The protein kinase C inhibitor Go6976 [12-(2-cyanoethyl)-6,7,12,13- tetrahydro-13-methyl-5-oxo-5H-indolo(2,3-a)pyrrolo(3,4-c)-carbazole] potentiates agonist-induced mitogen-activated protein kinase activation through tyrosine phosphorylation of the epidermal growth factor receptor

Molecular Pharmacology

Volumn 67, Issue 1, 2005, Pages 184-194

  Shah, Bukhtiar H ^a   Olivares Reyes, J Alberto ^a   Catt, Kevin J ^a  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

12 (2 CYANOETHYL) 6,7,12,13 TETRAHYDRO 13 METHYL 5 OXOINDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE; 2 [1 (3 DIMETHYLAMINOPROPYL) 5 METHOXY 1H INDOL 3 YL] 3 (1H INDOL 3 YL)MALEIMIDE; 4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; ANGIOTENSIN 1 RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; G PROTEIN COUPLED RECEPTOR KINASE; INOSITOL PHOSPHATE; LYSOPHOSPHATIDIC ACID; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN TYROSINE KINASE; VANADATE SODIUM;

ANIMAL CELL; ARTICLE; CELL CLONE; CHO CELL; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; INTERNALIZATION; KIDNEY CELL CULTURE; LIVER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; RECEPTOR BINDING; SIGNAL TRANSDUCTION; TRANSACTIVATION;

ANGIOTENSIN II; ANIMALS; CARBAZOLES; CELL LINE; CHO CELLS; CRICETINAE; ENZYME ACTIVATION; ENZYME INHIBITORS; EPITHELIAL CELLS; HUMANS; INDOLES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; KIDNEY; LIVER; PHOSPHORYLATION; PHOSPHOTYROSINE; PROTEIN KINASE C; RATS; RECEPTOR, EPIDERMAL GROWTH FACTOR;

EID: 11244253958     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.104.003533     Document Type: Article

References (37)

