The link between PKCα regulation and cellular transformation

Immunology Letters

Volumn 96, Issue 2, 2005, Pages 155-162

  Michie, Alison M ^a   Nakagawa, Rinako ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Cellular signalling; Protein kinase C ; Transformation

Indexed keywords

7 HYDROXYSTAUROSPORINE; ANTINEOPLASTIC AGENT; CYCLIN DEPENDENT KINASE INHIBITOR; FLAVOPIRIDOL; PROTEIN KINASE C ALPHA; PROTEIN KINASE C INHIBITOR; PROTEIN SERINE THREONINE KINASE; PRKCA PROTEIN, HUMAN; PROTEIN KINASE C;

APOPTOSIS; CANCER; CELL ADHESION; CELL CYCLE; CELL DIFFERENTIATION; CELL FUNCTION; CELL PROLIFERATION; CELL SURVIVAL; CELL TRANSFORMATION; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTO ONCOGENE; REVIEW; ANIMAL; DRUG DESIGN; METABOLISM;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL TRANSFORMATION, NEOPLASTIC; DRUG DESIGN; HUMANS; PROTEIN KINASE C; PROTEIN KINASE C-ALPHA;

EID: 10044298444     PISSN: 01652478     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.imlet.2004.08.013     Document Type: Review

References (70)

