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Volumn 35, Issue 4, 2003, Pages 193-200

Treatment Strategies for Organ Fibrosis Based on Regulation of Collagen Metabolism

Author keywords

Collagen; Fibrosis; Matrix metalloproteinase; Smad; TGF

Indexed keywords

ALPHA INTERFERON; COLLAGEN; COLLAGEN TYPE 1; COLLAGENASE 3; CYTOKINE; GAMMA INTERFERON; GROWTH FACTOR; INTERLEUKIN 10; INTERSTITIAL COLLAGENASE; PROTEIN INHIBITOR; RECOMBINANT INTERSTITIAL COLLAGENASE; RECOMBINANT PROTEIN; RECOMBINANT SCATTER FACTOR; SCATTER FACTOR; SMAD PROTEIN; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 1042302821     PISSN: 0916572X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (2)

References (63)
  • 1
    • 84991134895 scopus 로고
    • Fibrogenic processes during tissue repair
    • Nimni, M.E. (ed). CRC Press, Boca Raton
    • Diegelmann, R.F., Lindblad, W.J., and Cohen, I.K. (1988) Fibrogenic processes during tissue repair. In: Nimni, M.E. (ed) Collagen. Biochemistry and Biomechanics. vol. 2. CRC Press, Boca Raton, pp. 113-131
    • (1988) Collagen. Biochemistry and Biomechanics , vol.2 , pp. 113-131
    • Diegelmann, R.F.1    Lindblad, W.J.2    Cohen, I.K.3
  • 2
    • 0025344441 scopus 로고
    • Complex and diversified regulatory programs control the expression of vertebrate collagen genes
    • Ramirez, F. and Di Liberto, M. (1990) Complex and diversified regulatory programs control the expression of vertebrate collagen genes. FASEB J. 4, 1616-1623
    • (1990) FASEB J. , vol.4 , pp. 1616-1623
    • Ramirez, F.1    Di Liberto, M.2
  • 3
    • 0025375617 scopus 로고
    • Transforming growth factor-β. Major role in regulation of extracellular matrix
    • Roberts, A.B., Heine, V.I., Flanders, K.C., and Sporn, M. B. (1990) Transforming growth factor-β. Major role in regulation of extracellular matrix. Ann. NY Acad. Sci. 580, 225-232
    • (1990) Ann. NY Acad. Sci. , vol.580 , pp. 225-232
    • Roberts, A.B.1    Heine, V.I.2    Flanders, K.C.3    Sporn, M.B.4
  • 4
    • 0031438047 scopus 로고    scopus 로고
    • TGF-β signaling from cell membrane to nucleus via Smad proteins
    • Heldin, C.-H., Miyazono, K., ten Dijke, P. (1997) TGF-β signaling from cell membrane to nucleus via Smad proteins. Nature 390, 465-471
    • (1997) Nature , vol.390 , pp. 465-471
    • Heldin, C.-H.1    Miyazono, K.2    Ten Dijke, P.3
  • 5
    • 0032737234 scopus 로고    scopus 로고
    • Transcriptional activation of type I collagen gene during hepatic fibrogenesis
    • Inagaki, Y., Nemoto, T., Greenwel, P., and Ramirez, F. (1999) Transcriptional activation of type I collagen gene during hepatic fibrogenesis. Connective Tissue 31, 169-173
    • (1999) Connective Tissue , vol.31 , pp. 169-173
    • Inagaki, Y.1    Nemoto, T.2    Greenwel, P.3    Ramirez, F.4
  • 6
    • 0036324743 scopus 로고    scopus 로고
    • Transcriptional regulation of type I collagen gene expression by transforming growth factor-β/Smad signaling and its antagonistic factors
    • Inagaki, Y., Nemoto, T., and Nakao, A. (2002) Transcriptional regulation of type I collagen gene expression by transforming growth factor-β/Smad signaling and its antagonistic factors. Connective Tissue 34, 139-146
    • (2002) Connective Tissue , vol.34 , pp. 139-146
    • Inagaki, Y.1    Nemoto, T.2    Nakao, A.3
  • 7
    • 0028176086 scopus 로고
    • Transforming growth factor-β stimulates α2 (I) collagen gene expression through a cis-acting element that contains an Sp1 binding site
