Stereoselective synthesis and preliminary evaluation of (+)- and (-)-3-methyl-5-carboxy-thien-2-yl-glycine (3-MATIDA): Identification of (+)-3-MATIDA as a novel mGluR1 competitive antagonist

Farmaco

Volumn 59, Issue 2, 2004, Pages 93-99

  Costantino, Gabriele ^a   Marinozzi, Maura ^a   Camaioni, Emidio ^a   Natalini, Benedetto ^a   Sarichelou, Iran ^a   Micheli, Fabrizio ^b   Cavanni, Paolo ^b   Faedo, Stefania ^b   Noe, Christian ^c   Moroni, Flavio ^d   Pellicciari, Roberto ^a  

^a UNIVERSITY OF PERUGIA   (Italy)

^b GSK   (Italy)

^c UNIVERSITY OF VIENNA   (Austria)

^d Dipto Farmacol Preclinica e Clin   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

3 METHYL 5 CARBOXYTHIEN 2 YLGLYCINE; GLUTAMATE RECEPTOR ANTAGONIST; GLYCINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG SYNTHESIS; EVALUATION; LIGAND BINDING; POLYMERIZATION; STEREOCHEMISTRY;

EID: 10744223735     PISSN: 0014827X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.farmac.2003.11.008     Document Type: Article

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