Lerk2 (ephrin-b1) is a collapsing factor for a subset of cortical growth cones and acts by a mechanism different from AL-1 (ephrin-a5)

Molecular and Cellular Neurosciences

Volumn 9, Issue 4, 1997, Pages 314-328

  Meima, Leonie ^a   Moran, Paul ^a   Matthews, William ^a   Caras, Ingrid W ^a  

^a GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

F ACTIN; IMMUNOGLOBULIN G; LIGAND; PACLITAXEL; PROTEIN TYROSINE KINASE;

ANIMAL CELL; ARTICLE; BRAIN CORTEX; BRAIN NERVE CELL; CONTROLLED STUDY; CYTOSKELETON; GROWTH CONE; MICROTUBULE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALIA;

EID: 0030833727     PISSN: 10447431     EISSN: None     Source Type: Journal    
DOI: 10.1006/mcne.1997.0621     Document Type: Article

References (52)

1. Bartley T. D., Hunt R. W., Welcher A. A., Boyle W. J., Parker V. P., Lindberg R. A., Lu H. S., Colombero A. M., Elliott R. L., Guthrie B. A., Holst P. L., Skrine J. D., Toso R. J., Zhang M., Fernandez E., Trail G., Varnum B., Yarden Y., Hunter T., Fox G. M. B61 is a ligand for the ECK receptor protein-tyrosine kinase. Nature. 368:1994;558-560.
2. Becker N., Seitanidou T., Murphy P., Mattei M.-G., Topiko P., Nieto M. A., Wilkinson D. G., Charnay P., Gilardi-Hebenstreit P. Several receptor tyrosine kinase genes of the Eph family are segmentally expressed in the developing hindbrain. Mech. Dev. 47:1994;3-17.
3. Beckmann M. P., Cerretti D. P., Baum P., Vanden Bos T., James L., Farrah T., Kozlosky C., Hollingsworth T., Shilling H., Maraskovsky E., Fletcher F. A., Lhotak V., Pawson T., Lyman S. D. Molecular characterization of a family of ligands for eph-related tyrosine kinase receptors. EMBO J. 13:1994;3757-3762.
4. Bennett B. D., Wang Z., Kuang W.-J., Wang A., Groopman J. E., Goeddel D. V., Scadden D. T. Cloning and characterization of HTK, a novel transmembrane tyrosine kinase of the EPH subfamily. J. Biol. Chem. 269:1994;14211-14218.
5. Bennett B. D., Zeigler F. C., Gu Q., Fendley B., Goddard A. D., Gillett N., Matthews W. Molecular cloning of a ligand for the EPH-related receptor protein-tyrosine kinase, Htk. Proc. Natl. Acad. Sci. USA. 92:1995;1866-1870.
6. Bergemann A. D., Cheng H.-J., Brambilla R., Klein R., Flanagan J. G. Elf-2, a new member of the Eph ligand family, is segmentally expressed in mouse embryos in the region of the hindbrain and newly forming somites. Mol. Cell. Biol. 15:1995;4921-4929.
7. Brambilla R., Klein R. Telling axons where to grow: A role for the Eph receptor tyrosine kinases in guidance. Mol. Cell. Neurosci. 6:1995;487-495.
8. Brambilla R., Schnapp A., Casagranda F., Labrador J. P., Bergemann A. D., Flanagan J. G., Pasquale E. B., Klein R. Membrane-bound LERK2 ligand can signal through three different Eph-related receptor tyrosine kinases. EMBO J. 14:1995;3116-3126.
9. Brambilla R., Bruckner K., Orioli D., Bergemann A. D., Flanagan J. G., Klein R. Similarities and differences in the way transmembrane-type ligands interact with the Elk subclass of Eph receptors. Mol. Cell. Neurosci. 8:1996;199-209.
10. Bruckner K., Pasquale E. B., Klein R. Tyrosine phosphorylation of transmembrane ligands for Eph receptors. Science. 12:1997;1640-1643.
11. Capon D. J., Chamow S. M., Mordenti J., Marsters S. A., Gregory T., Mitsuya H., Byrn R. A., Lucas C., Wurm F. M., Groopman J. E. Designing CD4 immunoadhesins for AIDS therapy. Nature. 337:1989;525-531.
12. Cheng H.-J., Flanagan J. G. Identification and cloning of ELF-1, a developmentally expressed ligand for the Mek4 and Sek receptor tyrosine kinases. Cell. 79:1994;157-168.
