Diazoxide causes early activation of cardiac sarcolemmal KATP channels during metabolic inhibition by an indirect mechanism

Cardiovascular Research

Volumn 61, Issue 3, 2004, Pages 570-579

  Rodrigo, Glenn C ^a   Davies, Noel W ^a   Standen, Nicholas B ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

Ischemia; K ATP channel; Myocytes; Preconditioning; Rat

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM; CLAMIKALANT; DIAZOXIDE; FURA 2; IODOACETIC ACID; MAGNESIUM ION; POTASSIUM CHANNEL; SODIUM CYANIDE;

ACTION POTENTIAL; ANIMAL CELL; ARTICLE; CALCIUM HOMEOSTASIS; CONTROLLED STUDY; DRUG EFFECT; ELECTROSTIMULATION; HEART MUSCLE CELL; HEART MUSCLE REPERFUSION; HEART VENTRICLE; ISOLATED HEART; MALE; METABOLIC INHIBITION; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT; SARCOLEMMA;

ACTION POTENTIALS; ANIMALS; ANTIHYPERTENSIVE AGENTS; CALCIUM; DIAZOXIDE; MAGNESIUM; MALE; MYOCARDIAL CONTRACTION; MYOCARDIAL REPERFUSION INJURY; MYOCYTES, CARDIAC; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; RATS; RATS, WISTAR; SARCOLEMMA; SULFONAMIDES; THIOUREA;

EID: 1142285435     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cardiores.2003.10.004     Document Type: Article

References (35)

