Activation and nuclear translocation of PKCδ, Pyk2 and ERK1/2 by gonadotropin releasing hormone in HEK293 cells

Journal of Steroid Biochemistry and Molecular Biology

Volumn 85, Issue 2-5, 2003, Pages 337-347

  Farshori, Parvaiz Q ^a   Shah, Bukhtiar H ^a   Arora, Krishan K ^a   Martinez Fuentes, Antonio ^a   Catt, Kevin J ^a  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

c fos; ERK1 2 MAP kinases; GnRH; HEK293 cells; Nuclear translocation; PKC; Pyk2

Indexed keywords

2 [1 (3 DIMETHYLAMINOPROPYL) 5 METHOXY 1H INDOL 3 YL] 3 (1H INDOL 3 YL)MALEIMIDE; 4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; GONADORELIN; GONADORELIN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN KINASE C; PROTEIN KINASE C ALPHA; PROTEIN KINASE C DELTA; PROTEIN KINASE C EPSILON; PROTEIN KINASE C IOTA; PROTEIN KINASE C LAMBDA; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE PYK 2; RAF PROTEIN; SERINE; UNCLASSIFIED DRUG;

CELL LINE; CELL MEMBRANE; CELL STIMULATION; CELLULAR DISTRIBUTION; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; FOCAL ADHESION; GENE EXPRESSION; HUMAN; HUMAN CELL; INHIBITION KINETICS; MOLECULAR MIMICRY; ONCOGENE C FOS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; STIMULATION;

EID: 0042477742     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-0760(03)00226-7     Document Type: Conference Paper

References (61)

