Synthesis and pharmacological characterisation of 2,4-dicarboxy-pyrroles as selective non-competitive mGluR1 antagonists

Bioorganic and Medicinal Chemistry

Volumn 11, Issue 2, 2003, Pages 171-183

  Micheli, Fabrizio ^a   Di Fabio, Romano ^a   Cavanni, Paolo ^a   Rimland, Joseph M ^a   Capelli, Anna Maria ^a   Chiamulera, Cristiano ^a   Corsi, Mauro ^a   Corti, Corrado ^a   Donati, Daniele ^a   Feriani, Aldo ^a   Ferraguti, Francesco ^b   Maffeis, Micaela ^a   Missio, Andrea ^a   Ratti, Emiliangelo ^a   Paio, Alfredo ^a   Pachera, Roberta ^a   Quartaroli, Mauro ^a   Reggiani, Angelo ^a,c   Sabbatini, Fabio Maria ^a   Trist, David G ^a   Ugolini, Annarosa ^a   Vitulli, Giovanni ^a   more..

^a GSK   (Italy)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c Schering Plough   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

3,5 DIMETHYLPYRROLE 2,4 DICARBOXYLIC ACID 2 PROPYL ESTER 4 (1,2,2 TRIMETHYLPROPYL)ESTER; 3,5 DIMETHYLPYRROLE 2,4 DICARBOXYLIC ACID 4 (2 METHYLCYCLOPENTYL) 2 PROPYL ESTER; 3,5 DIMETHYLPYRROLE 2,4 DICARBOXYLIC ACID 4 (2,3 DIMETHYLPROPYL)ESTER 2 PROPYL ESTER; ANTINOCICEPTIVE AGENT; METABOTROPIC RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG; ANALGESIC AGENT; HYBRID PROTEIN; METABOTROPIC GLUTAMATE RECEPTOR TYPE 1; METABOTROPIC RECEPTOR; PYRROLE DERIVATIVE;

ANALGESIC ACTIVITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; MOUSE; NEUROPATHIC PAIN; NONHUMAN; PAIN; RAT; ANIMAL; CHEMISTRY; CHO CELL; COMBINATORIAL CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; ELECTROPHYSIOLOGY; GENETICS; HAMSTER; HUMAN; IC 50; METHODOLOGY; PAIN ASSESSMENT; PHYSIOLOGY; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; SPINAL CORD; STRUCTURE ACTIVITY RELATION; SYNTHESIS; XENOPUS LAEVIS;

ANALGESICS, NON-NARCOTIC; ANIMALS; CHO CELLS; COMBINATORIAL CHEMISTRY TECHNIQUES; CRICETINAE; ELECTROPHYSIOLOGY; HUMANS; INHIBITORY CONCENTRATION 50; PAIN MEASUREMENT; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PYRROLES; RATS; RECEPTORS, METABOTROPIC GLUTAMATE; RECOMBINANT FUSION PROTEINS; SPINAL CORD; STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS LAEVIS;

EID: 0037449355     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(02)00424-8     Document Type: Article

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