Protein tyrosine phosphatases as negative regulators of mitogenic signaling

Journal of Cellular Physiology

Volumn 180, Issue 2, 1999, Pages 173-181

  Chernoff, Jonathan ^a  

^a FOX CHASE CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH FACTOR; GROWTH FACTOR RECEPTOR; PROTEIN TYROSINE PHOSPHATASE;

ANIMAL CELL; CELL DIVISION; CELL GROWTH; CELL PROLIFERATION; EXTRACELLULAR MATRIX; GROWTH REGULATION; MITOGENESIS; NEGATIVE FEEDBACK; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; CELL DIVISION; FIBROBLASTS; HUMANS; MITOGENS; PROTEIN-TYROSINE-PHOSPHATASE; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0032988653     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4652(199908)180:2<173::AID-JCP5>3.0.CO;2-Y     Document Type: Review

References (94)

1. Ahmad F, Goldstein BJ. 1997. Functional association between the insulin receptor and the transmembrane protein-tyrosine phosphatase LAR in intact cells. J Biol Chem 272:448-457.
2. Ahmad F, Li P-M, Meyerovitch J, Goldstein BJ. 1995. Osmotic loading of neutralizing antibodies demonstrates a role for protein-tyrosine phosphatase 1B in negative regulation of the insulin action pathway. J Biol Chem 270:20502-20508.
3. Alessi DR, Smythe C, Keyse SM. 1993. The human CL100 gene encodes a Tyr-Thr-protein phosphatase which potently and specifically inactivates MAP kinase and suppresses its activation by oncogenic ras in Xenopus oocyte extracts. Oncogene 8:2015-2020.
4. Alessi DR, Gomez N, Moorhead G, Lewis T, Keyse SM, Cohen P. 1995. Inactivation of p42 MAP kinase by protein phosphatase 2A and a protein tyrosine phosphatase, but not CL100, in various cell lines. Curr Biol 5:283-295.
5. Arregui CO, Balsamo J, Lilien J. 1998. Impaired integrin-mediated adhesion and signaling in fibroblasts expressing a dominant-negative mutant PTP1B. J Cell Biol 143:861-873.
6. Assoian RK, Zhu X. 1997. Cell anchorage and the cytoskeleton as partners in growth factor dependent cell cycle progression. Curr Opin Cell Biol 9:93-98.
7. Auvinen M, Paasinen-Sohns A, Hirai H, Andersson LC, Holtta E. 1995. Ornithine decarboxylase- and ras-induced cell transformation: reversal by protein tyrosine kinase inhibitors and role of pp130CAS. Mol Cell Biol 15:6513-6525.
8. Bandyopadhyay D, Kusari A, Kenner KA, Liu F, Chernoff J, Gustafson TA, Kusari J. 1997. Protein-tyrosine phosphatase 1B complexes with the insulin receptor in vivo and is tyrosine-phosphorylated in the presence of insulin. J Biol Chem 272:1639-1645.
9. Berti A, Rigacci S, Raugei G, Degl'Innocenti D, Ramponi G. 1994. Inhibition of cellular response to platelet-derived growth factor by low M(r) phosphotyrosine protein phosphatase overexpression. FEBS Lett 349:7-12.
10. MAPK cascade. J Biol Chem 272:1368-1376.
11. Brown-Shimer S, Johnson KA, Hill DE, Bruskin AM. 1992. Effect of protein tyrosine phosphatase 1B expression on transformation by the human neu oncogene. Cancer Res 52:478-482.
12. Byon JC, Kusari AB, Kusari J. 1998. Protein-tyrosine phosphatase-1B acts as a negative regulator of insulin signal transduction. Mol Cell Biochem 182:101-108.
13. Camps M, Nichols A, Gillieron C, Antonsson B, Muda M, Chaber TC, Beschert U, Arkinstall S. 1998. Catalytic activation of the phosphatase MKP-3 by ERK2 mitogen-activated protein kinase. Science. 280:1262-1265.
