The ability of C/EBPβ but not C/EBPα to synergize with an Sp1 protein is specified by the leucine zipper and activation domain

Molecular and Cellular Biology

Volumn 17, Issue 4, 1997, Pages 2038-2047

  Lee, Ying Hue ^a   Williams, Simon C ^b,c   Baer, Mark ^b   Sterneck, Esta ^b   Gonzalez, Frank J ^a   Johnson, Peter F ^b  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c TEXAS TECH UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; LEUCINE ZIPPER PROTEIN; PROTEIN SERINE THREONINE KINASE; TRANSCRIPTION FACTOR SP1;

ANIMAL CELL; ARTICLE; CELL STRAIN HEPG2; CONTROLLED STUDY; DROSOPHILA; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; LIVER DEVELOPMENT; NONHUMAN; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; TRANSACTIVATION;

ANIMALIA; MURINAE;

EID: 0031000628     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/mcb.17.4.2038     Document Type: Article

References (43)

1. Akira, S., H. Isshiki, T. Sugita, O. Tanabe, S. Kinoshita, Y. Nishio, T. Nakajima, T. Hirano, and T. Kishimoto. 1990. A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family. EMBO J. 9:1897-1906.
2. Carey, M., Y. S. Lin, M. R. Green, and M. Ptashne. 1990. A mechanism for synergistic activation of a mammalian gene by GAL4 derivatives. Nature 345:361-364.
3. Chung, Y. T., and E. B. Keller. 1990. Positive and negative regulatory elements mediating transcription from the Drosophila melanogaster actin 5C distal promoter. Mol. Cell. Biol. 10:6172-6180.
4. Courey, A. J., and R. Tjian. 1988. Analysis of Sp1 in vivo reveals multiple transcriptional domains, including a novel glutamine-rich activation motif. Cell 55:887-898.
5. Descombes, P., M. Chojkier, S. Lichtsteiner, E. Falvey, and U. Schibler. 1990. LAP, a novel member of the C/EBP gene family, encodes a liver-enriched transcriptional activator protein. Genes Dev. 4:1541-1551.
6. de Wet, J. R., K. V. Wood, M. DeLuca, D. R. Helinski, and S. Subramani. 1987. Firefly luciferase gene: structure and expression in mammalian cells. Mol. Cell. Biol. 7:725-737.
7. Fischer, K. D., A. Haese, and J. Nowock. 1993. Cooperation of GATA-1 and Sp1 can result in synergistic transcriptional activation or interference. J. Biol. Chem. 268:23915-23923.
8. Friedman, A. D., W. H. Landschulz, and S. L. McKnight. 1989. CCAAT/ enhancer binding protein activates the promoter of the serum albumin gene in cultured hepatoma cells. Genes Dev. 3:1314-1322.
9. Giniger, E., and M. Ptashne. 1988. Cooperative DNA binding of the yeast transcriptional activator GAL4. Proc. Natl. Acad. Sci. USA 85:382-386.
10. Gonzalez, F. J., M. Yano, and S. Y. Liu. 1993. Regulation of cytochrome P450 genes: molecular mechanisms. Pharmacogenetics 3:51-57.
11. Gorman, C. M., L. F. Moffat, and B. H. Howard. 1982. Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. Mol. Cell. Biol. 2:1044-1051.
12. Graham, J. L., and A. J. van der Eb. 1973. A new technique for the assay of infectivity of human adenovirus S DNA. Virology 52:456-467.
13. Ham, J., G. Steger, and M. Yaniv. 1994. Cooperativity in vivo between the E2 transactivator and the TATA box binding protein depends on core promoter structure. EMBO J. 13:147-157.
14. Herbomel, P. 1990. Synergistic activation of eukaryotic transcription: the multiacceptor target hypothesis. New Biol. 2:1063-1070.
15. Herschlag, D., and F. B. Johnson. 1993. Synergism in transcriptional activation: a kinetic view. Genes Dev. 7:173-179.
16. Johnson, P., and S. C. Williams. 1994. CCAAT/enhancer binding (C/EBP) proteins, p. 231-258. In F. Tronche and M. Yaniv (ed.), Transcriptional regulation of liver-specific genes. R. G. Landes Company, Austin, Tex.
17. Johnson, P. F., and S. L. McKnight. 1989. Eukaryotic transcriptional regulatory proteins. Annu. Rev. Biochem. 58:799-839.
18. Kingsley, C., and A. Winoto. 1992. Cloning of GT box-binding proteins: a novel Sp1 multigene family regulating T-cell receptor gene expression. Mol. Cell. Biol. 12:4251-4261.
19. Kowenz-Leutz, E., G. Twamley, S. Ansieau, and A. Leutz. 1994. Novel mechanism of C/EBPβ (NF-M) transcriptional control: activation through derepression. Genes Dev. 8:2781-2791.
20. Lamb, P., and S. L. McKnight. 1991. Diversity and specificity in transcriptional regulation: the benefits of heterotypic dimerization. Trends Biochem. Sci. 16:417-422.
21. LeClair, K. P., M. A. Blanar, and P. A. Sharp. 1992. The p50 subunit of NF-KB associates with the NF-IL6 transcription factor. Proc. Natl. Acad. Sci. USA 89:8145-8149.
