Absence of the cell cycle inhibitor p21Cip1 reduces LPS-induced NO release and activation of the transcription factor NF-κB in mixed glial cultures

GLIA

Volumn 49, Issue 1, 2005, Pages 52-58

  Tusell, Josep Maria ^a   Saura, Josep ^a   Serratosa, Joan ^a,b  

^a BIOMEDICAL RESEARCH INSTITUTE SANT PAU IIB SANT PAU   (Spain)

^b INST D INVESTIGACIONS B   (Spain)

Author keywords

Astrocytes; Glia; Glial activation; Lipopolysaccharide; Microglia; p21Cip1

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; CELL PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NITRIC OXIDE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; CELL ACTIVATION; CELL COUNT; CELL CULTURE; CELL CYCLE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE RELEASE; ESCHERICHIA COLI; GENE ACTIVATION; GLIA CELL; INFLAMMATION; MITOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; WILD TYPE;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; CELL CYCLE PROTEINS; CELL PROLIFERATION; CELLS, CULTURED; COCULTURE TECHNIQUES; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DOWN-REGULATION; ENCEPHALITIS; GLIOSIS; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEUROGLIA; NF-KAPPA B; NITRIC OXIDE; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 11144252718     PISSN: 08941491     EISSN: None     Source Type: Journal    
DOI: 10.1002/glia.20095     Document Type: Article

References (47)