    • Inagaki, Y., Truter, S., and Ramirez, F. (1994) Transforming growth factor-β stimulates α2 (I) collagen gene expression through a cis-acting element that contains an Sp1 binding site. J. Biol. Chem. 269, 14828-14834
    • (1994) J. Biol. Chem. , vol.269 , pp. 14828-14834
    • Inagaki, Y.1    Truter, S.2    Ramirez, F.3
  • 8
    • 0028978771 scopus 로고
    • Regulation of the α2 (I) collagen gene transcription in fatstoring cells derived from a cirrhotic liver
    • Inagaki, Y., Truter, S., Greenwel, P., Rojkind, M., Unoura, M., Kobayashi, K., and Ramirez, F. (1995) Regulation of the α2 (I) collagen gene transcription in fatstoring cells derived from a cirrhotic liver. Hepatology 22, 573-579
    • (1995) Hepatology , vol.22 , pp. 573-579
    • Inagaki, Y.1    Truter, S.2    Greenwel, P.3    Rojkind, M.4    Unoura, M.5    Kobayashi, K.6    Ramirez, F.7
  • 9
    • 0030854850 scopus 로고    scopus 로고
    • Sp1 is required for the early response of α2 (I) collagen to transforming factor-β1
    • Greenwel, P., Inagaki, Y., Hu, W., Walsh, M., and Ramirez, F. (1997) Sp1 is required for the early response of α2 (I) collagen to transforming factor-β1. J. Biol. Chem. 272, 19738-19745
    • (1997) J. Biol. Chem. , vol.272 , pp. 19738-19745
    • Greenwel, P.1    Inagaki, Y.2    Hu, W.3    Walsh, M.4    Ramirez, F.5
  • 12
    • 0032921867 scopus 로고    scopus 로고
    • Stimulation of type I collagen transcription in human skin fibroblasts by transforming growth factor-β: Involvement of Smad3
    • Chen, S.-J., Yuan, W., Mori, Y., Levenson, A., Trojanowska, M., and Varga, J. (1999) Stimulation of type I collagen transcription in human skin fibroblasts by transforming growth factor-β: involvement of Smad3. J. Invest. Dermatol. 112, 49-57
    • (1999) J. Invest. Dermatol. , vol.112 , pp. 49-57
    • Chen, S.-J.1    Yuan, W.2    Mori, Y.3    Levenson, A.4    Trojanowska, M.5    Varga, J.6
  • 13
    • 0034011221 scopus 로고    scopus 로고
    • Interaction of Smad3 with a proximal Smad-binding element of the human α2 (I) procollagen gene promoter required for transcriptional activation by TGF-β
    • Chen, S.-J., Yuan, W., Lo, S., Trojanowska, M., and Varga, J. (2000) Interaction of Smad3 with a proximal Smad-binding element of the human α2 (I) procollagen gene promoter required for transcriptional activation by TGF-β. J. Cell. Physiol. 183, 381-392
    • (2000) J. Cell. Physiol. , vol.183 , pp. 381-392
    • Chen, S.-J.1    Yuan, W.2    Lo, S.3    Trojanowska, M.4    Varga, J.5
  • 14
    • 0034671506 scopus 로고    scopus 로고
    • Synergistic cooperation between Sp1 and Smad3/Smad4 mediates transforming growth factor β1 stimulation of α2 (I)-collagen (COL1A2) transcription
    • Zhang, W., Oul, J., Inagaki, Y., Greenwel, P., and Ramirez, F. (2000) Synergistic cooperation between Sp1 and Smad3/Smad4 mediates transforming growth factor β1 stimulation of α2 (I)-collagen (COL1A2) transcription. J. Biol. Chem. 275, 39237-39245
    • (2000) J. Biol. Chem. , vol.275 , pp. 39237-39245
    • Zhang, W.1    Oul, J.2    Inagaki, Y.3    Greenwel, P.4    Ramirez, F.5
  • 15
    • 0035844276 scopus 로고    scopus 로고
    • Interaction between GC box binding factors and Smad proteins modulates cell lineage-specific α2 (I) collagen gene transcription
    • Inagaki, Y., Nemoto, T., Nakao, A., ten Dijke, P., Kobayashi, K., Takehara, K., and Greenwel, P. (2001) Interaction between GC box binding factors and Smad proteins modulates cell lineage-specific α2 (I) collagen gene transcription. J. Biol. Chem. 276, 16573-16579
    • (2001) J. Biol. Chem. , vol.276 , pp. 16573-16579
