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Volumn 172, Issue 4, 2004, Pages 2247-2255

The Impact of Thymic Antigen Diversity on the Size of the Selected T Cell Repertoire

Author keywords

[No Author keywords available]

Indexed keywords

LIGAND; T LYMPHOCYTE ANTIGEN; T LYMPHOCYTE RECEPTOR;

EID: 0842321786     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.172.4.2247     Document Type: Article
Times cited : (16)

References (50)
  • 1
    • 0001937634 scopus 로고
    • The somatic generation of immune recognition
    • Jerne, N. K. 1971. The somatic generation of immune recognition. Eur. J. Immunol. 1:1.
    • (1971) Eur. J. Immunol. , vol.1 , pp. 1
    • Jerne, N.K.1
  • 2
    • 0023663430 scopus 로고
    • T cell tolerance by clonal elimination in the thymus
    • Kappler, J. W., N. Roehm, and P. Marrack. 1987. T cell tolerance by clonal elimination in the thymus. Cell 49:273.
    • (1987) Cell , vol.49 , pp. 273
    • Kappler, J.W.1    Roehm, N.2    Marrack, P.3
  • 6
    • 0028294682 scopus 로고
    • Positive and negative thymocyte selection induced by different concentrations of a single peptide
    • Sebzda, E., V. A. Wallace, J. Mayer, R. S. Yeung, T. W. Mak, and P. S. Ohashi. 1994. Positive and negative thymocyte selection induced by different concentrations of a single peptide. Science 263:1615.
    • (1994) Science , vol.263 , pp. 1615
    • Sebzda, E.1    Wallace, V.A.2    Mayer, J.3    Yeung, R.S.4    Mak, T.W.5    Ohashi, P.S.6
  • 7
    • 0029063148 scopus 로고
    • Kinetic proofreading in T-cell receptor signal transduction
    • McKeithan, T. W. 1995. Kinetic proofreading in T-cell receptor signal transduction. Proc. Natl. Acad. Sci. USA 92:5042.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 5042
    • McKeithan, T.W.1
  • 8
    • 0036898764 scopus 로고    scopus 로고
    • A temporal and spatial summation model for T-cell activation: Signal integration and antigen decoding
    • Rachmilewitz, J., and A. Lanzavecchia. 2002. A temporal and spatial summation model for T-cell activation: signal integration and antigen decoding. Trends Immunol. 23:592.
    • (2002) Trends Immunol. , vol.23 , pp. 592
    • Rachmilewitz, J.1    Lanzavecchia, A.2
  • 9
    • 0030979424 scopus 로고    scopus 로고
    • TCR signaling regulates thymic organization: Lessons from TCR-transgenic mice
    • Goverman, J., T. Brabb, E. S. Huseby, and A. G. Farr. 1997. TCR signaling regulates thymic organization: lessons from TCR-transgenic mice. Immunol. Today 18:204.
    • (1997) Immunol. Today , vol.18 , pp. 204
    • Goverman, J.1    Brabb, T.2    Huseby, E.S.3    Farr, A.G.4
  • 10
    • 0029966057 scopus 로고    scopus 로고
    • Essential flexibility in the T-cell recognition of antigen
    • Kersh, G. J., and P. M. Allen. 1996. Essential flexibility in the T-cell recognition of antigen. Nature 380:495.
    • (1996) Nature , vol.380 , pp. 495
    • Kersh, G.J.1    Allen, P.M.2
  • 11
    • 0032171644 scopus 로고    scopus 로고
    • A very high level of crossreactivity is an essential feature of the T-cell receptor
    • Mason, D. 1998. A very high level of crossreactivity is an essential feature of the T-cell receptor. Immunol. Today 19:395.
    • (1998) Immunol. Today , vol.19 , pp. 395
    • Mason, D.1
  • 12
    • 0033529036 scopus 로고    scopus 로고
    • T-cell development: A role for self-peptides in positive selection
    • Janeway, C. A., Jr. 1999. T-cell development: a role for self-peptides in positive selection. Curr. Biol. 9:R342.
    • (1999) Curr. Biol. , vol.9
    • Janeway Jr., C.A.1