1. Y. Nishizuka Protein kinase C and lipid signaling for sustained cellular responses Faseb J 9 1995 484 496
2. D.B. Parekh, W. Ziegler, and P.J. Parker Multiple pathways control protein kinase C phosphorylation EMBO J 19 2000 496 503
3. A.C. Newton Protein kinase C: structural and spatial regulation by phosphorylation, cofactors, and macromolecular interactions Chem Rev 101 2001 2353 2364
4. C. Pears, S. Stabel, S. Cazaubon, and P.J. Parker Studies on the phosphorylation of protein kinase C-α Biochem J 283 1992 515 518
5. S.M. Cazaubon, and P.J. Parker Identification of the phosphorylated region responsible for the permissive activation of protein kinase C J Biol Chem 268 1993 17559 17563
6. F. Bornancin, and P.J. Parker Phosphorylation of threonine 638 critically controls the dephosphorylation and inactivation of protein kinase Cα Curr Biol 6 1996 1114 1123
7. S. Cazaubon, F. Bornancin, and P.J. Parker Threonine-497 is a critical site for permissive activation of protein kinase Cα Biochem J 301 1994 443 448
8. E.M. Dutil, A. Toker, and A.C. Newton Regulation of conventional protein kinase C isozymes by phosphoinositide-dependent kinase 1 (PDK-1) Curr Biol 8 1998 1366 1375
9. F. Bornancin, and P.J. Parker Phosphorylation of protein kinase C-α on serine 657 controls the accumulation of active enzyme and contributes to its phosphatase-resistant state J Biol Chem 272 1997 3544 3549
10. T. Gao, A. Toker, and A.C. Newton The carboxyl terminus of protein kinase C provides a switch to regulate its interaction with the phosphoinositide- dependent kinase, PDK-1 J Biol Chem 276 2001 19588 19596
11. G. Hansra, F. Bornancin, R. Whelan, B.A. Hemmings, and P.J. Parker 12-O-Tetradecanoylphorbol-13-acetate-induced dephosphorylation of protein kinase Cα correlates with the presence of a membrane-associated protein phosphatase 2A heterotrimer J Biol Chem 271 1996 32785 32788
12. A.F. Kirwan, A.C. Bibby, T. Mvilongo, H. Riedel, T. Burke, S.Z. Millis, and A.M. Parissenti Inhibition of protein kinase C catalytic activity by additional regions within the human protein kinase Ca-regulatory domain lying outside of the pseudosubstrate sequence Biochem J 373 2003 571 581
13. T.M. Klauck, M.C. Faux, K. Labudda, L.K. Langeberg, S. Jaken, and J.D. Scott Coordination of three signaling enzymes by AKAP79, a mammalian scaffold protein Science 271 1996 1589 1592
14. D. Schechtman, and D. Mochly-Rosen Adaptor proteins in protein kinase C-mediated signal transduction Oncogene 20 2001 6339 6347
15. J. Staudinger, J. Zhou, R. Burgess, S.J. Elledge, and E.N. Olson PICK1: a perinuclear binding protein and substrate for protein kinase C isolated by the yeast two-hybrid system J Cell Biol 128 1995 263 271
16. J. Piontek, and R. Brandt Differential and regulated binding of cAMP-dependent protein kinase and protein kinase C isoenzymes to gravin in human model neurons: evidence that gravin provides a dynamic platform for the localization for kinases during neuronal development J Biol Chem 278 2003 38970 38979
17. M.C. Faux, E.N. Rollins, A.S. Edwards, L.K. Langeberg, A.C. Newton, and J.D. Scott Mechanism of A-kinase-anchoring protein 79 (AKAP79) and protein kinase C interaction Biochem J 343 1999 443 452
18. B.D. Grove, and A.K. Bruchey Intracellular distribution of gravin, a PKA and PKC binding protein, in vascular endothelial cells J Vasc Res 38 2001 163 175
19. I.H. Lee, J.O. You, K.S. Ha, D.S. Bae, P.G. Suh, S.G. Rhee, and Y.S. Bae AHNAK-mediated activation of phospholipase C-γ1 through protein kinase C J Biol Chem 279 2004 26645 26653
20. B. Leinweber, A.M. Parissenti, C. Gallant, S.S. Gangopadhyay, A. Kirwan-Rhude, P.C. Leavis, and K.G. Morgan Regulation of protein kinase C by the cytoskeletal protein calponin J Biol Chem 275 2000 40329 40336
21. T. Gao, and A.C. Newton The turn motif is a phosphorylation switch that regulates the binding of Hsp70 to protein kinase C J Biol Chem 277 2002 31585 31592
22. P. Acs, K. Bogi, P.S. Lorenzo, A.M. Marquez, T. Biro, Z. Szallasi, and P.M. Blumberg The catalytic domain of protein kinase C chimeras modulates the affinity and targeting of phorbol ester-induced translocation J Biol Chem 272 1997 22148 22153
23. A. Vallentin, C. Prevostel, T. Fauquier, X. Bonnefont, and D. Joubert Membrane targeting and cytoplasmic sequestration in the spatiotemporal localization of human protein kinase Cα J Biol Chem 275 2000 6014 6021
24. A.J. Melendez, M.M. Harnett, and J.M. Allen Crosstalk between ARF6 and protein kinase Cα in FcγRI-mediated activation of phospholipase D1 Curr Biol 11 2001 869 874
