The SCID mouse model: Novel therapeutic targets - Lessons from gene transfer

Springer Seminars in Immunopathology

Volumn 25, Issue 1, 2003, Pages 65-78

  Pierer, Matthias ^a   Müller Ladner, Ulf ^b   Pap, Thomas ^c   Neidhart, Michel ^a   Gay, Renate E ^a   Gay, Steffen ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b UNIVERSITY OF REGENSBURG   (Germany)

^c OTTO VON GUERICKE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; CATHEPSIN; CYTOKINE; INTERLEUKIN 10; MATRIX METALLOPROTEINASE; MITOGEN ACTIVATED PROTEIN KINASE; P38 MITOGEN ACTIVATED PROTEIN KINASE DELTA; PROTEIN P75; RETROVIRUS VECTOR; TUMOR NECROSIS FACTOR RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; CELL INVASION; CHRONIC INFLAMMATION; CLINICAL FEATURE; EXTRACELLULAR MATRIX; FIBROBLAST; GENE EXPRESSION; GENE TRANSFER; MOUSE; NONHUMAN; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; REVIEW; RHEUMATOID ARTHRITIS; SCID MOUSE; SYMPTOM; SYNOVIOCYTE; SYNOVIUM; VIRAL GENE DELIVERY SYSTEM;

ANIMALS; ARTHRITIS, RHEUMATOID; CYTOKINES; DISEASE MODELS, ANIMAL; FIBROBLASTS; GENE THERAPY; GENE TRANSFER TECHNIQUES; HUMANS; MATRIX METALLOPROTEINASES; MICE; MICE, SCID; SYNOVIAL MEMBRANE; TISSUE INHIBITOR OF METALLOPROTEINASE-1;

EID: 10744221572     PISSN: 03444325     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00281-003-0126-2     Document Type: Review

References (69)

