Phosphatidylinositol 3-kinase offsets cAMP-mediated positive inotropic effect via inhibiting Ca2+ influx in cardiomyocytes

Circulation Research

Volumn 95, Issue 12, 2004, Pages 1183-1190

  Leblais, Veronique ^a,c   Jo, Su Hyun ^a,d   Chakir, Khalid ^a   Maltsev, Victor ^a   Zheng, Ming ^a,b   Crow, Michael T ^a   Wang, Wang ^a   Lakatta, Edward G ^a   Xiao, Rui Ping ^a,b  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b PEKING UNIVERSITY   (China)

^c INSERM   (France)

^d Jeju National University School of Medicine   (South Korea)

Author keywords

1 adrenergic receptor; Cardiac contractility; L type calcium current; PI3K; PKA

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; BETA 1 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR KINASE; CALCIUM CHANNEL L TYPE; CALCIUM ION; CYCLIC AMP; FORSKOLIN; GUANINE NUCLEOTIDE BINDING PROTEIN; ISOPRENALINE; NORADRENALIN; PERTUSSIS TOXIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOLAMBAN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; DRUG POTENTIATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; EXTRACELLULAR CALCIUM; HEART MUSCLE CELL; INOTROPISM; MUSCLE FIBER CONTRACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANDROSTADIENES; ANIMALS; CALCIUM; CALCIUM CHANNELS, L-TYPE; CALCIUM SIGNALING; CELLS, CULTURED; CHROMONES; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ENZYME ACTIVATION; FORSKOLIN; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; GTP-BINDING PROTEIN BETA SUBUNITS; GTP-BINDING PROTEIN GAMMA SUBUNITS; INSULIN-LIKE GROWTH FACTOR I; ION TRANSPORT; ISOPROTERENOL; MORPHOLINES; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; NOREPINEPHRINE; PATCH-CLAMP TECHNIQUES; PEPTIDE FRAGMENTS; PERTUSSIS TOXIN; PHOSPHORYLATION; PRAZOSIN; PROPANOLAMINES; PROTEIN PROCESSING, POST-TRANSLATIONAL; RATS; RECEPTORS, ADRENERGIC, BETA-1; RECOMBINANT PROTEINS; SECOND MESSENGER SYSTEMS; SIGNAL TRANSDUCTION;

EID: 10644241900     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000150049.74539.8a     Document Type: Article

References (41)

