Mitochondria and autoimmunity in primary biliary cirrhosis

Mitochondrion

Volumn 4, Issue 5-6 SPEC. ISS., 2004, Pages 743-753

  Ichiki, Yasunori ^a   Leung, Patrick S C ^a   Ishibashi, Hiromi ^b   Coppel, Ross L ^c   Ansari, Aftab A ^d   Gershwin, M Eric ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NATIONAL HOSPITAL ORGANIZATION NAGASAKI MEDICAL CENTER   (Japan)

^c MONASH UNIVERSITY   (Australia)

^d EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

2 oxo acid dehydrogenase complexes; Antimitochondrial antibodies; Apoptosis; Biliary epithelial cells; IgA; Primary biliary cirrhosis

Indexed keywords

AUTOANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; EPITOPE; IMMUNOGLOBULIN A; IMMUNOGLOBULIN RECEPTOR; MITOCHONDRIAL PROTEIN; MITOCHONDRION ANTIBODY; OXIDOREDUCTASE; PYRUVATE DEHYDROGENASE; THIOCTIC ACID;

ANTIBODY TITER; ANTIGEN SPECIFICITY; APOPTOSIS; ARTICLE; AUTOIMMUNITY; BILE DUCT INJURY; DIAGNOSTIC PROCEDURE; DIAGNOSTIC VALUE; HUMAN; MITOCHONDRION; NONHUMAN; PRIMARY BILIARY CIRRHOSIS; PRIORITY JOURNAL; SEX DIFFERENCE; T LYMPHOCYTE; TISSUE SPECIFICITY;

EID: 10644282105     PISSN: 15677249     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mito.2004.07.024     Document Type: Article

References (59)

