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Volumn 89, Issue 4, 2004, Pages 1718-1726

Elevated fasting plasma ghrelin in Prader-Willi syndrome adults is not solely explained by their reduced visceral adiposity and insulin resistance

Author keywords

[No Author keywords available]

Indexed keywords

GHRELIN; GLUCAGON LIKE PEPTIDE 1; INSULIN; SOMATOMEDIN;

EID: 11144356346     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2003-031118     Document Type: Article
Times cited : (97)

References (65)
  • 2
    • 1042267409 scopus 로고    scopus 로고
    • Prader-Willi syndrome: Advances in its genetics, pathophysiology and treatment
    • Goldstone AP 2004 Prader-Willi syndrome: advances in its genetics, pathophysiology and treatment. Trends Endocrinol Metab 15:12-20
    • (2004) Trends Endocrinol Metab , vol.15 , pp. 12-20
    • Goldstone, A.P.1
  • 3
    • 0032076307 scopus 로고    scopus 로고
    • Imprinting in Prader-Willi and Angelman syndromes
    • Nicholls RD, Saltoh S, Horsthemke B 1998 Imprinting in Prader-Willi and Angelman syndromes. Trends Genet 14:194-200
    • (1998) Trends Genet , vol.14 , pp. 194-200
    • Nicholls, R.D.1    Saltoh, S.2    Horsthemke, B.3
  • 4
    • 0036181202 scopus 로고    scopus 로고
    • Resting metabolic rate, plasma leptin concentrations, leptin receptor expression, and adipose tissue measured by whole-body magnetic resonance imaging in women with Prader-Willi syndrome
    • Goldstone AP, Brynes AE, Thomas EL, Bell JD, Frost G, Holland A, Ghatei MA, Bloom SR 2002 Resting metabolic rate, plasma leptin concentrations, leptin receptor expression, and adipose tissue measured by whole-body magnetic resonance imaging in women with Prader-Willi syndrome. Am J Clin Nutr 75:468-475
    • (2002) Am J Clin Nutr , vol.75 , pp. 468-475
    • Goldstone, A.P.1    Brynes, A.E.2    Thomas, E.L.3    Bell, J.D.4    Frost, G.5    Holland, A.6    Ghatei, M.A.7    Bloom, S.R.8
  • 8
    • 0033540056 scopus 로고    scopus 로고
    • Ghrelin is a growth-hormone-releasing acylated peptide from stomach
    • Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K 1999 Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402:656-660
    • (1999) Nature , vol.402 , pp. 656-660
    • Kojima, M.1    Hosoda, H.2    Date, Y.3    Nakazato, M.4    Matsuo, H.5    Kangawa, K.6
  • 10
    • 0035097594 scopus 로고    scopus 로고
    • The expression of the growth hormone secretagogue receptor ligand ghrelin in normal and abnormal human pituitary and other neuroendocrine tumors
    • Korbonits M, Bustin SA, Kojima M, Jordan S, Adams EF, Lowe DG, Kangawa K, Grossman AB 2001 The expression of the growth hormone secretagogue receptor ligand ghrelin in normal and abnormal human pituitary and other neuroendocrine tumors. J Clin Endocrinol Metab 86:881-887
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 881-887
    • Korbonits, M.1    Bustin, S.A.2    Kojima, M.3    Jordan, S.4    Adams, E.F.5    Lowe, D.G.6    Kangawa, K.7    Grossman, A.B.8
  • 14
    • 0034687376 scopus 로고    scopus 로고
    • Ghrelin induces adiposity in rodents
    • Tschop M, Smiley DL, Heiman ML 2000 Ghrelin induces adiposity in rodents. Nature 407:908-913
    • (2000) Nature , vol.407 , pp. 908-913
    • Tschop, M.1    Smiley, D.L.2    Heiman, M.L.3