  • 13
    • 0029835390 scopus 로고    scopus 로고
    • Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex
    • Lauter, T. M., J. DeKoning, J. S. Markowitz, D. Lo, and L. H. Glimcher. 1996. Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex. Nature 383:81.
    • (1996) Nature , vol.383 , pp. 81
    • Lauter, T.M.1    DeKoning, J.2    Markowitz, J.S.3    Lo, D.4    Glimcher, L.H.5
  • 14
    • 0035282767 scopus 로고    scopus 로고
    • Dissociation of thymic positive and negative selection in transgenic mice expressing major histocompatibility complex class I molecules exclusively on thymic cortical epithelial cells
    • Capone, M., P. Romagnoli, F. Beermann, H. R. MacDonald, and J. P. van Meerwijk. 2001. Dissociation of thymic positive and negative selection in transgenic mice expressing major histocompatibility complex class I molecules exclusively on thymic cortical epithelial cells. Blood 97:1336.
    • (2001) Blood , vol.97 , pp. 1336
    • Capone, M.1    Romagnoli, P.2    Beermann, F.3    MacDonald, H.R.4    Van Meerwijk, J.P.5
  • 15
    • 0031058466 scopus 로고    scopus 로고
    • Targeted expression of major histocompatibility complex (MHC) class II molecules demonstrates that dendritic cells can induce negative but not positive selection of thymocytes in vivo
    • Brocker, T., M. Riedinger, and K. Karjalainen. 1997. Targeted expression of major histocompatibility complex (MHC) class II molecules demonstrates that dendritic cells can induce negative but not positive selection of thymocytes in vivo. J. Exp. Med. 185:541.
    • (1997) J. Exp. Med. , vol.185 , pp. 541
    • Brocker, T.1    Riedinger, M.2    Karjalainen, K.3
  • 16
    • 0029831662 scopus 로고    scopus 로고
    • Differing roles for B7 and intercellular adhesion molecule-1 in negative selection of thymocytes
    • Kishimoto, H., Z. Cai, A. Brunmark, M. R. Jackson, P. A. Peterson, and J. Sprent. 1996. Differing roles for B7 and intercellular adhesion molecule-1 in negative selection of thymocytes. J. Exp. Med. 184:531.
    • (1996) J. Exp. Med. , vol.184 , pp. 531
    • Kishimoto, H.1    Cai, Z.2    Brunmark, A.3    Jackson, M.R.4    Peterson, P.A.5    Sprent, J.6
  • 17
    • 0036644686 scopus 로고    scopus 로고
    • Promiscuous gene expression and central T-cell tolerance: More than meets the eye
    • Kyewski, B., J. Derbinski, J. Gotter, and L. Klein. 2002. Promiscuous gene expression and central T-cell tolerance: more than meets the eye. Trends Immunol. 23:364.
    • (2002) Trends Immunol. , vol.23 , pp. 364
    • Kyewski, B.1    Derbinski, J.2    Gotter, J.3    Klein, L.4
  • 18
    • 0029844638 scopus 로고    scopus 로고
    • Differential expression of CLIP:MHC class II and conventional endogenous peptide:MHC class II complexes by thymic epithelial cells and peripheral antigen-presenting cells
    • Farr, A., P. C. DeRoos, S. Eastman, and A. Y. Rudensky. 1996. Differential expression of CLIP:MHC class II and conventional endogenous peptide:MHC class II complexes by thymic epithelial cells and peripheral antigen-presenting cells. Eur. J. Immunol. 26:3185.
    • (1996) Eur. J. Immunol. , vol.26 , pp. 3185
    • Farr, A.1    DeRoos, P.C.2    Eastman, S.3    Rudensky, A.Y.4
  • 19
    • 0037141021 scopus 로고    scopus 로고
    • + T cell selection independently of its effect on invariant chain: A role in the generation of positively selecting peptide ligands
    • + T cell selection independently of its effect on invariant chain: a role in the generation of positively selecting peptide ligands. J. Exp. Med. 195:1349.
