Structural determinants for membrane trafficking and G protein selectivity of a mouse olfactory receptor

Journal of Neurochemistry

Volumn 90, Issue 6, 2004, Pages 1453-1463

  Katada, Sayako ^a   Tanaka, Motonari ^a   Touhara, Kazushige ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

G protein coupled receptor; HEK293 cells; Membrane trafficking; Odorant; Olfactory receptor

Indexed keywords

CHIMERIC PROTEIN; CHIMERIC RECEPTOR; EUGENOL; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; RHODOPSIN; UNCLASSIFIED DRUG; VANILLIN;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING SITE; C TERMINAL DOMAIN; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE; CELL SURFACE; CELLULAR DISTRIBUTION; CHEMICAL STRUCTURE; CONTROLLED STUDY; FLOW CYTOMETRY; GLYCOSYLATION; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; MEMBRANE TRANSPORT; N TERMINAL DOMAIN; ODOR; OLFACTORY RECEPTOR; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN INTERACTION; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS;

ANIMALS; BLOTTING, WESTERN; CALCIUM; CARBACHOL; CATTLE; CELL LINE; CYCLIC AMP; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYO; EUGENOL; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GLYCOSYLATION; GTP-BINDING PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; MICE; OLFACTORY RECEPTOR NEURONS; PRECIPITIN TESTS; PROTEIN CONFORMATION; PROTEIN TRANSPORT; RECEPTORS, ODORANT; RECOMBINANT FUSION PROTEINS; SENSORY RHODOPSINS; SEQUENCE ALIGNMENT; STRUCTURE-ACTIVITY RELATIONSHIP; TIME FACTORS; TRANSFECTION;

EID: 4544379386     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2004.02619.x     Document Type: Article

References (41)