1. Apparailly F, Verwaerde C, Jacquet C, et al (1998) Adenovirus-mediated transfer of viral IL-10 gene inhibits murine collagen-induced arthritis. J Immunol 160:5213
2. Aupperle KR, Boyle DL, Hendrix M, et al (1998) Regulation of synoviocyte proliferation, apoptosis, and invasion by the p53 tumor suppressor gene. Am J Pathol 152:1091
3. Brew K, Dinakarpandian D, Nagase H (2000) Tissue inhibitors of metalloproteinases: evolution, structure and function. Biochim Biophys Acta 1477:267
4. Brinckerhoff CE, Harris ED (1981) Survival of rheumatoid synovium implanted into nude mice. Am J Pathol 103:411
5. Burmester GR, Stuhlmuller B, Keyszer G, et al (1997) Mononuclear phagocytes and rheumatoid synovitis. Mastermind or workhorse in arthritis? Arthritis Rheum 40:5
6. Dinarello CA (2000) The role of the interleukin-1-receptor antagonist in blocking inflammation mediated by interleukin-1. N Engl J Med 343:732
7. Dodge GR, Jimenez S (1994) An in vitro model of synovial cell adhesion and invasiveness into human articular cartilage. Arthritis Rheum 37:311
8. Elliott MJ, Maini RN, Feldmann M (1994) Randomised double blind comparison of a chimaeric monoclonal antibody to tumour necrosis factor (cA2) versus placebo in rheumatoid arthritis. Lancet 344:1105
9. Fassbender HG (1983) Histomorphological basis of articular cartilage destruction in rheumatoid arthritis. Coll Relat Res 3:141
10. Feldmann M, Elliott MJ, Woody JN (1997) Anti tumour necrosis factor therapy of rheumatoid arthritis. Adv Immunol 64:283
11. Firestein GS, Echeverri F, Yeo M, et al (1997) Somatic mutations in the p53 tumor suppressor gene in rheumatoid arthritis synovium. Proc Natl Acad Sci USA 94:10895
12. Franz JK, Pap T, Hummel KM, et al (2000) Expression of sentrin, a novel antiapoptotic molecule, at sites of synovial invasion in rheumatoid arthritis. Arthritis Rheum 43:599
13. Gay S, Gay RE, Koopman WJ (1993) Molecular and cellular mechanisms of joint destruction in rheumatoid arthritis: two cellular mechanisms explain joint destruction? Ann Rheum Dis 52:39
14. Geiler T, Kriegsmann J, Keyszer GM, et al (1994) A new model for rheumatoid arthritis generated by engraftment of rheumatoid synovial tissue and normal human cartilage into SCID mice. Arthritis Rheum 37:1664
15. Gonzalez-Gronow M, Gawdi G, Pizzo SV (1994) Characterization of the plasminogen receptors of normal and rheumatoid arthritis human synovial fibroblasts. J Biol Chem 269:4360
16. Han Z, Boyle DL, Manning AM, et al (1998) AP-1 and NF-kappaB regulation in rheumatoid arthritis and murine collagen-induced arthritis. Autoimmunity 28:197
17. Han Z, Boyle DL, Shi Y, et al (1999) Dominant-negative p53 mutations in rheumatoid arthritis. Arthritis Rheum 42:1088
18. Hargreaves PG, Wang F, Antcliff J, et al (1998) Human myeloma cells shed the interleukin-6 receptor: inhibition by tissue inhibitor of metalloproteinase-3 and a hydroxamate-based metalloproteinase inhibitor. Br J Haematol 101:694
19. Harris ED (1993) Etiology and pathogenesis of rheumatoid arthritis, vol 4. Saunders, Philadelphia, pp 833-873
20. Henderson B, Edwards JCW, Pettipher ER (1995) Mechanisms and models in rheumatoid arthritis. Academic Press, London
21. Horai R, Saijo S, Tanioka H, et al (2000) Development of chronic inflammatory arthropathy resembling rheumatoid arthritis in interleukin 1 receptor antagonist-deficient mice. J Exp Med 191:313
22. Isomaki P, Luukkainen R, Saario R, et al (1996) Interleukin-10 functions as an antiinflammatory cytokine in rheumatoid synovium. Arthritis Rheum 39:386
23. Jiang Y, Genant HK, Watt I, et al (2000) A multicenter, double-blind, dose-ranging, randomized, placebo-controlled study of recombinant human interleukin-1 receptor antagonist in patients with rheumatoid arthritis: radiologic progression and correlation of Genant and Larsen scores. Arthritis Rheum 43:1001
24. Joosten LA, Lubberts E, Durez P, et al (1997) Role of interleukin-4 and interleukin-10 in murine collagen-induced arthritis: protective effect of interleukin-4 and interleukin-10 treatment on cartilage destruction. Arthritis Rheum 40:249
25. Jorgensen C, Gay S (1998) Gene therapy in osteoarticular diseases: where are we? Immunol Today 19:387