1. Rameh LE, Cantley LC. The role of phosphoinositide 3-kinase lipid products in cell function. J Biol Chem. 1999;274:8347-8350.
2. Toker A. Protein kinases as mediators of phosphoinositide 3-kinase signaling. Mol Pharmacol. 2000;57:652-658.
3. Kurosu H, Maehama T, Okada T, Yamamoto T, Hoshino S, Fukui Y, Ui M, Hazeki O, Katada T. Heterodimeric phosphoinositide 3-kinase consisting of p85 and p110β is synergistically activated by the βγ subunits of G proteins and phosphotyrosyl peptide. J Biol Chem. 1997;272:24252-24256.
4. βγ-induced activation of class I phosphoinositide 3-kinase isoforms beta and gamma. J Biol Chem. 1999;274:29311-29317.
5. i-dependent coupling to phosphatidylinositol 3′-kinase. Circ Res. 2000;87:1172-1179.
6. 2-adrenergic signaling in adult mouse cardiac myocytes. Proc Natl Acad Sci U S A. 2001;98:1607-1612.
7. 2-adrenergic stimulation. Circ Res. 2002;91:46-53.
8. 2+, contraction, and potential in cardiac myocytes. Am J Physiol. 1990;258:H574-86.
9. 2-adrenoceptor to a pertussis toxin-sensitive G protein in cardiac myocytes. Mol Pharmacol. 1995;47:322-329.
10. McGuire TF, Corey SJ, Sebti SM. Lovastatin inhibits platelet-derived growth factor (PDGF) stimulation of phosphatidylinositol 3-kinase activity as well as association of p85 subunit to tyrosine-phosphorylated PDGF receptor. J Biol Chem. 1993;268:22227-22230.
11. 2-adrenergic signaling. J Biol Chem. 1999;274:22048-22052.
12. 2-adrenergic cAMP signaling is uncoupled from phosphorylation of cytoplasmic proteins in canine heart. Circulation. 1999;99:2458-2465.
13. Foncea R, Andersson M, Ketterman A, Blakesley V, Sapag-Hagar M, Sugden PH, LeRoith D, Lavandero S. Insulin-like growth factor-I rapidly activates multiple signal transduction pathways in cultured rat cardiac myocytes. J Biol Chem. 1997;272:19115-19124.
14. Duan C, Bauchat JR, Hsieh T. Phosphatidylinositol 3-kinase is required for insulin-like growth factor-I-induced vascular smooth muscle cell proliferation and migration. Circ Res. 2000;86:15-23.
15. Koss KL, Kranias EG. Phospholamban: a prominent regulator of myocardial contractility. Circ Res. 1996;79:1059-1063.
16. 17 phospholamban phosphorylation in the β-adrenergic regulation of cardiac relaxation. Am J Physiol. 1999;276:H1625-33.
17. Koch WJ, Rockman HA, Samama P, Hamilton RA, Bond RA, Milano CA, Lefkowitz RJ. Cardiac function in mice overexpressing the β-adrenergic receptor kinase or a β ARK inhibitor. Science. 1995;268:1350-1353.
18. βγ-mediated signaling. J Biol Chem. 1994;269:6193-6197.
19. Naga Prasad SV, Barak LS, Rapacciuolo A, Caron MG, Rockman HA. Agonist-dependent recruitment of phosphoinositide 3-kinase to the membrane by β-adrenergic receptor kinase 1. A role in receptor sequestration. J Biol Chem. 2001;276:18953-18959.
20. Pitcher JA, Freedman NJ, Lefkowitz RJ. G protein-coupled receptor kinases. Annu Rev Biochem. 1998;67:653-692.
21. βγ sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101. Cell. 1997;89:105-114.
22. βγ stimulates phosphoinositide 3-kinase-gamma by direct interaction with two domains of the catalytic p110 subunit. J Biol Chem. 1998;273:7024-7029.
23. Morisco C, Zebrowski D, Condorelli G, Tsichlis P, Vatner SF, Sadoshima J. The Akt-glycogen synthase kinase 3beta pathway regulates transcription of atrial natriuretic factor induced by beta-adrenergic receptor stimulation in cardiac myocytes. J Biol Chem. 2000;275:14466-14475.
24. i proteins and its physiological relevance in murine cardiac myocytes. Circ Res. 1999;84:43-52.
25. 2-adrenergic modulation of cardiac excitation-contraction coupling. Am J Physiol. 1997;273:H1611-8.
26. 2+ channels. Biophys J. 2000;79:2547-2556.
27. 2-adrenergic receptors on cardiac myocyte apoptosis : role of a pertussis toxin-sensitive G protein. Circulation. 1999;100:2210-2212.
28. 2+/calmodulin kinase II. J Clin Invest. 2003;111:617-625.
29. Crackower MA, Oudit GY, Kozieradzki I, Sarao R, Sun H, Sasaki T, Hirsch E, Suzuki A, Shioi T, Irie-Sasaki J, Sah R, Cheng HY, Rybin VO, Lembo G, Fratta L, Oliveira-dos-Santos AJ, Benovic JL, Kahn CR, Izumo S, Steinberg SF, Wymann MP, Backx PH, Penninger JM. Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways. Cell. 2002;110:737-749.
30. Rybin VO, Xu X, Lisanti MP, Steinberg SF. Differential targeting of β-adrenergic receptor subtypes and adenylyl cyclase to cardiomyocyte caveolae. A mechanism to functionally regulate the cAMP signaling pathway. J Biol Chem. 2000;275:41447-41457.
31. Ostrom RS, Gregorian C, Drenan RM, Xiang Y, Regan JW, Insel PA. Receptor number and caveolar co-localization determine receptor coupling efficiency to adenylyl cyclase. J Biol Chem. 2001;276:42063-42069.
32. 1-adrenergic receptor. Involvement of G protein-coupled receptor kinases and cAMP-dependent protein kinase. J Biol Chem. 1995;270:17953-17961.
33. Brown LA, Humphrey SM, Harding SE. The anti-adrenergic effect of adenosine and its blockade by pertussis toxin: a comparative study in myocytes isolated from guinea-pig, rat and failing human hearts. Br J Pharmacol. 1990;101:484-488.
34. Mery PF, Abi-Gerges N, Vandecasteele G, Jurevicius J, Eschenhagen T, Fischmeister R. Muscarinic regulation of the L-type calcium current in isolated cardiac myocytes. Life Sci. 1997;60:1113-1120.
35. Pepe S, Xiao RP, Hohl C, Altschuld R, Lakatta EG. "Cross talk" between opioid peptide and adrenergic receptor signaling in isolated rat heart. Circulation. 1997;95:2122-2129.
36. Xiao RP, Pepe S, Spurgeon HA, Capogrossi MC, Lakatta EG. Opioid peptide receptor stimulation reverses β-adrenergic effects in rat heart cells. Am J Physiol. 1997;272:H797-805.
37. Naga Prasad SV, Esposito G, Mao L, Koch WJ, Rockman HA. Gβγ-dependent phosphoinositide 3-kinase activation in hearts with in vivo pressure overload hypertrophy. J Biol Chem. 2000;275:4693-4698.
38. 1-subtype in the rat heart. J Mol Cell Cardiol. 2001;33:561-573.
39. Nienaber JJ, Tachibana H, Naga Prasad SV, Esposito G, Wu D, Mao L, Rockman HA. Inhibition of receptor-localized PI3K preserves cardiac β-adrenergic receptor function and ameliorates pressure overload heart failure. J Clin Invest. 2003;112:1067-1079.
40. 3-adrenoceptors and altered contractile response to inotropic amines in human failing myocardium. Circulation. 2001;103:1649-1655.
41. 3-adrenergic receptor in the failing canine myocardium. Circ Res. 2001;89:599-606.