  • 18
    • 0037240916 scopus 로고    scopus 로고
    • Serum ghrelin levels are inversely correlated with body mass index, age, and insulin concentrations in normal children and are markedly increased in Prader-Willi syndrome
    • Haqq AM, Farooqi IS, O'Rahilly S, Stadler DD, Rosenfeld RG, Pratt KL, LaFranchi SH, Purnell JQ 2003 Serum ghrelin levels are inversely correlated with body mass index, age, and insulin concentrations in normal children and are markedly increased in Prader-Willi syndrome. J Clin Endocrinol Metab 88:174-178
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 174-178
    • Haqq, A.M.1    Farooqi, I.S.2    O'Rahilly, S.3    Stadler, D.D.4    Rosenfeld, R.G.5    Pratt, K.L.6    LaFranchi, S.H.7    Purnell, J.Q.8
  • 22
    • 0038030751 scopus 로고    scopus 로고
    • Effects of growth hormone on pulmonary function, sleep quality, behavior, cognition, growth velocity, body composition, and resting energy expenditure in Prader-Willi syndrome
    • Haqq AM, Stadler DD, Jackson RH, Rosenfeld RG, Pumell JQ, LaFranchi SH 2003 Effects of growth hormone on pulmonary function, sleep quality, behavior, cognition, growth velocity, body composition, and resting energy expenditure in Prader-Willi syndrome. J Clin Endocrinol Metab 88:2206-2212
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 2206-2212
    • Haqq, A.M.1    Stadler, D.D.2    Jackson, R.H.3    Rosenfeld, R.G.4    Pumell, J.Q.5    LaFranchi, S.H.6
  • 23
    • 4243634378 scopus 로고    scopus 로고
    • Euglycemic hyperinsulinemia, but not lipid infusion, decreases circulating ghrelin levels in humans
    • Mohlig M, Spranger J, Otto B, Ristow M, Tschop M, Pfeiffer AF 2002 Euglycemic hyperinsulinemia, but not lipid infusion, decreases circulating ghrelin levels in humans. J Endocrinol Invest 25:RC36-RC38
    • (2002) J Endocrinol Invest , vol.25
    • Mohlig, M.1    Spranger, J.2    Otto, B.3    Ristow, M.4    Tschop, M.5    Pfeiffer, A.F.6
  • 26
    • 0036896934 scopus 로고    scopus 로고
    • Fasting plasma ghrelin levels are negatively correlated with insulin resistance and PAI-1, but not with leptin, in obese children and adolescents
    • Ikezaki A, Hosoda H, Ito K, Iwama S, Miura N, Matsuoka H, Kondo C, Kojima M, Kangawa K, Sugihara S 2002 Fasting plasma ghrelin levels are negatively correlated with insulin resistance and PAI-1, but not with leptin, in obese children and adolescents. Diabetes 51:3408-3411
    • (2002) Diabetes , vol.51 , pp. 3408-3411
    • Ikezaki, A.1    Hosoda, H.2    Ito, K.3    Iwama, S.4    Miura, N.5    Matsuoka, H.6    Kondo, C.7    Kojima, M.8    Kangawa, K.9    Sugihara, S.10
  • 27
    • 0036854343 scopus 로고    scopus 로고
    • Circulating ghrelin concentrations are lowered by intravenous glucose or hyperinsulinemic euglycemic conditions in rodents
    • McCowen KC, Maykel JA, Bistrian BR, Ling PR 2002 Circulating ghrelin concentrations are lowered by intravenous glucose or hyperinsulinemic euglycemic conditions in rodents. J Endocrinol 175:R7-R11
    • (2002) J Endocrinol , vol.175
    • McCowen, K.C.1    Maykel, J.A.2    Bistrian, B.R.3    Ling, P.R.4
  • 28
    • 0036925201 scopus 로고    scopus 로고
    • Plasma ghrelin, obesity, and the polycystic ovary syndrome: Correlation with insulin resistance and androgen levels
