The VλJλ repertoire in human fetal spleen: Evidence for positive selection and extensive receptor editing

Journal of Immunology

Volumn 165, Issue 11, 2000, Pages 6322-6333

  Lee, J ^a   Monson, N L ^a   Lipsky, P E ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN KAPPA CHAIN; IMMUNOGLOBULIN M; RECEPTOR;

ARTICLE; FETUS; GENE; GENE REARRANGEMENT; HUMAN; HUMAN CELL; HUMAN TISSUE; PRIORITY JOURNAL; SPLEEN;

EID: 0034541166     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.165.11.6322     Document Type: Article

References (55)

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2. The B-cell antigen receptor complex and co-receptors
3. Positive and negative selection events during B lymphopoiesis
4. The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver
5. Co-receptors orb lymphocytes
6. Heavy chain directed B cell maturation: Continuous clonal selection beginning at the pre-B cell stage
7. Sequence homologies, N sequence insertion and J(H) gene utilization in V(H)DJ(H) joining: Implications for the joining mechanism and the ontogenic timing of LyI.B cell and B-CLL progenitor generation
8. Preferential utilization of the most J(H) proximal V(H) gene segments in pre-B cell lines
9. Developmentally controlled expression of immunoglobulin V(H) genes
10. The human V(H) repertoire: A restricted set of V(H) genes may be the target of immune regulation
11. V(H)-gene representation in autoantibodies reflects the normal B cell repertoire
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13. High frequency representation of a single V(H) gene in the expressed human B cell repertoire
14. Representation of rearranged V(H) gene segments in the human adult antibody repertoire
15. Evidence for the overexpression of the V(H)4-34(V(H)4.21) Ig gene segment in the normal human adult peripheral blood B cell repertoire
16. The human heavy chain Ig V region gene repertoire is biased at all stages of B cell ontogeny, including early pre-B cells
17. Predominance of V(H)-D-J(H) junctions occurring at sites of short sequence homology results in limited junctional diversity in neonatal antibodies
18. V-region directed selection in differentiating B lymphocytes
19. Most peripheral B cells in mice are ligand selected
20. Restricted immunoglobulin junctional diversity in neonatal B cells results from developmental selection rather than homology-based V(D)J joining
21. B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals
22. Positive selection of natural autoreactive B cells
23. Molecular mechanism and selection influence in the generation of human VλJλ repertoire
24. Analysis of the heavy chain repertoire of human peripheral B cells using single-cell polymerase chain reaction
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27. + adult B cells are oligoclonal
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44. Biased immunoglobulin variable region gene expression by Ly-1 B cells due to clonal selection
45. Frequent occurrence of identical heavy and light chain 1g rearrangements
46. Does positive selection determine the B cell repertoire?
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48. + B cells
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51. Light chain replacement: A new model for antibody gene rearrangement
52. - bone marrow B cells in vitro
53. Negative selection of immature B cells by receptor editing or deletion is determined by site of antigen encounter
54. Continued RAG expression in late stages of B cell development and no apparent re-induction after immunization