13. Cheng H.-J., Nakamoto M., Bergemann A. D., Flanagan J. G. Complementary gradients in expression and binding of Elf1 and Mek4 in development of the topographic retinotectal projection map. Cell. 82:1995;371-381.
14. Cooper J. A. Effects of cytochalasin and phalloidin on actin. J. Cell Biol. 105:1987;1473-1478.
15. Cox E. C., Muller B., Bonhoeffer F. Axonal guidance in the chick visual system: Posterior tectal membranes induce collapse of growth cones from the temporal retina. Neuron. 2:1990;31-37.
16. Davis S., Gale N. W., Aldrich T. H., Maisonpierre P. C., Lhotak V., Pawson T., Goldfarb M., Yancopoulos G. D. Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity. Science. 266:1994;816-819.
17. Drescher U., Kremoser C., Handwerker C., Loschinger J., Noda M., Bonhoeffer F. In vitro guidance of retinal ganglion cell axons by RAGS, a 25kDa tectal protein related to ligands for Eph receptor tyrosine kinases. Cell. 82:1995;359-370.
18. Dodd J., Schuchardt A. Axon guidance: A compelling case for repelling growth cones. Cell. 81:1995;471-474.
19. Eaton D. L., Wood W. I., Eaton D., Hass P. E., Hollingshead P., Wion K., Mather J., Lawn R. M., Vehar G. A., Gorman C. Construction and characterization of an active factor VIII variant lacking the central one-third of the molecule. Biochemistry. 25:1986;8343-8347.
20. Fan J., Mansfield S. G., Redmond T., Gordon-Weeks P. R., Raper J. A. The organization of F-actin and microtubules in growth cones exposed to a brain-derived collapsing factor. J. Cell Biol. 121:1993;867-878.
21. Fan J., Raper J. A. Localized collapsing cues can steer growth cones without inducing their full collapse. Neuron. 14:1995;263-274.
22. Forscher P., Smith S. J. Actions of cytochalasins on the organization of actin filaments and microtubules in a neuronal growth cone. J. Cell Biol. 107:1988;1505-1516.
23. Friedman G. C., O'Leary D. D. M. Eph receptor tyrosine kinases and their ligands in neural development. Curr. Opin. Neurobiol. 6:1996;127-133.
24. Gale N. W., Holland S. J., Valenzuela D. M., Flenniken A., Pan L., Ryan T. E., Henkemeyer M., Strebhardt K., Hirai H., Wilkinson D. G., Pawson T., Davis S., Yancopoulos G. D. Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis. Neuron. 17:1996a;9-19.
25. Gale N. W., Flenniken A., Compton D. C., Jenkins N., Copeland N. G., Gilbert D. J., Davis S., Wilkinson D. G., Yancopoulos G. D. Elk-L3, a novel transmembrane ligand for the Eph family of receptor tyrosine kinases, expressed in embryonic floor plate, roof plate and hindbrain segments. Oncogene. 13:1996b;1343-1352.
26. Ganju P., Shigemoto K., Brennan J., Entwistle A., Reith A. D. The eck receptor tyrosine kinase is implicated in pattern formation during gastrulation, hindbrain segmentation and limb development. Oncogene. 9:1994;1613-1624.
27. Gilardi-Hebenstreit P., Nieto M. A., Frain M., Mattei M. G., Chestier A., Wilkinson D. G., Charnay P. An Eph-related receptor protein tyrosine kinase gene segmentally expressed in the developing mouse hindbrain. Oncogene. 7:1992;2499-2506.
28. Henkemeyer M., Marengere L., McGlade J., Olivier J. P., Conlon R. A., Holmyard D. P., Letwin K., Pawson T. Immunolocalization of the nuk receptor tyrosine kinase suggests roles in segmental patterning of the brain and axonogenesis. Oncogene. 9:1994;1001-1014.
29. Henkemeyer M., Orioli D., Henderson J. T., Saxton T. M., Roder J., Pawson T., Klein R. Nuk controls pathfinding of commissural axons in the mammalian central nervous system. Cell. 86:1996;35-46.
30. Holland S. J., Gale N. W., Mbamalu G., Yancopoulus G. D., Henkemeyer M., Pawson T. Bidirectional signalling through the Eph-family receptor Nuk and its transmembrane ligands. Nature. 1996;722-725.
