Genetic modules and networks for behavior: Lessons from Drosophila

BioEssays

Volumn 26, Issue 12, 2004, Pages 1299-1306

  Anholt, Robert R H ^a  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BEHAVIOR; DROSOPHILA; ENVIRONMENT; GENE IDENTIFICATION; GENETIC ANALYSIS; GENETIC MODEL; GENETIC POLYMORPHISM; GENOME; NATURAL SELECTION; NONHUMAN; PHENOTYPE; PHENOTYPIC VARIATION; PLEIOTROPY; QUANTITATIVE TRAIT; REVIEW;

ANIMALS; BEHAVIOR, ANIMAL; DROSOPHILA MELANOGASTER; EPISTASIS, GENETIC; EVOLUTION; GENE EXPRESSION PROFILING; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHENOTYPE; SEX FACTORS;

EID: 10844241529     PISSN: 02659247     EISSN: None     Source Type: Journal    
DOI: 10.1002/bies.20131     Document Type: Review

References (65)

1. Mackay TFC. 2001. Quantitative trait loci in Drosophila. Nature Rev Genet 2:11-20.
2. Mackay TFC. 2001. The genetic architecture of quantitative traits. Annu Rev Genet 35:303-339.
3. Flint J, Mott R. 2001. Finding the molecular basis of quantitative traits: successes and pitfalls. Nat Rev Genet 2:437-445.
4. Nelson RJ, Young KA. 1998. Behavior in mice with targeted disruption of single genes. Neurosci Biobehav Rev 22:453-462.
5. Maxson SC, Canastar A. 2003. Conceptual and methodological issues in the genetics of mouse agonistic behavior. Horm Behav 44:258-262.
6. Nelson RJ, Demas GE, Huang PL, Fishman MC, Dawson VL, et al. 1995. Behavioural abnormalities in male mice lacking neuronal nitric oxide synthase. Nature 378:383-386.
7. Demas GE, Eliasson MJ, Dawson TM, Dawson VL, Kriegsfeld LJ, et al. 1997. Inhibition of neuronal nitric oxide synthase increases aggressive behavior in mice. Mol Med 3:610-616.
8. Demas GE, Kriegsfeld LJ, Blackshaw S, Huang P, Gammie SC, et al. 1999. Elimination of aggressive behavior in male mice lacking endothelial nitric oxide synthase. J Neurosci 19:RC30.
9. Le Roy I, Pothion S, Mortaud S, Chabert C, Nicolas L, et al. 2000. Loss of aggression, after transfer onto a C57BL/6J background, in mice carrying a targeted disruption of the neuronal nitric oxide synthase gene. Behav Genet 30:367-373.
10. Heath MJ, Hen R. 1995. Serotonin receptors. Genetic insights into serotonin function. Curr Biol 5:997-999.
11. Gingrich JA, Hen R. 2001. Dissecting the role of the serotonin system in neuropsychiatric disorders using knockout mice. Psychopharmacology (Berl) 155:1-10.
12. Gingrich JA, 2002. Mutational analysis of the serotonergic system: recent findings using knockout mice. Curr Drug Target CNS Neurol Disord 1:449-465.
13. Del Punta K, Leinders-Zufall T, Rodriguez I, Jukam D, Wysocki CJ, et al. 2002. Deficient pheromone responses in mice lacking a cluster of vomeronasal receptor genes. Nature 419:70-74.
14. Brodkin ES, Goforth SA, Keene AH, Fossella JA, Silver LM. 2002. Identification of quantitative trait loci that affect aggressive behavior in mice. J Neurosci 22:1165-1170.
15. Crabbe JC, Wahlsten D, Dudek BC. 1999. Genetics of mouse behavior: interactions with laboratory environment. Science 284:1670-1672.
16. Wahlsten D, Metten P, Phillips TJ, Boehm SL 2nd, Burkhart-Kasch S, et al. 2003. Different data from different labs: lessons from studies of gene-environment interaction. J Neurobiol 54:283-311.
17. Adams MD, Celniker SE, Holt RA, Evans CA, Gocayne JD, et al. 2000. The genome sequence of Drosophila melanogaster. Science 287:2185-2195.
