SCOPUS 정보 검색 플랫폼

Journal of Medicinal Chemistry

Volumn 44, Issue 25, 2001, Pages 4453-4461

Novel tropane-based irreversible ligands for the dopamine transporter

(6) Zou, M F a Kopajtic, T a Katz, J L a Wirtz, S b Justice Jr , J B b Newman, A H a

a NATIONAL INSTITUTE ON DRUG ABUSE (United States)

b EMORY UNIVERSITY (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3ALPHA [BIS(4'FLUOROPHENYL)METHOXY]TROPANE DERIVATIVE; 3BETA (4 FLUOROPHENYL) 2BETA TROPANECARBOXYLIC ACID METHYL ESTER; 4' AZIDO 3' IODOPHENYL DERIVATIVE; DOPAMINE TRANSPORTER; DOPAMINE UPTAKE INHIBITOR; ISOTHIOCYANIC ACID DERIVATIVE; LIGAND; N [4 (3 IODO 4 AZIDOPHENYL)BUTYL] 2BETA CARBOMETHOXY 3BETA (4 CHLOROPHENYL)TROPANE; N [4 (4 ISOTHIOCYANATOPHENYL)BUTYL] 2BETA CARBOMETHOXY 3BETA (4 CHLOROPHENYL)TROPANE; TROPANE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; MALE; NONHUMAN; PHOTOAFFINITY LABELING; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; AZIDES; BENZTROPINE; BINDING, COMPETITIVE; CELL LINE; COCAINE; DOPAMINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; DOPAMINE UPTAKE INHIBITORS; HUMANS; ISOTHIOCYANATES; LIGANDS; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; NERVE TISSUE PROTEINS; PUTAMEN; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP; TROPANES;

EID: 0035818888 PISSN: 00222623 EISSN: None Source Type: Journal
DOI: 10.1021/jm0101904 Document Type: Article

Times cited : (31)

References (32)

1
- 0023265754
- Cocaine receptors on dopamine transporters are related to self-administration of cocaine
- (1987) Science , vol.237 , pp. 1219-1223
- Ritz, M.C.¹ Lamb, R.J.² Goldberg, S.R.³ Kuhar, M.J.⁴

2
- 0025855256
- The dopamine hypothesis of the reinforcing properties of cocaine
- (1991) Trends Neurosci. , vol.14 , pp. 299-301
- Kuhar, M.J.¹ Ritz, M.C.² Boja, J.W.³

3
- 0029879993
- Addictive drugs and brain stimulation reward
- (1996) Annu. Rev. Neurosci. , vol.19 , pp. 319-340
- Wise, R.A.¹

4
- 0002379639
- Dopamine transporter uptake blockers
- Reith, MA, Ed.; Humana Press: Totowa, NJ
- (1997) Neurotransmitter Transporters: Structure, Function and Regulation , pp. 263-295
- Carroll, F.I.¹ Lewin, A.H.² Kuhar, M.J.³

5
- 0031833848
- Novel dopamine transporter ligands: The state of the art
- (1998) Med. Chem. Res. , vol.8 , Issue.SPEC. ISSUE
- Newman, A.H.¹

6
- 0033168395
- Dopaminergic agents for the treatment of cocaine abuse
- (1999) Drug Discovery Today , vol.4 , pp. 322-332
- Smith, M.P.¹ Hoepping, A.² Johnson, K.M.³ Trzcinska, M.⁴ Kozikowski, A.P.⁵

7
- 0033615028
- Pharmacotherapies for treatment of cocaine abuse: Preclinical aspects
- (1999) J. Med. Chem. , vol.42 , pp. 2721-2736
- Carroll, F.I.¹ Howell, L.I.² Kuhar, M.J.³

8
- 0033937290
- Novel pharmacotherapies for cocaine abuse 1997-2000
- (2000) Exp. Opin. Ther. Pat. , vol.10 , pp. 1095-1122
- Newman, A.H.¹

9
- 0030718479
- A novel photoaffinity label for the dopamine transporter based on N-substituted-4′,4″-difluoro-3α-(diphenylmethoxy)tropane
- (1997) Bioorg. Med. Chem. Lett. , vol.7 , pp. 3027-3032
- Agoston, G.E.¹ Vaughan, R.² Lever, J.R.³ Izenwasser, S.⁴ Terry, P.D.⁵ Newman, A.H.⁶