    • (2002) J. Exp. Med. , vol.195 , pp. 1349
    • Honey, K.1    Nakagawa, T.2    Peters, C.3    Rudensky, A.4
  • 20
    • 0030800996 scopus 로고    scopus 로고
    • Piecing together the thymic puzzle
    • Anderson, G., and E. Jenkinson. 1997. Piecing together the thymic puzzle. Immunol. Today 18:363.
    • (1997) Immunol. Today , vol.18 , pp. 363
    • Anderson, G.1    Jenkinson, E.2
  • 22
    • 0029855923 scopus 로고    scopus 로고
    • Tuning of activation thresholds explains flexibility in the selection and development of T cells in the thymus
    • Grossman, Z., and A. Singer. 1996. Tuning of activation thresholds explains flexibility in the selection and development of T cells in the thymus. Proc. Natl. Acad. Sci. USA 93:14747.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 14747
    • Grossman, Z.1    Singer, A.2
  • 23
    • 0032968708 scopus 로고    scopus 로고
    • The dynamics of T cell receptor signaling: Complex orchestration and the key roles of tempo and cooperation
    • Germain, R. N., and I. Stefanova. 1999. The dynamics of T cell receptor signaling: complex orchestration and the key roles of tempo and cooperation. Annu. Rev. Immunol. 17:467.
    • (1999) Annu. Rev. Immunol. , vol.17 , pp. 467
    • Germain, R.N.1    Stefanova, I.2
  • 25
    • 0033981410 scopus 로고    scopus 로고
    • Deriving quantitative constraints on T cell selection front data on the mature T cell repertoire
    • Detours, V., R. Mehr, and A. S. Perelson. 2000. Deriving quantitative constraints on T cell selection front data on the mature T cell repertoire. J. Immunol. 164:121.
    • (2000) J. Immunol. , vol.164 , pp. 121
    • Detours, V.1    Mehr, R.2    Perelson, A.S.3
  • 26
    • 0035925931 scopus 로고    scopus 로고
    • A reliable and safe T cell repertoire based on low-affinity T cell receptors
    • Van Den Berg, H. A., D. A. Rand, and N. J. Burroughs. 2001. A reliable and safe T cell repertoire based on low-affinity T cell receptors. J. Theor. Biol. 209:465.
    • (2001) J. Theor. Biol. , vol.209 , pp. 465
    • Van Den Berg, H.A.1    Rand, D.A.2    Burroughs, N.J.3
  • 27
    • 0033666867 scopus 로고    scopus 로고
    • ITAM multiplicity and thymocyte selection: How low can you go?
    • Love, P. E., and E. W. Shores. 2000. ITAM multiplicity and thymocyte selection: how low can you go? Immunity 12:591.
    • (2000) Immunity , vol.12 , pp. 591
    • Love, P.E.1    Shores, E.W.2
  • 31
    • 0025933951 scopus 로고
    • Kinetics and efficacy of positive selection in the thymus of normal and T cell receptor transgenic mice
    • Huesmann, M., B. Scott, P. Kisielow, and H. von Boehmer. 1991. Kinetics and efficacy of positive selection in the thymus of normal and T cell receptor transgenic mice. Cell 66:533.
    • (1991) Cell , vol.66 , pp. 533
    • Huesmann, M.1    Scott, B.2    Kisielow, P.3    Von Boehmer, H.4
  • 32
    • 0032445491 scopus 로고    scopus 로고
    • CD5 expression is developmentally regulated by T cell receptor (TCR) signals and TCR avidity
    • Azzam, H. S., A. Grinberg, K. Lui, H. Shen, E. W. Shores, and P. E. Love. 1998. CD5 expression is developmentally regulated by T cell receptor (TCR) signals and TCR avidity. J. Exp. Med. 188:2301.
    • (1998) J. Exp. Med. , vol.188 , pp. 2301
    • Azzam, H.S.1    Grinberg, A.2    Lui, K.3    Shen, H.4    Shores, E.W.5    Love, P.E.6
  • 33
    • 0028054017 scopus 로고
    • T-cell apoptosis detected in situ during positive and negative selection in the thymus
    • Surh, C. D., and J. Sprent. 1994. T-cell apoptosis detected in situ during positive and negative selection in the thymus. Nature 372:100.