    • Pagotto U, Gambineri A, Vicennati V, Heiman ML, Tschop M, Pasquali R 2002 Plasma ghrelin, obesity, and the polycystic ovary syndrome: correlation with insulin resistance and androgen levels. J Clin Endocrinol Metab 87:5625-5629
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 5625-5629
    • Pagotto, U.1    Gambineri, A.2    Vicennati, V.3    Heiman, M.L.4    Tschop, M.5    Pasquali, R.6
  • 29
  • 31
    • 0023638829 scopus 로고
    • Glucagon-like peptide-1 7-36: A physiological incretin in man
    • Kreymann B, Williams G, Ghatei MA, Bloom SR 1987 Glucagon-like peptide-1 7-36: a physiological incretin in man. Lancet 2:1300-1304
    • (1987) Lancet , vol.2 , pp. 1300-1304
    • Kreymann, B.1    Williams, G.2    Ghatei, M.A.3    Bloom, S.R.4
  • 32
    • 0021813187 scopus 로고
    • Homeostasis model assessment insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man
    • Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC 1985 Homeostasis model assessment insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28:412-419
    • (1985) Diabetologia , vol.28 , pp. 412-419
    • Matthews, D.R.1    Hosker, J.P.2    Rudenski, A.S.3    Naylor, B.A.4    Treacher, D.F.5    Turner, R.C.6
  • 34
    • 0345602037 scopus 로고    scopus 로고
    • Peptides associated with hyperphagia in adults with Prader-Willi syndrome before and during GH treatment
    • Höybye C, Barkeling B, Espelund U, Petersson M, Thoren M 2003 Peptides associated with hyperphagia in adults with Prader-Willi syndrome before and during GH treatment. Growth Horm IGF Res 13:322-327
    • (2003) Growth Horm IGF Res , vol.13 , pp. 322-327
    • Höybye, C.1    Barkeling, B.2    Espelund, U.3    Petersson, M.4    Thoren, M.5
  • 36
    • 0036141195 scopus 로고    scopus 로고
    • Ghrelin, a new gastrointestinal endocrine peptide that stimulates insulin secretion: Enteric distribution, ontogeny, influence of endocrine, and dietary manipulations
    • Lee HM, Wang G, Englander EW, Kojima M, Greeley GHJ 2002 Ghrelin, a new gastrointestinal endocrine peptide that stimulates insulin secretion: enteric distribution, ontogeny, influence of endocrine, and dietary manipulations. Endocrinology 143:185-190
    • (2002) Endocrinology , vol.143 , pp. 185-190
    • Lee, H.M.1    Wang, G.2    Englander, E.W.3    Kojima, M.4    Greeley, G.H.J.5
  • 37
    • 0019735952 scopus 로고
    • Blunted pancreatic polypeptide responses in children with obesity of Prader-Willi syndrome
    • Zipf WB, O'Dorisio TM, Cataland S, Sotos J 1981 Blunted pancreatic polypeptide responses in children with obesity of Prader-Willi syndrome. J Clin Endocrinol Metab 52:1264-1266
    • (1981) J Clin Endocrinol Metab , vol.52 , pp. 1264-1266
    • Zipf, W.B.1    O'Dorisio, T.M.2    Cataland, S.3    Sotos, J.4
  • 38
    • 0028008578 scopus 로고
    • An evaluation of autonomic nervous system function in patients with Prader-Willi syndrome
    • DiMario FJJ, Dunham B, Burleson JA, Moskovitz J, Cassidy SB 1994 An evaluation of autonomic nervous system function in patients with Prader-Willi syndrome. Pediatrics 93:76-81
    • (1994) Pediatrics , vol.93 , pp. 76-81
    • DiMario, F.J.J.1    Dunham, B.2    Burleson, J.A.3    Moskovitz, J.4    Cassidy, S.B.5