25. W.D. Singer, H.A. Brown, X. Jiang, and P.C. Sternweis Regulation of phospholipase D by protein kinase C is synergistic with ADP-ribosylation factor and independent of protein kinase activity J Biol Chem 271 1996 4504 4510
26. R. Mandil, E. Ashkenazi, M. Blass, I. Kronfeld, G. Kazimirsky, G. Rosenthal, F. Umansky, P.S. Lorenzo, P.M. Blumberg, and C. Brodie Protein kinase Cα and protein kinase Cδ play opposite roles in the proliferation and apoptosis of glioma cells Cancer Res 61 2001 4612 4619
27. G. Baier The PKC gene module: molecular biosystematics to resolve its T cell functions Immunol Rev 192 2003 64 79
28. M. Leitges, M. Plomann, M.L. Standaert, G. Bandyopadhyay, M.P. Sajan, Y. Kanoh, and R.V. Farese Knockout of PKCα enhances insulin signaling through PI3K Mol Endocrinol 16 2002 847 858
29. Z. Sun, C.W. Arendt, W. Ellmeier, E.M. Schaeffer, M.J. Sunshine, L. Gandhi, J. Annes, D. Petrzilka, A. Kupfer, P.L. Schwartzberg, and D.R. Littman PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes Nature 404 2000 402 407
30. M. Leitges, C. Schmedt, R. Guinamard, J. Davoust, S. Schaal, S. Stabel, and A. Tarakhovsky Immunodeficiency in protein kinase Cβ-deficient mice Science 273 1996 788 791
31. T. Iwamoto, M. Hagiwara, H. Hidaka, T. Isomura, D. Kioussis, and I. Nakashima Accelerated proliferation and interleukin-2 production of thymocytes by stimulation of soluble anti-CD3 monoclonal antibody in transgenic mice carrying a rabbit protein kinase Cα J Biol Chem 267 1992 18644 18648
32. D.K. Ways, C.A. Kukoly, J. deVente, J.L. Hooker, W.O. Bryant, K.J. Posekany, D.J. Fletcher, P.P. Cook, and P.J. Parker MCF-7 breast cancer cells transfected with protein kinase C-α exhibit altered expression of other protein kinase C isoforms and display a more aggressive neoplastic phenotype J Clin Invest 95 1995 1906 1915
33. W. Kolch, G. Heidecker, G. Kochs, R. Hummel, H. Vahidi, H. Mischak, G. Finkenzeller, D. Marme, and U.R. Rapp Protein kinase Cα activates RAF-1 by direct phosphorylation Nature 364 1993 249 252
34. C.G. Buitrago, V.G. Pardo, A.R. de Boland, and R. Boland Activation of RAF-1 through Ras and protein kinase Ca mediates 1α,25(OH)2-vitamin D3 regulation of the mitogen-activated protein kinase pathway in muscle cells J Biol Chem 278 2003 2199 2205
35. D.C. Schonwasser, R.M. Marais, C.J. Marshall, and P.J. Parker Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway by conventional, novel, and atypical protein kinase C isotypes Mol Cell Biol 18 1998 790 798
36. G.C. Grady, S.M. Mason, J. Stephen, J.C. Zúñiga- Pflücker, and A.M. Michie Cyclic adenosine 5′-monophosphate response element binding protein plays a central role in mediating proliferation and differentiation downstream of the pre-TCR complex in developing thymocytes J Immunol 173 2004 1802 1810
37. A.M. Michie, J.-W. Soh, R.G. Hawley, I.B. Weinstein, and J.C. Zúñiga-Pflücker Allelic exclusion and differentiation by protein kinase C-mediated signals in immature thymocytes Proc. Natl. Acad. Sci. U.S.A. 98 2001 609 614
38. J.H. Chang, J.C. Pratt, S. Sawasdikosol, R. Kapeller, and S.J. Burakoff The small GTP-binding protein Rho potentiates AP-1 transcription in T cells Mol Cell Biol 18 1998 4986 4993
39. S.A. Trushin, K.N. Pennington, E.M. Carmona, S. Asin, D.N. Savoy, D.D. Billadeau, and C.V. Paya Protein kinase Cα (PKCα) acts upstream of PKCα to activate IκB kinase and NF-κB in T lymphocytes Mol Cell Biol 23 2003 7068 7081
40. X. Lin, A. O'Mahony, Y. Mu, R. Geleziunas, and W.C. Greene Protein kinase C-θ participates in NF-κB activation induced by CD3-CD28 costimulation through selective activation of IκB kinase B Mol Cell Biol 20 2000 2933 2940
41. J.-W. Soh, and I.B. Weinstein Roles of specific isoforms of protein kinase C in the transcriptional control of cyclin D1 and related genes J Biol Chem 278 2003 34709 34716
42. Waf1/Cip1 in protein kinase C alpha-induced cell cycle progression Mol Cell Biol 20 2000 4580 4590
43. M.R. Frey, J.A. Clark, O. Leontieva, J.M. Uronis, A.R. Black, and J.D. Black Protein kinase C signaling mediates a program of cell cycle withdrawal in the intestinal epithelium J Cell Biol 151 2000 763 778
44. 1 arrest J Cell Sci 113 2000 3025 3035
45. R.D. Whelan, and P.J. Parker Loss of protein kinase C function induces an apoptotic response Oncogene 16 1998 1939 1944
46. M. Leirdal, and M. Sioud Ribozyme inhibition of the protein kinase Cα triggers apoptosis in glioma cells Br J Cancer 80 1999 1558 1564
47. A.A. Matassa, R.L. Kalkofen, L. Carpenter, T.J. Biden, and M.E. Reyland Inhibition of PKCα induces a PKCδ-dependent apoptotic program in salivary epithelial cells Cell Death Differ 10 2003 269 277
48. P.P. Ruvolo, X. Deng, B.K. Carr, and W.S. May A functional role for mitochondrial protein kinase Cα in Bcl2 phosphorylation and suppression of apoptosis J Biol Chem 273 1998 25436 25442
