Transition state analysis of the complex between coagulation factor VIIa and tissue factor: Suggesting a sequential domain-binding pathway

Biochemical and Biophysical Research Communications

Volumn 327, Issue 3, 2005, Pages 789-793

  Österlund, Maria ^a   Persson, Egon ^b   Svensson, Magdalena ^a   Carlsson, Uno ^a   Freskgård, Per Ola ^b  

^a LINKÖPING UNIVERSITY   (Sweden)

^b NOVO NORDISK A S   (Denmark)

Author keywords

Factor VIIa; Protein protein interaction; Tissue factor; Transition state

Indexed keywords

BLOOD CLOTTING FACTOR 7A; CYSTEINE; PROTEINASE; THROMBOPLASTIN;

ARTICLE; COMPLEX FORMATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; SURFACE PLASMON RESONANCE;

BLOOD COAGULATION; ENERGY TRANSFER; FACTOR VIIA; HUMANS; MODELS, MOLECULAR; PROTEIN STRUCTURE, TERTIARY; THERMODYNAMICS; THROMBOPLASTIN; TIME FACTORS;

EID: 11844253912     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2004.12.058     Document Type: Article

References (25)

1. F.B. Sheinerman, R. Nore, and B. Honig Electrostatic aspects of protein-protein interactions Curr. Opin. Struct. Biol. 10 2000 153 159
2. Y. Nemerson, and R. Gentry An ordered addition, essential activation model of the tissue factor pathway of coagulation: evidence for a conformational cage Biochemistry 25 1986 4020 4033
3. L.C. Petersen, S. Valentin, and U. Hedner Regulation of the extrinsic pathway system in health and disease: the role of factor VIIa and tissue factor pathway inhibitor Thromb. Res. 79 1995 1 47
4. E.W. Davie, K. Fujikawa, and W. Kisiel The coagulation cascade: initiation, maintenance, and regulation Biochemistry 30 1991 10363 10370
5. L.C. Petersen, P.-O. Freskgård, and M. Ezban Tissue factor-dependent factor VIIa signaling Trends Cardiovasc. Med. 10 2000 47 52
6. D.W. Banner, A. D'Arcy, C. Chène, F.K. Winkler, A. Guha, W.H. Konigsberg, Y. Nemerson, and D. Kirchhofer The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor Nature 380 1996 41 46
7. R. Owenius, M. Österlund, M. Lindgren, M. Svensson, O.H. Olsen, E. Persson, P.-O. Freskgård, and U. Carlsson Properties of spin and fluorescent labels at a receptor-ligand interface Biophys. J. 77 1999 2237 2250
8. L. Thim, S. Bjørn, M. Christensen, E.M. Nicolaisen, T. Lund-Hansen, A.H. Pedersen, and U. Hedner Amino acid sequence and posttranslational modifications of human factor VIIa from plasma and transfected baby hamster kidney cells Biochemistry 27 1988 7785 7793
9. 2+ and tissue factor studied using circular dichroism spectroscopy Protein Sci. 5 1996 1531 1540
10. E.M. Nicolaisen, L.C. Petersen, L. Thim, J.K. Jacobsen, M. Christensen, and U. Hedner Generation of Gla-domainless FVIIa by cathepsin G-mediated cleavage FEBS Lett. 306 1992 157 160
11. S.C. Gill, and P.H. von Hippel Calculation of protein extinction coefficients from amino acid sequence data Anal. Biochem. 182 1989 319 326
12. M. Österlund, R. Owenius, E. Persson, M. Lindgren, U. Carlsson, P.-O. Freskgård, and M. Svensson Spectroscopic probing of the influence of calcium and the Gla domain on the interaction between the first EGF1 domain in factor VIIa and tissue factor Eur. J. Biochem. 267 2000 6204 6211
13. R. Owenius, M. Österlund, M. Svensson, M. Lindgren, E. Persson, P.-O. Freskgård, and U. Carlsson Spin and fluorescent probing of the binding interface between tissue factor and factor VIIa at multiple sites Biophys. J. 40 2001 9324 9328
14. K. Harlos, D.M.A. Martin, D.P. O'Brien, E.Y. Jones, D.I. Stuart, I. Polikarpov, A. Miller, E.G.D. Tuddenham, and C.W.G. Boys Crystal structure of the extracellular region of human tissue factor Nature 370 1994 662 666
15. W. Ruf, C.R. Kelly, J.R. Schullek, D.M. Martin, I. Polikarpov, C.W. Boys, E.G. Tuddenham, and T.S. Edgington Energetic contributions and topographical organization of ligand binding residues of tissue factor Biochemistry 34 1995 6310 6315
16. C.D. Dickinson, C.R. Kelly, and W. Ruf Identification of surface residues mediating tissue factor binding and catalytic function of the serine protease factor VIIa Proc. Natl. Acad. Sci. USA 93 1996 14379 14384
17. E. Persson, L.S. Nielsen, and O.H. Olsen Substitution of aspartic acid for methionine-306 in Factor VIIa abolishes the allosteric linkage between the active site and the binding interface with tissue factor Biochemistry 40 2001 3251 3256
18. C.S. Gibbs, S.N. McCurdy, L.L. Leung, and L.R. Paborsky Identification of the factor VIIa binding sites on tissue factor by homologous loop swap and alanine scanning mutagenesis Biochemistry 33 1994 14003 14010
19. J.R. Schullek, W. Ruf, and T.S. Edgington Key ligand interface residues in tissue factor contribute independently to factor VIIa binding J. Biol. Chem. 269 1994 19399 19403
20. S. Dittmar, W. Ruf, and T.S. Edgington Influence of mutations in tissue factor on the fine specificity on macromolecular substrate activation Biochem. J. 321 1997 787 793
21. J. Sancho, E.M. Meiering, and A.R. Fersht Mapping transition states of protein unfolding by engineering of ligand-binding sites J. Mol. Biol. 221 1991 1007 1014
22. G. Schreiber Kinetic studies of protein-protein interactions Curr. Opin. Struct. Biol. 12 2002 41 47
23. M.G. Taylor, A. Rajpal, and J.F. Kirsch Kinetic epitope mapping of the chicken lysozyme•HyHEL-10 fab complex-delineation of docking trajectories Protein. Sci. 7 1998 1857 1867
24. L. Lo Conte, C. Chothia, and J. Janin The atomic structure of protein-protein recognition sites J. Mol. Biol. 285 1999 2177 2198
25. T.N. Bhat, G.A. Bentley, G. Boulot, M.I. Greene, D. Tello, W. Dall'Acqua, H. Souchon, F.P. Schwarz, R.A. Mariuzza, and R.J. Poljak Bound water molecules and conformational stabilization help mediate an antigen-antibody association Proc. Natl. Acad. Sci. USA 91 1994 1089 1093