopus 로고
    • The human reduced folate carrier gene is ubiquitously and differently expressed in normal human tissues: Identification of seven non-coding exons and characterization of a novel promoter
    • J.R. Whetstine, R.M. Flatley, and L.H. Matherly The human reduced folate carrier gene is ubiquitously and differently expressed in normal human tissues: identification of seven non-coding exons and characterization of a novel promoter Biochem. J. 367 2002 629 640
    • (2002) Biochem. J. , vol.367 , pp. 629-640
    • Whetstine, J.R.1    Flatley, R.M.2    Matherly, L.H.3
  • 14
    • 4143094813 scopus 로고    scopus 로고
    • Primary acute lymphoblastic leukemia cells use a novel promoter and 5′ non-coding exon for the human reduced folate carrier that encodes a modified carrier translated from an upstream translational start
    • R.M. Flatley, S.G. Payton, J.W. Taub, and L.H. Matherly Primary acute lymphoblastic leukemia cells use a novel promoter and 5′ non-coding exon for the human reduced folate carrier that encodes a modified carrier translated from an upstream translational start Clin. Cancer Res. 10 2004 5111 5122
    • (2004) Clin. Cancer Res. , vol.10 , pp. 5111-5122
    • Flatley, R.M.1    Payton, S.G.2    Taub, J.W.3    Matherly, L.H.4
  • 15
    • 0030868762 scopus 로고    scopus 로고
    • Tissue-specific promoters of the α human folate receptor gene yield transcripts with divergent 5′ leader sequences and different translational efficiencies
    • S.J. Roberts, K.N. Chung, K. Nachmanoff, and P.C. Elwood Tissue-specific promoters of the α human folate receptor gene yield transcripts with divergent 5′ leader sequences and different translational efficiencies Biochem. J. 326 1997 439 447
    • (1997) Biochem. J. , vol.326 , pp. 439-447
    • Roberts, S.J.1    Chung, K.N.2    Nachmanoff, K.3    Elwood, P.C.4
  • 16
    • 15844381051 scopus 로고    scopus 로고
    • Purification and properties of human cytosolic folylpoly-glutamate synthetase and organization, localization, and differential splicing of its gene
    • L. Chen, H. Qi, J. Korneberg, T.A. Garrow, Y.J. Choi, and B. Shane Purification and properties of human cytosolic folylpoly-glutamate synthetase and organization, localization, and differential splicing of its gene J. Biol. Chem. 271 1996 13077 13087
    • (1996) J. Biol. Chem. , vol.271 , pp. 13077-13087
    • Chen, L.1    Qi, H.2    Korneberg, J.3    Garrow, T.A.4    Choi, Y.J.5    Shane, B.6
  • 17
    • 0033572627 scopus 로고    scopus 로고
    • Tissue-specific expression of functional isoforms of mouse folylpoly-γ-glutamate synthetase: A basis for targeting folate antimetabolites
    • F.B. Turner, J.L. Andreassi, J. Ferguson, S. Titus, A. Tse, S.M. Taylor, and R.G. Moran Tissue-specific expression of functional isoforms of mouse folylpoly-γ-glutamate synthetase: a basis for targeting folate antimetabolites Cancer Res. 59 1999 6074 6079
    • (1999) Cancer Res. , vol.59 , pp. 6074-6079
    • Turner, F.B.1    Andreassi, J.L.2    Ferguson, J.3    Titus, S.4    Tse, A.5    Taylor, S.M.6    Moran, R.G.7
  • 18
    • 0034680860 scopus 로고    scopus 로고
    • Expression patterns of multiple transcripts from the folylpolyglutamate synthetase gene in human leukemias and normal differentiated tissues
    • F.B. Turner, S.M. Taylor, and R.G. Moran Expression patterns of multiple transcripts from the folylpolyglutamate synthetase gene in human leukemias and normal differentiated tissues J. Biol. Chem. 275 2000 35960 35968
    • (2000) J. Biol. Chem. , vol.275 , pp. 35960-35968
    • Turner, F.B.1    Taylor, S.M.2    Moran, R.G.3
  • 19
    • 0034177183 scopus 로고    scopus 로고
    • Post-transcriptional regulation of rat CYP2E1 expression: Role of CYP2E1 mRNA untranslated regions in control of translational efficiency and message stability
