Expression of BUB1 protein in gastric cancer correlates with the histological subtype, but not with DNA ploidy or microsatellite instability

Journal of Pathology

Volumn 202, Issue 2, 2004, Pages 208-214

  Grabsch, Heike I ^a   Askham, Jon M ^a   Morrison, Ewan E ^a   Pomjanski, Natalja ^b   Lickvers, Kristina ^b   Parsons, Wendy J ^c   Boecking, Alfred ^b   Gabbert, Helmut E ^b   Mueller, Wolfram ^d  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b HEINRICH HEINE UNIVERSITY   (Germany)

^c LEEDS TEACHING HOSPITALS NHS TRUST   (United Kingdom)

^d Gemeinschaftspraxis Pathologie ^*  (Germany)

Author keywords

BUB1; Gastric cancer; Immunohistochemistry; Microsatellite instability; Mitotic spindle checkpoint; Ploidy

Indexed keywords

MICROSATELLITE DNA; NUCLEAR PROTEIN; PROTEIN ANTIBODY; PROTEIN BUB1; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CANCER CLASSIFICATION; CANCER GENETICS; CANCER TISSUE; CONTROLLED STUDY; CORRELATION COEFFICIENT; FEMALE; GENE EXPRESSION; GENE FUNCTION; GENETIC ASSOCIATION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTESTINE CANCER; MAJOR CLINICAL STUDY; MALE; MICROSATELLITE INSTABILITY; MITOSIS SPINDLE; MORPHOGENESIS; NUCLEOTIDE SEQUENCE; PHENOTYPE; PLOIDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; STOMACH CANCER; STOMACH CARCINOGENESIS; TUMOR CELL;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; DISEASE PROGRESSION; DNA, NEOPLASM; FEMALE; GASTRIC MUCOSA; HUMANS; IMMUNOENZYME TECHNIQUES; MALE; MICROSATELLITE REPEATS; MIDDLE AGED; NEOPLASM PROTEINS; PLOIDIES; PROTEIN KINASES; SENSITIVITY AND SPECIFICITY; STOMACH NEOPLASMS;

EID: 1142275106     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/path.1499     Document Type: Article

References (44)

1. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000; 100: 57-70.
2. Lengauer C, Kinzler KW, Vogelstein B. Genetic instabilities in human cancers. Nature 1998; 396: 643-649.
3. Lengauer C, Kinzler KW, Vogelstein B. Genetic instability in colorectal cancer. Nature 1997; 386: 623-627.
4. Miyazaki M, Furuya T, Shiraki A, Sato T, Oga A, Sasaki K. The relationship of DNA ploidy to chromosomal instability in primary human colorectal cancers. Cancer Res 1999; 59: 5283-5285.
5. Furuya T, Uchiyama T, Murakami T, et al. Relationship between chromosomal instability and intratumoral regional DNA ploidy heterogeneity in primary gastric cancers. Clin Cancer Res 2000; 6: 2815-2820.
6. Cahill DP, Lengauer C, Yu J, et al. Mutations of mitotic checkpoint genes in human cancers. Nature 1998; 392: 300-303.
7. Amon A. The spindle checkpoint. Curr Opin Genet Dev 1999: 9: 69-75.
8. Li R, Murray A. Feedback control of mitosis in budding yeast. Cell 1991; 66: 519-531.
9. Hoyt M, Totis L, Roberts B. S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function. Cell 1991; 66: 507-517.
10. Imai Y, Shiratori Y, Kato N, Inoue T, Omata M. Mutational inactivation in mitotic checkpoint genes, hsMAD2 and hBUB1, is rare in sporadic digestive tract cancers. Jpn J Cancer Res 1999; 90: 837-840.
11. Gemma A, Seike M, Seike Y. et al. Somatic mutation of the hBUB1 mitotic checkpoint gene in primary lung cancer. Genes Chromosomes Cancer 2000; 29: 213-218.
12. Ouyang B, Knauf JA, Ain K, Nacev B, Fagin JA. Mechanisms of aneuploidy in thyroid cancer cell lines and tissues: evidence for mitotic checkpoint dysfunction without mutations in BUB1 and BUBR1. Clin Endocrinol 2002; 56: 341-350.
13. Saeki A, Tamura S, Ito N, et al. Frequent impairment of the spindle assembly checkpoint in hepatocellular carcinoma. Cancer 2002; 94: 2047-2054.
14. Olesen SH, Thykjaer T, Orntoft TF. Mitotic checkpoint genes hBUB1, hBUB1B, hBUB3 and TTK in human bladder cancer, screening for mutations and loss of heterozygosity. Carcinogenesis 2001; 22: 813-815.
15. Haruki N, Saito H, Harano T, et al. Molecular analysis of the mitotic checkpoint genes BUB1, BUBR1 and BUB3 in human lung cancers. Cancer Lett 2001; 162: 201-205.
16. Shigeishi H, Yokozaki H, Kuniyasu H, et al. No mutations of the BUB1 gene in human gastric carcinomas. Oncol Rep 2001; 8: 791-794.
17. Simpson AJG, Caballero OL, Pena SDJ. Microsatellite instability as a tool for the classification of gastric cancer. Trends Mol Med 2001; 7: 76-80.
18. Hayden JD, Martin IG, Cawkwell L, Quirke P. The role of microsatellite instability in gastric carcinoma. Gut 1998; 42: 300-303.
19. Baba H, Korenaga D, Kakeji Y, Haraguchi M, Okamura T, Maehara Y. DNA ploidy and its clinical implications in gastric cancer. Surgery 2002; 131: S63-S70.
20. Kim JY, Cho HJ. DNA ploidy patterns in gastric adenocarcinoma. J Korean Med Sci 2000; 15: 159-166.
21. Ming S-C. Cellular and molecular pathology of gastric carcinoma and precursor lesions: a critical review. Gastric Cancer 1998; 1: 31-50.
22. Mimori K, Inoue H, Alder H, Ueo H, Tanaka Y, Mori M. Mutation analysis of hBUB1, human mitotic checkpoint gene in multiple carcinomas. Oncol Rep 2001; 8: 39-42.
23. Sharp-Baker H, Chen R-H. Spindle checkpoint protein Bub1 is required for kinetochore localization of Mad1, Mad2, Bub3, and CENP-E, independently of its kinase activity. J Cell Biol 2001; 153: 1239-1249.
24. Ouyang B, Lan Z, Meadows J, et al. Human Bub1: a putative spindle checkpoint kinase closely linked to cell proliferation. Cell Growth Differ 1998; 9: 877-885.
25. Taylor SS, McKeon F. Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage. Cell 1997; 89: 727-735.
26. Grabsch H, Takeno S, Parsons WJ, et al. Overexpression of the mitotic checkpoint genes BUB1, BUBR1, and BUB3 in gastric cancer - association with tumour cell proliferation. J Pathol 2003; 200: 16-22.
27. Sobin LH, Wittekind Ch (eds). UICC: TNM Classification of Malignant Tumours (5th edn). Wiley-Liss: New York, 1997.
28. Hamilton SR, Aaltonen LA (eds). WHO Classification of Tumours. Pathology and Genetics of Tumours of the Digestive System. IARC Press: Lyon, 2000.
29. Laurén P. The two histological main types of gastric carcinoma: diffuse and so called intestinal-type carcinoma. Acta Pathol Microbiol Scand 1965; 64: 31-49.
30. Altschul S, Madden T, Schaeffer A, et al. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res 1997; 25: 2289-3402.
31. Morrison E, Wardleworth B, Askham J, Markham A, Meredith D. EB1, a protein which interacts with the APC tumour suppressor, is associated with the microtubule cytoskeleton throughout the cell cycle. Oncogene 1998; 17: 3471-3477.
32. Takahashi T, Haruki N, Nomoto S, Masuda A, Saji S, Osada H. Identification of frequent impairment of the mitotic checkpoint and molecular analysis of the mitotic checkpoint genes, hsMAD2 and p55CDC, in human lung cancers. Oncogene 1999; 18: 4295-4300.
33. Li Y, Benezra R. Identification of a human mitotic checkpoint gene: hsMAD2. Science 1996; 274: 246-248.
34. Miller R, Kubier P. Blocking of endogenous avidin-binding activity in immunohistochemistry: the use of egg whites. Appl Immunohistochem Mol Morphol 1997; 5: 63-66.
35. Merz H, Malisius R, Mannweiler S, et al. ImmunoMax. A maximized immunohistochemical method for the retrieval and enhancement of hidden antigens. Lab Invest 1995; 73: 149-156.
36. Boecking A. DNA measurements: When and why? In Compedium on Quality Assurance, Proficiency Testing and Workload Limitations in Clinical Cytology, Wied GL, Keebler CM, Rosenthal DL, Schenck U, Somrak TM, Vooijs GP (eds). Tutorials of Cytology: Chicago, IL, 1995; 170-188.
37. Haroske G, Baak JPA, Danielsen H, et al. Fourth updated ESACP consensus report on diagnostic DNA image cytometry. Anal Cell Pathol 2001; 23: 89-95.
38. Wirtz HC, Mueller W, Noguchi T, et al. Prognostic value and clinicopathological profile of microsatellite instability in gastric cancer. Clin Cancer Res 1998; 4: 1749-1754.
39. Jablonski SA, Chan GKT, Cooke CA, Earnshaw WC, Yen TJ. The hBUB1 and hBUBR1 kinases sequentially assemble onto kinetochores during prophase with hBUBR1 concentrating at the kinetochore plates in mitosis. Chromosoma 1998; 107: 386-396.
40. Tsujimoto H, Sugihara H, Hattori T, Hagiwara A. Microsatellite instability, DNA ploidy, and mutation of transforming growth factor-beta receptor type II gene in sporadic gastric cancer. Cancer J 1997; 10: 211-216.
41. Seruca R, Santos N, David L, et al. Sporadic gastric carcinomas with microsatellite instability display a particular clinicopathologic profile. Int J Cancer 1995; 64: 32-36.
42. dos Santos NR, Seruca R, Constancia M, Seixas M, Sobrinho-Simoes M. Microsatellite instability at multiple loci in gastric carcinoma: clinicopathologic implications and prognosis. Gastroenterology 1996; 110: 38-44.
43. Kimura T, Sato H, Manabe R, et al. Analysis of microsatellite regions and DNA ploidy pattern in signet ring cell carcinomas of the stomach. Gan To Kagaku Ryoho 1997; 24: 273-278.
44. Yoon D-S, Wersto RP, Zhou W, et al. Variable levels of chromosomal instability and mitotic spindle checkpoint defects in breast cancer. Am J Pathol 2002; 161: 391-397.