10
- 0033556371
- Differential binding sites of tropane-based photoaffinity ligands on the dopamine transporter
- (1999) J. Neurosci. , vol.19 , pp. 630-636
- Vaughan, R.A.¹ Agoston, G.E.² Lever, J.R.³ Newman, A.H.⁴

11
- 0033626244
- RTI-76, an isothiocyanate derivative of a phenyltropane cocaine analog, as a tool for irreversibly inactivating dopamine transporter function in vitro
- (2000) Naunyn-Schmiedeberg's Arch. Pharmacol. , vol.362 , pp. 238-247
- Wang, L.C.¹ Berfield, J.L.² Kuhar, M.J.³ Carroll, F.I.⁴ Reith, M.E.A.⁵

12
- 0026722234
- Dopamine transporter site-directed mutations differentially alter transport and cocaine binding
- (1992) Proc. Natl. Acad. Sci. U.S.A. , vol.89 , pp. 7782-7785
- Kitayama, S.¹ Shimada, S.² Xu, H.³ Donovan, D.M.⁴ Uhl, G.R.⁵

13
- 0028577297
- Chimeric dopamine-norepinephrine transporters delineate structural domains influencing selectivity for catecholamines and 1-methyl-4-phenylpyridinium
- (1994) Proc. Natl. Acad. Sci. U.S.A. , vol.91 , pp. 12584-12588
- Buck, K.¹ Amara, S.G.²

14
- 0028341658
- Delineation of discrete domains for substrate, cocaine, and tricyclic antidepressant interactions using chimeric dopamine-norepinephrine transporters
- (1994) J. Biol. Chem. , vol.269 , pp. 15985-15988
- Giros, B.¹ Wang, Y.-M.² Suter, S.³ McLesky, S.B.⁴ Pifl, C.⁵ Caron, M.⁶

15
- 0030575913
- 3H]WIN 35,428 binding
- (1996) Biochem. Pharmacol. , vol.52 , pp. 1435-1446
- Reith, M.A.¹ Xu, C.² Coffey, L.L.³

16
- 0032104581
- Neurotransmitter transporters as molecular targets for addictive drugs
- (1998) Drug Alcohol Depend , vol.51 , pp. 87-96
- Amara, S.G.¹ Sonders, M.S.²

17
- 0026642039
- Probes for the cocaine receptor. Potentially irreversible ligands for the dopamine transporter
- (1992) J. Med. Chem. , vol.35 , pp. 1813-1817
- Carroll, F.I.¹ Gao, Y.² Abraham, P.³ Lewin, A.H.⁴ Lew, R.⁵ Patel, A.⁶ Boja, J.W.⁷ Kuhar, M.J.⁸

18
- 0006917713
- Irreversible ligands for drug receptor characterization
- Allen, R. C., Ed.; Academic Press: New York
- (1990) Annual Reports in Medicinal Chemistry , pp. 271-280
- Newman, A.H.¹

19
- 0028104102
- Novel 3α-diphenylmethoxytropane analogs are potent dopamine uptake inhibitors without cocaine-like behavioral profiles
- (1994) J. Med. Chem. , vol.37 , pp. 2258-2261
- Newman, A.H.¹ Allen, A.C.² Izenwasser, S.³ Katz, J.L.⁴

20
- 0028804967
- Novel 4′- and 4′,4″-substituted-3α-(diphenyl-methoxy)tropane analogs are potent and selective dopamine uptake inhibitors
- (1995) J. Med. Chem. , vol.38 , pp. 3933-3940
- Newman, A.H.¹ Kline, R.H.² Allen, A.C.³ Izenwasser, S.⁴ George, C.⁵ Katz, J.L.⁶

21
- 0028133248
- The discovery of an unusually selective and novel cocaine analog: Difluoropine, synthesis and inhibition of binding at cocaine recognition sites
- (1994) J. Med. Chem. , vol.37 , pp. 2001-2110
- Meltzer, P.C.¹ Liang, A.Y.² Madras, B.K.³