    • T.A. Kocarek, R.C. Zangar, and R.F. Novak Post-transcriptional regulation of rat CYP2E1 expression: role of CYP2E1 mRNA untranslated regions in control of translational efficiency and message stability Arch. Biochem. Biophys. 376 2000 180 190
    • (2000) Arch. Biochem. Biophys. , vol.376 , pp. 180-190
    • Kocarek, T.A.1    Zangar, R.C.2    Novak, R.F.3
  • 20
    • 0034604154 scopus 로고    scopus 로고
    • The inhibitory effect of the 5′ untranslated region of muscle acylphosphatase mRNA on protein expression is relieved during cell differentiation
    • T. Fiaschi, P. Chiarugi, D. Veggi, G. Raugei, and G. Ramponi The inhibitory effect of the 5′ untranslated region of muscle acylphosphatase mRNA on protein expression is relieved during cell differentiation FEBS Lett. 473 2000 42 46
    • (2000) FEBS Lett. , vol.473 , pp. 42-46
    • Fiaschi, T.1    Chiarugi, P.2    Veggi, D.3    Raugei, G.4    Ramponi, G.5
  • 21
    • 0034745164 scopus 로고    scopus 로고
    • A mutation in the 5′ untranslated region increases stability of norA mRNA, encoding a multidrug resistance transporter of Staphylococcus aureus
    • B. Fournier, Q.C. Trunong-Bolduc, X. Zhang, and D.C. Hooper A mutation in the 5′ untranslated region increases stability of norA mRNA, encoding a multidrug resistance transporter of Staphylococcus aureus J. Bacteriol. 183 2001 2367 2371
    • (2001) J. Bacteriol. , vol.183 , pp. 2367-2371
    • Fournier, B.1    Trunong-Bolduc, Q.C.2    Zhang, X.3    Hooper, D.C.4
  • 22
    • 0035794180 scopus 로고    scopus 로고
    • The basal promoters for the human reduced folate carrier gene are regulated by a GC-box and a cAMP-response element/AP-1-like element
    • J.R. Whetstine, and L.H. Matherly The basal promoters for the human reduced folate carrier gene are regulated by a GC-box and a cAMP-response element/AP-1-like element J. Biol. Chem. 276 2001 6350 6358
    • (2001) J. Biol. Chem. , vol.276 , pp. 6350-6358
    • Whetstine, J.R.1    Matherly, L.H.2
  • 23
    • 0346037346 scopus 로고    scopus 로고
    • The human reduced folate carrier gene is regulated by the Ap2 and Sp1 transcription factor families and a functional 61-base pair polymorphism
    • J.R. Whetstine, T.L. Witt, and L.H. Matherly The human reduced folate carrier gene is regulated by the Ap2 and Sp1 transcription factor families and a functional 61-base pair polymorphism J. Biol. Chem. 277 2002 43873 43880
    • (2002) J. Biol. Chem. , vol.277 , pp. 43873-43880
    • Whetstine, J.R.1    Witt, T.L.2    Matherly, L.H.3
  • 24
    • 7444264527 scopus 로고    scopus 로고
    • Roles of USF, Ikaros, and Sp proteins in the transcriptional regulation of the human reduced folate carrier B promoter
    • M. Liu, J.R. Whetstine, S.G. Payton, Y. Ge, R.M. Flatley, and L.H. Matherly Roles of USF, Ikaros, and Sp proteins in the transcriptional regulation of the human reduced folate carrier B promoter Biochem. J. 383 2004 249 257
    • (2004) Biochem. J. , vol.383 , pp. 249-257
    • Liu, M.1    Whetstine, J.R.2    Payton, S.G.3    Ge, Y.4    Flatley, R.M.5    Matherly, L.H.6
  • 25
    • 0032807628 scopus 로고    scopus 로고
    • Isolation and characterization of genomic sequences involved in the regulation of the human reduced folate carrier gene (RFC1)
    • M. Gong, K.H. Cowan, J. Gudas, and J.A. Moscow Isolation and characterization of genomic sequences involved in the regulation of the human reduced folate carrier gene (RFC1) Gene 233 1999 21 31
    • (1999) Gene , vol.233 , pp. 21-31
    • Gong, M.1    Cowan, K.H.2    Gudas, J.3    Moscow, J.A.4
  • 26
    • 0032497805 scopus 로고    scopus 로고
    • Structure and organization of the human reduced folate carrier gene
    • L. Zhang, S.C. Wong, and L.H. Matherly Structure and organization of the human reduced folate carrier gene Biochim. Biophys. Acta 1442 1998 389 393
    • (1998) Biochim. Biophys. Acta , vol.1442 , pp. 389-393
    • Zhang, L.1    Wong, S.C.2    Matherly, L.H.3
  • 27