  • 39
    • 0029923140 scopus 로고    scopus 로고
    • Respiratory sinus arrhythmia in patients with Prader-Willi syndrome
    • DiMario FJJ, Bauer L, Volpe J, Cassidy SB 1996 Respiratory sinus arrhythmia in patients with Prader-Willi syndrome. J Child Neurol 11:121-125
    • (1996) J Child Neurol , vol.11 , pp. 121-125
    • DiMario, F.J.J.1    Bauer, L.2    Volpe, J.3    Cassidy, S.B.4
  • 41
    • 0032982267 scopus 로고    scopus 로고
    • Role of the vagus nerve in mediating proximal nutrient-induced glucagon-like peptide-1 secretion
    • Rocca AS, Brubaker PL 1999 Role of the vagus nerve in mediating proximal nutrient-induced glucagon-like peptide-1 secretion. Endocrinology 140:1687-1694
    • (1999) Endocrinology , vol.140 , pp. 1687-1694
    • Rocca, A.S.1    Brubaker, P.L.2
  • 42
    • 0032797341 scopus 로고    scopus 로고
    • Stimulation of the paraventricular nucleus modulates the activity of gut-sensitive neurons in the vagal complex
    • Zhang X, Fogel R, Renehan WE 1999 Stimulation of the paraventricular nucleus modulates the activity of gut-sensitive neurons in the vagal complex. Am J Physiol 277:G79-G90
    • (1999) Am J Physiol , vol.277
    • Zhang, X.1    Fogel, R.2    Renehan, W.E.3
  • 43
    • 0019497649 scopus 로고
    • Visceral afferent and efferent connections in the brain
    • Novin D, Rogers RC, Hermann G 1981 Visceral afferent and efferent connections in the brain. Diabetologia 20(Suppl):331-336
    • (1981) Diabetologia , vol.20 , Issue.SUPPL. , pp. 331-336
    • Novin, D.1    Rogers, R.C.2    Hermann, G.3
  • 45
    • 0032517157 scopus 로고    scopus 로고
    • Oxytocinergic inputs to the nucleus of the solitary tract and dorsal motor nucleus of the vagus in neonatal rats
    • Rinaman L 1998 Oxytocinergic inputs to the nucleus of the solitary tract and dorsal motor nucleus of the vagus in neonatal rats. J Comp Neurol 399:101-109
    • (1998) J Comp Neurol , vol.399 , pp. 101-109
    • Rinaman, L.1
  • 46
    • 0020999755 scopus 로고
    • Vasopressin and oxytocin: Distribution and putative functions in the brain
    • Buijs RM, De Vries GJ, van Leeuwen FW, Swaab DF 1983 Vasopressin and oxytocin: distribution and putative functions in the brain. Prog Brain Res 60:115-122
    • (1983) Prog Brain Res , vol.60 , pp. 115-122
    • Buijs, R.M.1    De Vries, G.J.2    Van Leeuwen, F.W.3    Swaab, D.F.4
  • 47
    • 0024158799 scopus 로고
    • A role of central oxytocin in autonomic functions: Its action in the motor nucleus of the vagus nerve
    • Dreifuss JJ, Raggenbass M, Charpak S, Dubois-Dauphin M, Tribollet E 1988 A role of central oxytocin in autonomic functions: its action in the motor nucleus of the vagus nerve. Brain Res Bull 20:765-770
    • (1988) Brain Res Bull , vol.20 , pp. 765-770
    • Dreifuss, J.J.1    Raggenbass, M.2    Charpak, S.3    Dubois-Dauphin, M.4    Tribollet, E.5
  • 48
    • 0028852641 scopus 로고
    • Alterations in the hypothalamic paraventricular nucleus and its oxytocin neurons (putative satiety cells) in Prader-Willi syndrome: A study of five cases
    • Swaab DF, Purba JS, Hofman MA 1995 Alterations in the hypothalamic paraventricular nucleus and its oxytocin neurons (putative satiety cells) in Prader-Willi syndrome: a study of five cases. J Clin Endocrinol Metab 80:573-579