    • Inagaki, Y.1    Nemoto, T.2    Nakao, A.3    Ten Dijke, P.4    Kobayashi, K.5    Takehara, K.6    Greenwel, P.7
  • 16
    • 0035831503 scopus 로고    scopus 로고
    • Sp1 and Smad proteins cooperate to mediate transforming growth factor-β1-induced α2 (I) collagen expression in human glomerular mesangial cells
    • Poncelet, A.-C. and Schnaper, H.W. (2001) Sp1 and Smad proteins cooperate to mediate transforming growth factor-β1-induced α2 (I) collagen expression in human glomerular mesangial cells. J. Biol. Chem. 276, 6983-6992
    • (2001) J. Biol. Chem. , vol.276 , pp. 6983-6992
    • Poncelet, A.-C.1    Schnaper, H.W.2
  • 17
    • 0035120166 scopus 로고    scopus 로고
    • Constitutive phosphorylation and nuclear localization of Smad3 are correlated with increased collagen gene transcription in activated hepatic stellate cells
    • Inagaki, Y., Mamura, M., Kanamaru, Y., Greenwel, P., Nemoto, T., Takehara, K., ten Dijke, P., and Nakao, A. (2001) Constitutive phosphorylation and nuclear localization of Smad3 are correlated with increased collagen gene transcription in activated hepatic stellate cells. J. Cell. Physiol. 187, 117-123
    • (2001) J. Cell. Physiol. , vol.187 , pp. 117-123
    • Inagaki, Y.1    Mamura, M.2    Kanamaru, Y.3    Greenwel, P.4    Nemoto, T.5    Takehara, K.6    Ten Dijke, P.7    Nakao, A.8
  • 20
    • 0034691764 scopus 로고    scopus 로고
    • Smad-dependent stimulation of type I collagen gene expression in human skin fibroblasts by TGF-β involves functional cooperation with p300/CBP transcriptional coactivators
    • Ghosh, A.K., Yuan, W., Mori, Y., and Varga, J. (2000) Smad-dependent stimulation of type I collagen gene expression in human skin fibroblasts by TGF-β involves functional cooperation with p300/CBP transcriptional coactivators. Oncogene 19, 3546-3555
    • (2000) Oncogene , vol.19 , pp. 3546-3555
    • Ghosh, A.K.1    Yuan, W.2    Mori, Y.3    Varga, J.4
  • 21
    • 0034596993 scopus 로고    scopus 로고
    • Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15 (Ink4B) transcription in response to TGF-beta
    • Feng, X.-H., Lin, X., and Derynck, R. (2000) Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15 (Ink4B) transcription in response to TGF-beta. EMBO J. 19, 5178-5193
    • (2000) EMBO J. , vol.19 , pp. 5178-5193
    • Feng, X.-H.1    Lin, X.2    Derynck, R.3
  • 22
    • 0035022130 scopus 로고    scopus 로고
    • Prevention of rat hepatic fibrosis by the protease inhibitor, camostat mesilate, via reduced generation of active TGF-β
    • Okuno, M., Akita, K., Moriwaki, H., Kawada, N., Ikeda, K., Kaneda, K., Suzuki, Y., and Kojima, S. (2001) Prevention of rat hepatic fibrosis by the protease inhibitor, camostat mesilate, via reduced generation of active TGF-β. Gastroenterology 120, 1784-1800
    • (2001) Gastroenterology , vol.120 , pp. 1784-1800
    • Okuno, M.1    Akita, K.2    Moriwaki, H.3    Kawada, N.4    Ikeda, K.5    Kaneda, K.6    Suzuki, Y.7    Kojima, S.8
  • 23
    • 0033515099 scopus 로고    scopus 로고
    • Blockade of type β transforming growth factor signaling prevents liver fibrosis and dysfunction in the rat
    • Qi, Z., Atsuchi, N., Ooshima, A., Takeshita, A., and Ueno, H. (1999) Blockade of type β transforming growth factor signaling prevents liver fibrosis and dysfunction in the rat. Proc. Natl. Acad. Sci. USA 96, 2345-2349
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 2345-2349
    • Qi, Z.1    Atsuchi, N.2    Ooshima, A.3    Takeshita, A.4    Ueno, H.5
  • 24
    • 0033854016 scopus 로고    scopus 로고
