HMR 1883, a novel cardioselective inhibitor of the atpsensitive potassium channel. Part I: Effects on cardiomyocytes, coronary flow and pancreatic β-cells

Journal of Pharmacology and Experimental Therapeutics

Volumn 286, Issue 3, 1998, Pages 1453-1464

  Gögelein, Heinz ^a   Härtung, Jens ^a   Englert, Heinrich C ^a   Schölkens, Bernward A ^a  

^a SANOFI   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CHROMAN DERIVATIVE; CLAMIKALANT; DEOXYGLUCOSE; DRUG DERIVATIVE; POTASSIUM CHANNEL BLOCKING AGENT; PYRROLIDINE DERIVATIVE; RILMAKALIM; SULFONAMIDE; THIOUREA; GLIBENCLAMIDE; POTASSIUM CHANNEL; SULFONYLUREA DERIVATIVE; THIOUREA DERIVATIVE; UNCLASSIFIED DRUG;

ACTION POTENTIAL; ANIMAL; ARTICLE; CORONARY ARTERY BLOOD FLOW; DOSE RESPONSE; DRUG EFFECT; FEMALE; GUINEA PIG; HEART; HEART PAPILLARY MUSCLE; MALE; PANCREAS ISLET; PERFUSION; PHYSIOLOGY; RAT; ANIMAL TISSUE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; HEART DEPOLARIZATION; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; HEART MUSCLE POTENTIAL; HYPERPOLARIZATION; HYPOXIA; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL;

ACTION POTENTIALS; ADENOSINE TRIPHOSPHATE; ANIMALS; CHROMANS; CORONARY CIRCULATION; DEOXYGLUCOSE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GUINEA PIGS; HEART; ISLETS OF LANGERHANS; MALE; PAPILLARY MUSCLES; PERFUSION; POTASSIUM CHANNEL BLOCKERS; PYRROLIDINES; RATS; SULFONAMIDES; THIOUREA;