14. Cao L, Zhang L, Ruiz-Lozano P, Yang Q, Chien KR, Graham RM, Zhou M. 1998. A novel putative protein tyrosine phosphatase contains a BRO1-like domain and suppresses Ha-ras mediated transformation. J Biol Chem 273:21077-21083.
15. Charest A, Wagner J, Jacob S, McGlade CJ, Trembley ML. 1996. Phosphotyrosine-independent binding of SHC to the NPLH sequence of murine protein-tyrosine phosphatase-PEST: evidence for extended phosphotyrosine binding/phosphotyrosine interaction domain recognition specificity. J Biol Chem 271:8424-8429.
16. Charles CH, Sun H, Lau LF, Tonks NK. 1993. The growth-factor-inducible immediate-early gene 3CH134 encodes a protein-tyrosine-phosphatase. Proc Natl Acad Sci USA 90:5292-5296.
17. Chen H, Wertheimer SJ, Lin CH, Katz SL, Amrein KE, Burn P, Quon MJ. 1997. Protein-tyrosine phosphatases PTP1B and Syp are modulators of insulin-stimulated translocation of GLUT4 in transfected rat adipose cells. J Biol Chem 272:8026-8031.
18. Chiarugi P, Cirri P, Raugei G, Camici G, Dolfi F, Berti A, Ramponi G. 1995. PDGF receptor as a specific in vivo target for low M(r) phosphotyrosine protein phosphatase. FEBS Lett 18:49-53.
19. Chiarugi P, Cirri P, Raugei G, Manao G, Taddei L, Ramponi G. 1996. Low M(r) phosphotyrosine protein phosphatase interacts with the PDGF receptor directly via its catalytic site. Biochem Biophys Res Commun 219:21-25.
20. Chiarugi P, Cirri P, Marra F, Raugei G, Fiaschi T, Camici G, Manao G, Romanelli RG, Ramponi G. 1998. The Src and signal transducers and activators of transcription pathways as specific targets for low molecular weight phosphotyrosine-protein phosphatase in platelet-derived growth factor signaling. J Biol Chem 273:6776-6785.
21. Chu Y, Solski PA, Khosravi-Far R, Der CJ, Kelly K. 1996. The mitogen-activated protein kinase phosphatases PAC1, MKP-1, and MKP-2 have unique substrate specificities and reduced activity in vivo toward the ERK2 sevenmaker mutation. J Biol Chem 271: 6497-6501.
22. Cirri P, Chiarugi P, Taddei L, Raugei G, Camici G, Manao G, Ramponi G. 1998. Low molecular weight protein-tyrosine phosphatase tyrosine phosphorylation by c-Src during platelet-derived growth factor-induced mitogenesis correlates with its subcellular targeting. J Biol Chem 273:32522-32527.
23. Clark EA, Brugge JS. 1995. Integrins and signal transduction pathways: the road taken. Science 268:233-239.
24. Davidson D, Cloutier JF, Gregorieff A, Veillette A. 1997. Inhibitory tyrosine protein kinase p50csk is associated with protein-tyrosine phosphatase PTP-PEST in hemopoietic and non-hemopoietic cells. J Biol Chem 272:23455-23462.
25. Dorfman K, Carrasco D, Gruda M, Ryan C, Lira SA, Bravo R. 1996. Disruption of the erp/mkp-1 gene does not affect mouse development: normal MAP kinase activity in ERP/MKP-1 deficient fibroblasts. Oncogene 13:925-931.
26. Dowd S, Sneddon AA, Keyse SM. 1998. Isolation of the human genes encoding the pyst1 and pyst2 phosphatases: isolation of Pyst2 as a cytosolic dual-specificity MAP kinase phosphatase and its catalytic activation by both MAP and SAP kinases. J Cell Sci 111:3389-3399.
27. Drake PG, Posner BI. 1998. Insulin receptor-associated tyrosine phosphatase(s): role in insulin action. Mol Cell Biochem 182:79-89.
28. Elchebly M, Payette P, Michaliszyn E, Cromlish W, Collins S, Loy AL, Normandin D, Cheng A, Himms-Hagen J, Chan CC, Ramachandran C, Gresser MJ, Tremblay ML, Kennedy BP. 1999. Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene. Science 283:1544-1548.