    • Inhibition of transforming growth factor-β prevents progression of liver fibrosis and enhances hepatocyte regeneration in demethylnitrosamine-treated rats
    • Nakamura, T., Sakata, R., Ueno, T., Sata, M., and Ueno, H. (2000) Inhibition of transforming growth factor-β prevents progression of liver fibrosis and enhances hepatocyte regeneration in demethylnitrosamine-treated rats. Hepatology 32, 247-255
    • (2000) Hepatology , vol.32 , pp. 247-255
    • Nakamura, T.1    Sakata, R.2    Ueno, T.3    Sata, M.4    Ueno, H.5
  • 25
    • 0033607304 scopus 로고    scopus 로고
    • In vivo inhibition of rat stellate cell activation by soluble transforming growth factor β type II receptor: A potential new therapy for hepatic fibrosis
    • George, J., Roulot, D., Koteliansky, V.E., and Bissell, D. M. (1999) In vivo inhibition of rat stellate cell activation by soluble transforming growth factor β type II receptor: A potential new therapy for hepatic fibrosis. Proc. Natl. Acad. Sci. USA 96, 12719-12724
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 12719-12724
    • George, J.1    Roulot, D.2    Koteliansky, V.E.3    Bissell, D.M.4
  • 26
    • 0033984336 scopus 로고    scopus 로고
    • A soluble transforming growth factor beta receptor expressed in muscle prevents liver fibrogenesis and dysfunction in rats
    • Ueno, H., Sakamoto, T., Nakamura, T., Qi, Z., Atsuchi, N., Takeshita, A., Shimizu, K., and Ohashi, H. (2000) A soluble transforming growth factor beta receptor expressed in muscle prevents liver fibrogenesis and dysfunction in rats. Hum. Gene Ther. 11, 33-42
    • (2000) Hum. Gene Ther. , vol.11 , pp. 33-42
    • Ueno, H.1    Sakamoto, T.2    Nakamura, T.3    Qi, Z.4    Atsuchi, N.5    Takeshita, A.6    Shimizu, K.7    Ohashi, H.8
  • 27
    • 0032719815 scopus 로고    scopus 로고
    • Transient gene transfer and expression of Smad7 prevents bleomycin-induced lung fibrosis in mice
    • Nakao, A., Fujii, M., Matsumura, R., Kumano, K., Saito, Y., Miyazono, K., and Iwamoto, I. (1999) Transient gene transfer and expression of Smad7 prevents bleomycin-induced lung fibrosis in mice. J. Clin. Invest. 104, 5-11
    • (1999) J. Clin. Invest. , vol.104 , pp. 5-11
    • Nakao, A.1    Fujii, M.2    Matsumura, R.3    Kumano, K.4    Saito, Y.5    Miyazono, K.6    Iwamoto, I.7
  • 28
    • 0025152119 scopus 로고
    • Tumor necrosis factor-α and interferon-γ suppress the activation of human type I collagen gene expression by transforming growth factor-β1. Evidence for two distinct mechanisms of inhibition at the transcriptional and post-transcriptional levels
    • Kahari, V.M., Chen, Y.Q., Su, M.W., Ramirez, F., and Uitto, J. (1990) Tumor necrosis factor-α and interferon-γ suppress the activation of human type I collagen gene expression by transforming growth factor-β1. Evidence for two distinct mechanisms of inhibition at the transcriptional and post-transcriptional levels. J. Clin. Invest. 86, 1489-1495
    • (1990) J. Clin. Invest. , vol.86 , pp. 1489-1495
    • Kahari, V.M.1    Chen, Y.Q.2    Su, M.W.3    Ramirez, F.4    Uitto, J.5
  • 29
    • 0028850885 scopus 로고
    • Overlapping pathways mediate the opposing actions of tumor necrosis factor-α and transforming growth factor-β on α2 (I) collagen gene transcription
    • Inagaki, Y., Truter, S., Tanaka, S., Di Liberto, M., and Ramirez, F. (1995) Overlapping pathways mediate the opposing actions of tumor necrosis factor-α and transforming growth factor-β on α2 (I) collagen gene transcription. J. Biol. Chem. 270, 3353-3358
