Cholangiocytes and primary biliary cirrhosis: Prediction and predication

Journal of Clinical Investigation

Volumn 108, Issue 2, 2001, Pages 187-188

  Gershwin, M Eric ^a   Van De Water, Judy ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MITOCHONDRION ANTIBODY;

ANTIGENICITY; APOPTOSIS; CATALYSIS; CELL STRUCTURE; GENE EXPRESSION; INCIDENCE; MODEL; NONHUMAN; NOTE; PREDICTION; PRIMARY BILIARY CIRRHOSIS; PRIORITY JOURNAL; PROTEIN MODIFICATION; PROTEIN STRUCTURE;

ACYLTRANSFERASES; ANIMALS; APOPTOSIS; AUTOANTIGENS; BILE DUCTS; BINDING SITES; CELL LINE; DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE; EPITHELIAL CELLS; GENE EXPRESSION REGULATION; GENES, BCL-2; GLUTATHIONE; HUMANS; LIVER CIRRHOSIS, BILIARY; MITOCHONDRIA; PYRUVATE DEHYDROGENASE COMPLEX; RATS; TRANSFECTION;

EID: 0034959159     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI200113583     Document Type: Note

References (15)

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3. Primary biliary cirrhosis: An orchestrated immune response against epithelial cells
4. Characterization of antimitochondrial antibodies in healthy adults
5. Natural history of early primary biliary cirrhosis
6. Heterogeneous response of antimitochondrial autoantibodies and bile duct apical staining monoclonal antibodies to pyruvate dehydrogenase complex E2: The molecule versus the mimic
7. Identification and precursor frequency analysis of a common T cell epitope motif in mitochondrial autoantigens in primary biliary cirrhosis
8. Bcl-2-dependent oxidation of pyruvate dehydrogenase-E2, a primary biliary cirrhosis autoantigen, during apoptosis
9. Glutathione depletion is associated with decreased Bcl-2 expression and increased apoptosis in cholangiocytes
10. The interaction of Bcl-2 and Bax regulates apoptosis in biliary epithelial cells of rats with obstructive jaundice
11. Hepatocytes in the bile duct-ligated rat express Bcl-2
12. Expression of antigens related to apoptosis and cell proliferation in chronic nonsuppurative destructive cholangitis in primary biliary cirrhosis
13. Expression of Bcl-2 familial proteins is reduced in small bile duct lesions of primary biliary cirrhosis
14. Bile duct cells in primary biliary cirrhosis are 'primed' for apoptosis
15. Immunization of experimental animals with dihydrolipoamide acetyl-transferase, as a purified recombinant polypeptide, generates mitochondrial antibodies but not primary biliary cirrhosis