    • (1995) J Clin Endocrinol Metab , vol.80 , pp. 573-579
    • Swaab, D.F.1    Purba, J.S.2    Hofman, M.A.3
  • 49
    • 0034642301 scopus 로고    scopus 로고
    • Disruption of the mouse Necdin gene results in hypothalamic and behavioral alterations reminiscent of the human Prader-Willi syndrome
    • Muscatelli F, Abrous DN, Massacrier A, Boccaccio I, Le Moal M, Cau P, Cremer H 2000 Disruption of the mouse Necdin gene results in hypothalamic and behavioral alterations reminiscent of the human Prader-Willi syndrome. Hum Mol Genet 9:3101-3110
    • (2000) Hum Mol Genet , vol.9 , pp. 3101-3110
    • Muscatelli, F.1    Abrous, D.N.2    Massacrier, A.3    Boccaccio, I.4    Le Moal, M.5    Cau, P.6    Cremer, H.7
  • 50
    • 0023089305 scopus 로고
    • Effect of continuous somatostatin and growth hormone-releasing hormone (GHRH) infusions on the subsequent growth hormone (GH) response to GHRH. Evidence for somatotroph desensitization independent of GH pool depletion
    • Rittmaster RS, Loriaux DL, Merriam GR 1987 Effect of continuous somatostatin and growth hormone-releasing hormone (GHRH) infusions on the subsequent growth hormone (GH) response to GHRH. Evidence for somatotroph desensitization independent of GH pool depletion. Neuroendocrinology 45:118-122
    • (1987) Neuroendocrinology , vol.45 , pp. 118-122
    • Rittmaster, R.S.1    Loriaux, D.L.2    Merriam, G.R.3
  • 51
    • 0022654569 scopus 로고
    • Dual effects of growth hormone (GH)-releasing hormone infusion in normal men: Somatotroph desensitization and increase in releasable GH
    • Vance ML, Kaiser DL, Rivier J, Vale W, Thorner MO 1986 Dual effects of growth hormone (GH)-releasing hormone infusion in normal men: somatotroph desensitization and increase in releasable GH. J Clin Endocrinol Metab 62:591-594
    • (1986) J Clin Endocrinol Metab , vol.62 , pp. 591-594
    • Vance, M.L.1    Kaiser, D.L.2    Rivier, J.3    Vale, W.4    Thorner, M.O.5
  • 53
    • 0242438600 scopus 로고    scopus 로고
    • Pattern-dependent suppression of growth hormone (GH) pulsatility by ghrelin and GH-releasing peptide-6 in moderately GH-deficient rats
    • Thompson NM, Davies JS, Mode A, Houston PA, Wells T 2003 Pattern-dependent suppression of growth hormone (GH) pulsatility by ghrelin and GH-releasing peptide-6 in moderately GH-deficient rats. Endocrinology 144: 4859-4867
    • (2003) Endocrinology , vol.144 , pp. 4859-4867
    • Thompson, N.M.1    Davies, J.S.2    Mode, A.3    Houston, P.A.4    Wells, T.5
  • 54
    • 0031765095 scopus 로고    scopus 로고
    • Expression of growth hormone secretagogue-receptors by growth hormone-releasing hormone neurons in the mediobasal hypothalamus
    • Tannenbaum GS, Lapointe M, Beaudet A, Howard AD 1998 Expression of growth hormone secretagogue-receptors by growth hormone-releasing hormone neurons in the mediobasal hypothalamus. Endocrinology 139:4420-4423
    • (1998) Endocrinology , vol.139 , pp. 4420-4423
    • Tannenbaum, G.S.1    Lapointe, M.2    Beaudet, A.3    Howard, A.D.4
  • 55
    • 0035085142 scopus 로고    scopus 로고
    • Interactions of growth hormone secretagogues and growth hormone-releasing hormone/somatostatin
