Effect of metabolic inhibition on glimepiride block of native and cloned cardiac sarcolemmal KATP channels

British Journal of Pharmacology

Volumn 136, Issue 5, 2002, Pages 746-752

  Lawrence, C L ^a   Rainbow, R D ^a   Davies, N W ^a   Standen, N B ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

Cardiac myocytes; Clones; Glimepiride; Kir6.2 SUR2A

Indexed keywords

ADENOSINE DIPHOSPHATE; CREATINE KINASE; DIAZOXIDE; GLIBENCLAMIDE; GLIMEPIRIDE; IODOACETIC ACID; OLIGOMYCIN; PINACIDIL; POTASSIUM CHANNEL BLOCKING AGENT; PROTEIN; PROTEIN KIR6 2; PROTEIN SUR2A; SULFONYLUREA; UNCLASSIFIED DRUG; INWARDLY RECTIFYING POTASSIUM CHANNEL; POTASSIUM CHANNEL; SULFONYLUREA DERIVATIVE;

ANIMAL CELL; ARTICLE; CELL ASSAY; CELL LEVEL; CELL LINE; CLONING; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; HEART MUSCLE CELL; HUMAN; HUMAN CELL; IC 50; MALE; METABOLIC INHIBITION; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; RAT; SARCOLEMMA; ANIMAL; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; HEART MUSCLE; METABOLISM; NERVE CELL INHIBITION; PHYSIOLOGY; WISTAR RAT;

ANIMALS; HUMANS; MALE; MYOCARDIUM; NEURAL INHIBITION; POTASSIUM CHANNELS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; RATS; RATS, WISTAR; SARCOLEMMA; SULFONYLUREA COMPOUNDS;

EID: 0035987784     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704770     Document Type: Article

References (32)

1. + channels
2. Pharmacological plasticity of cardiac ATP-sensitive potassium channels toward diazoxide revealed by ADP
3. Comparison of the efficacy of glibenclamide and glimepiride in reperfusion-induced arrhythmias in rats
4. + channels during metabolic stress in cardiac muscle
5. + channels
6. + channels. Possible mechanism of cardioprotection
7. The molecular assembly of ATP-sensitive potassium channels
8. ATP channels
9. ATP-sensitive potassium channels: A review of their cardioprotective pharmacology
10. + channel
11. The cell biology of acute myocardial ischaemia
12. Sulfonylureas and ischaemic preconditioning; a double-blind, placebo-controlled evaluation of glimepiride and glibenclamide
13. Repaglinide, glibenclamide and glimepiride administration to normal and hereditary diabetic rats
14. Glimepiride: A review of its use in the management of type 2 diabetes mellitus
15. ATP channels in mouse isolated pancreatic beta-cells but not rat heart or arterial smooth muscle cells
16. KNa) is present in guinea-pig but not rat ventricular myocytes
17. Mitochondrial ATP-dependent potassium channels: Novel effectors of cardioprotection?
18. Glimepiride, a novel sulphonylurea, does not abolish myocardial protection afforded by either ischemic preconditioning or diazoxide
19. Diadenosine diphosphates as an intracellular regulator of insulin secretion
20. Glimepiride (Hoe490) inhibits the rilmikalim induced decrease in intracellular free calcium and contraction of isolated heart muscle cells from guinea pigs to a lesser extent than glibenclamide
21. ATP channels by glibenclamide in rat ventricular myocytes
22. Beginning insulin treatment of obese patients with evening 70/30 insulin plus glimepiride versus insulin alone
23. Role of mitochondrial and sarcolemmal K(ATP) channels in ischemic preconditioning of the canine heart
24. A placebo-controlled, randomised study of glimepiride in patients with type 2 diabetes millitus for whom diet therapy is unsuccessful
25. Glimepiride block of cloned beta-cell, cardiac and smooth muscle K(ATP) channels
26. Short-term comparison of once-versus twice-daily administration of glimepiride in patients with non-insulin-dependent diabetes
27. ATP channels
28. + channel-opening drugs
29. ATP channels in adenosine-enhanced ischemic preconditioning
30. + loss in hypoxic and ischaemic mammalian ventricle
31. Electrophysiological effects of ATP sensitive potassium channel modulation: Implications for arrythmogenesis
32. Ischaemic preconditioning: Present and future directions