29. Flint AJ, Tiganis T, Barford D, and Tonks NK. 1997. Development of "substrate-trapping" mutants to identify physiological substrates of protein tyrosine phosphatases. Proc Natl Acad Sci USA 94:1680-1685.
30. Frangioni JV, Beahm PH, Shifrin V, Jost CA, Neel BG. 1992. The nontransmembrane tyrosine phosphatase PTP-1B localizes to the endoplasmic reticulum via its amino acid C-terminal sequence. Cell 68:545-560.
31. Frangioni JV, Oda A, Smith M, Salzman EW, Neel BG. 1993. Calpain-catalyzed cleavage and subcellular relocation of protein tyrosine phosphatase 1B (PTP-1B) in human platelets EMBO J 12:4843-4856.
32. Franklin CC, Kraft AS. 1997. Conditional expression of the mitogen-activated protein kinase (MAPK) phosphatase MKP-1 preferentially inhibits p38 MAPK and stress-activated protein kinase in U937 cells. J Biol Chem 272:16917-16923.
33. Garton AJ, Tonks N. 1999. Regulation of fibroblast motility by the protein tyrosine phosphatase PTP-PEST. J Biol Chem 274:3811-3818.
34. Cas as a substrate for the cytosolic tyrosine phosphatase PTP-PEST. Mol Cell Biol 16:6408-6418.
35. Goldstein BJ, Ahmad F, Ding W, Li PM, Zhang WR. 1998. Regulation of the insulin signalling pathway by cellular protein-tyrosine phosphatases. Mol Cell Biochem 182:91-99.
36. Gregorieff A, Cloutier JF, Veillette A. 1998. Sequence requirements for association of protein-tyrosine phosphatase PEP with the Src homology 3 domain of inhibitory tyrosine protein kinase p50(csk). J Biol Chem 273:13217-13222.
37. Groom LA, Sneddon AA, Alessi DR, Dowd S, Keyse SM. 1996. Differential regulation of the MAP, SAP, and RK/p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphatase. EMBO J 15:3621-3632.
38. Guan K-L, Butch E. 1995. Isolation and characterization of a novel dual specific phosphatase, HVH2, which selectively dephosphorylates the mitogen-activated protein kinase. J Biol Chem 270:7197-7203.
39. Habib T, Herrera R, Decker SJ. 1994. Activators of protein kinase C stimulate association of Shc and the PEST tyrosine phosphatase. J Biol Chem 269:25243-25246.
40. Hashimoto N, Feener EP, Zhang WR, Goldstein BJ. 1992. Insulin receptor protein-tyrosine phosphatases: leukocyte common antigen-related phosphatase rapidly deactivates the insulin receptor kinase by preferential dephosphorylation of the receptor regulatory domain. J Biol Chem 267:13811-13814.
41. Hendricks W, Schlepens J, Brugman C, Zeeuwen P, Wieringa B. 1995. A novel receptor type protein tyrosine phosphatase with a single catalytic domain is specifically expressed in mouse brain. Biochem J 305:499-504.
42. Hirsch DD, Stork PJS. 1997. Mitogen-activated protein kinase phosphatases inactivate stress-activated protein kinase pathways in vivo. J Biol Chem 272:4568-4575.
43. Ishibashi T, Bottaro DP, Michieli P, Kelly A, Aaronson SA. 1994. A novel dual specificity phosphatase induced by serum stimulation and heat shock. J Biol Chem 269:29897-29902.
44. Kenner KA, Anyanwu E, Olefsky JM, Kusari J. 1996. Protein-tyrosine phosphatase 1B is a negative regulator of insulin- and insulin-like growth factor-I-stimulated signaling. J Biol Chem 271:19810-19816.
45. Keyse SM, Emslie EA. 1992. Oxidative stress and heat-shock induce a human gene encoding a protein-tyrosine-phosphatase. Nature 359:644-647.
46. King AG, Ozanne BW, Smythe C, Ashworth A. 1995. Isolation and characterisation of a uniquely regulated threonine, tyrosine phosphatase (TYP 1) which inactivates ERK2 and p54jnk. Oncogene 11:2553-2563.