    • (1995) J. Biol. Chem. , vol.270 , pp. 3353-3358
    • Inagaki, Y.1    Truter, S.2    Tanaka, S.3    Di Liberto, M.4    Ramirez, F.5
  • 32
    • 0034730629 scopus 로고    scopus 로고
    • Tumor necrosis factor-α inhibits transforming growth factor-β/Smad signaling in human dermal fibroblasts via. AP-1 activation
    • Verrecchia, F., Pessah, M., Atfi, A., and Mauviel, A. (2000) Tumor necrosis factor-α inhibits transforming growth factor-β/Smad signaling in human dermal fibroblasts via. AP-1 activation. J. Biol. Chem. 275, 30226-30231
    • (2000) J. Biol. Chem. , vol.275 , pp. 30226-30231
    • Verrecchia, F.1    Pessah, M.2    Atfi, A.3    Mauviel, A.4
  • 33
    • 0026782189 scopus 로고
    • Inhibition of rat hepatic lipocyte activation in culture by interferon-γ
    • Rockey, D.C., Maher, J.J., Jarnagin, W.R., Gabbiani, G., and Friedman, S.L. (1992) Inhibition of rat hepatic lipocyte activation in culture by interferon-γ. Hepatology 16, 776-784
    • (1992) Hepatology , vol.16 , pp. 776-784
    • Rockey, D.C.1    Maher, J.J.2    Jarnagin, W.R.3    Gabbiani, G.4    Friedman, S.L.5
  • 34
    • 0028941524 scopus 로고
    • Interferon alpha and gamma inhibit proliferation and collagen synthesis of human Ito cells in culture
    • Mallat, A., Preaux, A.-M., Blazejewski, S., Rosenbaum, J., Dhumeaux, D., and Mavier, P. (1995) Interferon alpha and gamma inhibit proliferation and collagen synthesis of human Ito cells in culture. Hepatology 21, 1003-1010
    • (1995) Hepatology , vol.21 , pp. 1003-1010
    • Mallat, A.1    Preaux, A.-M.2    Blazejewski, S.3    Rosenbaum, J.4    Dhumeaux, D.5    Mavier, P.6
  • 36
    • 0029887586 scopus 로고    scopus 로고
    • Interferon gamma decreases hepatic stellate cell activation and extracellular matrix deposition in rat liver fibrosis
    • Baroni, G.S., D'Ambrosio, L., Curto, P., Casini, A., Mancini, R., Jezequel, A.M., and Benedetti, A. (1996) Interferon gamma decreases hepatic stellate cell activation and extracellular matrix deposition in rat liver fibrosis. Hepatology 23, 1189-1199
    • (1996) Hepatology , vol.23 , pp. 1189-1199
    • Baroni, G.S.1    D'Ambrosio, L.2    Curto, P.3    Casini, A.4    Mancini, R.5    Jezequel, A.M.6    Benedetti, A.7
  • 37
    • 0031003583 scopus 로고    scopus 로고
    • Lobular - But not periovular-inhibition of collagen deposition in the liver of S. mansoni infected mice using interferon-γ
    • Lortat-Jacob, H., Baltzer, F., Desmouliere, A., Peyrol, S., and Grimaud, J.A. (1997) Lobular-but not periovular -inhibition of collagen deposition in the liver of S. mansoni infected mice using interferon-γ. J. Hepatol. 26, 894-903
    • (1997) J. Hepatol. , vol.26 , pp. 894-903
    • Lortat-Jacob, H.1    Baltzer, F.2    Desmouliere, A.3    Peyrol, S.4    Grimaud, J.A.5
  • 38
    • 0032030879 scopus 로고    scopus 로고
    • Interferon gamma treatment prevents collagen gene expression without affecting transforming growth factor-β1 expression in pig serum-induced rat liver fibrosis in vivo
    • Sakaida, I., Uchida, K., Matsumura, Y., and Okita, K. (1998) Interferon gamma treatment prevents collagen gene expression without affecting transforming growth factor-β1 expression in pig serum-induced rat liver fibrosis in vivo. J. Hepatol. 28, 471-479
    • (1998) J. Hepatol. , vol.28 , pp. 471-479
    • Sakaida, I.1    Uchida, K.2    Matsumura, Y.3    Okita, K.4
  • 39
    • 0031913727 scopus 로고    scopus 로고
    • A proximal element within the human α2 (I) collagen (COL1A2) promoter, distinct from the tumor necrosis factor-α response element, mediates transcriptional repression by interferon-γ