1. Alblas J., van Etten I., Khanum A. and Moolenaar W. H. (1995) C-terminal truncation of the neurokinin-2 receptor causes enhanced and sustained agonist-induced signaling. Role of receptor phosphorylation in signal attenuation. J. Biol. Chem. 270, 8944-8951.
2. Araneda R. C., Kini A. D. and Firestein S. (2000) The molecular receptive range of an odorant receptor. Nat. Neurosci. 3, 1248-1255.
3. Asai H., Kasai H., Matsuda Y., Yamazaki N., Nagawa F., Sakano H. and Tsuboi A. (1996) Genomic structure and transcription of a murine odorant receptor gene: differential initiation of transcription in the olfactory and testicular cells. Biochem. Biophys. Res. Commun 221, 240-247.
4. Buck L. B. (1996) Information coding in the vertebrate olfactory system. Annu. Rev. Neurosci. 19, 517-544.
5. Cheung A. H., Huang R. R., Graziano M. P. and Strader C. D. (1991) Specific activation of Gs by synthetic peptides corresponding to an intracellular loop of the beta-adrenergic receptor. FEBS Lett. 279, 277-280.
6. Dayhoff M. O. (1978) Atlas of protein sequence and structure, Vol. 5 (Suppl.3). National Biomedical Research Foundation.
7. Dohlman H. G., Thorner J., Caron M. G. and Lefkowitz R. J. (1991) Model systems for the study of seven-transmembrane-segment receptors. Annu. Rev. Biochem. 60, 653-688.
8. Dwyer N. D., Troemel E. R., Sengupta P. and Bargmann C. I. (1998) Odorant receptor localization to olfactory cilia is mediated by ODR-4, a novel membrane-associated protein. Cell 93, 455-466.
9. Firestein S. (2001) How the olfactory system makes sense of scents. Nature 413, 211-218.
10. Gimelbrant A. A., Haley S. L. and McClintock T. S. (2001) Olfactory receptor trafficking involves conserved regulatory steps. J. Biol. Chem. 276, 7285-7290.
11. Gimelbrant A. A., Stoss T. D., Landers T. M. and McClintock T. S. (1999) Truncation releases olfactory receptors from the endoplasmic reticulum of heterologous cells. J. Neurochem. 72, 2301-2311.
12. Higashijima T., Uzu S., Nakajima T. and Ross E. M. (1988) Mastoparan, a peptide toxin from wasp venom, mimics receptors by activating GTP-binding regulatory proteins (G proteins) PG-649-4. J. Biol. Chem. 263, 6491-6494.
13. Kajiya K., Inaki K., Tanaka M., Haga T., Kataoka H. and Touhara K. (2001) Molecular bases of odor discrimination: Reconstitution of olfactory receptors that recognize overlapping sets of odorants. J. Neurosci. 21, 6018-6025.
14. Katada S., Nakagawa T., Kataoka H. and Touhara K. (2003) Odorant response assays for a heterologously expressed olfactory receptor. Biochem. Biophys. Res. Commun 305, 964-969.
15. Konig B., Arendt A., McDowell J. H., Kahlert M., Hargrave P. A. and Hofmann K. P. (1989) Three cytoplasmic loops of rhodopsin interact with transducin. Proc. Natl Acad. Sci. USA 86, 6878-6882.
16. van Koppen C. J. and Nathanson N. M. (1990) Siter-directed mutagenesis of the m2 muscarinic acetylcholine receptor. J. Biol. Chem. 265, 20887-20892.
17. Krautwurst D., Yau K. W. and Reed R. R. (1998) Identification of ligands for olfactory receptors by functional expression of a receptor library. Cell 95, 917-926.
18. Krieger J., Schleicher S., Strotmann J., Wanner I., Boekhoff I., Raming K., De Geus P. and Breer H. (1994) Probing olfactory receptors with sequence-specific antibodies. Eur. J. Biochem. 219, 829-835.
19. Lu M., Echeverri F. and Moyer B. D. (2003) Endoplasmic reticulum retention, degradation, and aggregation of olfactory G-protein coupled receptors. Traffic 4, 416-433.
20. Malnic B., Hirono J., Sato T. and Buck L. B. (1999) Combinatorial receptor codes for odors. Cell 96, 713-723.
21. Matus-Leibovitch N., Nussenzveig D. R., Gershengorn M. C. and Oron Y. (1995) Truncation of the thyrotropin-releasing hormone receptor carboxyl tail causes constitutive activity and leads to impaired responsiveness in Xenopus oocytes and AtT20 cells. J. Biol. Chem. 270, 1041-1047.
22. McClintock T. S., Landers T. M., Gimelbrant A. A., Fuller L. Z., Jackson B. A., Jayawickreme C. K. and Lerner M. R. (1997) Functional expression of olfactory-adrenergic receptor chimeras and intracellular retention of heterologously expressed olfactory receptors. Brain Res. Mol Brain Res. 48, 270-278.
23. McClintock T. S. and Sammeta N. (2003) Trafficking prerogatives of olfactory receptors. Neuroreport 14, 1547-1552.
24. Mombaerts P. (2004) Genes and ligands for odorant, vomeronasal and taste receptors. Nat. Rev. Neurosci. 5, 263-278.
25. Palczewski K., Kumasaka T., Hori T., Behnke C. A., Motoshima H., Fox B. A., Le Trong I., Teller D. C., Okada T., Stenkamp R.E., et al. (2000) Crystal structure of rhodopsin: a G protein-coupled receptor. Science 289, 739-745.
26. Parker E. M. and Ross E. M. (1991) Truncation of the extended carboxyl-terminal domain increases the expression and regulatory activity of the avian beta-adrenergic receptor. J. Biol. Chem. 266, 9987-9996.
27. Rands E., Candelore M. R., Cheung A. H., Hill W. S., Strader C. D. and Dixon R. A. F. (1990) Mutational analysis of β-adrenergic receptor glycosylation. J. Biol. Chem. 265, 10759-10764.
28. Schild D. and Restrepo D. (1998) Transduction mechanisms in vertebrate olfactory receptor cells. Physiol. Rev. 78, 429-466.
29. Schneider H., Feyen J. H. and Seuwen K. (1994) A C-terminally truncated human parathyroid hormone receptor is functional and activates multiple G proteins. FEBS Lett. 351, 281-285.
30. Spehr M., Wetzel C. H., Halt H. and Ache B. W. (2002) 3-phosphoinositides modulate cyclic nucleotide signaling in olfactory receptor neurons. Neuron 33, 731-739.
31. Sukumar M. and Higashijima T. (1992) G protein-bound conformation of mastoparan-X, a receptor-mimetic peptide. J. Biol. Chem. 267, 21421-21424.
32. Touhara K. (2001) Functional cloning and reconstitution of vertebrate odorant receptors. Life Sci. 68, 2199-2206.
33. Touhara K. (2002) Odor discrimination by G protein-coupled olfactory receptors. Microsc Res. Tech. 58, 135-141.
34. Touhara K., Sengoku S., Inaki K., Tsuboi A., Hirono J., Sato T., Sakano H. and Haga T. (1999) Functional identification and reconstitution of an odorant receptor in single olfactory neurons. Proc. Natl Acad. Sci. USA 96, 4040-4045.
35. Walensky L. D., Roskams A. J., Lefkowitz R. J., Snyder S. H. and Ronnett G. V. (1995) Odorant receptors and desensitization proteins colocalize in mammalian sperm. Mol. Med. 1, 130-141.
36. Wess J. (1998) Molecular basis of receptor/G-protein-coupling selectivity. Pharmacol. Ther. 80, 231-264.
37. Wetzel C. H., Oles M., Wellerdieck C., Kuczkowiak M., Gisselmann G. and Hatt H. (1999) Specificity and sensitivity of a human olfactory receptor functionally expressed in human embryonic kidney 293 cells and Xenopus laevis oocytes. J. Neurosci. 19, 7426-7433.
38. Wong S. K. (2003) G protein selectivity is regulated by multiple intracellular regions of GPCRs. Neurosignals 12, 1-12.
39. Wong S. K., Parker E, M. and Ross E. M. (1990) Chimeric muscarinic cholinergic: beta-adrenergic receptors that activate Gs in response to muscarinic agonists. J. Biol. Chem. 265, 6219-6224.
40. Zhang X. and Firestein S. (2002) The olfactory receptor gene superfamily of the mouse. Nat. Neurosci. 5, 124-133.
41. Zhao H., Ivic L., Otaki J. M., Hashimoto M., Mikoshiba K. and Firestein S. (1998) Functional expression of a mammalian odorant receptor. Science 279, 237-242.