18. Hall JC. 1994. The mating of a fly. Science 264:1702-1714.
19. Greenspan RJ, Ferveur JF. 2000. Courtship in Drosophila. Annu Rev Genet 34:205-232.
20. Allada R, Emery P, Takahashi JS, Rosbash M. 2001. Stopping time: the genetics of fly and mouse circadian clocks. Annu Rev Neurosci 24:1091-1119.
21. Ben-Shlomo R, Kyriacou CP. 2002. Circadian rhythm entrainment in flies and mammals. Cell Biochem Biophys 37:141-156.
22. Ashmore LJ, Sehgal A. 2003. A fly's eye view of circadian entrainment. J Biol Rhythms 18:206-216.
23. Cirelli C. 2003. Searching for sleep mutants of Drosophila melanogaster. Bioessays 25:940-949.
24. Strauss R. 2002. The central complex and the genetic dissection of locomotor behaviour. Curr Opin Neurobiol 12:633-638.
25. Toma DP, White KP, Hirsch J, Greenspan RJ. 2002. Identification of genes involved in Drosophila melanogaster geotaxis, a complex behavioral trait. Nat Genet 31:349-353.
26. Phillis RW, Bramlage AT, Wotus C, Whittaker A, Gramates LS, et al. 1993. Isolation of mutations affecting neural circuitry required for grooming behavior in Drosophila melanogaster. Genetics 133:581-592.
27. Anholt RRH, Mackay TFC. 2001. The genetic architecture of odor-guided behavior in Drosophila melanogaster. Behav Genet 31:17-27.
28. Kim J, Carlson JR, 2002. Gene discovery by e-genetics: Drosophila odor and taste receptors. J Cell Sci 115:1107-1112.
29. Devaud JM. 2003. Experimental studies of adult Drosophila chemosensory behaviour. Behav Processes 64:177-196.
30. Osborne KA, Robichon A, Burgess E, Butland S, Shaw RA, et al. 1997. Natural behavior polymorphism due to a Cgmp-dependent protein kinase of Drosophila. Science 277:834-836.
31. Renger JJ, Yao WD, Sokolowski MB, Wu CF. 1999. Neuronal polymorphism among natural alleles of a cGMP-dependent kinase gene, foraging, in Drosophila. J Neurosci 19:RC28.
32. Chen S, Lee AY, Bowens NM, Huber R, Kravitz EA. 2002. Fighting fruit flies: a model system for the study of aggression. Proc Natl Acad Sci USA 99:5664-5668.
33. Heisenberg M. 2003. Mushroom body memoir: from maps to models. Nat Rev Neurosci 4:266-275.
34. Dubnau J, Chiang AS, Tully T. 2003. Neural substrates of memory: from synapse to system. J Neurobiol 54:238-253.
35. Greenspan RJ. 2001. The flexible genome. Nat Rev Genet 2:383-387.
36. McDonald MJ, Rosbash M. 2001. Microarray analysis and organization of circadian gene expression in Drosophila. Cell 107:567-578.
37. Claridge-Chang A, Wijnen H, Naef F, Boothroyd C, Rajewsky N, et al. 2001. Circadian regulation of gene expression systems in the Drosophila head. Neuron 32:657-671.
38. Dauwalder B, Tsujimoto S, Moss J, Mattox W. 2002. The Drosophila takeout gene is regulated by the somatic sex-determination pathway and affects male courtship behavior. Genes Dev 16:2879-2892.
39. Fedorowicz GM, Fry JD, Anholt RRH, Mackay TFC. 1998. Epistatic interactions between smell-impaired loci in Drosophila melanogaster. Genetics 148:1885-1891.
40. Anholt RRH, Dilda CL, Chang S, Fanara JJ, Kulkarni NH, et al. 2003. The genetic architecture of odor-guided behavior in Drosophila: Epistasis and the transcriptome. Nature Genetics 35:180-184.
41. Sakai T, Ishida N. 2001. Circadian rhythms of female mating activity governed by clock genes in Drosophila. Proc Natl Acad Sci USA 98:9221-9225.