    • Higashi, K., Kouba, D.J., Song, Y.-J., Uitto, J., and Mauviel, A. (1998) A proximal element within the human α2 (I) collagen (COL1A2) promoter, distinct from the tumor necrosis factor-α response element, mediates transcriptional repression by interferon-γ. Matrix Biol. 16, 447-456
    • (1998) Matrix Biol. , vol.16 , pp. 447-456
    • Higashi, K.1    Kouba, D.J.2    Song, Y.-J.3    Uitto, J.4    Mauviel, A.5
  • 40
    • 0037900063 scopus 로고    scopus 로고
    • Y-boxbinding protein YB-1 mediates transcriptional repression of human α2 (I) collagen gene expression by interferon-γ
    • Higashi, K., Inagaki, Y., Suzuki, N., Mitsui, S., Mauviel, A., Kaneko, H., and Nakatsuka, I. (2003) Y-boxbinding protein YB-1 mediates transcriptional repression of human α2 (I) collagen gene expression by interferon-γ. J. Biol. Chem. 278, 5156-5162
    • (2003) J. Biol. Chem. , vol.278 , pp. 5156-5162
    • Higashi, K.1    Inagaki, Y.2    Suzuki, N.3    Mitsui, S.4    Mauviel, A.5    Kaneko, H.6    Nakatsuka, I.7
  • 41
    • 0033602101 scopus 로고    scopus 로고
    • Inhibition of transforming growth factor-β/Smad signalling by the interferon-γ/STAT pathway
    • Ulloa, L., Doody, J., and Massague, J. (1999) Inhibition of transforming growth factor-β/Smad signalling by the interferon-γ/STAT pathway. Nature 397, 710-713
    • (1999) Nature , vol.397 , pp. 710-713
    • Ulloa, L.1    Doody, J.2    Massague, J.3
  • 42
    • 0035815696 scopus 로고    scopus 로고
    • Antagonistic regulation of type I collagen gene expression by interferon-γ and transforming growth factor-β. Integration at the level of p300/CBP transcriptional coactivators
    • Ghosh, A.K., Yuan, W., Mori, Y., Chen, S.J., and Varga, J. (2001) Antagonistic regulation of type I collagen gene expression by interferon-γ and transforming growth factor-β. Integration at the level of p300/CBP transcriptional coactivators. J. Biol. Chem. 276, 11041-11048
    • (2001) J. Biol. Chem. , vol.276 , pp. 11041-11048
    • Ghosh, A.K.1    Yuan, W.2    Mori, Y.3    Chen, S.J.4    Varga, J.5
  • 43
    • 0242384852 scopus 로고    scopus 로고
    • Interferon-γ interferes with transforming growth factor-β signaling through direct interaction of YB-1 with Smad3
    • in press
    • Higashi, K., Inagaki, Y., Fujimori, K., Nakao, A., Kaneko, H., and Nakatsuka, I. (2003) Interferon-γ interferes with transforming growth factor-β signaling through direct interaction of YB-1 with Smad3. J. Biol. Chem. (in press)
    • (2003) J. Biol. Chem.
    • Higashi, K.1    Inagaki, Y.2    Fujimori, K.3    Nakao, A.4    Kaneko, H.5    Nakatsuka, I.6
  • 44
    • 0028970295 scopus 로고
    • Improvement of liver fibrosis in chronic hepatitis patients treated with natural interferon alpha
    • Hiramatsu, N., Hayashi, N., Kasahara, A., Hagiwara, H., Takehara, T., Haruna, Y., and Naito, M. (1995) Improvement of liver fibrosis in chronic hepatitis patients treated with natural interferon alpha. Hepatology 22, 135-142
    • (1995) Hepatology , vol.22 , pp. 135-142
    • Hiramatsu, N.1    Hayashi, N.2    Kasahara, A.3    Hagiwara, H.4    Takehara, T.5    Haruna, Y.6    Naito, M.7
  • 45
    • 0029145767 scopus 로고
    • Long-term decrease in serum N-terminal propeptide of type III procollagen in patients with chronic hepatitis C treated with interferon alpha
    • Suou, T., Hosho, K., Kishimoto, Y., Horie, Y., and Kawasaki, H. (1995) Long-term decrease in serum N-terminal propeptide of type III procollagen in patients with chronic hepatitis C treated with interferon alpha. Hepatology 22, 426-431
