Role of the kinesin neck linker and catalytic core in microtubule-based motility

Current Biology

Volumn 10, Issue 3, 2000, Pages 157-160

  Case, Ryan B ^a   Rice, Sarah ^a   Hart, Cynthia L ^a   Ly, Bernice ^a   Vale, Ronald D ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0034628619     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(00)00316-X     Document Type: Article

References (17)

1. Goldstein L.S.B., Philp A.V. The road less traveled: emerging principles of kinesin motor utilization. Annu Rev Cell Dev Biol. 15:1999;141-183.
2. Case R.B., Pierce D.W., Hom-Booher N., Hart C.L., Vale R.D. The directional preference of kinesin motors is specified by an element outside of the motor catalytic domain. Cell. 90:1997;959-966.
3. Henningsen U., Schliwa M. Reversal in the direction of movement of a molecular motor. Nature. 389:1997;93-96.
4. Rice S., Lin A.W., Safer D., Hart C.L., Naber N., Carragher B.O.et al. A structural change in the kinesin motor protein that drives motility. Nature. 402:1999;778-784.
5. Houdusse A., Kalabokis V.N., Himmel D., Szent-Gyorgyi A.G., Cohen C. Atomic structure of scallop myosin subfragment S1 complexed with MgADP: a novel conformation of the myosin head. Cell. 97:1999;459-470.
6. Wells A.L., Lin A.W., Chen L.Q., Safer D., Cain S.M., Hasson T.et al. Myosin VI is an actin-based motor that moves backwards. Nature. 401:1999;505-508.
7. Vale R.D., Fletterick R.J. The design plan of kinesin motors. Annu Rev Cell Dev Biol. 13:1997;745-777.
8. Kozielski F., Sack S., Marx A., Thormahlen M., Schonbrunn E., Biou V.et al. The crystal structure of dimeric kinesin and implications for microtubule-dependent motility. Cell. 91:1997;985-994.
9. Berliner E., Young E.C., Anderson K., Mahtani H., Gelles J. Failure of a single-headed kinesin to track parallel to microtubule protofilaments. Nature. 373:1995;718-721.
10. Jiang W., Stock M., Li X., Hackney D. Influence of the kinesin neck domain on dimerization and ATPase kinetics. J Biol Chem. 272:1997;7626-7632.
11. Romberg L., Pierce D.W., Vale R.D. Role of the kinesin neck region in processive microtubule-based motility. J Cell Biol. 140:1998;1407-1416.
12. Grummt M., Woehlke G., Henningsen U., Fuchs S., Schleicher M., Schliwa M. Importance of a flexible hinge near the motor domain in kinesin-driven motility. EMBO J. 17:1998;5536-5542.
13. Sablin E.P., Case R.B., Dai S.C., Hart C.L., Ruby A., Vale R.D.et al. Direction determination in the minus-end-directed kinesin motor ncd. Nature. 395:1998;813-816.
14. Kull F.J., Sablin E.P., Lau R., Fletterick R.J., Vale R.D. Crystal structure of the kinesin motor domain reveals a structural similarity to myosin. Nature. 380:1996;550-555.
15. Hirose K., Lockhart A., Cross R.A., Amos L.A. Three-dimensional cryoelectron microscopy of dimeric kinesin and ncd motor domains on microtubules. Proc Natl Acad Sci USA. 93:1996;9539-9544.
16. Endow S.A., Waligora K.W. Determinants of kinesin motor polarity. Science. 281:1998;1200-1202.
17. Woehlke G., Ruby A.K., Hart C.L., Ly B., Hom-Booher N., Vale R.D. Microtubule interaction site of the kinesin motor. Cell. 90:1997;207-216.