42. Tauber E, Roe H, Costa R, Hennessy JM, Kyriacou CP. 2003. Temporal mating isolation driven by a behavioral gene in Drosophila. Curr Biol 13:140-145.
43. Mackay TFC, Hackett JB, Lyman RF, Wayne ML, Anholt RRH. 1996. Quantitative genetic variation of odor-guided behavior in a natural population of Drosophila melanogaster. Genetics 144:727-735.
44. Ranz JM, Castillo-Davis CI, Meiklelohn CD, Hartl DL. 2003. Sex-dependent geen expression and evolution of the Drosophila transcriptome. Science 300:1742-1745.
45. Meiklejohn CD, Parsch J, Ranz JM, Hartl DL. 2003. Rapid evolution of male-biased gene expression in Drosophila. Proc Natl Acad Sci USA 100:9894-9899.
46. Anholt RRH, Lyman RF, Mackay TFC. 1996. Effects of single P-element insertions on olfactory behavior in Drosophila melanogaster. Genetics 143:293-301.
47. Ganguly I, Mackay TFC, Anholt RRH. 2003. scribble is essential for olfactory behavior in Drosophila. Genetics 164:1447-1457.
48. Jin W, Riley RM, Wolfinger RD, White KP, Passador-Gurgel G, et al. 2001. The contributions of sex, genotype and age to transcriptional variance in Drosophila melanogaster. Nature Genetics 29:389-395.
49. Fujii S, Amrein H. 2002. Genes expressed in the Drosophila head reveal a role for fat cells in sex-specific physiology. EMBO J 21:5353-5363.
50. Konopka RJ, Benzer S. 1971. Clock mutants of Drosophila melanogaster. Proc Natl Acad Sci USA 68:2112-2116.
51. Kyriacou CP, Hall JC. 1980. Circadian rhythm mutations in Drosophila melanogaster affect short-term fluctuations in the male's courtship song. Proc Natl Acad Sci USA 77:6729-6733.
52. Quinn WG, Sziber PP, Booker R. 1979. The Drosophila memory mutant amnesiac. Nature 277:212-214.
53. Feany MB, Quinn WG. 1995. A neuropeptide gene defined by the Drosophila memory mutant amnesiac. Science 268:869-873.
54. 2+ oscillations, and the memory gene amnesiac. Neuron 30:653-656.
55. Ackerman SL, Siegel RW. 1986. Chemically reinforced conditioned courtship in Drosophila: responses of wild-type and the dunce, amnesiac and don giovanni mutants. J Neurogenet 3:111-123.
56. Moore MS, DeZazzo J, Luk AY, Tully T, Singh CM, et al. 1998. Ethanol intoxication in Drosophila: Genetic and pharmacological evidence for regulation by the cAMP signaling pathway. Cell 93:997-1007.
57. Baker BS, Taylor BJ, Hall JC. 2001. Are complex behaviors specified by dedicated regulatory genes? Reasoning from Drosophila. Cell 105:13-24.
58. Kalidas S, Smith DP. 2002. Novel genomic cDNA hybrids produce effective RNA interference in adult Drosophila. Neuron 33:177-184.
59. Bilder D. 2003. PDZ domain polarity complexes. Curr Biol 13:R661-R662.
60. Bilder D, Perrimon N. 2000. Localization of apical epithelial determinants by the basolateral PDZ protein Scribble. Nature 403:676-680.
61. Bilder D, Li M, Perrimon N. 2000. Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors. Science 289:113-116.
62. Brumby AM, Richardson HE. 2003. scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila. EMBO J 22:5769-5779.
63. Pagliarini RA, Xu T. 2003. A genetic screen in Drosophila for metastatic behavior. Science 302:1227-1231.
64. Roche JP, Packard MC, Moeckel-Cole S, Budnik V. 2002. Regulation of synaptic plasticity and synaptic vesicle dynamics by the PDZ protein Scribble. J Neurosci 22:6471-6479.
65. Barabási AL, Oltvai ZN. 2004. Network biology: Understanding the cell's functional organization. Nature Rev Genet 5:101-113.