Synthesis and anti-HIV activity of some [Nucleoside Reverse Transcriptase Inhibitor]-C5′-linker-[Integrase Inhibitor] heterodimers as inhibitors of HIV replication

Journal of Enzyme Inhibition and Medicinal Chemistry

Volumn 19, Issue 6, 2004, Pages 497-509

  Sugeac, Elena ^a   Fossey, Christine ^a   Ladurée, Daniel ^a   Schmidt, Sylvie ^b   Laumond, Geraldine ^b   Aubertin, Anne Marie ^b  

^a CENTRE D ETUDES ET DE RECHERCHE SUR LE MÉDICAMENT DE NORMANDIE   (France)

^b INSERM   (France)

Author keywords

Cleavable linker; Heterodimer; HIV; INI; Integrase inhibitor; NRTI; Reverse transcriptase inhibitor

Indexed keywords

4 (3,5 DIBENZYLOXYPHENYL) 2,4 DIOXOBUTYRIC ACID; 4 [1 (4 FLUOROBENZYL) 1H PYRROL 2YL] 2,4 DIOXOBUTYRIC ACID; 4 [1 (4 FLUOROBENZYL) 2 PYRROLYL] 2,4 DIOXOBUTYRIC ACID; 5' O [7 (3,5 DIBENZYLOXYPHENYL) 5,7 DIOXOBUTYRYLGLYCYL] 2',3' DIDEHYDRO 2',3' DIDEOXYTHYMIDINE; 5' O [7 [1 (4 FLUOROBENZYL) 1H PYRROL 2 YL] 5,7 DIOXOBUTYRYLGLYCYL] 2',3' DIDEHYDRO 2',3' DIDEOXYTHYMIDINE; 5' O [7 [1 (4 FLUOROBENZYL) 1H PYRROL 2 YL] 5,7 DIOXOBUTYRYLGLYCYL] 2',3' DIDEHYDRO 2',3' DIDEOXYURIDINE; 5' O [7 [1 (4 FLUOROBENZYL) 1H PYRROL 2 YL] 5,7 DIOXOBUTYRYLGLYCYL] 2',3' DIDEOXYURIDINE; 5' O [8 (3,5 DIBENZYLOXYPHENYL) 6,8 DIOXOBUTYRYL BETA ALANYL] 2',3' DIDEHYDRO 2',3' DIDEOXYTHYMIDINE; 5' O [8 [1 (4 FLUOROBENZYL) 1H PYRROL 2 YL] 6,8 DIOXOBUTYLRYL BETA ALANYL] 2',3' DIDEHYDRO 2',3' DIDEOXYTHYMIDINE; 5' O [8 [1 (4 FLUOROBENZYL) 1H PYRROL 2 YL] 6,8 DIOXOBUTYLRYL BETA ALANYL] 2',3' DIDEHYDRO 2',3' DIDEOXYURIDINE; 5' O [8 [1 (4 FLUOROBENZYL) 1H PYRROL 2 YL] 6,8 DIOXOBUTYLRYL BETA ALANYL] 2',3' DIDEOXYURIDINE; 5' O BETA ALANYL 2',3' DIDEHYDRO 2',3' DIDEOXYTHYMIDINE; 5' O BETA ALANYL 2',3' DIDEHYDRO 2',3' DIDEOXYURIDINE; 5' O BETA ALANYL 2',3' DIDEOXYURIDINE; ANTIRETROVIRUS AGENT; L 708906; RNA DIRECTED DNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG; ZIDOVUDINE;

ANTIVIRAL ACTIVITY; ARTICLE; CHEMICAL PROCEDURES; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; IN VITRO STUDY; PRIORITY JOURNAL; VIRUS REPLICATION;

ANTI-HIV AGENTS; CELL LINE; CELL LINE, TUMOR; CELL SURVIVAL; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; HIV INTEGRASE INHIBITORS; HIV-1; HUMANS; LEUKOCYTES, MONONUCLEAR; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; REVERSE TRANSCRIPTASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; VIRUS REPLICATION;

EID: 11244349766     PISSN: 14756366     EISSN: None     Source Type: Journal    
DOI: 10.1080/14756360412331280554     Document Type: Article

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