Eicosanoid biosynthesis: Differential inhibition of cytochrome P450 epoxygenase and ω-hydroxylase

Bioorganic and Medicinal Chemistry Letters

Volumn 7, Issue 23, 1997, Pages 3053-3056

  Falck, J R ^a   Belosludtsev, Yuri Y ^a   Reddy, K Kishta ^a   Reddy, Komandla Malla ^a   Shortt, M Fiona ^a   Chauhan, Kamlesh ^a   Capdevilaand, Jorge H ^b   Wei, Shozou ^b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONATE LIPOXYGENASE; CYTOCHROME P450; ENZYME INHIBITOR; ICOSANOID;

ANIMAL TISSUE; ARACHIDONIC ACID METABOLISM; ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; ENZYME INHIBITION; IN VITRO STUDY; KIDNEY MICROSOME; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; RAT;

EID: 0030708712     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(97)10144-5     Document Type: Article

References (23)

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14. The widely used P450 inhibitors ketoconazole, metyrapone, and SKF 525-A also block other branches of the arachidonic acid cascade: Beetens, J. R.; Loots, W.; Somers, Y.; Coene, M. C.; De Clerck, F. Biochem. Pharm. 1986, 35, 883; Pretus, H. A.; Ignarro, L. J.; Ensley, H. E.; Feigan, L. P. Prostaglandins 1985, 30, 591. Conversely, nordihydroguaiaretic acid (NDGA), eicosatetraynoic acid (ETYA), and indomethacin, extensively utilized inhibitors of cyclooxygenase and lipoxidases, block Cyt P450 arachidonate metabolism (ref 15).
15. The widely used P450 inhibitors ketoconazole, metyrapone, and SKF 525-A also block other branches of the arachidonic acid cascade: Beetens, J. R.; Loots, W.; Somers, Y.; Coene, M. C.; De Clerck, F. Biochem. Pharm. 1986, 35, 883; Pretus, H. A.; Ignarro, L. J.; Ensley, H. E.; Feigan, L. P. Prostaglandins 1985, 30, 591. Conversely, nordihydroguaiaretic acid (NDGA), eicosatetraynoic acid (ETYA), and indomethacin, extensively utilized inhibitors of cyclooxygenase and lipoxidases, block Cyt P450 arachidonate metabolism (ref 15).
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20. 3) of 4: δ 2.03 (dd, J = 7.6, 8.6 Hz, 2H), 2.40 (s, 1H), 2.43 (d, J = 2.9 Hz, 2H), 2.57-2.83 (m, 2H), 4.36 (s, 2H), 7.15-7.56 (m, 8H); inhibitor 8: δ 1.20-1.49 (m, 8H), 1.55-1.74 (m, 2H), 2.09 (q, J = 7.2 Hz, 2H), 2.33 (t, J = 7.6 Hz, 2H), 3.31 (s, 3H), 6.38 (t, J = 7.2 Hz, 1H), 8.59 (br s, 1H).
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