MTSEA prevents ligand binding to the human melanocortin-4 receptor by modification of cysteine 130 in transmembrane helix 3

FEBS Letters

Volumn 579, Issue 1, 2005, Pages 285-291

  Cox, Alan ^a   Donnelly, Dan ^a   Kaur, Manminder ^a   Cheetham, Sharon C ^b   Cockcroft, Victor B ^b   Findlay, John B C ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b ABBOTT LABORATORIES   (United States)

Author keywords

MSH; G protein coupled receptor; Melanocortin 4 receptor; MTSEA

Indexed keywords

ALANINE; AMMONIUM DERIVATIVE; CYSTEINE DERIVATIVE; INTERMEDIN; IODINE 125; MELANOCORTIN 4 RECEPTOR; N ACETYL ALPHA INTERMEDIN[4-10]CYCLO[4 NORLEUCINE 5 ASPARTIC ACID 7 [3 (2 NAPHTHYL)ALANINE] 10 LYSINAMIDE]; THIOL REAGENT;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; COVALENT BOND; HUMAN; HUMAN CELL; INCUBATION TIME; LIGAND BINDING; PRIORITY JOURNAL;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; BINDING SITES; CYSTEINE; ETHYL METHANESULFONATE; HUMANS; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN STRUCTURE, SECONDARY; RECEPTOR, MELANOCORTIN, TYPE 4;

EID: 11144296970     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2004.11.087     Document Type: Article

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