The androgen metabolite, 5α-androstane-3β, 17β-diol, is a potent modulator of estrogen receptor-β1-mediated gene transcription in neuronal cells

Endocrinology

Volumn 146, Issue 1, 2005, Pages 147-155

  Pak, Toni R ^a   Chung, Wilson C J ^a   Lund, Trent D ^a   Hinds, Laura R ^a   Clay, Colin M ^a   Handa, Robert J ^a  

^a Department of Environmental and Radiological Health Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3BETA ANDROSTANEDIOL; ANDROGEN; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; ESTROGEN RECEPTOR BETA1; ESTROGEN RECEPTOR BETA2; LUCIFERASE; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG; ANDROSTANEDIOL; ESTROGEN; ESTROGEN RECEPTOR; ISOPROTEIN; LIGAND;

ANIMAL CELL; ARTICLE; BRAIN NERVE CELL; CELL LINE; CONSENSUS; CONTROLLED STUDY; ESTROGEN RESPONSIVE ELEMENT; EXPRESSION VECTOR; GENETIC TRANSCRIPTION; LIGAND BINDING; METABOLITE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REPORTER GENE; ANIMAL; BINDING COMPETITION; DNA RESPONSIVE ELEMENT; DRUG EFFECT; GENETIC TRANSFECTION; GENETICS; METABOLISM; NERVE CELL; PHYSIOLOGY; PROMOTER REGION;

ANDROSTANE-3,17-DIOL; ANIMALS; BINDING, COMPETITIVE; CELL LINE; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; ESTROGENS; LIGANDS; LUCIFERASES; MICE; NEURONS; PROMOTER REGIONS (GENETICS); PROTEIN ISOFORMS; RECEPTORS, ESTROGEN; RESPONSE ELEMENTS; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 11144222196     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.2004-0871     Document Type: Article

References (46)