1. Stojilkovic S.S., Catt K.J. Novel aspects of GnRH-induced intracellular signaling and secretion in pituitary gonadotrophs. J. Neuroendocrinol. 10:1995;739-757.
2. Reiss N., Levi L.N., Shacham S., Harris D., Seger R., Naor Z. Mechanism of mitogen activated protein kinase activation by gonadotropin-releasing hormone in the pituitary of αT3-1 cell line: differential roles of calcium and protein kinase C. Endocrinology. 138(4):1997;1673-1682.
3. Han X.B., Conn P.M. The role of protein kinases A and C pathways in the regulation of mitogen-activated protein kinase activation in response to gonadotropin-releasing hormone receptor activation. Endocrinology. 140(5):1999;2241-2251.
4. Grosse R., Roelle S., Herrlich A., Hohn J., Gudermann T. Epidermal growth factor receptor tyrosine kinase mediates Ras activation by gonadotropin-releasing hormone. J. Biol. Chem. 275(16):2000;12251-12260.
5. Naor Z., Benard O., Seger R. Activation of MAPK cascades by G-protein-coupled receptors: the case of gonadotropin-releasing hormone receptor. Trends Endocrinol. Metab. 3:2000;91-99.
6. Benard O., Naor Z., Seger R. Role of dynamin, Src, and Ras in the protein kinase C-mediated activation of ERK by gonadotropin-releasing hormone. J. Biol. Chem. 276(7):2001;4554-4563.
7. Marinissen M.J., Gutkind J.S. G-protein-coupled receptors and signaling networks: emerging paradigms. Trends Pharmacol. Sci. 7:2001;368-376.
8. Naor Z., Dan-Cohen H., Hermon J., Limor R. Mechanism of action of gonadotrophin-releasing hormone on pituitary gonadotrophin secretion. J. Reprod. Fertil. Suppl. 37:1989;295-300.
9. Harris D., Reiss N., Naor Z. Differential activation of protein kinase C delta and epsilon gene expression by gonadotropin-releasing hormone in alphaT3-1 cells. Autoregulation by protein kinase C. J. Biol. Chem. 272(21):1997;13534-13540.
10. Poulin B., Rich N., Mas J.L., Kordon C., Enjalbert A., Drouva S.V. GnRH signalling pathways and GnRH-induced homologous desensitization in a gonadotrope cell line (αT3-1). Mol. Cell. Endocrinol. 142(1-2):1998;99-117.
11. Luttrell L.M., Daaka Y., Lefkowitz R.J. Regulation of tyrosine kinase cascades by G-protein-coupled receptors. Curr. Opin. Cell Biol. 11(2):1999;177-183.
12. Mondorf U.F., Geiger H., Herrero M., Zeuzem S., Piiper A. Involvement of the platelet-derived growth factor receptor in angiotensin II-induced activation of extracellular regulated kinases 1 and 2 in human mesangial cells. FEBS Lett. 472(1):2000;129-132.
13. Roudabush F.L., Pierce K.L., Maudsley S., Khan K.D., Luttrell L.M. Transactivation of the EGF receptor mediates IGF-1-stimulated Shc phosphorylation and ERK1/2 activation in COS-7 cells. J. Biol. Chem. 275(29):2000;22583-22589.
14. Saito Y., Berk B.C. Transactivation: a novel signaling pathway from angiotensin II to tyrosine kinase receptors. J. Mol. Cell. Cardiol. 33:2001;3-7.
15. Maudsley S., Pierce K.L., Zamah A.M., Miller W.E., Ahn S., Daaka Y., Lefkowitz R.J., Luttrell L.M. The β2-adrenergic receptor mediates extracellular signal-regulated kinase activation via assembly of a multi-receptor complex with the epidermal growth factor receptor. J. Biol. Chem. 275(13):2000;9572-9580.
16. Soltoff S.P., Avraham H., Avraham S., Cantley L.C. Activation of P2Y2 receptors by UTP and ATP stimulates mitogen-activated kinase activity through a pathway that involves related adhesion focal tyrosine kinase and protein kinase C. J. Biol. Chem. 273(5):1998;2653-2660.
17. Daub H., Wallasch C., Lankenau A., Herrlich A., Ullrich A. Signal characteristics of G protein-transactivated EGF receptor. EMBO J. 16(23):1997;7032-7044.
18. Della Rocca G.J., Maudsley S., Daaka Y., Lefkowitz R.J., Luttrell L.M. Pleiotropic coupling of G protein-coupled receptors to the mitogen-activated protein kinase cascade. Role of focal adhesions and receptor tyrosine kinases. J. Biol. Chem. 274(20):1999;13978-13984.
19. Gschwind A., Zwick E., Prenzel N., Leserer M., Ullrich A. Cell communication networks: epidermal growth factor receptor transactivation as the paradigm for interreceptor signal transmission. Oncogene. 20(13):2001;1594-1600.
20. Hislop J.N., Everest H.M., Flynn A., Harding T., Uney J.B., Troskie B.E., Millar R.P., McArdle C.A. Differential internalization of mammalian and non-mammalian gonadotropin-releasing hormone receptors. Uncoupling of dynamin-dependent internalization from mitogen-activated protein kinase signaling. J. Biol. Chem. 276(43):2001;39685-39694.