47. Kulas DT, Zhang WR, Goldstein BJ, Furlanetto RW, Mooney RA. 1995. Insulin receptor signaling is augmented by antisense inhibition of the protein tyrosine phosphatase LAR. J Biol Chem 270: 2435-2438.
48. Kulas DT, Goldstein BJ, Mooney RA. 1996. The transmembrane protein-tyrosine phosphatase LAR modulates signaling by multiple receptor tyrosine kinases. J Biol Chem 271:748-754.
49. Kwak SP, Dixon JE. 1995. Multiple dual specificity protein tyrosine phosphatases are expressed and regulated differentially in liver cells. J Biol Chem 270:1156-1160.
50. Lammers R, Bossenmaier B, Cool DE, Tonks NK, Schlessinger J, Fischer EH, Ullrich A. 1993. Differential activities of protein tyrosine phosphatases in intact cells. J Biol Chem 268:22456-22462.
51. Lammers R, Moller NP, Ullrich A. 1997. The transmembrane protein tyrosine phosphatase alpha dephosphorylates the insulin receptor in intact cells. FEBS Lett 404:37-40.
52. LaMontagne KRJ, Hannon G, Tonks NK. 1998. Protein tyrosine phosphatase PTP1B suppresses p210 bcr-abl-induced transformation of rat-1 fibroblasts and promotes differentiation of K562 cells. Proc Natl Acad Sci USA 95:14094-14099.
53. Lee S-R, Kwon K-S, Kim S-R, Rhee SG. 1998. Reversible inactivation of protein-tyrosine phosphatase 1B in A431 cells stimulated with epidermal growth factor. J Biol Chem 273:15366-15372.
54. Li PM, Zhang WR, Goldstein BJ. 1996. Suppression of insulin receptor activation by overexpression of the protein-tyrosine phosphatase LAR in hepatoma cells. Cell Signal 8:467-473.
55. Liu F, Chernoff J. 1997. PTP1B associates with and is tyrosine phosphorylated by epidermal growth factor receptor in cultured cells. Biochem J 327:139-145.
56. Liu F, Chernoff J. 1998. Suppression of oncogene-mediated transformation of rat 3Y1 fibroblasts by protein tyrosine phosphatase 1B requires a functional SH3-ligand. Mol Cell Biol 18:250-259.
57. Liu F, Sells MA, Chernoff J. 1998. Protein tyrosine phosphatase 1B negatively regulates integrin signaling. Curr Biol 8:173-176.
58. Lombroso PL, Murdoch G, Lerner M. 1991. Molecular characterization of a protein-tyrosine-phosphatase enriched in striatum. Proc Natl Acad Sci USA 88:7242-7246.
59. Maehama T, Dixon JE. 1998. The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-triphosphate. J Biol Chem 273:13375-13378.
60. Manie SN, Astier A, Haghayeghi N, Canty T, Druker BJ, Hirai H, Freedman AS. 1997. Regulation of integrin-mediated p130(Cas) tyrosine phosphorylation in human B cells. A role for p59(Fyn) and SHP2. J Biol Chem 272:15636-15641.
61. Milarski KL, Zhu G, Pearl CG, McNamara DJ, Dobrusin EM, MacLean D, Thieme-Sefler A, Zhang Z-Y, Sawyer T, Decker SJ, Dixon JE, Saltiel AR. 1993. Sequence specificity in recognition of the epidermal growth factor receptor by protein tyrosine phosphatase 1B. J Biol Chem 268:23634-23639.
62. Misra-Press A, Rim CS, Yao H, Roberson MS, Stork PJS. 1995. A novel mitogen-activated protein kinase phosphatase. Structure, expression, and regulation. J Biol Chem 270:14587-14596.
63. Moller NP, Moller KB, Lammers R, Kharitonenkov A, Hoppe E, Wiberg FC, Sures I, Ullrich A. 1995. Selective down-regulation of the insulin receptor signal by protein-tyrosine phosphatases alpha and epsilon. J Biol Chem 270:23126-23131.