1. Grover PK, Odell WD 1975 Correlation of in vivo and in vitro activities of some naturally occurring androgens using a radioreceptor assay for 5α-dihydrotestosterone with rat prostate cytosol receptor protein. J Steroid Biochem 6:1373-1379
2. Ahmad N, Warren DW, Haltmeyer GC 1978 The effects of 5α-reduced androgens on maintenance and regeneration of prostate glands and seminal vesicles in castrated and hypophysectomized rats. Anat Rec 192:543-554
3. Weihua Z, Mäkelä S, Andersson LC, Salmi S, Saji S, Webster JI, Jensen EV, Nilsson S, Warner M, Gustafsson JA 2001 A role for estrogen receptor β in the regulation of growth of the ventral prostate. Proc Natl Acad Sci USA 98:6330-6335
4. Weihua Z, Lathe R, Warner M, Gustafsson JA 2002 An endocrine pathway in the prostate, ERβ, AR, 5α-androstane-3β, 17β-diol, and CYP7B1 regulates prostate growth. Proc Natl Acad Sci USA 99:13589-13594
5. Torn S, Nokelainen P, Kurkela R, Pulkka A, Menjivar M, Ghosh S, Cocaprados M, Peltoketo H, Isomaa V, Vihko P 2003 Production, purification, and functional analysis of recombinant human and mouse 17β-hydroxysteroid dehydrogenase type 7. Biochem Biophys Res Commun 305:37-45
6. Steckelbroeck S, Jin Y, Gopishetty S, Oyesanmi B, Penning TM 2004 Human cytosolic 3α-hydroxysteroid dehydrogenase of the aldo-keto reductase superfamily display significant 3β-hydroxysteroid dehydrogenase activity: implications for steroid hormone metabolism and action. J Biol Chem 279:10784-10795
7. Guennoun R, Fiddles RJ, Gouezou M, Lombes M, Baulieu EE 1995 A key enzyme in the biosynthesis of neurosteroids, 3β-hydroxysteroid dehydrogenase/δ5-δ 4-isomerase (3β-HSD), is expressed in rat brain. Brain Res Mol Brain Res 30:287-300
8. Pelletier G, Luu-The V, Labrie F 1995 Immunocytochemical localization of type I 17-β hydroxysteroid dehydrogenase in the rat brain. Brain Res 704: 233-239
9. Ibanez C, Guennoun R, Liere P, Eychenne B, Pianos A, El-Etr M, Baulieu EE, Schumacher M 2003 Developmental expression of genes involved in neurosteroidogenesis: 3β-hydroxysteroid dehydrogenase/Δ5-Δ4 isomerase in the rat brain. Endocrinology 144:2902-2911
10. McKenna NJ, O'Malley BW 2002 Combinatorial control of gene expression by nuclear receptors and coregulators. Cell 108:465-474
11. Kuiper GG, Carlsson B, Grandien K, Enmark E, Haggblad J, Nilsson S, Gustafsson JA 1997 Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors α and β. Endocrinology 138: 863-870
12. Mosselman S, Polman J, Dijkema R 1996 ERβ: identification and characterization of a novel human estrogen receptor. FEBS Lett 392:49-53
13. 2, a functional variant of estrogen receptor β expressed in normal rat tissues. Endocrinology 139:1082-1092
14. Hanstein B, Liu H, Yancisin MC, Brown M 1999 Functional analysis of a novel estrogen receptor-β isoform. Mol Endocrinol 13:129-137
15. Price Jr RH, Lorenzon N, Handa RJ 2000 Differential expression of estrogen receptor β splice variants in rat brain: identification and characterization of a novel variant missing exon 4. Mol Brain Res 80:260-268
16. Price Jr RH, Butler CA, Webb PA, Uht R, Kushner P, Handa RJ 2001 A splice variant of estrogen receptor β missing exon 3 displays altered subnuclear localization and capacity for transcriptional activation. Endocrinology 142: 2039-2049
17. Kuiper GG, Lemmen JG, Carlsson B, Corton JC, Safe SH, van der Saag PT, van der Burg B, Gustafsson JA 1998 Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor β. Endocrinology 139:4252-4263
18. Kumar V, Chambon P 1988 The estrogen receptor binds tightly to its responsive element as a ligand-induced homodimer. Cell 55:145-156
19. Klein-Hitpass L, Tsai SY, Greene GL, Clark JH, Tsai MJ, O'Malley BW 1989 Specific binding of estrogen receptor to the estrogen response element. Mol Cell Biol 9:43-49
20. Paech K, Webb P, Kuiper GG, Nilsson S, Gustafsson JA, Kushner PJ, Scanlan TS 1997 Differential ligand activation of estrogen receptors ERα and ERβ at AP1 sites. Science 277:1508-1510
21. Kushner PJ, Agard DA, Greene GL, Scanlan TS, Shiau AK, Uht RM, Webb P 2000 Estrogen receptor pathways to AP-1. J Steroid Biochem Mol Biol 74: 311-317
22. Kim H, Bang OY, Jung MW, Ha SD, Hong HS, Huh K, Kim SU, Mook-Jung I 2001 Neuroprotective effects of estrogen against β-amyloid toxicity are mediated by estrogen receptors in cultured neuronal cells. Neurosci Lett 302: 58-62
23. Handa RJ, Stadelman HL, Resko JA 1987 Effect of estrogen on androgen receptor dynamics in female rat pituitary. Endocrinology 121:84-89
