1-Phenylpyrazolo[3,4-d]pyrimidines as adenosine antagonists: The effects of substituents at C4 and C6

Bioorganic and Medicinal Chemistry

Volumn 5, Issue 2, 1997, Pages 311-322

  Chebib, Mary ^a   Quinn, Ronald J ^a  

^a GRIFFITH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE A1 RECEPTOR; ADENOSINE A2A RECEPTOR; ADENOSINE RECEPTOR BLOCKING AGENT; PHENYLISOPROPYLADENOSINE; PYRAZOLO[3,4 D]PYRIMIDINE DERIVATIVE; RECEPTOR SUBTYPE;

ANIMAL TISSUE; ARTICLE; BRAIN; CONTROLLED STUDY; CORPUS STRIATUM; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; IN VITRO STUDY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; RAT; REACTION ANALYSIS; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

ANIMALS; BRAIN; MAGNETIC RESONANCE SPECTROSCOPY; PYRIMIDINES; RATS; RATS, WISTAR; RECEPTORS, PURINERGIC P1; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA;

EID: 0031081620     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(96)00240-4     Document Type: Article

References (15)

1. 1. Collis, M. G.; Hourani, S. M. O. Trends Pharmacol. Sci. 1993, 14, 360.
2. 2. Müller, C. E.; Scior, T. Pharm. Acta Helv. 1993, 68, 77.
3. 3. Davies, L. P.; Brown, D. J.; Chow, S. C.; Johnston, G. A. R. Neurosci. Lett. 1983, 41, 189.
4. 4. Davies, L. P.; Chow, S. C.; Skerritt, J. H.; Brown, D. J.; Johnston, G. A. R. Life Sci. 1984, 34, 2117.
5. 5. Quinn, R. J.; Scammells, P. J.; Tucker, D. J. Aust. J. Chem. 1991, 44, 753.
6. 6. Chebib, M.; Quinn, R. J. Bioorg. Med. Chem. Lett. 1995, 5, 2409.
7. 7. Derome, A. E. Modern NMR Techniques for Chemistry Research; Pergamon Press: Oxford, 1987.
8. 8. Summers, M. F.; Marzilli, L. G.; Bax, A. J Am. Chem. Soc. 1986, 108, 4285.
9. 9. Daly, J. W.; Padgett, W.; Thompson, R. D.; Kusachi, S.; Bugni, W. J.; Olsson, R. A. Biochem. Pharmacol. 1986, 35, 2467.
10. 10. Jarvis, M. F.; Schulz, R.; Hutchison, A. J.; Do, U. H.; Sills, M. A.; Williams, M. J. Pharmacol. Exp. Ther. 1989, 251, 888.
11. 11. Schwabe, U.; Trost, T. Naunyn-Schmiedeberg's Arch. Pharmacol. 1980, 313, 179.
12. 12. Cheng, Y. C.; Prusoff, W. H. Biochem. Pharmacol. 1973, 22, 3099.
13. 13. Gray, E. G.; Whittaker, V. P. J. Anatom. 1962, 96, 79.
14. 14. Peterson, G. L. Anal. Biochem. 1977, 83, 346.
15. 15. McPherson, G. A. A Collection of Radioligand Binding Analysis Programs; Elsevier-Biosoft: Amsterdam, 1985.