    • (1994) Nature , vol.372 , pp. 100
    • Surh, C.D.1    Sprent, J.2
  • 34
    • 0030058657 scopus 로고    scopus 로고
    • The repertoire of T cells shaped by a single MHC/peptide ligand
    • Ignatowicz, L., J. Kappler, and P. Marrack. 1996. The repertoire of T cells shaped by a single MHC/peptide ligand. Cell 84:521.
    • (1996) Cell , vol.84 , pp. 521
    • Ignatowicz, L.1    Kappler, J.2    Marrack, P.3
  • 37
    • 0030064106 scopus 로고    scopus 로고
    • Antigen receptor "capacity" and the sensitivity of self-tolerance
    • Nemazee, D. 1996. Antigen receptor "capacity" and the sensitivity of self-tolerance. J. Immunol. Today 17:25.
    • (1996) J. Immunol. Today , vol.17 , pp. 25
    • Nemazee, D.1
  • 38
    • 0032780361 scopus 로고    scopus 로고
    • A minimal level of MHC class II expression is sufficient to abrogate autoreactivity
    • de Bont, E. S., C. R. Reilly, D. Lo, L. H. Glimcher, and T. M. Laufer. 1999. A minimal level of MHC class II expression is sufficient to abrogate autoreactivity. Int. Immunol. 11:1295.
    • (1999) Int. Immunol. , vol.11 , pp. 1295
    • De Bont, E.S.1    Reilly, C.R.2    Lo, D.3    Glimcher, L.H.4    Laufer, T.M.5
  • 39
    • 0035912837 scopus 로고    scopus 로고
    • Positive selection of an MHC class-I restricted TCR in the absence of classical MHC class I molecules
    • Maurice, M. M., D. S. Gould, J. Carroll, Y. Vugmeyster, and H. L. Ploegh. 2001. Positive selection of an MHC class-I restricted TCR in the absence of classical MHC class I molecules. Proc. Natl. Acad. Sci. USA 98:7437.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 7437
    • Maurice, M.M.1    Gould, D.S.2    Carroll, J.3    Vugmeyster, Y.4    Ploegh, H.L.5
  • 41
    • 0030790791 scopus 로고    scopus 로고
    • Functionality of major histocompatibility complex class II molecules in mice doubly deficient for invariant chain and H-2M complexes
    • Tourne, S., T. Miyazaki, P. Wolf, H. Ploegh, C. Benoist, and D. Mathis. 1997. Functionality of major histocompatibility complex class II molecules in mice doubly deficient for invariant chain and H-2M complexes. Proc. Natl. Acad. Sci. USA 94:9255.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 9255
    • Tourne, S.1    Miyazaki, T.2    Wolf, P.3    Ploegh, H.4    Benoist, C.5    Mathis, D.6
  • 42
    • 0032943540 scopus 로고    scopus 로고
    • Requirement for diverse, low-abundance peptides in positive selection of T cells
    • Barton, G. M., and A. Y. Rudensky. 1999. Requirement for diverse, low-abundance peptides in positive selection of T cells. Science 283:67.
    • (1999) Science , vol.283 , pp. 67
    • Barton, G.M.1    Rudensky, A.Y.2
  • 44
    • 0035927093 scopus 로고    scopus 로고
    • Dynamic tuning of T cell reactivity by self-peptide-major histocompatibility complex ligands
    • Wong, P., G. M. Barton, K. A. Forbush, and A. Y. Rudensky. 2001. Dynamic tuning of T cell reactivity by self-peptide-major histocompatibility complex ligands. J. Exp. Med. 193:1179.
    • (2001) J. Exp. Med. , vol.193 , pp. 1179
    • Wong, P.1    Barton, G.M.2    Forbush, K.A.3    Rudensky, A.Y.4
  • 47
    • 0026801063 scopus 로고
    • Why is clonal deletion of neonatal thymocytes defective?
    • Signorelli, K., C. Benoist, and D. Mathis. 1992. Why is clonal deletion of neonatal thymocytes defective? Eur. J. Immunol. 22:2487.
    • (1992) Eur. J. Immunol. , vol.22 , pp. 2487
    • Signorelli, K.1    Benoist, C.2    Mathis, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.