22
- 0030837830
- 2-Carbomethoxy-3-aryl-8-oxabicyclo-[3.2.1]octanes: Potent non-nitrogen inhibitors of monoamine transporters
- (1997) J. Med. Chem. , vol.40 , pp. 2661-2673
- Meltzer, P.C.¹ Liang, A.Y.² Blundell, P.³ Gonzales, M.D.⁴ Chen, Z.⁵ George, C.⁶ Madras, B.K.⁷

23
- 0033539136
- A Comparative Molecular Field Analysis (CoMFA) study of novel ring-substituted 3α-(Diphenylmethoxy)tropane analogues at the dopamine transporter
- (1999) J. Med. Chem. , vol.42 , pp. 3502-3509
- Newman, A.H.¹ Robarge, M.² Izenwasser, S.³ Kline, R.H.⁴

24
- 0034704820
- Highly selective chiral N-substituted 3α-[Bis(4′-fluorophenyl)methoxy]tropane analogues for the dopamine transporter: Synthesis and comparative molecular field analysis
- (2000) J. Med. Chem. , vol.43 , pp. 1085-1093
- Robarge, M.J.¹ Agoston, G.E.² Izenwasser, S.³ Kopajtic, T.⁴ George, C.⁵ Newman, A.H.⁶

25
- 0031434059
- Novel N-substituted 4′,4″-difluoro-3α-(diphenylmethoxy)tropane analogues: Selective ligands for the dopamine transporter
- (1997) J. Med. Chem. , vol.40 , pp. 4329-4339
- Agoston, G.E.¹ Wu, J.H.² Izenwasser, S.³ George, C.⁴ Katz, J.⁵ Kline, R.H.⁶ Newman, A.H.⁷

26
- 0030051988
- 2-Carbomethoxy-3-(diarylmethoxy)-1αH,5αH-tropane analogs: Synthesis and inhibition of binding at the dopamine transporter and comparison with piperazines of the GBR series
- (1996) J. Med. Chem. , vol.39 , pp. 371-379
- Meltzer, P.C.¹ Liang, A.Y.² Madras, B.K.³

27
- 0002295847
- The thermal decomposition product of "Crack," AEME, and analogs do not appear to contribute to the pharmacological or toxicological actions of cocaine
- (1994) Med. Chem. Res. , vol.4 , pp. 93-110
- Newman, A.H.¹ Allen, A.C.² Witkin, J.M.³ Izenwasser, S.⁴ Mash, D.⁵ Katz, J.L.⁶

28
- 0029122828
- Chemistry and biology of the 2β-alkyl-3β-phenyl analogues of cocaine: Subnanomolar affinity ligands that suggest a new pharmacophore model at the C-2 position
- (1995) J. Med. Chem. , vol.38 , pp. 3086-3093
- Kozikowski, A.P.¹ Saiah, M.K.E.² Johnson, K.M.³ Bergman, J.S.⁴

29
- 0026009418
- Synthesis, ligand binding, QSAR, and CoMFA study of 3β-(p-substituted-phenyl-)tropane-2β-carboxylic acid methyl esters
- (1991) J. Med. Chem. , vol.34 , pp. 2719-2725
- Carroll, F.I.¹ Gao, Y.² Rahman, M.A.³ Abraham, P.⁴ Parham, K.⁵ Lewin, A.H.⁶ Boja, J.W.⁷ Kuhar, M.J.⁸

30
- 0025108546
- New, potent cocaine analogs: Ligand binding and transport studies in rat striatum
- (1990) Eur. J. Pharmacol. , vol.184 , pp. 329-332
- Boja, J.W.¹ Carroll, F.I.² Rahman, M.A.³ Philip, A.⁴ Lewin, A.H.⁵ Kuhar, M.J.⁶

31
- 0027468956
- Substituted 3-phenyltropane analogs of cocaine: Synthesis, inhibition of binding at cocaine recognition sites, and position emission tomography imaging
- (1993) J. Med. Chem. , vol.36 , pp. 855-862
- Meltzer, P.C.¹ Liang, A.Y.² Brownell, A.L.³ Elmaleh, D.R.⁴ Madras, B.K.⁵

32
- 0003633894
- Iowa State University Press: Ames, IA
- (1967) Statistical Methods, 6th ed. , pp. 135-171
- Snedecor, G.W.¹ Cochran, W.G.²

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.