21. Mulvaney J.M., Zhang T., Fewtrell C., Roberson M.S. Calcium influx through L-type channels is required for selective activation of extracellular signal-regulated kinase by gonadotropin-releasing hormone. J. Biol. Chem. 274(42):1999;29796-29804.
22. Han X.B., Conn P.M. The role of protein kinases A and C pathways in the regulation of mitogen-activated protein kinase activation in response to gonadotropin-releasing hormone receptor activation. Endocrinology. 140(5):1999;2241-2251.
23. Levi N.L., Hanoch T., Benard O., Rozenblat M., Harris D., Reiss N., Naor Z., Seger R. Stimulation of Jun N-terminal kinase (JNK) by gonadotropin-releasing hormone in pituitary αT3-1 cell line is mediated by protein kinase C, c-Src, and CDC42. Mol. Endocrinol. 6:1998;815-824.
24. Liu F., Austin D.A., Mellon P.L., Olefsky J.M., Webster N.J. GnRH activates ERK1/2 leading to the induction of c-fos and LHβ protein expression in LβT2 cells. Mol. Endocrinol. 3:2002;419-434.
25. Eguchi S., Iwasaki H., Ueno H., Frank G.D., Motley E.D., Eguchi K., Marumo F., Hirata Y., Inagami T. Intracellular signaling of angiotensin II-induced p70 S6 kinase phosphorylation at Ser(411) in vascular smooth muscle cells. Possible requirement of epidermal growth factor receptor, Ras, extracellular signal-regulated kinase, and Akt. J. Biol. Chem. 274(52):1999;36843-36845.
26. 2 receptor. Biochem. Biophys. Res. Commun. 282(5):2001;1085-1091.
27. Sorokin A., Kozlowski P., Graves L., Philip A. Protein-tyrosine kinase Pyk2 mediates endothelin-induced p38 MAPK activation in glomerular mesangial cells. J. Biol. Chem. 276(24):2001;21521-21528.
28. Iwasaki H., Shichiri M., Marumo F., Hirata Y. Adrenomedullin stimulates proline-rich tyrosine kinase 2 in vascular smooth muscle cells. Endocrinology. 142:2001;564-572.
29. 2+, PYK-2, and p60(src). J. Biol. Chem. 275:2000;12619-12625.
30. Andreev J., Galisteo M.L., Kranenburg O., Logan S.K., Chiu E.S., Okigaki M., Cary L.A., Moolenaar W.H., Schlessinger J. Src and Pyk2 mediate G-protein-coupled receptor activation of epidermal growth factor receptor (EGFR) but are not required for coupling to the mitogen-activated protein (MAP) kinase signaling cascade. J. Biol. Chem. 276(23):2001;20130-20135.
31. Arora K.K., Sakai A., Catt K.J. Effects of second intracellular loop mutations on signal transduction and internalization of the gonadotropin-releasing hormone receptor. J. Biol. Chem. 270:1995;22820-22826.
32. Arora K.K., Cheng Z., Catt K.J. Mutations of the conserved DRS motif in the second intracellular loop of the gonadotropin-releasing hormone receptor affect expression, activation, and internalization. Mol. Endocrinol. 9:1997;1203-1212.
33. Farshori P.Q., Kachar B. Redistribution and phosphorylation of occludin during opening and resealing of tight junctions in cultured epithelial cells. J. Membr. Biol. 170(2):1999;147-156.
34. Shah B.H., Olivares-Reyes J.A., Yesilkaya A., Catt K.J. Independence of angiotensin II-Induced MAP kinase activation from angiotensin type 1 receptor internalization in clone 9 hepatocytes. Mol. Endocrinol. 16:2002;610-620.
35. Dikic I., Tokiwa G., Lev S., Courtneidge S.A., Schlessinger J. A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation. Nature. 383:1996;547-550.
36. Blaukat A., Ivankovic-Dikic I., Gronroos E., Dolfi F., Tokiwa G., Vuori K., Dikic I. Adaptor proteins Grb2 and Crk couple Pyk2 with activation of specific mitogen-activated protein kinase cascades. J. Biol. Chem. 274(21):1999;14893-14901.
37. Shah B.H., Catt K.J. Calcium-independent activation of extracellularly regulated kinases 1 and 2 by angiotensin II in hepatic C9 cells: roles of protein kinase C delta, Src/proline-rich tyrosine kinase 2, and epidermal growth receptor trans-activation. Mol. Pharmacol. 1(2):2002;343-351.
38. 2+, PKC, and Rho kinase. Am. J. Physiol. Cell Physiol. 282(6):2002;C1432-C1444.
39. Tapia J.A., Ferris H.A., Jensen R.T., García L.J. Cholecystokinin activates PYK2/CAK by a phospholipase C-dependent mechanism and its association with the mitogen-activated protein kinase signaling pathway in pancreatic acinar cells. J. Biol. Chem. 274:1999;31261-31271.
40. Matsuya M., Sasaki H., Aoto H., Mitaka T., Nagura K., Ohba T., Ishino M., Takahashi S., Suzuki R., Sasaki T. Cell adhesion kinase β forms a complex with a new member, Hic-5, of proteins localized at focal adhesions. J. Biol. Chem. 273(2):1998;1003-1014.
