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Volumn 30, Issue 10, 2000, Pages 2908-2917

Sequence analysis of light chain genes from human intestinal plasma cells demonstrates that lambda genes are almost all in-frame and highly mutated and most kappa genes are highly mutated when in-frame and minimally mutated when out-of-frame

Author keywords

Human; Immunoglobulin gene; Mucosa; Plasma cell

Indexed keywords

IMMUNOGLOBULIN A; IMMUNOGLOBULIN LIGHT CHAIN; IMMUNOGLOBULIN M;

EID: 0033793199     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200010)30:10<2908::AID-IMMU2908>3.0.CO;2-E     Document Type: Article
Times cited : (6)

References (38)
  • 1
    • 0020534965 scopus 로고
    • Somatic generation of antibody diversity
    • (1983) Nature , vol.302 , pp. 575-581
    • Tonegawa, S.1
  • 4
    • 0018890794 scopus 로고
    • Mouse pre-B cells synthesize and secrete μ heavy chains but not light chains
    • (1980) Cell , vol.19 , pp. 617-625
    • Levitt, D.1    Cooper, M.D.2
  • 6
    • 0027216295 scopus 로고
    • Unusual patterns of immunoglobulin gene rearrangement and expression during human B cell ontogeny: Human B cells can simultaneously express cell surface κ and λ light chains
    • (1993) J. Exp. Med. , vol.178 , pp. 139-149
    • Pauza, M.E.1    Rehmann, J.A.2    LeBien, T.W.3
  • 11
    • 0030006070 scopus 로고    scopus 로고
    • Clonal selection and learning in the antibody system
    • (1996) Nature , vol.381 , pp. 751-758
    • Rajewsky, K.1
  • 15
    • 0032585719 scopus 로고    scopus 로고
    • Somatic hypermutation of VκJκ rearrangements: Targeting of RGYW motifs on both DNA strands and preferential selection of mutated codons within RGYW motifs
    • (1999) Eur. J. Immunol. , vol.29 , pp. 4011-4021
    • Foster, J.1    Dorner, T.2    Lipsky, P.E.3
  • 28
    • 0030063726 scopus 로고    scopus 로고
    • Somatic hypermutation of immunoglobulin genes is linked to transcription initiation
    • (1996) Immunity , vol.4 , pp. 57-65
    • Peters, A.1    Storb, U.2
  • 32
    • 0025630537 scopus 로고
    • Boundaries of somatic mutation in rearranged immunoglobulin genes: 5' Boundary is near the promoter, and 3' boundary is ~ 1 kb from V(D) J gene
    • (1990) J. Exp. Med. , vol.172 , pp. 1717-1727
    • Lebecque, S.G.1    Gearhart, P.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.