64. Mooney RA, Kulas DT, Bleyle LA, Novak JS. 1997. The protein tyrosine phosphatase LAR has a major impact on insulin receptor dephosphorylation. Biochem Biophys Res Commun 235:709-712.
65. Mourey RJ, Vega QC, Campbell JS, Wenderoth MP, Hauschka SD, Krebs EG, Dixon JE. 1996. A novel cytoplasmic dual specificity protein tyrosine phosphatase implicated in muscle and neuronal differentiation. J Biol Chem 271:4319-4326.
66. Muda M, Boschert U, Smith A, Antonsson B, Gillieron C, Chabert C, Camps M, Martinou I, Ashworth A, Arkinstall S. 1998. Molecular cloning and functional characterization of a novel mitogen-activated protein kinase phosphatase, MKP-4. J Biol Chem 272:5141-5151.
67. Muda M, Theodosiou A, Rodriguesi N, Boschert U, Camps M, Gillieron C, Davies K, Ashworth A, Arkinstall S. 1996. The dual specificity phosphatases M3/6 and MKP-3 are highly selective for inactivation of distinct mitogen-activated protein kinases. J Biol Chem 271:27205-27208.
68. Muda M, Theodosiou A, Gillieron C, Smith A, Chabert C, Camps M, Boschert U, Rodriguesi N, Davies K, Ashworth A, Arkinstall S. 1998. The mitogen-activated protein kinase phosphatase-3 N-terminal noncatalytic region is responsible for tight substrate binding and enzymatic specificity. J Biol Chem 273:9323-9329.
69. Myers MP, Pass I, Batty IH, Van der Kaay J, Stolarov JP, Hemmings BA, Wigler MH, Downes CP, Tonks NK. 1998. The lipid phosphatase activity of PTEN is critical for its tumor suppressor function. Proc Natl Acad Sci USA 95:13513-13518.
70. Ogata M, Sawada M, Fujino Y, Hamaoka T. 1995. cDNA cloning and characterization of a novel receptor-type protein tyrosine phosphatase expressed predominantly in the brain. J Biol Chem 270:2337-2343.
71. Petruzelli L, Takami M, Herrera R. 1996. Adhesion through the interaction of lymphocyte function-associated antigen-1 with intracellular-1 induced tyrosine phosphorylation of p130cas and its association with c-CrkII. J Biol Chem 271:7796-7801.
72. Pulido R, Zuniga A, Ullrich A. 1998. PTP-SL and STEP protein tyrosine phosphatases regulate the activation of the extracellular signal-regulated kinases ERK1 and ERk2 by association through a kinase interaction motif. EMBO J 17:7337-7350.
73. Ramponi G, Ruggiero M, Raugei G, Berti A, Modesti A, Degl'Innocenti D, Magnelli L, Pazzagli C, Chiarugi VP, Camici G. 1992. Overexpression of a synthetic phosphotyrosine protein phosphatase gene inhibits normal and transformed cell growth. Int J Cancer 51:652-665.
74. Ren JM, Li PM, Zhang WR, Sweet LJ, Cline G, Shulman GI, Livingston JN, Goldstein BJ. 1998. Transgenic mice deficient in the LAR protein-tyrosine phosphatase exhibit profound defects in glucose homeostasis. Diabetes 47:493-497.
75. Rigacci S, Degl'Innocenti D, Bucciantini M, Cirri P, Berti A, Ramponi G. 1996. pp60v-src phosphorylates and activates low molecular weight phosphotyrosine-protein phosphatase. J Biol Chem 271: 1278-1281.
76. Roach T, Slater S, Koval M, White L, McFarland EC, Okumura M, Thomas M, Brown E. 1997. CD45 regulates Src family member kinase activity associated with macrophage integrin-mediated adhesion. Curr Biol 7:408-417.
77. Rock MT, Brooks WH, Roszman TL. 1997. Calcium-dependent signaling pathways in T cells: potential role of calpain, protein tyrosine phosphatase 1B, and p130Cas in integrin-mediated signaling events. J Biol Chem 272:33377-33383.