1. Acarin L, Gonzalez B, Castellano B, Castro AJ. 1996. Microglial response to N-methyl-D-aspartate-mediated excitotoxicity in the immature rat brain. J Comp Neurol 367:361-374.
2. Akiyama H, Tooyama I, Kondo H, Ikeda K, Kimura H, McGeer EG, McGeer PL. 1994. Early response of brain resident microglia to kainic acid-induced hippocampal lesions. Brain Res 635:257-268.
3. Albrecht JH, Poon RY, Ahonen CL, Rieland BM, Deng C, Crary GS. 1998. Involvement of p21 and p27 in the regulation of CDK activity and cell cycle progression in the regenerating liver. Oncogene 16:2141-2150.
4. Banati RB, Gehrmann J, Schubert P, Kreutzberg GW. 1993. Cytotoxicity of microglia. Glia 7:111-118.
5. Barron KD, Marciano FF, Amundson R, Mankes R. 1990. Perineuronal glial responses after axotomy of central and peripheral axons. A comparison. Brain Res 523:219-229.
6. Benveniste EN, Sparacio SM, Norris JG, Grenett HE, Fuller GM. 1990. Induction and regulation of interleukin-6 gene expression in rat astrocytes. J Neuroimmunol 30:210-222.
7. Boje KM, Arora PK. 1992. Microglial-produced nitric oxide and reactive nitrogen oxides mediate neuronal cell death. Brain Res 587:250-256.
8. Brown JP, Wei W, Sedivy JM. 1997. Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblasts. Science 277:831-834.
9. Brugarolas J, Chadrasekaran C, Gordon J, Beach D, Jacks T, Hannon G. 1995. Radiation-induced cell cycle arrest compromised by p21 deficiency. Nature 377:552-557.
10. Casal C, Tusell JM, Serratosa J. 2001. Role of calmodulin in the differentiation/activation of microglial cells. Brain Res 902:101-107.
11. Chang BD, Watanabe K, Broude EV, Fang J, Poole JC, Kalinchenko TV, Roninson IB. 2000. Effects of p21Waf1/Cip1/Sd1 on cellular gene expression: implications for carcinogenesis, senescence, and age-related diseases. Proc Natl Acad Sci USA 97:4291-4296.
12. Chao CC, Hu S, Peterson PK. 1995. Glia, cytokines and neurotoxicity. Crit Rev Neurobiol 9:189-205.
13. El-Deiry W, Tokino T, Velculescu V, Levy D, Parsons R, Trent J, Lin D, Mercer W, Kinzler K, Vogelstein B. 1993. WAF1, a potential mediator of p53 tumor suppression. Cell 75:817-825.
14. Cip1 on E-cyclin-dependent kinase 2 activity. J Biol Chem 274:33161-33165.
15. Fassbender K, Schneider S, Bertsch T, Schlueter D, Fatar M, Ragoschke A, Kühl S, Kischka U, Hennerci M. 2000. Temporal profile of release of interleukin-1β in neurotrauma. Neurosci Lett 284:135-138.
16. Giulian G, Baker TJ. 1986. Characterization of ameboid microglia isolated from developing mammalian brain. J Neurosci 6:2163-2178.
17. Giulian G, Robertson C. 1990. Inhibition of mononuclear phagocytes reduces ischemic injury in the spinal cord. Ann Neurol 27:33-42.
18. Giulian G, Vaca K, Corpuz M. 1993. Brain glia release factors with opposing actions upon neuronal survival. J Neurosci 13:29-37.
19. Graeber MB, Kreutzberg GW. 1986. Astrocytes increase in glial fibrillary acidic protein during retrograde changes of facial motor neurons. J Neurocytol 15:363-373.
20. Harper JW, Adami G, Wei N, Keyomarsi K, Elledge S. 1993. The p21 cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 75:805-816.
21. Heyen JR, Ye S, Finck BN, Johnson RW. 2000. Interleukin (IL)-10 inhibits IL-6 production in microglia by preventing activation of NF-kappaB. Mol Brain Res 77:138-147.
22. Cip1 protein, a cyclin inhibitor, regulates the levels and the intranuclear localization of CDC25A in mice regenerating livers. Hepatology 35:1063-1071.
23. Jorgensen MB, Finsen BR, Jensen MB, Castellano B, Diemer NH, Zimmer J. 1993. Microglial and astroglial reactions to ischemic and kainic acid-induced lesions to the adult rat hippocampus. Exp Neurol 120:70-78.
24. LaBaer J, Garrett MD, Stevenson LF, Slingerland JM, Sandhu C, Chou HS, Fattaey A. 1997. New functional activities for the p21 family of CDK inhibitors. Genes Dev 11:847-862.
25. Ledeboer A, Brevé JJ, Poole S, Tlders FJ, Van Dam AM. 2000. Interleukin-10, interleukin-4 and transforming growth factor-β differentially regulate lipopolysaccharide-induced production of pro-inflammatory cytokines and nitric oxide in co-cultures of rat astroglial and microglial cells. Glia 30:134-142.
26. Lee MH, Reynisdottir I, Massagué J. 1995. Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution. Genes Dev 9:639-649.
27. Lee SC, Liu W, Dickson DW, Brosnan CF, Berman JW. 1993. Cytokine production by human fetal microglia and astrocytes: differential induction by lipopolysaccharide and IL-1β. J Immunol 150:2659-2667.
28. Lehnardt S, Massillon L, Follet P, Jensen FE, Ratan R, Rosenberg PA. 2003. Activation of innate immunity in the CNS triggers neurodegeneration through a toll-like receptor 4-dependent pathway. Proc Natl Acad Sci USA 100:8514-8519.
29. Cip1/Waf1 at both the G1/S and the G2/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication. Mol Cell Biol 18:629-643.
30. Noda A, Ning Y, Venable SF, Pereira-Smith OM, Smith JR. 1994. Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen. Exp Cell Res 211:90-98.
31. Ogryzko W, Wong P, Howard BH. 1997. WAF1 retards S-phase progression primarily by inhibition of cyclin-dependent kinases. Mol Cell Biol 17:4877-4882.
32. Kip1 with cyclin E-CDK2 during rat liver regeneration. J Hepatol 33:266-274.
33. Qureshi ST, Lariviere I, Leveque G, Clermont S, Moore K, Gros P, Malo D. 1999. Endotoxin-tolerant mice have mutations in toll-like receptor 4 (Tlr4). J Exp Med 189:615-625.
34. Raivich G, Bohatschek M, Kloss CUA, Werner A, Jones LL, Kreutzberg GW. 1999. Neuroglial activation repertoire in the injured brain: graded response, molecular mechanisms and cues to physiological function. Brain Res Rev 30:77-105.
35. Waf1/Cip1) is an inflammatory response gene in the mouse central nervous system. Neurosci Lett 350:73-76.
36. Rischke R, Krieglstein J. 1991. Postischemic neuronal damage causes astroglial activation and increase in local cerebral glucose utilization of rat hippocampus. Cereb Blood Flow Metab 11:106-113.
37. Roberts JM. 1999. Evolving ideas about cyclins. Cell 98:129-132.
38. Sawada M, Kondo N, Suzumura A, Marunouchi T. 1989. Production of tumor necrosis factor-alpha by microglia and astrocytes in culture. Brain Res 491:394-397.
39. Sawada M, Suzumura A, Marunouchi T. 1992. TNF-alpha induces IL-6 production by astrocytes but no by microglia. Brain Res 583:296-299.
40. Sebire G, Emilie D, Wallon C, Hery C, Devergne O, Delfraissy JF, Galanaud P, Tardieu M. 1993. In vitro production of IL-6, IL-1 beta, and tumour necrosis alpha by human embryonic microglial and neural cells. J Immunol 150:1517-1523.
41. Sherr CJ, Roberts JM. 1995. Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev. 9:1149-1163.
42. Sola C, Casal C, Tusell JM, Serratosa J. 2002. Astrocytes enhance lipopolysaccharide-induced nitric oxide production by microglial cells. Eur J Neurosci. 16:1275-1283.
43. Streit WJ, Walter SA, Pennell NA. 1999. Reactive microgliosis. Prog Neurobiol 57:563-581.
44. Suzumura A, Sawada T, Yamamoto H. 1991. Morphological transformation of microglia in vitro. Brain Res 545:301-306.
45. Toyoshima H, Hunter T. 1994. p27 a novel inhibitor of G1 cyclin/cdk protein kinase activity, is related to p21. Cell 78:67-74.
46. Vitkovic L, Bockaert J, Jacque C. 2000. "Inflammatory" cytokines: neuromodulators in normal brain? J Neurochem 74:457-471.
47. Xiong Y, Hannon G, Zhang H, Casso D, Kobayashi R, Beach D. 1993. p21 is a universal inhibitor of cyclin kinases. Nature 366:701-704.