    • (1995) Hepatology , vol.22 , pp. 426-431
    • Suou, T.1    Hosho, K.2    Kishimoto, Y.3    Horie, Y.4    Kawasaki, H.5
  • 46
    • 0027491648 scopus 로고
    • Interferon-α 2b therapy reduces liver fibrosis in chronic non-A, non-B hepatitis: A quantitative histological evaluation
    • Manabe, N., Chevallier, M., Chossegros, P., Causse, X., Guerret, S., Trepo, C., and Grimaudo, J.A. (1993) Interferon-α 2b therapy reduces liver fibrosis in chronic non-A, non-B hepatitis: a quantitative histological evaluation. Hepatology 18, 1344-1349
    • (1993) Hepatology , vol.18 , pp. 1344-1349
    • Manabe, N.1    Chevallier, M.2    Chossegros, P.3    Causse, X.4    Guerret, S.5    Trepo, C.6    Grimaudo, J.A.7
  • 47
    • 0032124863 scopus 로고    scopus 로고
    • Changes in liver fibrosis at the end of alpha interferon therapy and 6 to 18 months later in patients with chronic hepatitis C: Quantitative assessment by a morphometric method
    • Duchatelle, V., Marcellin, P., Giostra, E., Bregeaud, L., Pouteau, M., Boyer, N., and Auperin, A. (1998) Changes in liver fibrosis at the end of alpha interferon therapy and 6 to 18 months later in patients with chronic hepatitis C: quantitative assessment by a morphometric method. J. Hepatol. 29, 20-28
    • (1998) J. Hepatol. , vol.29 , pp. 20-28
    • Duchatelle, V.1    Marcellin, P.2    Giostra, E.3    Bregeaud, L.4    Pouteau, M.5    Boyer, N.6    Auperin, A.7
  • 49
    • 0032955814 scopus 로고    scopus 로고
    • Reduced plasma transforming growth factor-β1 levels in patients with chronic hepatitis C after interferon-α therapy: Association with regression of hepatic fibrosis
    • Tsushima, H., Kawata, S., Tamura, S., Ito, N., Shirai, Y., Kiso, S., Doi, Y., Yamada, A., Oshikawa, O., and Matsuzawa, Y. (1999) Reduced plasma transforming growth factor-β1 levels in patients with chronic hepatitis C after interferon-α therapy: association with regression of hepatic fibrosis. J. Hepatol. 30, 1-7
    • (1999) J. Hepatol. , vol.30 , pp. 1-7
    • Tsushima, H.1    Kawata, S.2    Tamura, S.3    Ito, N.4    Shirai, Y.5    Kiso, S.6    Doi, Y.7    Yamada, A.8    Oshikawa, O.9    Matsuzawa, Y.10
  • 51
    • 0034022483 scopus 로고    scopus 로고
    • Interleukin 10 treatment reduces fibrosis in patients with chronic hepatitis C: A pilot trial of interferon nonresponders
    • Nelson, D.R., Lauwers, G.Y., Lau, J.Y.N., and Davis, G. L. (2000) Interleukin 10 treatment reduces fibrosis in patients with chronic hepatitis C: a pilot trial of interferon nonresponders. Gastroenterology 118, 655-660
    • (2000) Gastroenterology , vol.118 , pp. 655-660
    • Nelson, D.R.1    Lauwers, G.Y.2    Lau, J.Y.N.3    Davis, G.L.4
  • 52
  • 54
    • 0030741845 scopus 로고    scopus 로고
    • Tissue inhibitor of metalloproteinese-1 in the liver of patients with chronic liver disease
    • Murawaki, Y., Ikuta, Y., Idobe, Y., Kitamura, Y., and Kawasaki, H. (1997) Tissue inhibitor of metalloproteinese-1 in the liver of patients with chronic liver disease. J. Hepatol. 26, 1213-1219
    • (1997) J. Hepatol. , vol.26 , pp. 1213-1219
    • Murawaki, Y.1    Ikuta, Y.2    Idobe, Y.3    Kitamura, Y.4    Kawasaki, H.5
  • 57
    • 0029817895 scopus 로고    scopus 로고
    • Antifibrotic effect of a deletion variant of hepatocyte growth factor on liver fibrosis in rats
    • Yasuda, H., Imai, E., Shiota, A., Fujise, N., Morinaga, T., and Higashio, K. (1996) Antifibrotic effect of a deletion variant of hepatocyte growth factor on liver fibrosis in rats. Hepatology 24, 636-642
