Inhibition of neuronal nitric oxide synthase increases aggressive behavior in mice

Molecular Medicine

Volumn 3, Issue 9, 1997, Pages 610-616

  Demas, Gregory E ^a   Eliasson, Mikael J L ^b   Dawson, Ted M ^b   Dawson, Valina L ^b   Kriegsfeld, Lance J ^a   Nelson, Randy J ^a,b   Snyder, Solomon H ^b  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 INDAZOLINONE; 7 NITROINDAZOLE; CITRULLINE; INDAZOLE DERIVATIVE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; OIL; UNCLASSIFIED DRUG;

AGGRESSION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY TEMPERATURE; CONTROLLED STUDY; ENZYME INHIBITION; LOCOMOTION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0030708886     PISSN: 10761551     EISSN: None     Source Type: Journal    
DOI: 10.1007/bf03401818     Document Type: Article

References (21)

1. Jaffrey SR, Snyder SH. (1995) Nitric oxide: A neural messenger. Annu. Cell. Dev. Biol. 11: 417-440.
2. Huang PL, Dawson TM, Bredt DS, Snyder SH, Fishman MC. (1993) Targeted disruption of the neuronal nitric oxide synthase gene. Cell 75: 1273-1286.
3. Huang Z, Huang PL, Panahian N, Dalkara T, Fishman MC, Moskowitz MA. (1994) Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase. Science 265: 1883-1885.
4. Nelson RJ, Demas GE, Huang PL, Fishman MC, Dawson VL, Dawson TM, Snyder SH. (1995) Behavioural abnormalities in male mice lacking neuronal nitric oxide synthase. Nature 378: 383-386.
5. Burnett AL, Nelson RJ, Calvin DC, Liu J-X, Demas GE, Klein SL, Kriegsfeld LJ, Dawson VL, Dawson TM, Snyder SH. (1996) Nitric oxide-dependent penile erection in mice lacking neuronal nitric oxide synthase. Mol. Med. 2: 288-296.
6. O'Dell TJ, Huang PL, Dawson TM, Dinerman JL, Snyder SH, Kandel ER, Fishman MC. (1994) Endothelial NOS and the blockade of LTP by NOS inhibitors in mice lacking neuronal NOS. Science 265: 542-546.
7. Linden DJ, Dawson TM, Dawson VL. (1995) An evaluation of the nitric oxide/cGMP/cGMP-dependent protein kinase cascade in the induction of cerebellar long-term depression in culture. J. Neurosci. 15: 5098-5105.
8. Good M. (1996) Targeted deletion of neuronal nitric oxide: A step closer to understanding its functional significance? Trends Neurosci. 19: 93-84.
9. Moore PK, Wallace P, Garren Z, Hart SL, Babbedge RC. (1993) Characterization of the novel nitric oxide synthase inhibitor 7-nitro indazole and related indazoles: Antinociceptive and cardiovascular effects. Br. J. Pharmacol. 110: 219-224.
10. Eliasson MJL, Blackshaw S, Schell MJ, Snyder SH. (1997) Neuronal nitric oxide synthase alternatively spliced forms: Prominent functional localizations in the brain. Proc. Natl. Acad. Sci. U.S.A. 94: 3396-3401.
11. Babbedge RC, Bland-Ward PA, Hart SL, Moore PK. (1993) Inhibition of rat cerebellar nitric oxide synthase by 7-nitroindazole and related substituted indazoles. Br. J. Pharmacol. 110: 225-228.
12. Przedborski S, Jackson-Lewis V, Yokoyama R, Shibata T, Dawson VL, Dawson TM. (1996) Role of neuronal nitric oxide in 1-methyl-4-pheny- 1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity. Proc. Natl. Acad. Sci. U.S.A. 93: 4565-4571.
13. Bland-Ward PA, Moore PK. (1995) 7-Nitro indazole derivatives are potent inhibitors of brain, endothelium and inducible isoforms of nitric oxide synthase. Life Sci. 110: 225-228.
14. Dawson VL, Kizushi, VM, Huang PL, Snyder SH, Dawson TM. (1996) Resistance to neurotoxicity in cortical cultures from neuronal nitric oxide synthase-deficient mice. J. Neurosci. 16: 2479-2487.
15. G-Nitroarginine in brain in vitro and in vivo. Biochem. Biophys. Res. Commun. 176: 1136-1141.
16. Jaffrey SR, Snyder SH. (1996) PIN: An associated protein inhibitor of neuronal nitric oxide synthase. Science 274: 774-777.
17. Brenman JE, Chao DS, Gee SH, McGee AW, Craven SE, Santillano DR, Wu Z, Huang F, Xia H, Peters MF, Froehner SC, Bredt DS. (1996) Interaction of nitric oxide synthase with the postsynaptic density PSD-95 and alpha 1-syntrophin mediated by PDZ domains. Cell 84: 757-767.
18. 2-terminal truncated nitric-oxide synthase. J. Biol. Chem. 272: 11392-11401.
19. Morris R. (1996) NOS and aggression. Trends Neurosci. 19: 277-278.
20. Faraci, FM, Brian JE. (1994) Nitric oxide and the cerebral circulation. Stroke 25: 692-703.
21. Dawson TM, Snyder SH. (1994) Gases as biological messengers: Nitric oxide and carbon monoxide in the brain. J. Neurosci. 14: 5147-5159.