1. Murry C.E., Jennings R.B., Reimer K.A. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation. 74:1986;1124-1136.
2. ATP channel. Annu. Rev. Physiol. 62:2000;79-109.
3. + channels in cardiac muscle. Nature. 305:1983;147-148.
4. + channels. Possible mechanism of cardioprotection. Circ. Res. 81:1997;1072-1082.
5. Liu Y., Sato T., O'Rourke B., Marban E. Mitochondrial ATP-dependent potassium channels: novel effectors of cardioprotection? Circulation. 97:1998;2463-2469.
6. Grover G.J., Garlid K.D. ATP-Sensitive potassium channels: a review of their cardioprotective pharmacology. J. Mol. Cell. Cardiol. 32:2000;677-695.
7. Schafer G., Portenhauser R., Trolp R. Inhibition of mitochondrial metabolism by the diabetogenic thiadiazine diazoxide: I. Action on succinate dehydrogenase and TCA-cycle oxidations. Biochem. Pharmacol. 20:1971;1271-1280.
8. ATP channel-independent targets of diazoxide and 5-hydroxydecanoate in the heart. J. Physiol. 542:2002;735-741.
9. Lim K.H., Javadov S.A., Das M., Clarke S.J., Suleiman M.S., Halestrap A.P. The effects of ischaemic preconditioning, diazoxide and 5-hydroxydecanoate on rat heart mitochondrial volume and respiration. J. Physiol. 545:2002;961-974.
10. ATP channels in rat mitochondria. J. Physiol. 547:2003;893-902.
11. ATP channels in ischemic preconditioning of the canine heart. Am. J. Physiol. 280:2001;H256-H263.
12. ATP channels. Naunyn Schmiedebergs Arch. Pharmacol. 364:2001;226-232.
13. ATP channels in adenosine-enhanced ischemic preconditioning. Am. J. Physiol. 279:2000;H2694-H2703.
14. ATP channels in cardioprotection against ischemia/reperfusion injury in mice. J. Clin. Invest. 109:2002;509-516.
15. + channel for cardiac protection against ischemic injury is dependent on protein kinase C activity. Circ. Res. 85:1999;731-741.
16. ATP channel opener diazoxide protects cardiac myocytes during metabolic inhibition without causing mitochondrial depolarization or flavoprotein oxidation. Br. J. Pharmacol. 134:2001;535-542.
17. Rodrigo G.C., Lawrence C.L., Standen N.B. Dinitrophenol pretreatment of rat ventricular myocytes protects against damage by metabolic inhibition and reperfusion. J. Mol. Cell Cardiol. 34:2002;555-569.
18. Lederer W.J., Nichols C.G., Smith G.L. The mechanism of early contractile failure of isolated rat ventricular myocytes subjected to complete metabolic inhibition. J. Physiol. 413:1989;329-349.
19. Stern M.D., Silverman H.S., Houser S.R.et al. Anoxic contractile failure in rat heart myocytes is caused by failure of intracellular calcium release due to alteration of the action potential. Proc. Natl. Acad. Sci. U. S. A. 85:1988;6954-6958.
20. Zhu Z., Li Y.L., Li D.P., He R.R. Effect of anoxic preconditioning on ATP-sensitive potassium channels in guinea-pig ventricular myocytes. Pflugers Arch. 439:2000;808-813.
21. Kakei M., Noma A., Shibasaki T. Properties of adenosine-triphosphate- regulated potassium channels in guinea-pig ventricular cells. J. Physiol. 363:1985;441-462.
22. D'hahan N., Moreau C., Prost A.L.et al. Pharmacological plasticity of cardiac ATP-sensitive potassium channels toward diazoxide revealed by ADP. Proc. Natl. Acad. Sci. U. S. A. 96:1999;12162-12167.
23. 2+ and contraction in single adult mammalian cardiac myocytes. Am. J. Physiol. 266:1994;C222-C233.
24. i studied in isolated rat cardiomyocytes. J. Physiol. 496:1996;111-128.
25. Gogelein H., Hartung J., Englert H.C., Scholkens B.A. HMR 1883, a novel cardioselective inhibitor of the ATP-sensitive potassium channel: Part I. Effects on cardiomyocytes, coronary flow and pancreatic beta-cells. J. Pharmacol. Exp. Ther. 286:1998;1453-1464.
26. ATP channels. Mol. Pharmacol. 59:2001;225-230.
27. Kolocassides K.G., Seymour A.M., Galiñanes M., Hearse D.J. Paradoxical effect of ischemic preconditioning on ischemic contracture? NMR studies of energy metabolism and intracellular pH in the rat heart. J. Mol. Cell. Cardiol. 28:1996;1045-1057.
28. Liu Y., Sato T., Seharaseyon J., Szewczyk A., O'Rourke B., Marban E. Mitochondrial ATP-dependent potassium channels. Viable candidate effectors of ischemic preconditioning. Ann. N. Y. Acad. Sci. 874:1999;27-37.
29. Carrasco A.J., Dzeja P.P., Alekseev A.E.et al. Adenylate kinase phosphotransfer communicates cellular energetic signals to ATP-sensitive potassium channels. Proc. Natl. Acad. Sci. U. S. A. 98:2001;7623-7628.
30. ATP channels in cardiac myocytes. Am. J. Physiol. 280:2001;H1882-H1888.
31. Suzuki M., Saito T., Sato T.et al. Cardioprotective effect of diazoxide is mediated by activation of sarcolemmal but not mitochondrial ATP-sensitive potassium channels in mice. Circulation. 107:2003;682-685.
32. ATP) channels by Mg-nucleotides. J. Physiol. 547:2003;159-168.
33. ATP channels. Br. J. Pharmacol. 136:2002;746-752.
34. Miyata H., Lakatta E.G., Stern M.D., Silverman H.S. Relation of mitochondrial and cytosolic free calcium to cardiac myocyte recovery after exposure to anoxia. Circ. Res. 71:1992;605-613.
35. Rakhit R.D., Mojet M.H., Marber M.S., Duchen M.R. Mitochondria as targets for nitric oxide-induced protection during simulated ischemia and reoxygenation in isolated neonatal cardiomyocytes. Circulation. 103:2001;2617-2623.