Synthesis and anti-HIV activity of some heterodimers [NRTI]-glycyl-succinyl-[Trovirdine analogue] of known HIV-1 reverse transcriptase inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry

Volumn 18, Issue 2, 2003, Pages 175-186

  Sugeac, Elena ^a   Fossey, Christine ^a   Ladurée, Daniel ^a   Schmidt, Sylvie ^b   Laumond, Geraldine ^b   Aubertin, Anne Marie ^b  

^a UNIVERSITÉ DE CAEN   (France)

^b INSERM   (France)

Author keywords

Cleavable linker; Heterodimer; HIV; NNRTI; NRTI

Indexed keywords

5 [(5 BROMOPYRIDIN 2 YL)THIOUREIDOETHYLPIPERAZINYLSUCCINYLGLYCYLPROP 1 YNYL]2',3' DIDEOXYURIDINE; 5' O [(5 BROMOPYRIDIN 2 YL) THIOUREIDOETHYLPIPERAZINYLSUCCINYLGLYCYL]2',3' DIDEHYDRO 2',3' DIDEOXYURIDINE; 5' O [(5 BROMOPYRIDIN 2 YL) THIOUREIDOETHYLPIPERAZINYLSUCCINYLGLYCYL]2',3' DIDEOXYURIDINE; 5' O ACETYL 5 [(5 BROMOPYRIDIN 2 YL) THIOUREIDOETHYLPIPERAZINYLSUCCINYLGLYCYLPROP 1 YNYL]2',3' DIDEOXYURIDINE; ANTIRETROVIRUS AGENT; GLYCINE CLEAVAGE SYSTEM; RNA DIRECTED DNA POLYMERASE INHIBITOR; THIOUREA DERIVATIVE; TROVIRDINE; UNCLASSIFIED DRUG; URIDINE DERIVATIVE;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG CONJUGATION; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; VIRUS INHIBITION; VIRUS REPLICATION;

ANTI-HIV AGENTS; CELL LINE; DIMERIZATION; GLYCINE; HIV-1; HIV-1 REVERSE TRANSCRIPTASE; HUMANS; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; PYRIDINES; REVERSE TRANSCRIPTASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; SUCCINIC ACID;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; RNA VIRUSES;

EID: 0038440582     PISSN: 14756366     EISSN: None     Source Type: Journal    
DOI: 10.1080/1475636032000069846     Document Type: Article

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