31. Kapfhammer J. P., Raper J. A. Collapse of growth cone structure on contact with specific neurotes in culture. J. Neurosci. 7:1987;201-212.
32. Kozlosky C. J., Maraskovsky E., McGrew J. T., VandenBos T., Teepe M., Lyman S. D., Srinivasan S., Fletcher F. A., Gayle R. B. III, Cerretti D. P., Beckman M. P. Ligands for the receptor tyrosine kinases hek and elk: Isolation of cDNAs encoding a family of proteins. Oncogene. 10:1995;299-306.
33. Lin C.-H., Forscher P. Cytoskeletal remodeling during growth cone-target interactions. J. Cell Biol. 121:1993;1369-1383.
34. Lin C.-H., Forscher P. Growth cone advance is inversely proportional to retrograde F-actin flow. Neuron. 14:1995;763-771.
35. Meima L., Kljavin I., Moran P., Shih A., Winslow J. W., Caras I. W. AL-1-induced growth cone collapse of rat cortical neurons is correlated with REK7 expression and rearrangement of the actin cytoskeleton. Eur. J. Neurosci. 9:1997;177-188.
36. Muller B., Stahl B., Bonhoeffer F. In vitro experiments on axonal guidance and growth cone collapse. J. Exp. Biol. 153:1990;29-46.
37. Nakamoto M., Cheng H.-J., Friedman G. C., McLaughlin T., Hansen M. J., Yoon C. H., O'Leary D. D. M., Flanagan J. G. Topographically specific effects of Elf-1 on retinal axon guidance in vitro and retinal axon mapping in vivo. Cell. 86:1996;755-766.
38. Orioli D., Henkemeyer M., Lemke G., Klein R., Pawson T. Sek4 and Nuk receptors cooperate in guidance of commissural axons and in palate formation. EMBO J. 15:1996;6035-6049.
39. Peterson C., Neal J. H., Cotman C. W. Development ofND. Dev. Brain Res. 48:1989;187-195.
40. Raper J. A., Kapfhammer J. P. The enrichment of a neuronal growth cone collapsing activity from embryonic chick brain. Neuron. 4:1990;21-29.
41. Sampath P., Pollard T. D. Effects of cytochalasin, phalloidin, and pH on the elongation of the actin filaments. Biochemistry. 30:1991;1973-1980.
42. Schiff P. B., Horwitz S. B. Taxol stabilizes microtubules in mouse fibroblast cells. Proc. Natl. Acad. Sci. USA. 77:1980;1561-1565.
43. Schnapp B. J., Vale R. D., Sheetz M. P., Reese T. S. Microtubules and the mechanism of directed organelle movement. Ann. N.Y. Acad. Sci. 466:1986;909-918.
44. Tanaka E., Kirschner M. W. Microtubule behaviour in the growth cones of living neurons during axon elongation. J. Cell Biol. 115:1991;345-363.
45. Tanaka E., Kirschner M. W. The role of microtubules in growth cone turning at substrate boundaries. J. Cell Biol. 128:1995;127-137.
46. Tanaka E., Ho T., Kirschner M. W. The role of microtubule dynamics in growth cone motility and axonal growth. J. Cell Biol. 128:1995;139-155.
47. Tanaka E., Sabry J. Making the connection: Cytoskeletal rearrangements during growth cone guidance. Cell. 83:1995;171-176.
48. Tessier-Lavigne M., Goodman C. S. The molecular biology of axon guidance. Science. 274:1996;1123-1133.
49. Tuzi N. L., Gullick W. J. eph, Br. J. Cancer. 69:1994;417-421.
50. Winslow J. W., Moran P., Ai Shih, Valverde J., Yuan J. Q., Beck K. D., Wong S. C., Tsai S. P., Goddard A., Henzel W. J., Hefti F., Caras I. W. Cloning of AL-1, a ligand for an EPH-related tyrosine kinase receptor involved in axon bundle formation. Neuron. 14:1995;973-981.
51. Xu Q., Alldus G., Holder N., Wilkinson D. G. Expression of truncated Sek1 receptor tyrosine kinase disrupts the segmental restriction of gene expression in theXenopus. Development. 121:1995;4005-4016.
52. Xu Q., Alldus G., Macdonald R., Wilkinson D. G., Holder N. Function of the Eph-related kinase rtk1 in patterning of the zebrafish forebrain. Nature. 381:1996;319-322.