Primary fibroblasts from BRCA1 heterozygotes display an abnormal G 1/S cell cycle checkpoint following UVA irradiation but show normal levels of micronuclei following oxidative stress or mitomycin C treatment

International Journal of Radiation Oncology Biology Physics

Volumn 58, Issue 2, 2004, Pages 470-478

  Shorrocks, Julie ^a   Tobi, Simon E ^a   Latham, Harry ^a   Peacock, John H ^b   Eeles, Ros ^b   Eccles, Diana ^c   McMillan, Trevor J ^a  

^a LANCASTER UNIVERSITY   (United Kingdom)

^b INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^c PRINCESS ANNE HOSPITAL   (United Kingdom)

Author keywords

BRCA1; Cell cycle; Checkpoint; DNA damage; Radiation

Indexed keywords

CHROMOSOMES; CYTOLOGY; DNA; GENES; HYDROGEN PEROXIDE;

FIBROBLASTS;

ONCOLOGY;

HYDROGEN PEROXIDE; MITOMYCIN C;

BREAST CANCER; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CONFERENCE PAPER; CONTROLLED STUDY; DNA DAMAGE; FIBROBLAST; GENE FUNCTION; GENE MUTATION; GENOTYPE; HETEROZYGOTE; HUMAN; HUMAN CELL; MICRONUCLEUS; MITOSIS INHIBITION; ONCOGENE; OXIDATIVE STRESS; PRIORITY JOURNAL; RADIATION EXPOSURE; ULTRAVIOLET A RADIATION;

EID: 0942289877     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2003.09.042     Document Type: Conference Paper

References (30)

1. Easton D.F., Ford D., Bishop D.T. Breast and ovarian cancer incidence in BRCA1 mutation carriers. Am J Hum Genet. 56:1995;65-71.
2. Easton D.F., Bishop D.T., Ford D., et al. Breast Linkage Consortium. Genetic linkage analysis in familial breast and ovarian cancer Results from 214 families . Am J Hum Genet. 52:1993;678-701.
3. Gilmore P.M., Quinn J.E., Mullan P.B., et al. Role played by BRCA1 in regulating the cellular response to stress. Biochem Soc Trans. 31:2003;257-262.
4. Welsch P.L., Owens K.N., King M.-C. Insights into the functions of BRCA1 and BRCA2. Trends in Genetics. 16:2000;69-74.
5. Cortez D., Wang Y., Qin J., Elledge S.J. Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks. Science. 286:1999;1162-1166.
6. Tibbetts R.S., Cortez D., Brumbaugh K.M., et al. Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress. Genes Dev. 14:2000;2989-3002.
7. Scully R., Chen J., Ochs R.L., et al. Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage. Cell. 90:1997;425-435.
8. Moynahan M.E., Cui T.Y., Jasin M. Homology-directed DNA repair, mitomycin-C resistance and chromosome stability is restored with correction of a BRCA1 mutation. Cancer Res. 61:2001;4842-4850.
9. Jasin M. Homologous repair of DNA damage and tumorigenesis The BRCA connection . Oncogene. 21:2002;8981-8993.
10. Hartman A.R., Ford J.M. BRCA1 induces DNA damage recognition factors and enhances nucleotide excision repair. Nat Genet. 32:2002;180-184.
11. Gowen L.C., Avrutskaya A.V., Latour A.M., Koller B.H., Leadon S.A. BRCA1 required for transcription-coupled repair of oxidative DNA damage. Science. 14:1998;1009-1012.
12. Holt J.T., Thomson M.E., Szabo C., et al. Growth retardation and tumour inhibition by BRCA1. Nat Genet. 12:1996;298-302.
13. Williamson E.A., Dadmanesh F., Koeffler H.P. BRCA1 transactivates the cyclin-dependent kinase inhibitor p27 (Kip1). Oncogene. 21:2002;3199-3206.
14. Xu B., Kim S., Kastan M.B. Involvement of Brca1 in S-phase and G(2) phase checkpoints after ionizing irradiation. Mol Cell Biol. 21:2002;3445-3450.
15. Aprelikova O.N., Fang B.S., Meissner E.G., et al. BRCA1-associated growth arrest is RB-dependent. Proc Natl Acad Sci. 96:1999;11866-11871.
16. Hakem R., de la Pompa J.L., Sirard C., et al. The tumour suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse. Cell. 85:1996;1009-1023.
17. Boyd M., Harris F., McFarlane R., et al. A human BRCA1 gene knockout. Nature. 375:1995;541-544.
18. Shrieve D.C., Begg A.C. Cell cycle kinetics of aerated, hypoxic, and re-aerated cells in vitro using flow cytometric determination of cellular DNA and incorporated bromodeoxyuridine. Cell Tissue Kinet. 18:1985;641-651.
19. Michel B., Ehrlich S.D., Uzest M. DNA double-strand breaks caused by replication arrest. EMBO J. 16:1997;430-438.
20. Bennett L.M., McAllister K.A., Malphurs J., et al. Mice heterozygous for a Brca1 or Brca2 mutation display distinct mammary gland and ovarian phenotypes in response to diethylstilbestrol. Cancer Res. 60:2000;3461-3469.
21. Chen Y.M., Farmer A.A., Chen C.F., et al. BRCA1 is a 220-kda nuclear phosphoprotein that is expressed and phosphorylated in a cell cycle dependent manner. Cancer Res. 56:1996;1368-1372.
22. Yarden R.I., Pardo-Reoyo S., Sgagias M., et al. BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage. Nat Genet. 30:2002;285-289.
23. Foray N., Randrianarison V., Marot D., et al. Gamma-rays-induced death of human cells carrying mutations of BRCA1 or BRCA2. Oncogene. 18:1999;7334-7342.
24. Fell L.J., Paul N.D., McMillan T.J. Role for non-homologous end-joining in the repair of UVA-induced DNA damage. Int J Radiat Biol. 78:2002;1023-1027.
25. Baldeyron C., Jacquemin E., Smith J., et al. A single mutated BRCA1 allele leads to impaired fidelity of double strand break end-joining. Oncogene. 21:2002;1401-1410.
26. Rothfuss A., Schutz P., Bochum S., et al. Induced micronucleus frequencies in peripheral lymphocytes as a screening test for carriers of a BRCA1 mutation in breast cancer families. Cancer Res. 60:2000;390-394.
27. Trenz K., Landgraf J., Speit G. Mutagen sensitivity of human lymphoblastoid cells with a BRCA1 mutation. Breast Cancer Res Treat. 78:2003;69-79.
28. Liu N., Hamerdin J.E., Tebbs R.S., et al. XRCC2 and XRCC3, new human Rad51-family members, promote chromosomal stability and protect against DNA cross-links and other damages. Mol Cell. 1:1998;783-793.
29. Bhattacharyya A., Ear U.S., Koller B.H., et al. The breast cancer susceptibility gene BRCA1 is required for subnuclear assembly of rad51 and survival following treatment with the DNA cross-linking agent cisplatin. J Biol Chem. 275:2000;23899-23903.
30. De Silva I., McHugh P.J., Clingen P.H., Hartley J.A. Defining the roles of nucleotide excision repair and recombination in the repair of interstrand cross-links in mammalian cells. Mol Cell Biol. 20:2000;7980-7990.