49. T. Jiffar, S. Kurinna, G. Suck, D. Carlson-Bremer, M.R. Ricciardi, M. Konopleva, M. Andreeff, and P.P. Ruvolo PKC α mediates chemoresistance in acute lymphoblastic leukemia through effects on Bcl2 phosphorylation Leukemia 18 2004 505 512
50. R.V. Blackburn, S.S. Galoforo, C.M. Berns, N.M. Motwani, P.M. Corry, and Y.J. Lee Differential induction of cell death in human glioma cell lines by sodium nitroprusside Cancer 82 1998 1137 1145
51. W.L. Wang, S.F. Yeh, Y.I. Chang, S.F. Hsiao, W.N. Lian, C.H. Lin, C.Y. Huang, and W.J. Lin PICK1, an anchoring protein that specifically targets protein kinase Cα to mitochondria selectively upon serum stimulation in NIH 3T3 cells J Biol Chem 278 2003 37705 37712
52. X. Zeng, H. Xu, and R.I. Glazer Transformation of mammary epithelial cells by 3-phosphoinositide-dependent protein kinase-1 (PDK1) is associated with the induction of protein kinase Cα Cancer Res 62 2002 3538 3543
53. T. Ng, D. Shima, A. Squire, P.I. Bastiaens, S. Gschmeissner, M.J. Humphries, and P.J. Parker PKCα regulates β1 integrin-dependent cell motility through association and control of integrin traffic EMBO J 18 1999 3909 3923
54. W.H. Ziegler, U. Tigges, A. Zieseniss, and B.M. Jockusch A lipid-regulated docking site on vinculin for protein kinase C J Biol Chem 277 2002 7396 7404
55. J.R. Couchman, S. Vogt, S.T. Lim, Y. Lim, E.S. Oh, G.D. Prestwich, A. Theibert, W. Lee, and A. Woods Regulation of inositol phospholipid binding and signaling through syndecan-4 J Biol Chem 277 2002 49296 49303
56. N. Anilkumar, M. Parsons, R. Monk, T. Ng, and J.C. Adams Interaction of fascin and protein kinase Cα: a novel intersection in cell adhesion and motility EMBO J 22 2003 5390 5402
57. M. Holinstat, D. Mehta, T. Kozasa, R.D. Minshall, and A.B. Malik Protein kinase Cα-induced p115RhoGEF phosphorylation signals endothelial cytoskeletal rearrangement J Biol Chem 278 2003 28793 28798
58. A. Vallentin, T.C. Lo, and D. Joubert A single point mutation in the V3 region affects protein kinase Cα targeting and accumulation at cell-cell contacts Mol Cell Biol 21 2001 3351 3363
59. C. Quittau-Prevostel, N. Delaunay, A. Collazos, A. Vallentin, and D. Joubert Targeting of PKCα and ε in the pituitary: a highly regulated mechanism involving a GD(E)E motif of the V3 region J Cell Sci 117 2004 63 72
60. J.C. Adams, J.D. Clelland, G.D. Collett, F. Matsumura, S. Yamashiro, and L. Zhang Cell-matrix adhesions differentially regulate fascin phosphorylation Mol Biol Cell 10 1999 4177 4190
61. M. Izquierdo, J. Downward, J.D. Graves, and D.A. Cantrell Role of protein kinase C in T-cell antigen receptor regulation of p21ras: evidence that two p21ras regulatory pathways coexist in T cells Mol Cell Biol 12 1992 3305 3312
62. J. Downward, J.D. Graves, P.H. Warne, S. Rayter, and D.A. Cantrell Stimulation of p21ras upon T-cell activation Nature 346 1990 719 723
63. J. Ruland, G.S. Duncan, A. Elia, I.B. Barrantes, L. Nguyen, S. Plyte, D.G. Millar, D. Bouchard, A. Wakeham, P. Ohashi, and T.W. Mak Bcl10 is a positive regulator of antigen receptor-induced activation of NF-κB and neural tube closure Cell 104 2001 33 42
64. X.Y. Wang, E. Repasky, and H.T. Liu Antisense inhibition of protein kinase Ca reverses the transformed phenotype in human lung carcinoma cells Exp Cell Res 250 1999 253 263
65. S. Kitada, J.M. Zapata, M. Andreeff, and J.C. Reed Protein kinase inhibitors flavopiridol and 7-hydroxy-staurosporine down-regulate antiapoptosis proteins in B-cell chronic lymphocytic leukemia Blood 96 2000 393 397
66. J.Q. Yin, J. Gao, R. Shao, W.N. Tian, J. Wang, and Y. Wan siRNA agents inhibit oncogene expression and attenuate human tumor cell growth J Exp Ther Oncol 3 2003 194 204
67. R. Bannerji, and J.C. Byrd Update on the biology of chronic lymphocytic leukemia Curr Opin Oncol 12 2000 22 29
68. S. Kitada, J. Andersen, S. Akar, J.M. Zapata, S. Takayama, S. Krajewski, H.G. Wang, X. Zhang, F. Bullrich, C.M. Croce, K. Rai, J. Hines, and J.C. Reed Expression of apoptosis-regulating proteins in chronic lymphocytic leukemia: correlations with in vitro and in vivo chemoresponses Blood 91 1998 3379 3389
69. M. Barragán, B. Bellosillo, C. Campàs, D. Colomer, G. Pons, and J. Gil Involvement of protein kinase C and phosphatidylinositol 3-kinase pathways in the survival of B-cell chronic lymphocytic leukemia cells Blood 99 2002 2969 2976
70. M. Huigsloot, R.B. Tijdens, and B. van de Water Inhibition of protein kinase Cα enhances anticancer agent-induced loss of anchorage-independent growth regardless of protection against apoptosis by Bcl-2 Mol Pharmacol 64 2003 965 973