    • Tannenbaum GS, Bowers CY 2001 Interactions of growth hormone secretagogues and growth hormone-releasing hormone/somatostatin. Endocrine 14: 21-27
    • (2001) Endocrine , vol.14 , pp. 21-27
    • Tannenbaum, G.S.1    Bowers, C.Y.2
  • 57
    • 0038469984 scopus 로고    scopus 로고
    • 2003 Hypothalamic growth hormone-releasing hormone (GHRH) cell number is increased in human illness, but is not reduced in Prader-Willi syndrome or obesity
    • Oxf [Erratum (2003) 59:266]
    • Goldstone AP, Unmehopa UA, Swaab DF 2003 2003 Hypothalamic growth hormone-releasing hormone (GHRH) cell number is increased in human illness, but is not reduced in Prader-Willi syndrome or obesity. Clin Endocrinol (Oxf) [Erratum (2003) 59:266] 58:743-755
    • (2003) Clin Endocrinol , vol.58 , pp. 743-755
    • Goldstone, A.P.1    Unmehopa, U.A.2    Swaab, D.F.3
  • 58
    • 0035513696 scopus 로고    scopus 로고
    • Chronic central infusion of ghrelin increases hypothalamic neuropeptide Y and agouti-related protein mRNA levels and body weight in rats
    • Kamegai J, Tamura H, Shimizu T, Ishii S, Sugihara H, Wakabayashi I 2001 Chronic central infusion of ghrelin increases hypothalamic neuropeptide Y and agouti-related protein mRNA levels and body weight in rats. Diabetes 50: 2438-2443
    • (2001) Diabetes , vol.50 , pp. 2438-2443
    • Kamegai, J.1    Tamura, H.2    Shimizu, T.3    Ishii, S.4    Sugihara, H.5    Wakabayashi, I.6
  • 59
    • 0036172575 scopus 로고    scopus 로고
    • Hypothalamic NPY and agouti-related protein are increased in human illness but not in Prader-Willi syndrome and other obese subjects
    • Goldstone AP, Unmehopa UA, Bloom SR, Swaab DF 2002 Hypothalamic NPY and agouti-related protein are increased in human illness but not in Prader-Willi syndrome and other obese subjects. J Clin Endocrinol Metab 87:927-937
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 927-937
    • Goldstone, A.P.1    Unmehopa, U.A.2    Bloom, S.R.3    Swaab, D.F.4
  • 60
    • 70350727149 scopus 로고    scopus 로고
    • Neurobiology and neuropathology of the human hypothalamus
    • Bloom FE, Hökfelt T, eds. Amsterdam: Elsevier
    • Swaab DF 1997 Neurobiology and neuropathology of the human hypothalamus. In: Bloom FE, Hökfelt T, eds. Handbook of chemical neuroanatomy, vol 13, part I. Amsterdam: Elsevier; 39-137
    • (1997) Handbook of Chemical Neuroanatomy , vol.13 , Issue.PART I , pp. 39-137
    • Swaab, D.F.1
  • 61
    • 0026619925 scopus 로고
    • Brain banking and the human hypothalamus: Factors to match for, pitfalls and potentials
    • Ravid R, Van Zwleten EJ, Swaab DF 1992 Brain banking and the human hypothalamus: factors to match for, pitfalls and potentials. Prog Brain Res 93:83-95
    • (1992) Prog Brain Res , vol.93 , pp. 83-95
    • Ravid, R.1    Van Zwleten, E.J.2    Swaab, D.F.3
  • 63
    • 0033038418 scopus 로고    scopus 로고
    • Interacting appetite-regulating pathways in the hypothalamic regulation of body weight
    • Kalra SP, Dube MG, Pu S, Xu B, Horvath TL, Kalra PS 1999 Interacting appetite-regulating pathways in the hypothalamic regulation of body weight. Endocr Rev 20:68-100
    • (1999) Endocr Rev , vol.20 , pp. 68-100
    • Kalra, S.P.1    Dube, M.G.2    Pu, S.3    Xu, B.4    Horvath, T.L.5    Kalra, P.S.6


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