Proinflammatory role of leptin in experimental colitis in rats benefit of cholecystokinin-B antagonist and β3-agonist

Life Sciences

Volumn 69, Issue 5, 2001, Pages 567-580

  Barbier, Maryse ^a   Attoub, Samir ^b,c   Joubert, Madeleine ^a   Bado, André ^b   Laboisse, Christian ^a   Cherbut, Christine ^a   Galmiche, Jean Paul ^a  

^a HÔTEL DIEU   (France)

^b BICHAT HOSPITAL   (France)

^c HÔPITAL SAINT ANTOINE   (France)

Author keywords

BRL37344; Experimental rat intestinal inflammation; Inflammatory bowel disease; Leptin; YM022

Indexed keywords

1 [2,3 DIHYDRO 1 (2' METHYLPHENACYL) 2 OXO 5 PHENYL 1H 1,4 BENZODIAZEPIN 3 YL] 3 (3 METHYLPHENYL)UREA; 4 [2 [[2 (3 CHLOROPHENYL) 2 HYDROXYETHYL]AMINO]PROPYL]PHENOXYACETIC ACID; BETA 3 ADRENERGIC RECEPTOR STIMULATING AGENT; CHOLECYSTOKININ B RECEPTOR ANTAGONIST; LEPTIN; MYELOPEROXIDASE; TRINITROBENZENESULFONIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COLITIS; COLON; CONTROLLED STUDY; DISEASE COURSE; DISEASE SEVERITY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; MALE; NONHUMAN; PATHOGENESIS; PROTEIN SECRETION; RAT;

ADRENERGIC BETA-AGONISTS; ANALYSIS OF VARIANCE; ANIMALS; BENZODIAZEPINES; COLITIS; DISEASE MODELS, ANIMAL; ETHANOLAMINES; HORMONE ANTAGONISTS; INFLAMMATORY BOWEL DISEASES; LEPTIN; MALE; RATS; RATS, WISTAR; RECEPTOR, CHOLECYSTOKININ B; RECEPTORS, ADRENERGIC, BETA-3; RECEPTORS, CHOLECYSTOKININ; SEVERITY OF ILLNESS INDEX;

EID: 0035933377     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(01)01148-1     Document Type: Article

References (47)

1. Positional cloning of the mouse ob gene and its human homologue
2. Recombinant mouse OB protein: Evidence for a peripheral signal linking adiposity and central neural networks
3. Weight-reducing effects of the plasma protein encoded by the obese gene
4. Nonadipose tissue production of leptin: Leptin as a novel placenta-derived hormone in humans
5. OB-Rb gene transfer to leptin-resistant islets reverses diabetogenic phenotype
6. The stomach is a source of leptin
7. Early onset of reproductive function in normal female mice treated with leptin
8. Leptin inhibits bone formation through a hypothalamic relay: A central control of bone mass
9. Novel B219/OB receptor isoforms: Possible role of leptin in hematopoiesis and reproduction
10. Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells
11. Leptin regulates proinflammatory immune responses
12. Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression
13. Leptin, the product of ob gene, promotes angiogenesis
14. Biological action of leptin as an angiogenic factor
15. Identification and expression cloning of a leptin receptor, OB-R
16. Threading analysis suggests that the obese gene product may be a helical cytokine
17. Impairment of cell-mediated immunity in mutation diabetic mice (db/db)
18. Nutrition and immunity: Lessons from the past and new insights into the future
19. Cell-mediated immunity in anorexia nervosa
20. Low lymphocyte interferon-gamma production and variable proliferative response in anorexia nervosa patients
21. Human leptin stimulates proliferation and activation of human circulating monocytes
22. Elevated plasma leptin concentrations in early stages of experimental intestinal inflammation in rats
23. Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamsters
24. Multiple cytokines and acute inflammation raise mouse leptin levels: Potential role in inflammatory anorexia
25. Plasma leptin levels are increased in survivors of acute sepsis: Associated loss of diurnal rhythm in cortisol and leptin secretion
26. Interleukin 1α increases serum leptin concentrations in humans
27. Tumor necrosis factor increases serum leptin levels in humans
28. Hapten-induced model of chronic inflammation and ulceration in the rat colon
29. Antibodies to interleukin 12 abrogate established experimental colitis in mice
30. A peptide leptin antagonist reduces food intake in rats
31. Activation of β3 adrenergic receptors suppresses leptin expression and mediates a leptin-independent inhibition of food intake in mice
32. Physiological role of cholecystokinin B/gastrin receptor in leptin secretion
33. The effect of exogenous administration of Lactobacillus reuteri R2LC and oat fiber on acetic-induced colitis in the rat
34. Quantitative assay for acute intestinal inflammation based on myeloperoxidase activity
35. Leptin is an endogenous protective protein against the toxicity exerted by tumor necrosis factor
36. Leptin deficiency enhances sensitivity to endotoxin-induced lethality
37. 3-adrenergic-mediated suppression of leptin gene expression in rats
38. Isoproterenol and somatostatin decrease plasma leptin in humans: A novel mechanism regulating leptin secretion
39. Regulation of expression of ob mRNA and protein by glucocorticoids and cAMP
40. The β3-adrenergic receptor inhibits insulin-stimulated leptin secretion from isolated rat adipocytes
41. β-adrenoceptors regulate myoelectric activity in the small intestine of rats: Stimulation by β2 and inhibition by β3 subtypes
42. Beta-3 adrenergic receptor agonists cause an increase in gastrointestinal transit time in wild-type mice, but not in mice lacking the beta-3 adrenergic receptor
43. Beta 3-adrenoceptor: An update
44. Multiple sources of 1,2-diacylglycerol in isolated rat pancreatic acini stimulated by cholecystokinin. Involvement of phosphatidylinositol bisphosphate and phosphatidylcholine hydrolysis
45. Leptin-deficient (ob/ob) mice are protected from T cell-mediated hepatotoxicity: Role of tumor necrosis factor α and IL18
46. A novel therapy for colitis utilizing PPAR-γ ligands to inhibit the epithelial inflammatory response
47. Thiazolidinediones repress ob gene expression in rodents via activation of peroxisome proliferator-activated receptor γ