26. Kasama T, Strieter RM, Lukacs NW, et al (1995) Interleukin-10 expression and chemokine regulation during the evolution of murine type II collagen-induced arthritis. J Clin Invest 95:2868
27. Kawakami A, Eguchi K, Matsuoka N, et al (1997) Inhibitory effects of interleukin-10 on synovial cells of rheumatoid arthritis. Immunology 91:252
28. Keffer J, Probert L, Cazlaris H, et al (1991) Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis. EMBO J 10:4025
29. Lechman ER, Jaffurs D, Ghivizzani SC, et al (1999) Direct adenoviral gene transfer of viral IL-10 to rabbit knees with experimental arthritis ameliorates disease in both injected and contralateral control knees. J Immunol 163:2202
30. Lubberts E, Joosten LA, Helsen MM, et al (1998) Regulatory role of interleukin 10 in joint inflammation and cartilage destruction in murine streptococcal cell wall (SCW) arthritis. More therapeutic benefit with IL-4/IL-10 combination therapy than with IL-10 treatment alone. Cytokine 10:361
31. Ma Y, Thornton S, Duwel LE, et al (1998) Inhibition of collagen-induced arthritis in mice by viral IL-10 gene transfer. J Immunol 161:1516
32. Maeda S, Sawai T, Uzuki M, et al (1995) Determination of interstitial collagenase (MMP-1) in patients with rheumatoid arthritis. Ann Rheum Dis 54:970
33. Mageed RA, Adams G, Woodrow D, et al (1998) Prevention of collagen-induced arthritis by gene delivery of soluble p75 tumour necrosis factor receptor. Gene Ther 5:1584
34. Maini RN, Taylor PC, Paleolog E (1999) Anti-tumour necrosis factor specific antibody (infliximab) treatment provides insights into the pathophysiology of rheumatoid arthritis. Ann Rheum Dis 58:I56
35. Makarov SS, Johnston WN, Olsen JC, et al (1997) NF-kappa B as a target for anti-inflammatory gene therapy: suppression of inflammatory responses in monocytic and stromal cells by stable gene transfer of I kappa B alpha cDNA. Gene Ther 4:846
36. Martel-Pelletier J, Welsch DJ, Pelletier JP (2001) Metalloproteases and inhibitors in arthritic diseases. Best Pract Res Clin Rheumatol 15:805
37. Medcalf RL, Hamilton JA (1986) Human synovial fibroblasts produce urokinase-type plasminogen activator. Arthritis Rheum 29:1397
38. Miossec P (1995) Pro- and antiinflammatory cytokine balance in rheumatoid arthritis. Clin Exp Rheumatol 13:13
39. Muller-Ladner U, Evans CH, Franklin BN, et al (1999) Gene transfer of cytokine inhibitors into human synovial fibroblasts in the SCID mouse model. Arthritis Rheum 42:490
40. Muller-Ladner U, Gay RE, Gay S (1996) Cysteine proteinases in arthritis and inflammation. Perspect Drug Discovery Design 6
41. Muller-Ladner U, Kriegsmann J, Franklin BN, et al (1996) Synovial fibroblasts of patients with rheumatoid arthritis attach to and invade normal human cartilage when engrafted into SCID mice. Am J Pathol 149:1607
42. Muller-Ladner U, Kriegsmann J, Gay RE, et al (1995) Oncogenes in rheumatoid synovium. Rheum Dis Clin North Am 21:675
43. Muller-Ladner U, Roberts CR, Franklin BN, et al (1997) Human IL-1Ra gene transfer into human synovial fibroblasts is chondroprotective. J Immunol 158:3492
44. Nawrath M, Hummel KM, Pap T, et al (1998) Effect of dominant negative mutants of raf-1 and c-myc on rheumatoid arthritis synovial fibroblasts in the SCID mouse model. Arthritis Rheum 41:95
45. Nawrocki B, Polette M, Clavel C, et al (1994). Expression of stromelysin 3 and tissue inhibitors of matrix metallo- proteinases, TIMP-1 and TIMP-2, in rheumatoid arthritis. Pathol Res Pract 190:690
46. Neidhart M, Gay RE, Gay S (2000) Anti-interleukin-1 and anti-CD44 interventions producing significant inhibition of cartilage destruction in an in vitro model of cartilage invasion by rheumatoid arthritis synovial fibroblasts. Arthritis Rheum 43:1719
47. Neidhart M, Rethage J, Kuchen S, et al (2000) Retrotransposable L1 elements expressed in rheumatoid arthritis synovial tissue: association with genomic DNA hypomethylation and influence on gene expression. Arthritis Rheum 43:2634
48. Pap T, Aupperle KR, Gay S, et al (2001) Invasiveness of synovial fibroblasts is regulated by p53 in the SCID mouse in vivo model of cartilage invasion. Arthritis Rheum 44:676