41. Litvak V., Tian D., Shaul Y.D., Lev S. Targeting of PYK2 to focal adhesions as a cellular mechanism for convergence between integrins and G protein-coupled receptor signaling cascades. J. Biol. Chem. 275:2000;32736-32746.
42. Sasaki H., Nagura K., Ishino M., Tobioka H., Kotani K., Sasaki T. Cloning and characterization of cell adhesion kinase β, a novel protein-tyrosine kinase of the focal adhesion kinase subfamily. J. Biol. Chem. 270(36):1995;21206-21219.
43. Avraham H., Park S.Y., Schinkmann K., Avraham S. RAFTK/Pyk2-mediated cellular signaling. Cell Signal. 12(3):2000;123-133.
44. Tokiwa G., Dikic I., Lev S., Schlessinger J. Activation of Pyk2 by stress signals and coupling with JNK signaling pathway. Science. 273(5276):1996;792-794.
45. Zwick E., Wallasch C., Dau H., Ullrich A. Distinct calcium-dependent pathways of epidermal growth factor receptor transactivation and PYK2 tyrosine phosphorylation in PC12 cells. J. Biol. Chem. 274:1999;20989-20996.
46. 2+-induced regulation of ion channel and MAP kinase functions. Nature. 376(6543):1995;737-745.
47. Eguchi S., Dempsey P.J., Frank G.D., Motley E.D., Inagami T. Activation of MAPKs by angiotensin II in vascular smooth muscle cells. Metalloprotease-dependent EGF receptor activation is required for activation of ERK and p38 MAPK but not for JNK. J. Biol. Chem. 276(11):2001;7957-7962.
48. Aoto H., Sasaki H., Ishino M., Sasaki T. Nuclear translocation of cell adhesion kinase beta/proline-rich tyrosine kinase 2. Cell Struct. Funct. 27(1):2002;47-61.
49. Pendergast A.M. Nuclear tyrosine kinases: from Abl to WEE1. Curr. Opin. Cell Biol. 8:1996;174-181.
50. Ivankovic-Dikic I., Gronroos E., Blaukat A., Barth B.U., Dikic I. Pyk2 and FAK regulate neurite outgrowth induced by growth factors and integrins. Nat. Cell Biol. 9:2000;574-581.
51. Maloney J.A., Tsygankova O., Szot A., Yang L., Li Q., Williamson J.R. Differential translocation of protein kinase C isozymes by phorbol esters, EGF, and ANG II in rat liver WB cells. Am. J. Physiol. 274(4 (Part 1)):1998;C974-C982.
52. Olah Z., Lehel C., Anderson W.B., Brenneman D.E., van Agoston D. Subnanomolar concentration of VIP induces the nuclear translocation of protein kinase C in neonatal rat cortical astrocytes. J. Neurosci. Res. 39(4):1994;355-363.
53. Wang Q.J., Bhattacharyya D., Garfield S., Nacro K., Marquez V.E., Blumberg M.P. Differential localization of protein kinase C δ by phorbol esters and related compounds using a fusion protein with green fluorescent protein. J. Biol. Chem. 274(52):1999;37233-37239.
54. Jimenez S.A., Gaidarova S., Saitta B., Sandorfi N., Herrich D.J., Rosenbloom J.C., Kucich U., Abrams W.R., Rosenbloom J. Role of protein kinase C-delta in the regulation of collagen gene expression in scleroderma fibroblasts. J. Clin. Invest. 108(9):2001;1395-1403.
55. McArdle C.A., Franklin J., Green L., Hislop J.N. Signalling, cycling and desensitisation of gonadotrophin-releasing hormone receptors. J. Endocrinol. 173(1):2002;1-11.
56. DeGraff J.L., Gagnon A.W., Benovic J.L., Orsini M.J. Role of arrestins in endocytosis and signaling of α2-adrenergic receptor subtypes. J. Biol. Chem. 274(16):1999;11253-11259.
57. 2+-sensitive adenylyl cyclase in gonadotropin-releasing hormone neurons. Mol. Endocrinol. 3:2001;429-440.
58. Shah B.H., Soh J.W., Catt K.J. Dependence of gonadotropin-releasing hormone-induced neuronal MAP kinase signaling on epidermal growth factor receptor transactivation. J. Biol. Chem. 278(5):2003;2866-2875.
59. Heding A., Vrecl M., Bogerd J., McGregor A., Sellar R., Taylor P.L., Eidne K.A. Gonadotropin-releasing hormone receptors with intracellular carboxyl-terminal tails undergo acute desensitization of total inositol phosphate production and exhibit accelerated internalization kinetics. J. Biol. Chem. 273(19):1998;11472-11477.
60. Willars G.B., Heding A., Vrecl M., Sellar R., Blomenrohr M., Nahorski S.R., Eidne K.A. Lack of a C-terminal tail in the mammalian gonadotropin-releasing hormone receptor confers resistance to agonist-dependent phosphorylation and rapid desensitization. J. Biol. Chem. 274(42):1999;30146-30153.
61. Shah B.H., Parvaiz Farshori M., Jambusaria A., Catt K.J. Roles of Src and EGF receptor transactivation in transient and sustained ERK1/2 MAP kinase responses to GnRH receptor activation. J. Biol. Chem. 278(21):2003;19118-19126.