1. Behrens MM, Strasser U, and Choi DW (1999) Go 6976 is a potent inhibitor of neurotrophin-receptor intrinsic tyrosine kinase. J Neurochem 72:919-924.
2. Beltman J, McCormick F, and Cook SJ (1996) The selective protein kinase C inhibitor, Ro-31-8220, inhibits mitogen-activated protein kinase phosphatase-1 (MKP-1) expression, induces c-Jun expression and activates Jun N-terminal kinase. J Biol Chem 271:27018-27024.
3. Camps M, Nichols A, and Arkinstall S (2000) Dual specificity phosphatases: a gene family for control of MAP kinase function. FASEB J 14:6-16.
4. Chernoff J (1999) Protein tyrosine phosphatases as negative regulators of mitogenic signaling. J Cell Physiol 180:173-181.
5. Davies SP, Reddy H, Caivano M, and Cohen P (2000) Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J 351:95-105.
6. De Witt BJ, Kaye AD, Ibrahim IN, Bivalacqua TJ, D'Souza FM, Banister RE, Arif AS, and Nossaman BD (2001) Effects of PKC isozyme inhibitors on constrictor responses in the feline pulmonary vascular bed. Am J Physiol 280:L50-L57.
7. Djafarzadeh S and Niggli V (1997) Signaling pathways involved in dephosphorylation and localization of the actin-binding protein cofilin in stimulated human neutrophils. Exp Cell Res 236:427-435.
8. Farshori PQ, Shah BH, Arora KK, Martinez-Fuentes A, and Catt KJ (2003) Activation and nuclear translocation of PKCdelta, Pyk2 and ERK1/2 by gonadotropin releasing hormone in HEK293 cells. J Steroid Biochem Mol Biol 85:337-347.
9. Fischer OM, Hart S, Gschwind A, and Ullrich A (2003) EGFR signal transactivation in cancer cells. Biochem Soc Trans 31:1203-1208.
10. Ghosh PM, Bedolla R, Thomas CA, and Kreisberg JI (2004) Role of protein kinase C in arginine vasopressin-stimulated ERK and p70S6 kinase phosphorylation. J Cell Biochem 91:1109-1129.
11. Goekjian PG and Jirousek MR (1999) Protein kinase C in the treatment of disease: signal transduction pathways, inhibitors and agents in development. Curr Med Chem 6:877-903.
12. Greco S, Muscella A, Elia MG, Romano S, Storelli C, and Marsigliante S (2004) Mitogenic signalling by B2 bradykinin receptor in epithelial breast cells. J Cell Physiol 201:84-96.
13. Haj FG, Markova B, Klaman LD, Bohmer FD, and Neel BG (2003) Regulation of receptor tyrosine kinase signaling by protein tyrosine phosphatase-1B. J Biol Chem 278:739-744.
14. 2+-sensitive PKC-dependent tyrosine kinase pathway. Acta Physiol Scand 168:301-309.
15. Iankov I, Praskova M, Kalenderova S, Tencheva Z, Mitov I, and Mitev V (2002) The effect of chemical blockade of PKC with Go6976 and Go6983 on proliferation and MAPK activity in IL-6-dependent plasmacytoma cells. Leukoc Res 26:363-368.
16. Jeohn GH, Wilson B, Wetsel WC, and Hong JS (2000) The indolocarbazole Go6976 protects neurons from lipopolysaccharide/interferon-gamma-induced cytotoxicity in murine neuron/glia co-cultures. Brain Res Mol Brain Res 79:32-44.
17. Kolch W, Heidecker G, Kochs G, Hummel R, Vahidi H, Mischak H, Finkenzeller G, Marme D, and Rapp UR (1993) Protein kinase C alpha activates RAF-1 by direct phosphorylation. Nature (Lond) 364:249-522.
18. Lang W, Wang H, Ding L, and Xiao L (2004) Cooperation between PKC-alpha and PKC-epsilon in the regulation of JNK activation in human lung cancer cells. Cell Signal 16:457-467.
19. Luttrell LM (2002) Activation and targeting of mitogen-activated protein kinases by G-protein-coupled receptors. Can J Physiol Pharmacol 80:375-382.
20. Martiny-Baron G, Kazanietz MG, Mischak H, Blumberg PM, Kochs G, Hug H, Marme D, and Schachtele C (1993) Selective inhibition of protein kinase C isozymes by the indolocarbazole Go 6976. J Biol Chem 268:9194-9197.
21. Matrougui K, Eskildsen-Helmond YE, Fiebeler A, Henrion D, Levy BI, Tedgui A, and Mulvany MJ (2000) Angiotensin II stimulates extracellular signal-regulated kinase activity in intact pressurized rat mesenteric resistance arteries. Hypertension 36:617-621.
22. Pierce KL, Premont RT, and Lefkowitz RJ (2002) Seven-transmembrane receptors. Nat Rev Mol Cell Biol 3:639-650.
23. Praskova M, Kalenderova S, Miteva L, Poumay Y, and Mitev V (2002) Dual role of protein kinase C on mitogen-activated protein kinase activation and human keratinocyte proliferation. Exp Dermatol 11:344-348.
24. Prenzel N, Zwick E, Daub H, Leserer M, Abraham R, Wallasch C, and Ullrich A (1999) EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF. Nature (Lond) 402:884-888.
25. Saxena M and Mustelin T (2000) Extracellular signals and scores of phosphatases: all roads lead to MAP kinase. Semin Immunol 12:387-396.
26. Schlessinger J (2000) Cell signaling by receptor tyrosine kinases. Cell 103:211-225.
27. Schlessinger J (2003) Signal transduction. Autoinhibition control. Science (Wash DC) 300:750-752.
28. Sellers LA, Simon J, Lundahl TS, Cousens DJ, Humphrey PP, and Barnard EA (2001) Adenosine nucleotides acting at the human P2Y1 receptor stimulate mitogen-activated protein kinases and induce apoptosis. J Biol Chem 276:16379-16390.
29. Shah BH and Catt KJ (2002) Calcium-independent activation of extracellularly regulated kinases 1 and 2 by angiotensin II in hepatic C9 cells: roles of protein kinase Cδ, Src/proline-rich tyrosine kinase 2 and epidermal growth receptor transactivation. Mol Pharmacol 61:343-351.
30. Shah BH and Catt KJ (2003) A central role of EGF receptor transactivation in angiotensin II-induced cardiac hypertrophy. Trends Pharmacol Sci 24:239-244.
31. Shah BH, Soh JW, and Catt KJ (2003) Dependence of gonadotropin-releasing hormone-induced neuronal MAPK signaling on epidermal growth factor receptor transactivation. J Biol Chem 278:2866-2875.
32. Standaert ML, Bandyopadhyay G, Antwi EK, and Farese RV (1999) RO 31-8220 activates c-Jun N-terminal kinase and glycogen synthase in rat adipocytes and L6 myotubes. Comparison to actions of insulin. Endocrinology 140:2145-2151.
33. Tiganis T (2002) Protein tyrosine phosphatases: dephosphorylating the epidermal growth factor receptor. IUBMB Life 53:3-14.
34. Violin JD and Newton AC (2003) Pathway illuminated: visualizing protein kinase C signaling. IUBMB Life 55:653-660.
35. Wang Z, Wang M, Lazo JS, and Carr BI (2002) Identification of epidermal growth factor receptor as a target of Cdc25A protein phosphatase. J Biol Chem 277:19470-19475.
36. Wetzker R and Bohmer FD (2003) Transactivation joins multiple tracks to the ERK/MAPK cascade. Nat Rev Mol Cell Biol 4:651-657.
37. Zhao Z, Tan Z, Diltz CD, You M, and Fischer EH (1996) Activation of mitogen-activated protein (MAP) kinase pathway by pervanadate, a potent inhibitor of tyrosine phosphatases. J Biol Chem 271:22251-22255.