    • (1996) Hepatology , vol.24 , pp. 636-642
    • Yasuda, H.1    Imai, E.2    Shiota, A.3    Fujise, N.4    Morinaga, T.5    Higashio, K.6
  • 58
    • 0032080835 scopus 로고    scopus 로고
    • Hepatocyte growth factor prevents renal fibrosis and dysfunction in a mouse model of chronic renal disease
    • Mizuno, S., Kurosaw, T., Matsumoto, K., Mizuno-Horikawa, Y., Okamoto, M., and Nakamura, T. (1998) Hepatocyte growth factor prevents renal fibrosis and dysfunction in a mouse model of chronic renal disease. J. Clin. Invest. 101, 1827-1834
    • (1998) J. Clin. Invest. , vol.101 , pp. 1827-1834
    • Mizuno, S.1    Kurosaw, T.2    Matsumoto, K.3    Mizuno-Horikawa, Y.4    Okamoto, M.5    Nakamura, T.6
  • 59
    • 0033746079 scopus 로고    scopus 로고
    • Endogenous hepatocyte growth factor ameliorates chronic renal injury by activating matrix degradation pathways
    • Liu, Y., Rajur, K., Tolbert, E., and Dworkin, L.D. (2000) Endogenous hepatocyte growth factor ameliorates chronic renal injury by activating matrix degradation pathways. Kidney International 58, 2028-2043
    • (2000) Kidney International , vol.58 , pp. 2028-2043
    • Liu, Y.1    Rajur, K.2    Tolbert, E.3    Dworkin, L.D.4
  • 61
    • 0036172597 scopus 로고    scopus 로고
    • Hepatocyte growth factor induces collagenase (matrix metalloproteinase-1) via. The transcription factor Ets-1 in human hepatic stellate cells
    • Ozaki, I., Zhao, G., Mizuta, T., Ogawa, Y., Hara, T., Kajihara, S., Hisatomi, A., Sakai, T., and Yamamoto, K. (2002) Hepatocyte growth factor induces collagenase (matrix metalloproteinase-1) via. the transcription factor Ets-1 in human hepatic stellate cells. J. Hepatol. 36, 169-178
    • (2002) J. Hepatol. , vol.36 , pp. 169-178
    • Ozaki, I.1    Zhao, G.2    Mizuta, T.3    Ogawa, Y.4    Hara, T.5    Kajihara, S.6    Hisatomi, A.7    Sakai, T.8    Yamamoto, K.9
  • 62
    • 0033914211 scopus 로고    scopus 로고
    • Gene expression of interstitial collagenase in both progressive and recovery phase of rat liver fibrosis induced by carbon tetrachloride
    • Watanabe, T., Niioka, M., Hozawa, S., Kameyama, K., Hayashi, T., Arai, M., Ishikawa, A., Maruyama, K., and Okazaki, I. (2000) Gene expression of interstitial collagenase in both progressive and recovery phase of rat liver fibrosis induced by carbon tetrachloride. J. Hepatol 33, 224-235
    • (2000) J. Hepatol. , vol.33 , pp. 224-235
    • Watanabe, T.1    Niioka, M.2    Hozawa, S.3    Kameyama, K.4    Hayashi, T.5    Arai, M.6    Ishikawa, A.7    Maruyama, K.8    Okazaki, I.9
  • 63
    • 1042308383 scopus 로고    scopus 로고
    • Stem cells expressing matrix metalloproteinase-13 mRNA appear during regression reversal of hepatic cirrhosis
    • Okazaki, I., Ninomiya, Y., Friedman, S.L., and Tanikawa, K. (eds). Academic Press, New York
    • Watanabe, T., Niioka, M., Hozawa, S., Sugioka, Y., Arai, M., Maruyama, K., Okano, H., and Okazaki, I. (2003) Stem cells expressing matrix metalloproteinase-13 mRNA appear during regression reversal of hepatic cirrhosis. In: Okazaki, I., Ninomiya, Y., Friedman, S.L., and Tanikawa, K. (eds) Extracellular Matrix and The Liver-Approach to Gene Therapy. Academic Press, New York, pp. 361-388
    • (2003) Extracellular Matrix and the Liver-Approach to Gene Therapy , pp. 361-388
    • Watanabe, T.1    Niioka, M.2    Hozawa, S.3    Sugioka, Y.4    Arai, M.5    Maruyama, K.6    Okano, H.7    Okazaki, I.8


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