1. S.C. Afford J. Ahmed-Choudhury S. Randhawa C. Russell J. Youster H.A. Crosby A. Eliopoulos S.G. Hubscher L.S. Young D.H. Adams CD40 activation-induced, Fas-dependent apoptosis and NF-kappaB/AP-1 signaling in human intrahepatic biliary epithelial cells FASEB J. 15 2001 2345-2354
2. J. Bai J.A. Odin Apoptosis and the liver: Relation to autoimmunity and related conditions Autoimmun. Rev. 2 2003 36-42
3. M. Bomsel M. Heyman H. Hocini S. Lagaye L. Belec C. Dupont C. Desgranges Intracellular neutralization of HIV transcytosis across tight epithelial barriers by anti-HIV envelope protein dIgA or IgM Immunity 9 1998 277-287
4. P. Brandtzaeg P. Krajci M.E. Lamm Epithelial and hepatobiliary transport of polymeric immunoglobulins in: P.L. Ogra J. Mestecky M.E. Lamm W. Strober J.R. McGhee J. Bienenstock(Eds.) Handbook of Mucosal Immunology 1994 Academic Press San Diego 11-39
5. P. Brandtzaeg E.S. Baekkevold I.N. Farstad F.L. Jahnsen F.E. Johansen E.M. Nilsen T. Yamanaka Regional specialization in the mucosal immune system: What happens in the microcompartments? Immunol. Today 20 1999 141-151
6. W.R. Brown T.M. Kloppel The liver and IgA: Immunological, cell biological and clinical implications Hepatology 9 1989 763-784
7. S.F.A. Bruggraber P.S.C. Leung K. Amano C.B.S. Quan M.J. Kurth M.H. Nantz G.D. Benson J. Van De Water V. Luketic T. Roche A.A. Ansari R.L. Coppel M.E. Gershwin Autoreactivity to lipoate and a conjugated form of lipoate as hapten and hapten/carrier in primary biliary cirrhosis Gastroenterology 125 2003 1705-1713
8. R.L. Coppel L.J. McNeilage C.D. Surh J. Van de Water T.W. Spithill S. Whittingham M.E. Gershwin Primary structure of the human M2 mitochondrial autoantigen of primary biliary cirrhosis: Dihydrolipoamide acetyltransferase Proc. Natl. Acad. Sci. USA 85 1988 7317-7321
9. C.J. Danpure The molecular basis of alanine: Glyoxylate aminotransferase mistargeting: The most common single cause of primary hyperoxaluria type 1 J. Nephrol. 11 Suppl. 1 1998 8-12
10. P.A. Davis P. Leung M. Manns M. Kaplan S.J. Munoz F.A. Gorin E.R. Dickson E. Krawitt R. Coppel M.E. Gershwin M4 and M9 antibodies in the overlap syndrome of primary biliary cirrhosis and chronic active hepatitis: Epitopes or epiphenomena? Hepatology 16 1992 1128-1136
11. L. Dubel A. Tanaka P.S. Leung J. Van de Water R. Coppel T. Roche C. Johanet Y. Motokawa A. Ansari M.E. Gershwin Autoepitope mapping and reactivity of autoantibodies to the dihydrolipoamide dehydrogenase-binding protein (E3BP) and the glycine cleavage proteins in primary biliary cirrhosis Hepatology 29 1999 1013-1018
12. O. Epstein H.C. Thomas S. Sherlock Primary biliary cirrhosis is a dry gland syndrome with features of chronic graft-versus-host disease Lancet 1 1980 1166-1168
13. G.R. Flannery A.K. Burroughs P. Butler J. Chelliah J. Hamilton-Miller W. Brumfitt H. Baum Antimitochondrial antibodies in primary biliary cirrhosis recognize both specific peptides and shared epitopes of the M2 family of antigens Hepatology 10 1989 370-374
14. D.R. Fregeau P.A. Davis D.J. Danner A. Ansari R.L. Coppel E.R. Dickson M.E. Gershwin Antimitochondrial antibodies of primary biliary cirrhosis recognize dihydrolipoamide acyltransferase and inhibit enzyme function of the branched chain alpha-ketoacid dehydrogenase complex J. Immunol. 142 1989 3815-3820
15. N. Fukushima G. Nalbandian J. Van De Water K. White A.A. Ansari P. Leung T. Kenny S.G. Kamita B.D. Hammock R.L. Coppel F. Stevenson H. Ishibashi M.E. Gershwin Characterization of recombinant monoclonal IgA anti-PDC-E2 autoantibodies derived from patients with PBC Hepatology 36 2002 1383-1392
16. D.C. Gajdusek An auto-immune reaction against human tissue antigens in certain chronic diseases Nature 179 1957 666-668
17. M.E. Gershwin J. Van de Water Cholangiocytes and primary biliary cirrhosis: Prediction and predication J. Clin. Invest. 108 2001 187-188
18. M.E. Gershwin I.R. Mackay A. Sturgess R.L. Coppel Identification and specificity of a cDNA encoding the 70 kDa mitochondrial antigen recognized in primary biliary cirrhosis J. Immunol. 138 1987 3525-3531
19. M.E. Gershwin A.A. Ansari I.R. Mackay Y. Nakanuma A. Nishio M.J. Rowley R.L. Coppel Primary biliary cirrhosis: An orchestrated immune response against epithelial cells Immunol. Rev. 174 2000 210-225
20. D. Giffroy P.J. Courtoy J.P. Vaerman Polymeric IgA binding to the human pIgR elicits intracellular signalling, but fails to stimulate pIgR-transcytosis Scand. J. Immunol. 53 2001 56-64
