Design and synthesis of a potent and selective peptidomimetic inhibitor of caspase-3

Journal of Medicinal Chemistry

Volumn 47, Issue 26, 2004, Pages 6455-6458

  Micale, Nicola ^a,d   Vairagoundar, Rajendran ^b   Yakovlev, Alexander G ^c   Kozikowski, Alan P ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b ChemBridge Research Laboratories   (United States)

^c GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^d Dipartimento Farmaco Chimico   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLAMINO N [1 [[(2 HYDROXY 5 OXO TETRAHYDROFURAN 3 YL)CARBAMOYL]METHYL] 2 OXO 5 PHENYL 2,3 DIHYDRO 1H BENZ[E][1,4]DIAZEPIN 3 YL]SUCCINAMIC ACID; BENZODIAZEPINE DERIVATIVE; CASPASE 3; CASPASE 3 INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; DRUG CONFORMATION; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION;

4-BUTYROLACTONE; BENZODIAZEPINONES; CASPASE 3; CASPASES; CELL LINE, TUMOR; CELL MEMBRANE PERMEABILITY; HUMANS; MOLECULAR CONFORMATION; OLIGOPEPTIDES; RECOMBINANT PROTEINS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 10644225944     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm049248f     Document Type: Article

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