EID: 0032161952     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Ashcroft FM (1988) Adenosine 5-triphosphate-sensitive potassium channels. Ann Rev Neurosci 11:97-118.
2. Bellemin-Baurreau J, Poizot A, Hicks PE, Röchelte L and Armstrong JM (1994) Effects of ATP-dependent K+ channel modulators on an ischemia-reperfusion rabbit isolated heart model with programmed electrical stimulation. Eur J Pharmacol 256:115-124.
3. Billman GE, Avendano CE, Halliwill JR and Burroughs JM (1993) The effects of the ATP-dependent potassium channel antagonist, glyburide, on coronary blood flow and susceptibility to ventricular fibrillation in unanesthetized dogs. J Cardiovasc Pharmacol 21:197-204.
4. Billman GE, Englert HC and Schölkens BE (1998) HMR 1883, a novel cardioselective inhibitor of the ATP-sensitive potassium channel. Part II: Effects on susceptibility to ventricular fibrillation induced by myocardial ischemia in conscious dogs. J Pharmacol Exp Ther 286:1465-1473.
5. Cacciapuoti F, Spiezia R, Bianchi U, Lama D, D'Avino M and Varricchio M (1991) Effectiveness of glibenclamide on myocardial ischémie ventricular arrhythmias in non-insulin-dependent diabetes mellitus. Am J Cardiol 67:843-847.
6. Chi L, Uprichard ACG and Lucchesi BR (1990) Profibrillatory actions of pinacidil in a conscious canine model of sudden coronary death. J Cardiouasc Pharmacol 15:452-464.
7. Chi L, Black SC, Kuo PI, Fagbemi SO and Lucchesi BR (1993) Actions of pinacidil at a reduced potassium concentration: A direct cardiac effect possibly involving the ATP-dependent potassium channel. J Cardiovasc Pharmacol 21:179-190.
8. Daut J, Maier-Rudolph W, Von Beckenrath N, Mehrke G, Günther K and GoedelMeinen L (1990) Hypoxie dilation of coronary arteries is mediated by ATPsensitive potassium channels. Science 247:1341-1344.
9. Davis TME, Parson RW, Broadhurst R, Hobbs M and Jamrozik K (1996) Arrhythmias and mortality after myocardial infarction in diabetic patients: relationship to diabetes treatment. Diabetologia 39:A51.
10. Deutsch N, Hitzner TS, Lamp ST and Weiss JN (1991) Activation of cardiac ATPsensitive K+ current during hypoxia: correlation with tissue ATP levels. Am J Physiol 261:H671-H676.
11. Dünne MJ, Illot MC and Petersen OH (1987) Interaction of diazoxide, tolbutamide and ATP4' on nucleotide-dependent K+ channels in an insulin-secreting cell line. J Membr Biol 99:215-224.
12. Fabiani ME and Story DF (1995) Effects of cromakalün, pinacidil and glibenclamide on cholinergic transmission in rat isolated atria. Pharmacol Res 32:155-163.
13. Faivre JF and Findlay I (1989) Effects of tolbutamide, glibenclamide and diazoxide upon action potentials recorded from rat ventricular muscle. Biochimica et Biophyisca Acta 984:1-5.
14. Findlay I (1992a) Inhibition of ATP-sensitive K+ channels in cardiac muscle by the sulphonylurea drug glibenclamide. J Pharmacol Exp Ther 261:540-545.
15. Findlay I (1992b) Effects of pH upon the inhibition by sulphonylurea drugs of ATP-sensitive K+ channels in cardiac muscle. J Pharmacol Exp Ther 262:71-79.
16. Findlay I (1993) Sulphonylurea drugs no longer inhibit ATP-sensitive Kchannels during metabolic stress in cardiac muscle. J Pharmcol Exp Ther 266:456-467.
17. Gasser RNA and Vaughan-Jones RD (1990) Mechanism of potassium efflux and action potential shortening during ischaemia in isolated mammalian cardiac muscle. J Physiol (Land) 431:713-741.
18. Gwilt M, Henderson CG, Orme J and Rourke JD (1992) Effects of drugs on ventricular fibrillation and ischaemic K+ loss in a model of ischemia in perfused guineapig hearts in vitro. Eur J Pharmacol 220:231-236.
19. Hamill OP, Marty M, Neher E, Sakmann B and Sigworth FJ (1981) Improved patch-clamp techniques for high-resolution current recording from cells and cellfree membrane patches. Pflugers Arch 391:85-100.
20. Hayashi H, Terada H and McDonald TF (1997) Arrhythmia and electrical heterogeneity during prolonged hypoxia in guinea pig papillary muscles. Can J Physiol Pharmacol 75:44-51.
21. Hill JL and Gettes LS (1980) Effect of acute coronary artery occlusion on local myocardial extracellular K+ activity in swine. Circulation 61:768-778.
22. Inagaki N, Gonoi T, Clement JP IV, Namba N, Inazawa J, Gonzalez G, Aguilar-Bryan L, Seino S and Bryan J (1995) Reconstitution of IKATP: An inward rectifier subunit plus the sulfonylurea receptor. Science 270:1166-1170.
23. + channels. Neuron 16:1011-1017.
24. Isomoto S, Kondo T, Yamada M, Matsumoto S, Higashiguchi 0, Horio Y, MatsuzEwa Y and Kurachi Y (1996) A novel sulfonylurea receptor forms with BIR(Kir6.2) a smooth muscle type ATP-sensitive K+channel. J Biol Chem 271:24321-24324.
25. Janse MJ and Wit AL (1989) Electrophysiological mechanisms of ventricular arrhythmias resulting from myocardial ischemia and infarction. Physiol Rev 69: 1049-1169.
26. Kantor PF, Coetzee WA, Carmeliet EE, Dennis SC and Opie LH (1990) Reduction of ischémie K+ loss arid arrhythmias in rat hearts. Circ Res 66:478-485.
27. Krause E, Englert H and Gögelein H (1995) Adenosine triphosphate-dependem; K currents activated by metabolic inhibition in rat ventricular myocytes differ from those elicited by the channel opener rilmakalim. Pflugers Arch 429:625-635.
28. Linz W, Klaus E, Albus U, Becker R, Mania D, Englert HC and Schölkens BA (1932) Cardiovascular effects of the novel potassium channel opener (3S,4R)-3-hydroxy-2,2-dimethyl-4-(2-oxo-l-pyrrolidinyl)-6-phenylsulfonylchromane hemihydrate. Br J Pharmacol 121:1024-1030.
29. Lomuscio A and Fiorentini C (1996) Influence of oral antidiabetic treatment on electrocardiac alterations induced by myocardial infarction. Diabetes Res Clin Pract 31:S21-S26.
30. Nakaya H, Takeda Y, Tohse N and Kanno M (1991) Effects of ATP-sensitive X+ channel blockers on the action potential shortening in hypoxic and ischaenic myocardium. Br J Pharmacol 103:1019-1026.
31. Noma A (1983) ATP-regulated K+ channels in cardiac muscle. Nature 305:147-148.
32. Noma A and Shibasaki T (1985) Membrane current through adenosine-triphosphate-regulated potassium channels in guinea-pig ventricular cells. J Physiol (Lor d) 363:463-480.
33. Rorsman P and Trübe G (1986) Calcium and delayed potassium currents in moi se pancreatic B-cells under voltage-clamp conditions. J Physiol (Land) 374:531-5!>0.
34. Takizawa T, Hara Y, Saito T, Masuda Y and Nakaya H (1996) aradrenocep1,or stimulation partially inhibits ATP-sensitive K current in guinea pig ventricul ar cells: Attenuation of action potential shortening induced by hypoxia and K+ channel openers. J Cardiovasc Pharmacol 28:799-808.
35. Terzic A, Jahangir A and Kurachi Y (1994) HOE-234, a second generation Kchannel opener, antagonizes the ATP-dependent gating of cardiac ATP-sensitive K+ channels. J Pharmacol Exp Ther 268:818-825.
36. Tosaki A and Hellegouarch A (1994) Adenosine triphosphate-sensitive potassium channel blocking agent ameliorates, but the opening agent aggravates, ischem.a/ reperfusion-induced injury. Heart function studies in nonfibrillating isolated hearts. J Am Coll Cardiol 23:487-496.
37. Vleugels A, Vereecke J and Carmeliet E (1980) Ionic currents during hypoxia in voltage-clamped cat ventricular muscle. Circ Res 47:501-508.
38. Wang Y-X, Zheng Y-M and Zhou X-B (1996) Inhibitory effects of berberine on ATP-sensitive K+-channels in cardiac myocytes. Eur J Pharmacol 316:307-31,1.
39. Wilde AAM, Escande D, Schumacher CA, Thüringer D, Mestre M, Fiolet JWM and Janse MJ (1990) Potassium accumulation in the globally ischémie mammalian heart. Circ Res 67:835-843.
40. Wolleben CD, Sanguinetti MC and Siegl PKS (1989) Influence of ATP-sensitive potassium channel modulators on ischemia-induced fibrillation in isolated rat hearts. J Mol Cell Cardiol 21:783-788.