21. K. Harada S. Ozaki M.E. Gershwin Y. Nakanuma Enhanced apoptosis relates to bile duct loss in primary biliary cirrhosis Hepatology 26 1997 1399-1405
22. K. Harada Y. Sudo N. Kono S. Ozaki K. Tsuneyama M.E. Gershwin Y. Nakanuma In situ nucleic acid detection of PDC-E2, BCOADC-E2, OGDC-E2, PDC-E1alpha, BCOADC-E1alpha, OGDC-E1, and the E3 binding protein (protein X) in primary biliary cirrhosis Hepatology 30 1999 36-45
23. M.J. Howard C. Fuller R.W. Broadhurst R.N. Perham J.G. Tang J. Quinn A.G. Diamond S.J. Yeaman Three-dimensional structure of the major autoantigen in primary biliary cirrhosis Gastroenterology 115 1998 139-146
24. H. Ishibashi M. Nakamura S. Shimoda M.E. Gershwin T cell immunity and primary biliary cirrhosis Autoimmun. Rev. 2 2003 19-24
25. E. Johnsson G. Andersson G. Lindahl L.O. Heden Identification of the IgA-binding region in streptococcal protein Arp J. Immunol. 153 1994 3557-3564
26. R.E. Joplin G.D. Johnson J.B. Matthews J. Hamburger J.G. Lindsay S.G. Hubscher A.J. Strain J.M. Neuberger Distribution of pyruvate dehydrogenase dihydrolipoamide acetyltransferase (PDC-E2) and another mitochondrial marker in salivary gland and biliary epithelium from patients with primary biliary cirrhosis Hepatology 19 1994 1375-1380
27. M.M. Kaplan Primary biliary cirrhosis N. Engl. J. Med. 335 1996 1570-1580
28. M.A. Kerr The structure and function of human IgA Biochem. J. 271 1990 285-296
29. H. Kita Z.X. Lian J. Van de Water X.S. He S. Matsumura M. Kaplan V. Luketic R.L. Coppel A.A. Ansari M.E. Gershwin Identification of HLA-A2-restricted CD8(+) cytotoxic T cell responses in primary biliary cirrhosis: T cell activation is augmented by immune complexes cross-presented by dendritic cells J. Exp. Med. 195 2002 113-123
30. H. Kita S. Matsumura X.S. He A.A. Ansari Z.X. Lian J. Van de Water R.L. Coppel M.M. Kaplan M.E. Gershwin Quantitative and functional analysis of PDC-E2-specific autoreactive cytotoxic T lymphocytes in primary biliary cirrhosis J. Clin. Invest. 109 2002 1231-1240
31. M. Koscec E. Koren M. Wolfson-Reichlin R.D. Fugate E. Trieu I.N. Targoff M. Reichlin Autoantibodies to ribosomal P proteins penetrate into live hepatocytes and cause cellular dysfunction in culture J. Immunol. 159 1997 2033-2041
32. P.S. Leung D.T. Chuang R.M. Wynn S. Cha D.J. Danner A. Ansari R.L. Coppel M.E. Gershwin Autoantibodies to BCOADC-E2 in patients with primary biliary cirrhosis recognize a conformational epitope Hepatology 22 1995 505-513
33. P.S.C. Leung P. Obermayer-Strab M.P. Manns A. Ansari M.E. Gershwin Inflammatory hepatobiliary cirrhosis R.R. Rich Clinical Immunology: Principles and Practice vol. I and II 2001 Mosby-Year Book, Inc St Louis, MO 881-8814
34. I.R. Mackay Primary biliary cirrhosis showing a high titer of autoantibody; report of a case N. Engl. J. Med. 258 1958 185-188
35. I.R. Mackay M.E. Gershwin Molecular basis of mitochondrial autoreactivity in primary biliary cirrhosis Immunol. Today 10 1989 315-318
36. A.C. Malmborg D.B. Shultz F. Luton K.E. Mostov E. Richly P.S. Leung G.D. Benson A.A. Ansari R.L. Coppel M.E. Gershwin J. Van de Water Penetration and co-localization in MDCK cell mitochondria of IgA derived from patients with primary biliary cirrhosis J. Autoimmun. 11 1998 573-580
37. S. Matsumura H. Kita X.S. He A.A. Ansari Z.X. Lian J. Van De Water K. Yamamoto T. Tsuji R.L. Coppel M. Kaplan M.E. Gershwin Comprehensive mapping of HLA-A0201-restricted CD8 T-cell epitopes on PDC-E2 in primary biliary cirrhosis Hepatology 36 2002 1125-1134
38. S. Matsumura J. Van De Water H. Kita R.L. Coppel T. Tsuji K. Yamamoto A.A. Ansari M.E. Gershwin Contribution to antimitochondrial antibody production: Cleavage of pyruvate dehydrogenase complex-E2 by apoptosis-related proteases Hepatology 35 2002 14-22
39. J.V. Metcalf H.C. Mitchison J.M. Palmer D.E. Jones M.F. Bassendine O.F. James Natural history of early primary biliary cirrhosis Lancet 348 1996 1399-1402
40. C. Migliaccio J. Van de Water A.A. Ansari M.M. Kaplan R.L. Coppel K.S. Lam R.K. Thompson F. Stevenson M.E. Gershwin Heterogeneous response of antimitochondrial autoantibodies and bile duct apical staining monoclonal antibodies to pyruvate dehydrogenase complex E2: The molecule versus the mimic Hepatology 33 2001 792-801