78. Rohan PJ, Davis P, Moskaluk CA, Kearns M, Krutzsch H, Siebenlist U, Kelly K. 1993. PAC-1: a mitogen-induced nuclear protein tyrosine phosphatase. Science 259:1763-1766.
79. Ruggiero M, Pazzagli C, Rigacci S, Magnelli L, Raugei G, Berti A, Chiarugi VP, Pierce JH, Camici G, Ramponi G. 1993. Negative growth control by a novel low M(r) phosphotyrosine protein phosphatase in normal and transformed cells. FEBS Lett 326:294-298.
80. Seely BL, Staubs PA, Reichart DR, Berhanu P, Milarski KL, Saltiel AR, Kusari J, Olefsky JM. 1996. Protein tyrosine phosphatase 1B interacts with the activated insulin receptor. Diabetes 45:1379-1385.
81. Sharma E, Zhao F, Bult A, Lombroso PJ. 1995. Identification of two alternatively spliced transcripts of STEP: a subfamily of brain-enriched protein tyrosine phosphatases. Brain Res Mol Brain Res 32:87-93.
82. Shin DY, Ishibashi T, Choi TS, Chung E, Chung IY, Aaronson SA, Bottaro DP. 1997. A novel human ERK phosphatase regulates H-ras and v-raf signal transduction. Oncogene 14:2633-2639.
83. Shiozuka K, Watanabe Y, Ikeda T, Hashimoto S, Kawashima H. 1995. Cloning and expression of PCPTP1 encoding protein tyrosine phosphatase. Gene 162:279-284.
84. Sun H, Charles CH, Lau LF, Tonks NK. 1993. MKP-1 (3CH134), an immediate early gene product, is a dual-specificity phosphatase that dephosphorylates MAP kinase in vivo. Cell 75:487.
85. Tamura M, Gu J, Matsumoto K, Aota S-I, Parsons R, Yamada KM. 1998. Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN. Science 280:1614-1617.
86. Tamura M, Gu J, Takino T, Yamada KM. 1999. Tumor suppressor PTEN inhibition of cell invasion, migration, and growth: differential involvement of focal adhesion kinase and p130Cas. Cancer Res 59:442-449.
87. Tiganis T, Bennett AM, Ravichandran KS, Tonks NK. 1998. Epidermal growth factor receptor and the adaptor protein p52Shc are specific substrates of T-cell protein tyrosine phosphatase. Mol Cell Biol 18:1622-1634.
88. Tonks NK, Cicirelli MF, Diltz CD, Krebs EG, Fischer EH. 1990. Effect of microinjection of low-Mr human placenta protein tyrosine phosphatase on induction of meiotic cell division in Xenopus oocytes. Mol Cell Biol 10:458-463.
89. Ward Y, Gupta S, Jensen P, Wartmann M, Davis RJ, Kelly K. 1994. Control of MAP kinase activation by the mitogen-induced threonine/tyrosine phosphatase PAC1. Nature 367:651-654.
90. Woodford-Thomas TA, Rhodes JD, Dixon JE. 1992. Expression of a protein tyrosine phosphatase in normal and v-src-transformed mouse 3T3 fibroblasts. J Cell Biol 117:401-414.
91. Wu J, Lau L, Sturgill TW. 1994. Rapid deactivation of MAP kinase in PC12 cells occurs independently of induction of phosphatase MKP-1. FEBS Lett 353:9-12.
92. Zander NF, Cool DE, Diltz CD, Rohrschneider LR, Krebs EG, Fischer EH. 1993. Suppression of v-fms-induced transformation by overexpression of a truncated T-cell protein tyrosine phosphatase. Oncogene 8:1175-1182.
93. Zhai Y, Wirth J, Kang S, Welsch CW, Esselman WJ. 1995. LAR-PTPase cDNA transfection suppression of tumor growth of neu oncogene-transformed human breast carcinoma cells. Mol Carcinogen 14:103-110.
94. Zhang WR, Li PM, Oswald MA, Goldstein BJ. 1996. Modulation of insulin signal transduction by ectopic overexpression of the receptor-type protein-tyrosine phosphatase LAR. Mol Endocrinol 10:575-584.