22. Lee, Y.-H., M. Yano, S.-Y. Liu, E. Matsunaga, P. F. Johnson, and F. J. Gonzalez. 1994. A novel cis-acting element controlling the rat CYP2D5 gene and requiring cooperativity between C/EBPβ and an Sp1 factor. Mol. Cell. Biol. 14:1383-1394.
23. 22a. Lee, Y.-H., S. C. Williams, and P. F. Johnson. Unpublished data.
24. Lin, Y. S., M. Carey, M. Ptashne, and M. R. Green. 1990. How different eukaryotic transcriptional activators can cooperate promiscuously. Nature 345:359-361.
25. Matsusaka, T., K. Fujikawa, Y. Nishio, N. Mukaida, K. Matsushima, T. Kishimoto, and S. Akira. 1993. Transcription factors NF-IL6 and NF-κB synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8. Proc. Natl. Acad. Sci. USA 90:10193-10197.
26. Merika, M., and S. H. Orkin. 1995. Functional synergy and physical interactions of the erythroid transcription factor GATA-1 with the Krüppel family proteins Sp1 and EKLF. Mol. Cell. Biol. 15:2437-2447.
27. Nerlov, C., and E. B. Ziff. 1994. Three levels of functional interaction determine the activity of CCAAT/enhancer binding protein-alpha on the serum albumin promoter. Genes Dev. 8:350-362.
28. Perkins, N. D., A. B. Agranoff, E. Pascal, and G. J. Nabel. 1994. An interaction between the DNA-binding domains of RelA(p65) and Sp1 mediates human immunodeficiency virus gene activation. Mol. Cell. Biol. 14:6570-6583.
29. Perkins, N. D., N. L. Edwards, C. S. Duckett, A. B. Agranoff, R. M. Schmid, and G. J. Nabel. 1993. A cooperative interaction between NF-kappa B and Sp1 is required for HIV-1 enhancer activation. EMBO J. 12:3551-3558.
30. Poli, V., and G. Ciliberto. 1994. Transcriptional regulation of acute phase genes by IL-6 and related cytokines, p. 131-151. In F. Tronche and M. Yaniv (ed.), Transcriptional regulation of liver-specific genes. R. G. Landes Company, Austin, Tex.
31. Pontoglio, M., J. Barra, M. Hadchouel, A. Doyen, C. Kress, J. P. Bach, C. Babinet, and M. Yaniv. 1996. Hepatocyte nuclear factor 1 inactivation results in hepatic dysfunction, phenylketonuria, and renal Fanconi syndrome. Cell 84:575-585.
32. Quinn, P. G. 1994. Inhibition by insulin of protein kinase A-induced transcription of the phosphoenolpyruvate carboxykinase gene. Mediation by the activation domain of cAMP response element-binding protein (CREB) and factors bound to the TATA box. J. Biol. Chem. 269:14375-14378.
33. Screpanti, I., L. Romani, P. Musiani, A. Modesti, E. Fattori, D. Lazzaro, C. Sellitto, S. Scarpa, D. Bellavia, G. Lattanzio, F. Bistoni, L. Frati, R. Cortese, A. Gulino, G. Ciliberto, F. Costantini, and V. Poli. 1995. Lymphoproliferative disorder and imbalanced T-helper response in C/EBPβ-deficient mice. EMBO J. 14:1932-1941.
34. Stein, B., P. C. Cogswell, and A. S. Baldwin, Jr. 1993. Functional and physical associations between NF-KB and C/EBP family members: a Rel domain-bZIP interaction. Mol. Cell. Biol. 13:3964-3974.
35. 33a. Sterneck, E., L. Tessarollo, and P. Johnson. Submitted for publication.
36. Tanaka, T., S. Akira, K. Yoshida, M. Umemoto, Y. Yoneda, N. Shirafuji, H. Fujiwara, S. Suematsu, N. Yoshida, and T. Kishimoto. 1995. Targeted distruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity by macrophages. Cell 80:353-361.
37. Tsai, S. Y., M. J. Tsai, and B. W. O'Malley. 1989. Cooperative binding of steroid hormone receptors contributes to transcriptional synergism at target enhancer elements. Cell 57:443-448.
38. Williams, S. C., M. Baer, A. J. Dillner, and P. F. Johnson. 1995. CRP2 (C/EBPβ) contains a bipartite regulatory domain that controls transcriptional activation, DNA binding and cell specificity. EMBO J. 14:3170-3183.
39. Williams, S. C., C. A. Cantwell, and P. F. Johnson. 1991. A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro. Genes Dev. 5:1553-1567.
40. Wong, G., T. Itakura, K. Kawajiri, L. Skow, and M. Negishi. 1989. Gene family of male specific testosterone 16α-hydroxylase (CP-450α) in mice: organization, differential regulation, and chromosome localization. J. Biol. Chem. 264:2920-2927.
41. Xiao, H., O. Perisic, and J. T. Lis. 1991. Cooperative binding of Drosophila heat shock factor to arrays of a conserved 5 bp unit. Cell 64:585-593.
42. Zawel, L., and D. Reinberg. 1995. Common themes in assembly and function of eukaryotic transcription complexes. Annu. Rev. Biochem. 64:533-561.
43. Zhang, Y., M. Broser, and W. N. Rom. 1994. Activation of the interleukin 6 gene by Mycobacterium tuberculosis or lipopolysaccharide is mediated by nuclear factors NF-IL6 and NFkB. Proc. Natl. Acad. Sci. USA 91:225-229.