41. T. Mori K. Ono M. Hakozaki R. Kasukawa H. Kochi Autoantibodies of sera from patients with primary biliary cirrhosis recognize the alpha subunit of the decarboxylase component of human branched-chain 2-oxo-acid dehydrogenase complex J. Hepatol. 34 2001 799-804
42. S. Moteki P.S. Leung E.R. Dickson D.H. Van Thiel C. Galperin T. Buch D. Alarcon-Segovia D. Kershenobich K. Kawano R.L. Coppel M.E. Gershwin Epitope mapping and reactivity of autoantibodies to the E2 component of 2-oxoglutarate dehydrogenase complex in primary biliary cirrhosis using recombinant 2-oxoglutarate dehydrogenase complex Hepatology 23 1996 436-444
43. M.H. Nathanson J.L. Boyer Mechanisms and regulation of bile secretion Hepatology 14 1991 551-566
44. A. Nishio J. Van de Water P.S. Leung R. Joplin J.M. Neuberger J. Lake A. Bjorkland T.H. Totterman M. Peters H.J. Worman A.A. Ansari R.L. Coppel M.E. Gershwin Comparative studies of antimitochondrial autoantibodies in sera and bile in primary biliary cirrhosis Hepatology 25 1997 1085-1089
45. J.A. Odin R.C. Huebert L. Casciola-Rosen N.F. LaRusso A. Rosen Bcl-2-dependent oxidation of pyruvate dehydrogenase-E2, a primary biliary cirrhosis autoantigen, during apoptosis J. Clin. Invest. 108 2001 223-232
46. J. Quinn A.G. Diamond J.M. Palmer M.F. Bassendine O.F. James S.J. Yeaman Lipoylated and unlipoylated domains of human PDC-E2 as autoantigens in primary biliary cirrhosis: Significance of lipoate attachment Hepatology 18 1993 1384-1391
47. S. Reynoso-Paz P.S. Leung J. Van De Water A. Tanaka S. Munoz N. Bass K. Lindor P.J. Donald R.L. Coppel A.A. Ansari M.E. Gershwin Evidence for a locally driven mucosal response and the presence of mitochondrial antigens in saliva in primary biliary cirrhosis Hepatology 31 2000 24-29
48. C. Sandin S. Linse T. Areschoug J.M. Woof J. Reinholdt G. Lindahl Isolation and detection of human IgA using a streptococcal IgA-binding peptide J. Immunol. 169 2002 1357-1364
49. S. Shimoda M. Nakamura H. Ishibashi K. Hayashida Y. Niho HLA DRB4 0101-restricted immunodominant T cell autoepitope of pyruvate dehydrogenase complex in primary biliary cirrhosis: Evidence of molecular mimicry in human autoimmune diseases J. Exp. Med. 181 1995 1835-1845
50. S. Shimoda J. Van de Water A. Ansari M. Nakamura H. Ishibashi R.L. Coppel J. Lake E.B. Keeffe T.E. Roche M.E. Gershwin Identification and precursor frequency analysis of a common T cell epitope motif in mitochondrial autoantigens in primary biliary cirrhosis J. Clin. Invest. 102 1998 1831-1840
51. W. Song J.P. Vaerman K.E. Mostov Dimeric and tetrameric IgA are transcytosed equally by the polymeric Ig receptor J. Immunol. 155 1995 715-721
52. C.D. Surh R. Coppel M.E. Gershwin Structural requirement for autoreactivity on human pyruvate dehydrogenase-E2, the major autoantigen of primary biliary cirrhosis. Implication for a conformational autoepitope J. Immunol. 144 1990 3367-3374
53. A. Tanaka G. Nalbandian P.S. Leung G.D. Benson S. Munoz J.A. Findor A.D. Branch R.L. Coppel A.A. Ansari M.E. Gershwin Mucosal immunity and primary biliary cirrhosis: Presence of antimitochondrial antibodies in urine Hepatology 32 2000 910-915
54. A. Tanaka H. Miyakawa V.A. Luketic M. Kaplan W.B. Storch M.E. Gershwin The diagnostic value of anti-mitochondrial antibodies, especially in primary biliary cirrhosis Cell Mol. Biol. (Noisy-le-grand) 48 2002 295-299
55. K. Tsuneyama J. Van de Water P.S. Leung S. Cha Y. Nakanuma M. Kaplan R. De Lellis R. Coppel A. Ansari M.E. Gershwin Abnormal expression of the E2 component of the pyruvate dehydrogenase complex on the luminal surface of biliary epithelium occurs before major histocompatibility complex class II and BB1/B7 expression Hepatology 21 1995 1031-1037
56. J. Van de Water D. Fregeau P. Davis A. Ansari D. Danner P. Leung R. Coppel M.E. Gershwin Autoantibodies of primary biliary cirrhosis recognize dihydrolipoamide acetyltransferase and inhibit enzyme function J. Immunol. 141 1988 2321-2324
57. J. Van de Water M.E. Gershwin P. Leung A. Ansari R.L. Coppel The autoepitope of the 74-kDa mitochondrial autoantigen of primary biliary cirrhosis corresponds to the functional site of dihydrolipoamide acetyltransferase J. Exp. Med. 167 1988 1791-1799
58. J.G. Walker D. Doniach I.M. Roitt S. Sherlock Serological tests in diagnosis of primary biliary cirrhosis Lancet 39 1965 827-831
59. K. Yanase R.M. Smith A. Puccetti L. Jarett M.P. Madaio Receptor-mediated cellular entry of nuclear localizing anti-DNA antibodies via myosin 1 J. Clin. Invest. 100 1997 25-31