24. McDonnell DP, Wijayaratne A, Chang CY, Norris JD 2002 Elucidation of the molecular mechanism of action of selective estrogen receptor modulators. Am J Cardiol 90:35F-43F
25. Price Jr RH, Handa RJ 2000 Expression of estrogen receptor-β protein and mRNA in the cerebellum of the rat. Neurosci Lett 288:115-118
26. Shughrue PJ, Merchenthaler I 2001 Distribution of estrogen receptor β immunoreactivity in the rat central nervous system. J Comp Neurol 436:64-81
27. Jakab RL, Wong JK, Belcher SM 2001 Estrogen receptor β immunoreactivity in differentiating cells of the developing rat cerebellum. J Comp Neurol 430: 396-409
28. Shang Y, Hu X, DiRenzo J, Lazar MA, Brown M 2000 Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription. Cell 103:843-852
29. Heery DM, Kalkhoven E, Hoare S, Parker MG 1997 A signature motif in transcriptional co-activators mediates binding to nuclear receptors. Nature 387:733-736
30. Feng W, Ribeiro RC, Wagner RL, Nguyen H, Apriletti JW, Fletterick RJ, Baxter JD, Kushner PJ, West BL 1998 Hormone-dependent coactivator binding to a hydrophobic cleft on nuclear receptors. Science 280:1747-1749
31. Perissi V, Dasen JS, Kurokawa R, Wang Z, Korzus E, Rose DW, Glass CK, Rosenfeld MG 1999 Factor-specific modulation of CREB-binding protein acetyltransferase activity. Proc Natl Acad Sci USA 96:3652-3657
32. Zhang QX, Borg A, Wolf DM, Oesterreich S, Fuqua SA 1997 An estrogen receptor mutant with strong hormone-independent activity from a metastatic breast cancer. Cancer Res 57:1244-1249
33. Shapiro RA, Xu C, Dorsa DM 2000 Differential transcriptional regulation of rat vasopressin gene expression by estrogen receptor α and β. Endocrinology 141:4056-4064
34. Power RF, Mani SK, Codina J, Conneely OM, O'Malley BW 1991 Dopaminergic and ligand-independent activation of steroid hormone receptors. Science 254:1636-1639
35. Ignar-Trowbridge DM, Nelson KG, Bidwell MC, Curtis SW, Washburn TF, McLachlan JA, Korach KS 1992 Coupling of dual signaling pathways: epidermal growth factor action involves the estrogen receptor. Proc Natl Acad Sci USA 89:4658-4662
36. Klotz DM, Hewitt SC, Ciana P, Raviscioni M, Lindzey JK, Foley J, Maggi A, DiAugustine RP, Korach KS 2002 Requirement of estrogen receptor-α in insulin-like growth factor-1 (IGF-1)-induced uterine responses and in vivo evidence for IGF-1/estrogen receptor cross-talk. J Biol Chem 277:8531-8537
37. Schlegel A, Wang C, Pestell RG, Lisanti MP 2001 Ligand-independent activation of oestrogen receptor a by caveolin-1. Biochem J 359:203-210
38. Goff PL, Montano MM, Schodin DJ, Katzenellenbogen BS 1994 Phosphorylation of the human estrogen receptor. Identification of hormone-regulated sites and examination of their influence on transcriptional activity. J Biol Chem 269:4458-4466
39. Arnold SF, Obourn JD, Jaffe H, Notides AC 1994 Serine 167 is the major estradiol-induced phosphorylation site on human estrogen receptor. Mol Endocrinol 8:1208-1214
40. Tremblay A, Tremblay GB, Labrie F, Giguere V 1999 Ligand-independent recruitment of SRC-1 to estrogen receptor β through phosphorylation of activation function AF-1. Mol Cell 3:513-519
41. Tremblay A, Giguere V 2001 Contribution of steroid receptor coactivator-1 and CREB binding protein in ligand-independent activity of estrogen receptor β. J Steroid Biochem Mol Biol 77:19-27
42. Webb P, Nguyen P, Shinsako J, Anderson C, Feng W, Nguyen MP, Chen D, Huang SM, Subramanian S, McKinerney E, Katzenellenbogen BS, Stallcup MR, Kushner PJ 1998 Estrogen receptor activation function 1 works by binding p160 coactivator proteins. Mol Endocrinol 12:1605-1618
43. Murdoch FE, Meier DA, Furlow JD, Granwald KA, Gorski J 1990 Estrogen receptor binding to a DNA response element in vitro is not dependent upon estradiol. Biochemistry 29:8377-8385
44. Webb P, Nguyen P, Valentine C, Lopez GN, Kwok GR, McInerney E, Katzenellenbogen BS, Enmark E, Gustafsson JA, Nilsson S, Kushner PJ 1999 The estrogen receptor enhances AP-1 activity by two distinct mechanisms with different requirements for receptor transactivation functions. Mol Endocrinol 13:1672-1685
45. Webb P, Lopez GN, Uht RM, Kushner PJ 1995 Tamoxifen activation of the estrogen receptor/AP-1 pathway: potential origin for the cell-specific estrogen-like effects of antiestrogens. Mol Endocrinol 9:443-456
46. Tremblay GB, Tremblay A, Labrie F, Giguere V 1998 Ligand-independent activation of the estrogen receptors α and β by mutations of a conserved tyrosine can be abolished by antiestrogens. Cancer Res 58:877-881