    • 0025326334 scopus 로고
    • Gene splicing by overlap extension: Tailor-made genes using the polymerase chain reaction
    • R.M. Horton, Z.L. Cai, S.N. Ho, and L.R. Pease Gene splicing by overlap extension: tailor-made genes using the polymerase chain reaction BioTechniques 8 1990 528 535
    • (1990) BioTechniques , vol.8 , pp. 528-535
    • Horton, R.M.1    Cai, Z.L.2    Ho, S.N.3    Pease, L.R.4
  • 29
    • 0037441871 scopus 로고    scopus 로고
    • Transcriptional regulation of human cystathionine beta synthase gene expression in Down syndrome and non-Down syndrome megakaryocytic leukemia cell lines
    • Y. Ge, T.L Jensen, L.H. Matherly, and J.W. Taub Transcriptional regulation of human cystathionine beta synthase gene expression in Down syndrome and non-Down syndrome megakaryocytic leukemia cell lines Blood 101 2003 1551 1557
    • (2003) Blood , vol.101 , pp. 1551-1557
    • Ge, Y.1    Jensen, T.L.2    Matherly, L.H.3    Taub, J.W.4
  • 30
    • 0028140275 scopus 로고
    • A novel cis-acting element controlling the rat CYP2D5 gene and requiring cooperativity between C/EBPβ and an Sp1 factor
    • Y.H. Lee, M. Yano, S.Y. Liu, E. Matsunaga, P.F. Johnson, and F.J. Gonzalez A novel cis-acting element controlling the rat CYP2D5 gene and requiring cooperativity between C/EBPβ and an Sp1 factor Mol. Cell. Biol. 14 1994 1383 1394
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 1383-1394
    • Lee, Y.H.1    Yano, M.2    Liu, S.Y.3    Matsunaga, E.4    Johnson, P.F.5    Gonzalez, F.J.6
  • 31
    • 0030716266 scopus 로고    scopus 로고
    • CCAAT-enhancer-binding proteins (C/EBP) regulate the tissue specific activity of the CD11c integrin gene promoter through functional interactions with Sp1 proteins
    • C. Lopez-Rodriguez, L. Botella, and A.L. Corbi CCAAT-enhancer-binding proteins (C/EBP) regulate the tissue specific activity of the CD11c integrin gene promoter through functional interactions with Sp1 proteins J. Biol. Chem. 272 1997 29120 29126
    • (1997) J. Biol. Chem. , vol.272 , pp. 29120-29126
    • Lopez-Rodriguez, C.1    Botella, L.2    Corbi, A.L.3
  • 32
    • 0024276524 scopus 로고
    • Analysis of Sp1 in vivo reveals multiple transcriptional domains, including a novel glutamine-rich activation motif
    • A.J. Courey, and R. Tjian Analysis of Sp1 in vivo reveals multiple transcriptional domains, including a novel glutamine-rich activation motif Cell 55 1988 887 898
    • (1988) Cell , vol.55 , pp. 887-898
    • Courey, A.J.1    Tjian, R.2
  • 33
    • 0025995937 scopus 로고
    • Different activation domains of Sp1 govern formation of multimers and mediate transcriptional synergism
    • E. Pascal, and R. Tjian Different activation domains of Sp1 govern formation of multimers and mediate transcriptional synergism Genes Dev. 5 1991 1646 1656
    • (1991) Genes Dev. , vol.5 , pp. 1646-1656
    • Pascal, E.1    Tjian, R.2
  • 34
    • 0031000628 scopus 로고    scopus 로고
    • The ability of C/EBP beta but not C/EBP alpha to synergize with an Sp1 protein is specified by the leucine zipper and activation domain
    • Y.H. Lee, S.C. Willimans, M. Baer, E. Sterneck, F.J. Gonzalez, and P.F. Johnson The ability of C/EBP beta but not C/EBP alpha to synergize with an Sp1 protein is specified by the leucine zipper and activation domain Mol. Cell. Biol. 17 1997 2038 2047
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 2038-2047
    • Lee, Y.H.1    Willimans, S.C.2    Baer, M.3    Sterneck, E.4    Gonzalez, F.J.5    Johnson, P.F.6
  • 35
    • 0036683653 scopus 로고    scopus 로고
    • CCAAT/enhancer-binding proteins: Structure, function and regulation
    • D.P. Ramji, and P. Foka CCAAT/enhancer-binding proteins: structure, function and regulation Biochem. J. 365 2002 561 575
    • (2002) Biochem. J. , vol.365 , pp. 561-575
    • Ramji, D.P.1    Foka, P.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.