Inhibition of intracellular degradation increases secretion of a mutant form of α1-antitrypsin associated with profound deficiency

Journal of Clinical Investigation

Volumn 101, Issue 12, 1998, Pages 2693-2701

  Novoradovskaya, Natalia ^a   Lee, JungHwa ^a   Yu, Zu Xi ^b   Ferrans, Victor J ^b   Brantly, Mark ^a,b  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

Cirrhosis; Degradation; Emphysema; Proteasome; 1 antitrypsin

Indexed keywords

ALPHA 1 ANTITRYPSIN; CYCLOHEXIMIDE; MUTANT PROTEIN; PROTEASOME; PROTEINASE;

ALPHA 1 ANTITRYPSIN DEFICIENCY; ANIMAL CELL; ARTICLE; CHO CELL; CONTROLLED STUDY; EMPHYSEMA; ENZYME RELEASE; HUMAN; HUMAN CELL; LIVER CIRRHOSIS; LIVER DISEASE; LUNG ALVEOLUS MACROPHAGE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION;

EID: 0032526051     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI549     Document Type: Article

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