49. Pap T, Laan WH van der, Aupperle KR, et al (2000) Modulation of fibroblast-mediated cartilage degradation by articular chondrocyies in rheumatoid arthritis. Arthritis Rheum 43:2531
50. Pim D, Storey A, Thomas M, et al (1994) Mutational analysis of HPV-18 E6 identifies domains required for p53 degradation in vitro, abolition of p53 transactivation in vivo and immortalisation of primary BMK cells. Oncogene 9:1869
51. Posthumus MD, Limburg PC, Westra J, et al (1999) Serum levels of matrix metalloproteinase-3 in relation to the development of radiological damage in patients with early rheumatoid arthritis. Rheumatology 38:1081
52. Quattrocchi E, Walmsley M, Browne K, et al (1999) Paradoxical effects of adenovirus-mediated blockade of TNF activity in murine collagen-induced arthritis. J Immunol 163:1000
53. Ramachandrula A, Tiku K, Tiku ML (1992) Tripeptide RGD-dependent adhesion of articular chondrocytes to synovial fibroblasts. J Cell Sci 101:859
54. Rankin ECC, Choy EHS, Kassimos D (1995) The therapeutic effects of an engineered human antitumour necrosis factor alpha antibody (CD571) in rheumatoid arthritis. Br J Rheumatol 34:334
55. Ronday HK, Smits HH, Muijen GNP van, et al (1996) Difference in expression of the plasminogen activation system in synovial tissue of patients with rheumatoid arthritis and osteoarthritis. Br J Rheumatol 35:416
56. Ronday HK, Te Koppele JM, Greenwald RA, et al (1998) Tranexamic acid, an inhibitor of plasminogen activation, reduces urinary collagen cross-link excretion in both experimental and rheumatoid arthritis. Br J Rheumatol 7:34
57. Schedel J, Gay RE, Kuenzler P, et al (2002) FLICE-inhibitory protein expression in synovial fibroblasts and at sites of cartilage and bone erosion in rheumatoid arthritis. Arthritis Rheum 46:1512
58. Scheffner M, Werness BA, Huibregtse JM, et al (1990) The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell 63:1129
59. Smith MR, Kung H, Durum SK, et al (1997) TIMP-3 induces cell death by stabilizing TNF-alpha receptors on the surface of human colon carcinoma cells. Cytokine 9:770
60. Takayanagi H, Juji T, Miyazaki T, et al (1999) Suppression of arthritic bone destruction by adenovirus-mediated csk gene transfer to synoviocytes and osteoclasts. J Clin Invest 104:137
61. Takizawa M, Ohuchi E, Yamanaka H, et al (2000) Production of tissue inhibitor of metalloproteinases 3 is selectively enhanced by calcium pentosan polysulfate in human rheumatoid synovial fibroblasts. Arthritis Rheum 43:812
62. Van der Laan WH, Pap T, Ronday HK, et al (2000) Cartilage degradation and invasion by rheumatoid synovial fibroblasts is inhibited by gene transfer of a cell surface-targeted plasmin inhibitor. Arthritis Rheum 43:1710
63. Van der Laan WH, Quax PHA, Seemayer CA, et al (2002) Cartilage degradation and invasion by rheumatoid synovial fibroblasts is inhibited by gene transfer of TIMP-1 and TIMP-3. Gene Ther (in press)
64. Vincenti MP, Coon CI, Brinckerhoff CE (1998) Nuclear factor kappaB/p50 activates an element in the distal matrix metalloproteinase 1 promoter in interleukin-1beta-stimulated synovial fibroblasts. Arthritis Rheum 41:1987
65. Wakisaka S, Suzuki N, Saito N, et al (1998) Possible correction of abnormal rheumatoid arthritis synovial cell function by jun D transfection in vitro. Arthritis Rheum 41:470
66. Walmsley M, Katsikis PD, Abney E, et al (1996) Interleukin-10 inhibition of the progression of established collagen-induced arthritis. Arthritis Rheum 39:495
67. Werb Z, Mainardi CL, Vater CA, et al (1977) Endogenous activation of latent collagenase by rheumatoid synovial cells. Evidence for a role of plasminogen activator. N Engl J Med 296:1017
68. Whalen JD, Lechman EL, Carlos CA, et al (1999) Adenoviral transfer of the viral IL-10 gene periarticularly to mouse paws suppresses development of collagen-induced arthritis in both injected and uninjected paws. J Immunol 162:3625
69. Yoshihara Y, Nakamura H, Obata K, et al (2000) Matrix metalloproteinases and tissue inhibitors of metalloproteinases in synovial fluids from patients with rheumatoid arthritis or osteoarthritis. Ann Rheum Dis 59:455